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Abnormal labia morphology

MedGen UID:
871394
•Concept ID:
C4025892
•
Anatomical Abnormality
Synonym: Abnormality of the labia
 
HPO: HP:0000058

Definition

An anomaly of the labia, the externally visible portions of the vulva. [from HPO]

Professional guidelines

PubMed

Clinicopathologic Diagnostic Criteria for Vulvar Lichen Planus.
Day T, Wilkinson E, Rowan D, Scurry J; ISSVD Difficult Pathologic Diagnoses Committee*
J Low Genit Tract Dis 2020 Jul;24(3):317-329. doi: 10.1097/LGT.0000000000000532. PMID: 32205763
Relationship between phenotype and genotype of 102 Chinese newborns with Prader-Willi syndrome.
Ge MM, Gao YY, Wu BB, Yan K, Qin Q, Wang H, Zhou W, Yang L
Mol Biol Rep 2019 Oct;46(5):4717-4724. Epub 2019 Jul 3 doi: 10.1007/s11033-019-04916-2. PMID: 31270759
Meier-Gorlin syndrome genotype-phenotype studies: 35 individuals with pre-replication complex gene mutations and 10 without molecular diagnosis.
de Munnik SA, Bicknell LS, Aftimos S, Al-Aama JY, van Bever Y, Bober MB, Clayton-Smith J, Edrees AY, Feingold M, Fryer A, van Hagen JM, Hennekam RC, Jansweijer MC, Johnson D, Kant SG, Opitz JM, Ramadevi AR, Reardon W, Ross A, Sarda P, Schrander-Stumpel CT, Schoots J, Temple IK, Terhal PA, Toutain A, Wise CA, Wright M, Skidmore DL, Samuels ME, Hoefsloot LH, Knoers NV, Brunner HG, Jackson AP, Bongers EM
Eur J Hum Genet 2012 Jun;20(6):598-606. Epub 2012 Feb 15 doi: 10.1038/ejhg.2011.269. PMID: 22333897Free PMC Article

Recent clinical studies

Etiology

A Study of Adolescent Female Genitalia: What is Normal?
Brodie K, Alaniz V, Buyers E, Caldwell B, Grantham E, Sheeder J, Wilcox D, Huguelet P
J Pediatr Adolesc Gynecol 2019 Feb;32(1):27-31. Epub 2018 Sep 20 doi: 10.1016/j.jpag.2018.09.007. PMID: 30244193
Anatomy and Aesthetics of the Labia Minora: The Ideal Vulva?
Clerico C, Lari A, Mojallal A, Boucher F
Aesthetic Plast Surg 2017 Jun;41(3):714-719. Epub 2017 Mar 10 doi: 10.1007/s00266-017-0831-1. PMID: 28314908
Meier-Gorlin syndrome.
de Munnik SA, Hoefsloot EH, Roukema J, Schoots J, Knoers NV, Brunner HG, Jackson AP, Bongers EM
Orphanet J Rare Dis 2015 Sep 17;10:114. doi: 10.1186/s13023-015-0322-x. PMID: 26381604Free PMC Article
Female epispadias.
Shetty MV, Bhaskaran A, Sen TK
Afr J Paediatr Surg 2011 May-Aug;8(2):215-7. doi: 10.4103/0189-6725.86066. PMID: 22005369
Vulval disease in pre-pubertal girls.
Fischer GO
Australas J Dermatol 2001 Nov;42(4):225-34; quiz, 235-6. doi: 10.1046/j.1440-0960.2001.00526.x. PMID: 11903151

Diagnosis

Anatomy and Aesthetics of the Labia Minora: The Ideal Vulva?
Clerico C, Lari A, Mojallal A, Boucher F
Aesthetic Plast Surg 2017 Jun;41(3):714-719. Epub 2017 Mar 10 doi: 10.1007/s00266-017-0831-1. PMID: 28314908
Meier-Gorlin syndrome.
de Munnik SA, Hoefsloot EH, Roukema J, Schoots J, Knoers NV, Brunner HG, Jackson AP, Bongers EM
Orphanet J Rare Dis 2015 Sep 17;10:114. doi: 10.1186/s13023-015-0322-x. PMID: 26381604Free PMC Article
Female epispadias.
Shetty MV, Bhaskaran A, Sen TK
Afr J Paediatr Surg 2011 May-Aug;8(2):215-7. doi: 10.4103/0189-6725.86066. PMID: 22005369
Hypertrophic labia minora.
Reddy J, Laufer MR
J Pediatr Adolesc Gynecol 2010 Feb;23(1):3-6. Epub 2009 Jul 15 doi: 10.1016/j.jpag.2009.01.071. PMID: 19608442
Mixed gonadal dysgenesis.
Zäh W, Kalderon AE, Tucci JR
Acta Endocrinol Suppl (Copenh) 1975;197:1-39. PMID: 1094776

