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Total anosmia

MedGen UID:
869342
Concept ID:
C4023768
Finding
HPO: HP:0010632

Definition

Inability to detect any qualitative olfactory sensation. [from HPO]

Term Hierarchy

Conditions with this feature

Peroxisome biogenesis disorder 9B
MedGen UID:
440765
Concept ID:
C2749346
Disease or Syndrome
Adult Refsum disease (ARD is associated with elevated plasma phytanic acid levels, late childhood-onset (or later) retinitis pigmentosa, and variable combinations of anosmia, polyneuropathy, deafness, ataxia, and ichthyosis. Onset of symptoms ranges from age seven months to older than age 50 years. Cardiac arrhythmia and heart failure caused by cardiomyopathy are potentially severe health problems that develop later in life.

Professional guidelines

PubMed

Nag AK, Saltagi AK, Saltagi MZ, Wu AW, Higgins TS, Knisely A, Ting JY, Illing EA
Ann Otol Rhinol Laryngol 2023 Jul;132(7):806-817. Epub 2022 Aug 12 doi: 10.1177/00034894221118186. PMID: 35959948
Takada T, Hoogland J, Hansen JG, Lindbaek M, Autio T, Alho OP, Ebell MH, Reitsma JB, Venekamp RP
Br J Gen Pract 2022 Aug;72(721):e601-e608. Epub 2022 Jul 28 doi: 10.3399/BJGP.2021.0585. PMID: 35817585Free PMC Article
Struyf T, Deeks JJ, Dinnes J, Takwoingi Y, Davenport C, Leeflang MM, Spijker R, Hooft L, Emperador D, Domen J, Horn SRA, Van den Bruel A; Cochrane COVID-19 Diagnostic Test Accuracy Group
Cochrane Database Syst Rev 2021 Feb 23;2(2):CD013665. doi: 10.1002/14651858.CD013665.pub2. PMID: 33620086Free PMC Article

Recent clinical studies

Etiology

Sheng MZ, Fang TC, Chen YH, Chang MH, Yang CP, Lin CH
PLoS One 2021;16(6):e0252451. Epub 2021 Jun 4 doi: 10.1371/journal.pone.0252451. PMID: 34086764Free PMC Article
Salmon Ceron D, Bartier S, Hautefort C, Nguyen Y, Nevoux J, Hamel AL, Camhi Y, Canouï-Poitrine F, Verillaud B, Slama D, Haim-Boukobza S, Sourdeau E, Cantin D, Corré A, Bryn A, Etienne N, Rozenberg F, Layese R, Papon JF, Bequignon E; APHP COVID-19 research collaboration
J Infect 2020 Oct;81(4):614-620. Epub 2020 Jul 7 doi: 10.1016/j.jinf.2020.07.005. PMID: 32650110Free PMC Article
Joussain P, Bessy M, Faure F, Bellil D, Landis BN, Hugentobler M, Tuorila H, Mustonen S, Vento SI, Delphin-Combe F, Krolak-Salmon P, Rouby C, Bensafi M
Eur Arch Otorhinolaryngol 2016 Feb;273(2):381-90. Epub 2015 Feb 25 doi: 10.1007/s00405-015-3536-6. PMID: 25711735
Mirlohi S, Dietrich AM, Duncan SE
Environ Sci Technol 2011 Aug 1;45(15):6575-83. Epub 2011 Jul 8 doi: 10.1021/es200633p. PMID: 21736386
Nee LE, Scott J, Polinsky RJ
Clin Auton Res 1993 Aug;3(4):281-2. doi: 10.1007/BF01829019. PMID: 8292885

Diagnosis

Sheng MZ, Fang TC, Chen YH, Chang MH, Yang CP, Lin CH
PLoS One 2021;16(6):e0252451. Epub 2021 Jun 4 doi: 10.1371/journal.pone.0252451. PMID: 34086764Free PMC Article
Salmon Ceron D, Bartier S, Hautefort C, Nguyen Y, Nevoux J, Hamel AL, Camhi Y, Canouï-Poitrine F, Verillaud B, Slama D, Haim-Boukobza S, Sourdeau E, Cantin D, Corré A, Bryn A, Etienne N, Rozenberg F, Layese R, Papon JF, Bequignon E; APHP COVID-19 research collaboration
J Infect 2020 Oct;81(4):614-620. Epub 2020 Jul 7 doi: 10.1016/j.jinf.2020.07.005. PMID: 32650110Free PMC Article
Joussain P, Bessy M, Faure F, Bellil D, Landis BN, Hugentobler M, Tuorila H, Mustonen S, Vento SI, Delphin-Combe F, Krolak-Salmon P, Rouby C, Bensafi M
Eur Arch Otorhinolaryngol 2016 Feb;273(2):381-90. Epub 2015 Feb 25 doi: 10.1007/s00405-015-3536-6. PMID: 25711735
Tallab HF, Doty RL
BMJ Case Rep 2014 May 13;2014 doi: 10.1136/bcr-2014-203959. PMID: 24825557Free PMC Article
Bartoshuk LM, Beauchamp GK
Annu Rev Psychol 1994;45:419-49. doi: 10.1146/annurev.ps.45.020194.002223. PMID: 8135507

