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Breast secretory carcinoma

MedGen UID:
87226
•Concept ID:
C0334371
•
Neoplastic Process
Synonym: Juvenile carcinoma (formerly)
SNOMED CT: Juvenile carcinoma of the breast (41919003); Secretory carcinoma of the breast (41919003)
 
Monarch Initiative: MONDO:0003208

Definition

A rare, low grade invasive adenocarcinoma of the breast characterized by the presence of cells that secrete milk-like material. Morphologically, it usually appears as a circumscribed lesion, composed of cystic spaces, tubular structures, and solid areas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast secretory carcinoma

Professional guidelines

PubMed

Canadian Consensus for Biomarker Testing and Treatment of TRK Fusion Cancer in Adults.
Bebb DG, Banerji S, Blais N, Desmeules P, Gill S, Grin A, Feilotter H, Hansen AR, Hyrcza M, Krzyzanowska M, Melosky B, Noujaim J, Purgina B, Ruether D, Simmons CE, Soulieres D, Torlakovic EE, Tsao MS
Curr Oncol 2021 Jan 15;28(1):523-548. doi: 10.3390/curroncol28010053. PMID: 33467570Free PMC Article
Genotype-Phenotype Correlations in Breast Cancer.
Marotti JD, Schnitt SJ
Surg Pathol Clin 2018 Mar;11(1):199-211. Epub 2017 Dec 15 doi: 10.1016/j.path.2017.09.008. PMID: 29413657
The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877

Recent clinical studies

Diagnosis

Secretory Carcinoma with ETV6-NTRK3 Gene Fusion and Lymph Node Metastasis in Maxillary Gingiva: A Case Report with Pathological and Molecular Correlative Studies.
Fujita J, Krishnan B, Green LK, Sandulache VC, Lai S
Ann Clin Lab Sci 2023 Sep;53(5):800-805. PMID: 37945013
Approaches to the diagnosis of secretory carcinoma of the salivary glands: a case series and review.
Hermann CR, Gama-Cuellar AG, Díaz KP, Gondak R
Gen Dent 2023 Mar-Apr;71(2):23-27. PMID: 36825969
A Parotid Gland Mammary Analogue Secretory Carcinoma in a 4-Year-Old Boy: Case Report and Literature Review.
Meng Z, Si W, Xiuli Z, Liu Y
Fetal Pediatr Pathol 2023 Apr;42(2):342-350. Epub 2022 Sep 2 doi: 10.1080/15513815.2022.2116621. PMID: 36053082
Pan-Trk immunohistochemistry reliably identifies ETV6-NTRK3 fusion in secretory carcinoma of the salivary gland.
Bell D, Ferrarotto R, Liang L, Goepfert RP, Li J, Ning J, Broaddus R, Weber RS, El-Naggar AK
Virchows Arch 2020 Feb;476(2):295-305. Epub 2019 Aug 19 doi: 10.1007/s00428-019-02640-7. PMID: 31423558
Secretory Carcinoma of the Thyroid Gland: Report of a Highly Aggressive Case Clinically Mimicking Undifferentiated Carcinoma and Review of the Literature.
Desai MA, Mehrad M, Ely KA, Bishop JA, Netterville J, Aulino JM, Lewis JS Jr
Head Neck Pathol 2019 Dec;13(4):562-572. Epub 2018 Dec 18 doi: 10.1007/s12105-018-0995-2. PMID: 30564997Free PMC Article

Therapy

Unlocking pathology archives for molecular genetic studies: a reliable method to generate probes for chromogenic and fluorescent in situ hybridization.
Lambros MB, Simpson PT, Jones C, Natrajan R, Westbury C, Steele D, Savage K, Mackay A, Schmitt FC, Ashworth A, Reis-Filho JS
Lab Invest 2006 Apr;86(4):398-408. doi: 10.1038/labinvest.3700390. PMID: 16446704

Prognosis

Secretory Carcinoma of the Thyroid Gland: Report of a Highly Aggressive Case Clinically Mimicking Undifferentiated Carcinoma and Review of the Literature.
Desai MA, Mehrad M, Ely KA, Bishop JA, Netterville J, Aulino JM, Lewis JS Jr
Head Neck Pathol 2019 Dec;13(4):562-572. Epub 2018 Dec 18 doi: 10.1007/s12105-018-0995-2. PMID: 30564997Free PMC Article
Mammary Analogue Secretory Carcinoma of Minor Salivary Glands: A Rare Case Series and Review of the Literature.
Roy S, Saluja K, Zhu H, Zhao B
Ann Clin Lab Sci 2018 Jan;48(1):94-99. PMID: 29531003

Supplemental Content

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