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Abnormality of the clivus

MedGen UID:
869365
•Concept ID:
C4023791
•
Anatomical Abnormality
HPO: HP:0010558

Definition

An abnormality of the clivus, which is the inclined bony region of the posterior cranial fossa located between the sella turcica and the foramen magnum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of the clivus

Professional guidelines

PubMed

Prenatal diagnosis and postnatal outcome of closed spinal dysraphism.
Bedei I, Krispin E, Sanz Cortes M, Lombaard H, Zemet R, Whitehead WE, Belfort MA, Huisman TAGM
Prenat Diagn 2024 Apr;44(4):499-510. Epub 2023 Nov 27 doi: 10.1002/pd.6454. PMID: 38013494
Prenatal diagnosis of vermian cyst: a new type of posterior fossa cyst.
Chanclud J, Valence S, Perre SV, Guilbaud L, Moutard ML, Jouannic JM, Ducou Le Pointe H, Blondiaux E, Garel C
Pediatr Radiol 2023 Mar;53(3):461-469. Epub 2022 Oct 24 doi: 10.1007/s00247-022-05531-3. PMID: 36274068
Prenatal diagnosis of spina bifida: from intracranial translucency to intrauterine surgery.
Sepulveda W, Wong AE, Sepulveda F, Alcalde JL, Devoto JC, Otayza F
Childs Nerv Syst 2017 Jul;33(7):1083-1099. Epub 2017 Jun 7 doi: 10.1007/s00381-017-3445-7. PMID: 28593553

Recent clinical studies

Etiology

Refining the Neuroimaging Definition of the Dandy-Walker Phenotype.
Whitehead MT, Barkovich MJ, Sidpra J, Alves CA, Mirsky DM, Öztekin Ö, Bhattacharya D, Lucato LT, Sudhakar S, Taranath A, Andronikou S, Prabhu SP, Aldinger KA, Haldipur P, Millen KJ, Barkovich AJ, Boltshauser E, Dobyns WB, Mankad K
AJNR Am J Neuroradiol 2022 Oct;43(10):1488-1493. Epub 2022 Sep 22 doi: 10.3174/ajnr.A7659. PMID: 36137655Free PMC Article
Surgical Treatment of Chiari I Malformation.
Rocque BG, Oakes WJ
Neurosurg Clin N Am 2015 Oct;26(4):527-31. Epub 2015 Aug 4 doi: 10.1016/j.nec.2015.06.010. PMID: 26408062
Pathogenesis and Cerebrospinal Fluid Hydrodynamics of the Chiari I Malformation.
Buell TJ, Heiss JD, Oldfield EH
Neurosurg Clin N Am 2015 Oct;26(4):495-9. Epub 2015 Aug 4 doi: 10.1016/j.nec.2015.06.003. PMID: 26408057Free PMC Article
Congenital basis of posterior fossa anomalies.
Cotes C, Bonfante E, Lazor J, Jadhav S, Caldas M, Swischuk L, Riascos R
Neuroradiol J 2015 Jun;28(3):238-53. doi: 10.1177/1971400915576665. PMID: 26246090Free PMC Article
Congenital abnormalities of the posterior fossa.
Bosemani T, Orman G, Boltshauser E, Tekes A, Huisman TA, Poretti A
Radiographics 2015 Jan-Feb;35(1):200-20. doi: 10.1148/rg.351140038. PMID: 25590398