Therapy

Arabzadeh Bahri R, Esmaeilpur Abianeh F, Peisepar M, Hadi R, Basti FA, Maleki S, Radkhah H
Ear Nose Throat J 2024 Jun;103(1_suppl):164S-170S. Epub 2024 Feb 27 doi: 10.1177/01455613241233098. PMID: 38411125
Mirlohi S, Dietrich AM, Duncan SE
Environ Sci Technol 2011 Aug 1;45(15):6575-83. Epub 2011 Jul 8 doi: 10.1021/es200633p. PMID: 21736386

Prognosis

Salmon Ceron D, Bartier S, Hautefort C, Nguyen Y, Nevoux J, Hamel AL, Camhi Y, Canouï-Poitrine F, Verillaud B, Slama D, Haim-Boukobza S, Sourdeau E, Cantin D, Corré A, Bryn A, Etienne N, Rozenberg F, Layese R, Papon JF, Bequignon E; APHP COVID-19 research collaboration
J Infect 2020 Oct;81(4):614-620. Epub 2020 Jul 7 doi: 10.1016/j.jinf.2020.07.005. PMID: 32650110Free PMC Article
Joussain P, Bessy M, Faure F, Bellil D, Landis BN, Hugentobler M, Tuorila H, Mustonen S, Vento SI, Delphin-Combe F, Krolak-Salmon P, Rouby C, Bensafi M
Eur Arch Otorhinolaryngol 2016 Feb;273(2):381-90. Epub 2015 Feb 25 doi: 10.1007/s00405-015-3536-6. PMID: 25711735
Wise JB, Moonis G, Mirza N
Ann Otol Rhinol Laryngol 2006 Feb;115(2):124-7. doi: 10.1177/000348940611500208. PMID: 16514795
Jackman AH, Doty RL
Laryngoscope 2005 Dec;115(12):2209-12. doi: 10.1097/01.mlg.0000183194.17484.bb. PMID: 16369168
Varney NR
J Clin Exp Neuropsychol 1988 Mar;10(2):250-4. doi: 10.1080/01688638808408239. PMID: 3350923

Clinical prediction guides

Arabzadeh Bahri R, Esmaeilpur Abianeh F, Peisepar M, Hadi R, Basti FA, Maleki S, Radkhah H
Ear Nose Throat J 2024 Jun;103(1_suppl):164S-170S. Epub 2024 Feb 27 doi: 10.1177/01455613241233098. PMID: 38411125
Sheng MZ, Fang TC, Chen YH, Chang MH, Yang CP, Lin CH
PLoS One 2021;16(6):e0252451. Epub 2021 Jun 4 doi: 10.1371/journal.pone.0252451. PMID: 34086764Free PMC Article
Salmon Ceron D, Bartier S, Hautefort C, Nguyen Y, Nevoux J, Hamel AL, Camhi Y, Canouï-Poitrine F, Verillaud B, Slama D, Haim-Boukobza S, Sourdeau E, Cantin D, Corré A, Bryn A, Etienne N, Rozenberg F, Layese R, Papon JF, Bequignon E; APHP COVID-19 research collaboration
J Infect 2020 Oct;81(4):614-620. Epub 2020 Jul 7 doi: 10.1016/j.jinf.2020.07.005. PMID: 32650110Free PMC Article
Joussain P, Bessy M, Faure F, Bellil D, Landis BN, Hugentobler M, Tuorila H, Mustonen S, Vento SI, Delphin-Combe F, Krolak-Salmon P, Rouby C, Bensafi M
Eur Arch Otorhinolaryngol 2016 Feb;273(2):381-90. Epub 2015 Feb 25 doi: 10.1007/s00405-015-3536-6. PMID: 25711735
Nee LE, Scott J, Polinsky RJ
Clin Auton Res 1993 Aug;3(4):281-2. doi: 10.1007/BF01829019. PMID: 8292885

Recent systematic reviews

Arabzadeh Bahri R, Esmaeilpur Abianeh F, Peisepar M, Hadi R, Basti FA, Maleki S, Radkhah H
Ear Nose Throat J 2024 Jun;103(1_suppl):164S-170S. Epub 2024 Feb 27 doi: 10.1177/01455613241233098. PMID: 38411125
Samaranayake LP, Fakhruddin KS, Panduwawala C
Acta Odontol Scand 2020 Aug;78(6):467-473. Epub 2020 Aug 7 doi: 10.1080/00016357.2020.1787505. PMID: 32762282

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