Therapy

Molecular subtype and growth hormone effects on dysmorphology in Prader-Willi syndrome.
Oldzej J, Manazir J, Gold JA, Mahmoud R, Osann K, Flodman P, Cassidy SB, Kimonis VE
Am J Med Genet A 2020 Jan;182(1):169-175. Epub 2019 Nov 29 doi: 10.1002/ajmg.a.61408. PMID: 31782896
Vaginoplasty and creating labia minora in children with disorders of sex development.
Acimi S, Bessahraoui M, Acimi MA, Abderrahmane N, Debbous L
Int Urol Nephrol 2019 Mar;51(3):395-399. Epub 2018 Dec 13 doi: 10.1007/s11255-018-2058-8. PMID: 30547360
Unilateral hypertrophy of the labia minora: A case series.
Boulos S, Rubin AI, Yan AC, McMahon PJ, Perman MJ
Pediatr Dermatol 2018 May;35(3):e198-e199. Epub 2018 Mar 24 doi: 10.1111/pde.13467. PMID: 29573456
Sclerotherapy of peripheral low-flow vascular malformations: technical aspects and mid-term clinical outcome.
Giurazza F, Corvino F, Cangiano G, Amodio F, Cavaglià E, Silvestre M, De Magistris G, Tecame S, Niola R
Radiol Med 2018 Jun;123(6):474-480. Epub 2018 Feb 23 doi: 10.1007/s11547-018-0869-4. PMID: 29476439
LUMBAR syndrome: A case manifesting as cutaneous infantile hemangiomas of the lower extremity, perineum and gluteal region, and a review of published work.
Yu X, Zhang J, Wu Z, Liu M, Chen R, Gu Y, Li M, Yao Z
J Dermatol 2017 Jul;44(7):808-812. Epub 2017 Feb 13 doi: 10.1111/1346-8138.13763. PMID: 28191659

Prognosis

Labia majora labioplasty in HIV-related vaginal lipodystrophy: technique description and literature review.
Lapalorcia LM, Podda S, Campiglio G, Cordellini M
Aesthetic Plast Surg 2013 Aug;37(4):711-4. Epub 2013 Jun 15 doi: 10.1007/s00266-013-0159-4. PMID: 23771244
Female epispadias.
Shetty MV, Bhaskaran A, Sen TK
Afr J Paediatr Surg 2011 May-Aug;8(2):215-7. doi: 10.4103/0189-6725.86066. PMID: 22005369
Two sisters resembling Gorlin-Chaudhry-Moss syndrome.
Aravena T, Passalacqua C, Pizarro O, Aracena M
Am J Med Genet A 2011 Oct;155A(10):2552-5. Epub 2011 Sep 9 doi: 10.1002/ajmg.a.34204. PMID: 21910232
Resection of perihilar biliary schwannoma.
Panait L, Learn P, Dimaio C, Klimstra D, Do KG, Schwarz T, D'Angelica M, DeMatteo R, Kingham P, Allen P, Fong Y, Jarnagin WR
Surg Oncol 2011 Dec;20(4):e157-9. Epub 2011 Jun 12 doi: 10.1016/j.suronc.2011.05.002. PMID: 21665464
Screening of genital anomalies in newborns and infants in two egyptian governorates.
Mazen I, El-Ruby M, Kamal R, El-Nekhely I, El-Ghandour M, Tantawy S, El-Gammal M
Horm Res Paediatr 2010;73(6):438-42. Epub 2010 Apr 20 doi: 10.1159/000313588. PMID: 20407231

Clinical prediction guides

Labia minora reduction techniques: a comprehensive literature review.
Oranges CM, Sisti A, Sisti G
Aesthet Surg J 2015 May;35(4):419-31. doi: 10.1093/asj/sjv023. PMID: 25908699
Normative values of skin temperature and thermal sensory thresholds in the pudendal nerve territory.
Beco J, Seidel L, Albert A
Neurourol Urodyn 2015 Aug;34(6):571-7. Epub 2014 Apr 30 doi: 10.1002/nau.22614. PMID: 24782126
A comprehensive newborn exam: part II. Skin, trunk, extremities, neurologic.
Lewis ML
Am Fam Physician 2014 Sep 1;90(5):297-302. PMID: 25251089
Labia majora labioplasty in HIV-related vaginal lipodystrophy: technique description and literature review.
Lapalorcia LM, Podda S, Campiglio G, Cordellini M
Aesthetic Plast Surg 2013 Aug;37(4):711-4. Epub 2013 Jun 15 doi: 10.1007/s00266-013-0159-4. PMID: 23771244
Opitz trigonocephaly syndrome.
Haaf T, Hofmann R, Schmid M
Am J Med Genet 1991 Sep 15;40(4):444-6. doi: 10.1002/ajmg.1320400413. PMID: 1746609

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