Diagnosis

Refining the Neuroimaging Definition of the Dandy-Walker Phenotype.
Whitehead MT, Barkovich MJ, Sidpra J, Alves CA, Mirsky DM, Öztekin Ö, Bhattacharya D, Lucato LT, Sudhakar S, Taranath A, Andronikou S, Prabhu SP, Aldinger KA, Haldipur P, Millen KJ, Barkovich AJ, Boltshauser E, Dobyns WB, Mankad K
AJNR Am J Neuroradiol 2022 Oct;43(10):1488-1493. Epub 2022 Sep 22 doi: 10.3174/ajnr.A7659. PMID: 36137655Free PMC Article
The growth of the posterior cranial fossa in FGFR2-induced faciocraniosynostosis: A review.
Coll G, Abed Rabbo F, Jecko V, Sakka L, Di Rocco F, Delion M
Neurochirurgie 2019 Nov;65(5):221-227. Epub 2019 Sep 23 doi: 10.1016/j.neuchi.2019.09.005. PMID: 31557489
Hydrocephalus in Dandy-Walker malformation.
Spennato P, Mirone G, Nastro A, Buonocore MC, Ruggiero C, Trischitta V, Aliberti F, Cinalli G
Childs Nerv Syst 2011 Oct;27(10):1665-81. Epub 2011 Sep 17 doi: 10.1007/s00381-011-1544-4. PMID: 21928031
Posterior fossa malformations.
Shekdar K
Semin Ultrasound CT MR 2011 Jun;32(3):228-41. doi: 10.1053/j.sult.2011.02.003. PMID: 21596278
Neurocutaneous vascular syndromes.
Puttgen KB, Lin DD
Childs Nerv Syst 2010 Oct;26(10):1407-15. Epub 2010 Jun 27 doi: 10.1007/s00381-010-1201-3. PMID: 20582592

Therapy

Chiari Malformation Type 1 in Adults.
Zisakis A, Sun R, Pepper J, Tsermoulas G
Adv Tech Stand Neurosurg 2023;46:149-173. doi: 10.1007/978-3-031-28202-7_8. PMID: 37318574
Supratentorial Hemangioblastoma in Adults: A Systematic Review and Comparison of Infratentorial and Spinal Cord Locations.
Jankovic D, Vuong K, Splavski B, Rotim K, Arnautovic KI
World Neurosurg 2023 May;173:48-62. Epub 2023 Feb 22 doi: 10.1016/j.wneu.2023.02.071. PMID: 36822402
Efficacy and safety of embolization of dural arteriovenous fistulas via the ophthalmic artery.
Mayercik VA, Sussman ES, Pulli B, Dodd RL, Do HM, Telischak NA, Marks MP, Steinberg GK, Chang SD, Heit JJ
Interv Neuroradiol 2021 Jun;27(3):444-450. Epub 2020 Oct 26 doi: 10.1177/1591019920969270. PMID: 33106085Free PMC Article
The effect of posterior fossa decompression in adult Chiari malformation and basilar invagination: a systematic review and meta-analysis.
de Oliveira Sousa U, de Oliveira MF, Heringer LC, Barcelos ACES, Botelho RV
Neurosurg Rev 2018 Jan;41(1):311-321. Epub 2017 May 2 doi: 10.1007/s10143-017-0857-5. PMID: 28466256
Fusions at the craniovertebral junction.
Ahmed R, Traynelis VC, Menezes AH
Childs Nerv Syst 2008 Oct;24(10):1209-24. Epub 2008 Apr 4 doi: 10.1007/s00381-008-0607-7. PMID: 18389260

Prognosis

Functional and morphological changes in hypoplasic posterior fossa.
Bianchi F, Benato A, Frassanito P, Tamburrini G, Massimi L
Childs Nerv Syst 2021 Oct;37(10):3093-3104. Epub 2021 Jun 25 doi: 10.1007/s00381-021-05193-w. PMID: 34169386Free PMC Article
Blake's Pouch Cyst.
Society for Maternal-Fetal Medicine (SMFM), Post A, Norton ME, Monteagudo A
Am J Obstet Gynecol 2020 Dec;223(6):B47-B50. doi: 10.1016/j.ajog.2020.08.187. PMID: 33757627
Dandy-Walker Malformation.
Society for Maternal-Fetal Medicine (SMFM), Monteagudo A
Am J Obstet Gynecol 2020 Dec;223(6):B38-B41. Epub 2020 Nov 7 doi: 10.1016/j.ajog.2020.08.184. PMID: 33168220
Congenital abnormalities of the posterior fossa.
Bosemani T, Orman G, Boltshauser E, Tekes A, Huisman TA, Poretti A
Radiographics 2015 Jan-Feb;35(1):200-20. doi: 10.1148/rg.351140038. PMID: 25590398
Hydrocephalus in Dandy-Walker malformation.
Spennato P, Mirone G, Nastro A, Buonocore MC, Ruggiero C, Trischitta V, Aliberti F, Cinalli G
Childs Nerv Syst 2011 Oct;27(10):1665-81. Epub 2011 Sep 17 doi: 10.1007/s00381-011-1544-4. PMID: 21928031

