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Abnormal malleus morphology

MedGen UID:
868936
Concept ID:
C4023349
Anatomical Abnormality
Synonym: Abnormality of the malleus
 
HPO: HP:0011454

Definition

An abnormality of the malleus, an ossicle in the middle ear. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal malleus morphology

Conditions with this feature

Thickened earlobes-conductive deafness syndrome
MedGen UID:
343676
Concept ID:
C1851896
Finding
Thickened earlobes-conductive deafness syndrome is characterized by microtia with thickened ear lobes, micrognathia and conductive hearing loss due to congenital ossicular anomalies. It has been described in two families. The mode of inheritance is autosomal dominant.

Recent clinical studies

Etiology

Célérier C, Thierry B, Coudert C, Blanchard M, Loundon N, Garabédian EN, Denoyelle F
Int J Pediatr Otorhinolaryngol 2017 Feb;93:83-87. Epub 2016 Dec 29 doi: 10.1016/j.ijporl.2016.12.038. PMID: 28109505
Mukherjee S, Kesser BW, Raghavan P
AJNR Am J Neuroradiol 2014 Nov-Dec;35(11):2181-5. Epub 2014 Jul 3 doi: 10.3174/ajnr.A4022. PMID: 24994825Free PMC Article
Miller ME, Kirsch C, Canalis RF
Ann Otol Rhinol Laryngol 2010 May;119(5):319-24. doi: 10.1177/000348941011900508. PMID: 20524577
De la Cruz A, Angeli S, Slattery WH
Otolaryngol Head Neck Surg 1999 Apr;120(4):487-92. doi: 10.1053/hn.1999.v120.a89626. PMID: 10187939
Mutlu C, da Costa SS, Paparella MM, Schachern PA
Eur Arch Otorhinolaryngol 1998;255(4):189-94. doi: 10.1007/s004050050041. PMID: 9592676

Diagnosis

El Youbi ABA, Alami M, Benmansour N, El Alami El Amine MN
Pan Afr Med J 2024;47:168. Epub 2024 Apr 5 doi: 10.11604/pamj.2024.47.168.43187. PMID: 39036014Free PMC Article
Kantaputra PN, Tripuwabhrut K, Intachai W, Carlson BM, Quarto N, Ngamphiw C, Tongsima S, Sonsuwan N
Clin Otolaryngol 2020 Sep;45(5):695-702. Epub 2020 May 25 doi: 10.1111/coa.13560. PMID: 32351010
Marchioni D, Soloperto D, Villari D, Tatti MF, Colleselli E, Genovese E, Presutti L
Eur Arch Otorhinolaryngol 2016 Jul;273(7):1723-9. Epub 2015 Aug 8 doi: 10.1007/s00405-015-3743-1. PMID: 26253427
Subotic R, Mladina R, Risavi R
Acta Otolaryngol 1998 Nov;118(6):833-6. doi: 10.1080/00016489850182530. PMID: 9870629
De la Cruz A, Doyle KJ
Otolaryngol Clin North Am 1994 Aug;27(4):799-811. PMID: 7984377

Therapy

Alvi SA, Jones JW, Lin J
Ann Otol Rhinol Laryngol 2018 Mar;127(3):209-212. Epub 2018 Jan 9 doi: 10.1177/0003489417751956. PMID: 29313370
Babighian G, Albu S
Clin Otolaryngol 2011 Dec;36(6):543-9. doi: 10.1111/j.1749-4486.2011.02406.x. PMID: 22024022
Moerike S, Pantzar JT, De Sa D
Pediatr Dev Pathol 2002 Jul-Aug;5(4):405-9. Epub 2002 May 21 doi: 10.1007/s10024-001-0258-0. PMID: 12016535
Takeda Y, Nishizaki K, Masuda Y, Watanabe S
Auris Nasus Larynx 1996;23:1-12. doi: 10.1016/s0385-8146(96)80002-2. PMID: 8809317
Lesinski SG
Laryngoscope 1986 Nov;96(11):1211-20. doi: 10.1002/lary.1986.96.11.1211. PMID: 3773619

Prognosis

Kantaputra PN, Tripuwabhrut K, Intachai W, Carlson BM, Quarto N, Ngamphiw C, Tongsima S, Sonsuwan N
Clin Otolaryngol 2020 Sep;45(5):695-702. Epub 2020 May 25 doi: 10.1111/coa.13560. PMID: 32351010
Célérier C, Thierry B, Coudert C, Blanchard M, Loundon N, Garabédian EN, Denoyelle F
Int J Pediatr Otorhinolaryngol 2017 Feb;93:83-87. Epub 2016 Dec 29 doi: 10.1016/j.ijporl.2016.12.038. PMID: 28109505
Sugimoto H, Ito M, Hatano M, Yoshizaki T
Auris Nasus Larynx 2014 Dec;41(6):582-5. Epub 2014 Sep 4 doi: 10.1016/j.anl.2014.05.024. PMID: 25194854
Martin C, Oletski A, Prades JM
Otol Neurotol 2009 Feb;30(2):165-9. doi: 10.1097/mao.0b013e318191a66d. PMID: 19180677
Park K, Choung YH
Acta Otolaryngol 2009 Apr;129(4):419-22. doi: 10.1080/00016480802587846. PMID: 19116789

Clinical prediction guides

Célérier C, Thierry B, Coudert C, Blanchard M, Loundon N, Garabédian EN, Denoyelle F
Int J Pediatr Otorhinolaryngol 2017 Feb;93:83-87. Epub 2016 Dec 29 doi: 10.1016/j.ijporl.2016.12.038. PMID: 28109505
Burford CM, Mason MJ
J Anat 2016 Dec;229(6):857-870. Epub 2016 Jul 26 doi: 10.1111/joa.12520. PMID: 27456698Free PMC Article
Park K, Choung YH
Acta Otolaryngol 2009 Apr;129(4):419-22. doi: 10.1080/00016480802587846. PMID: 19116789
Hudde H, Weistenhofer C
ORL J Otorhinolaryngol Relat Spec 2006;68(6):324-8. Epub 2006 Oct 26 doi: 10.1159/000095274. PMID: 17065824
De la Cruz A, Doyle KJ
Otolaryngol Clin North Am 1994 Aug;27(4):799-811. PMID: 7984377

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