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Flattened knee epiphyses

MedGen UID:
870696
Concept ID:
C4025150
Anatomical Abnormality
Synonym: Flattened end part of knee bone
 
HPO: HP:0005715

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFlattened knee epiphyses

Conditions with this feature

Epiphyseal dysplasia, multiple, 2
MedGen UID:
333092
Concept ID:
C1838429
Disease or Syndrome
Autosomal dominant multiple epiphyseal dysplasia (MED) presents in early childhood, usually with pain in the hips and/or knees after exercise. Affected children complain of fatigue with long-distance walking. Waddling gait may be present. Adult height is either in the lower range of normal or mildly shortened. The limbs are relatively short in comparison to the trunk. Pain and joint deformity progress, resulting in early-onset osteoarthritis, particularly of the large weight-bearing joints.
Spondyloepiphyseal dysplasia tarda with characteristic facies
MedGen UID:
325071
Concept ID:
C1838653
Disease or Syndrome

Recent clinical studies

Etiology

Dare DM, Fabricant PD, McCarthy MM, Rebolledo BJ, Green DW, Cordasco FA, Jones KJ
Am J Sports Med 2015 Jul;43(7):1632-9. doi: 10.1177/0363546515579182. PMID: 26129958
Atanda A Jr, Shah SA, O'Brien K
Am Fam Physician 2011 Feb 1;83(3):285-91. PMID: 21302869
Kwee TC, Beemer FA, Beek FJ, Nievelstein RA
Pediatr Radiol 2006 Jan;36(1):8-15. Epub 2005 Oct 25 doi: 10.1007/s00247-005-0011-3. PMID: 16249889
Thompson GH, Carter JR, Smith CW
J Pediatr Orthop 1984 Mar;4(2):185-94. doi: 10.1097/01241398-198403000-00007. PMID: 6699160

Diagnosis

Dare DM, Fabricant PD, McCarthy MM, Rebolledo BJ, Green DW, Cordasco FA, Jones KJ
Am J Sports Med 2015 Jul;43(7):1632-9. doi: 10.1177/0363546515579182. PMID: 26129958
Atanda A Jr, Shah SA, O'Brien K
Am Fam Physician 2011 Feb 1;83(3):285-91. PMID: 21302869
Kwee TC, Beemer FA, Beek FJ, Nievelstein RA
Pediatr Radiol 2006 Jan;36(1):8-15. Epub 2005 Oct 25 doi: 10.1007/s00247-005-0011-3. PMID: 16249889
Schlesinger AE, Poznanski AK, Pudlowski RM, Millar EA
Radiology 1986 May;159(2):515-9. doi: 10.1148/radiology.159.2.3961186. PMID: 3961186
Thompson GH, Carter JR, Smith CW
J Pediatr Orthop 1984 Mar;4(2):185-94. doi: 10.1097/01241398-198403000-00007. PMID: 6699160

Therapy

Sharma R, Anand R, Chandra J, Seth A, Pemde H, Singh V
Pediatr Blood Cancer 2013 Dec;60(12):1957-62. Epub 2013 Aug 13 doi: 10.1002/pbc.24678. PMID: 23940095

Prognosis

Dare DM, Fabricant PD, McCarthy MM, Rebolledo BJ, Green DW, Cordasco FA, Jones KJ
Am J Sports Med 2015 Jul;43(7):1632-9. doi: 10.1177/0363546515579182. PMID: 26129958
Thompson GH, Carter JR, Smith CW
J Pediatr Orthop 1984 Mar;4(2):185-94. doi: 10.1097/01241398-198403000-00007. PMID: 6699160

Clinical prediction guides

Zhou T, Yang X, Chen Z, Zhou Y, Cao X, Zhao C, Zhao J
J Clin Lab Anal 2021 Apr;35(4):e23728. Epub 2021 Feb 16 doi: 10.1002/jcla.23728. PMID: 33590889Free PMC Article
Ozols D, Blums K, Krumins M, Butnere MM, Nefjodovs V
Microsurgery 2021 Mar;41(3):280-285. Epub 2020 Dec 8 doi: 10.1002/micr.30691. PMID: 33289931
Dare DM, Fabricant PD, McCarthy MM, Rebolledo BJ, Green DW, Cordasco FA, Jones KJ
Am J Sports Med 2015 Jul;43(7):1632-9. doi: 10.1177/0363546515579182. PMID: 26129958
Tüysüz B, Yılmaz S, Erener-Ercan T, Bilguvar K, Günel M
Pediatr Radiol 2015 Apr;45(5):771-6. Epub 2014 Sep 26 doi: 10.1007/s00247-014-3159-x. PMID: 25256152
Holderbaum D, Malvitz T, Ciesielski CJ, Carson D, Corr MP, Moskowitz RW
Arthritis Rheum 2005 Oct;52(10):3300-4. doi: 10.1002/art.21352. PMID: 16200603

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