Clinical prediction guides

Prenatal diagnosis and postnatal outcome of closed spinal dysraphism.
Bedei I, Krispin E, Sanz Cortes M, Lombaard H, Zemet R, Whitehead WE, Belfort MA, Huisman TAGM
Prenat Diagn 2024 Apr;44(4):499-510. Epub 2023 Nov 27 doi: 10.1002/pd.6454. PMID: 38013494
Functional and morphological changes in hypoplasic posterior fossa.
Bianchi F, Benato A, Frassanito P, Tamburrini G, Massimi L
Childs Nerv Syst 2021 Oct;37(10):3093-3104. Epub 2021 Jun 25 doi: 10.1007/s00381-021-05193-w. PMID: 34169386Free PMC Article
Comprehensive review of the mastoid foramen.
Wang C, Lockwood J, Iwanaga J, Dumont AS, Bui CJ, Tubbs RS
Neurosurg Rev 2021 Jun;44(3):1255-1258. Epub 2020 Jun 7 doi: 10.1007/s10143-020-01329-9. PMID: 32507931
Utility of the clivo-axial angle in assessing brainstem deformity: pilot study and literature review.
Henderson FC Sr, Henderson FC Jr, Wilson WA 4th, Mark AS, Koby M
Neurosurg Rev 2018 Jan;41(1):149-163. Epub 2017 Mar 3 doi: 10.1007/s10143-017-0830-3. PMID: 28258417Free PMC Article
Pathogenesis and Cerebrospinal Fluid Hydrodynamics of the Chiari I Malformation.
Buell TJ, Heiss JD, Oldfield EH
Neurosurg Clin N Am 2015 Oct;26(4):495-9. Epub 2015 Aug 4 doi: 10.1016/j.nec.2015.06.003. PMID: 26408057Free PMC Article

Recent systematic reviews

Evaluation of Long-Term Follow-Up in Ecchordosis Physaliphora versus Chordoma.
Stuebe CM, Rindler RS, Laack N, Carr CM, Choby G, Inwards CY, Van Gompel JJ
World Neurosurg 2023 Jun;174:157-168. Epub 2023 Mar 9 doi: 10.1016/j.wneu.2023.03.016. PMID: 36898627
Supratentorial Hemangioblastoma in Adults: A Systematic Review and Comparison of Infratentorial and Spinal Cord Locations.
Jankovic D, Vuong K, Splavski B, Rotim K, Arnautovic KI
World Neurosurg 2023 May;173:48-62. Epub 2023 Feb 22 doi: 10.1016/j.wneu.2023.02.071. PMID: 36822402
Biometric assessments of the posterior fossa by fetal MRI: A systematic review.
Mckinnon K, Kendall GS, Tann CJ, Dyet L, Sokolska M, Baruteau KP, Marlow N, Robertson NJ, Peebles D, Srinivasan L
Prenat Diagn 2021 Jan;41(2):258-270. Epub 2020 Dec 18 doi: 10.1002/pd.5874. PMID: 33251640
Arteriovenous malformations of the posterior fossa: a systematic review.
Magro E, Darsaut TE, Mezui EDO, Bojanowski MW, Ziegler D, Gentric JC, Roy D, Raymond J
Acta Neurochir (Wien) 2020 Apr;162(4):905-910. Epub 2020 Feb 18 doi: 10.1007/s00701-020-04260-6. PMID: 32067118
Systematic review and meta-analysis of isolated posterior fossa malformations on prenatal imaging (part 2): neurodevelopmental outcome.
D'Antonio F, Khalil A, Garel C, Pilu G, Rizzo G, Lerman-Sagie T, Bhide A, Thilaganathan B, Manzoli L, Papageorghiou AT
Ultrasound Obstet Gynecol 2016 Jul;48(1):28-37. doi: 10.1002/uog.15755. PMID: 26394557

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