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Impaired sensitivity to thyroid stimulating hormone

MedGen UID:
868784
Concept ID:
C4023189
Finding
Synonyms: Thyroid-stimulating hormone receptor defect; TSHR defect
 
HPO: HP:0011789

Definition

Reduced sensitivity of thyroid follicle cells to stimulation by biologically active thyroid-stimulating hormone (TSH). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImpaired sensitivity to thyroid stimulating hormone

Professional guidelines

PubMed

Zhao Y, Guan Q, Shi J, Sun J, Wang Q, Yang J, Retnakaran R, Han J, Zhang X, Hao W, Huang X, Zhang R, Zhai D, Wen SW
Schizophr Res 2022 Mar;241:244-250. Epub 2022 Feb 15 doi: 10.1016/j.schres.2022.02.010. PMID: 35180663
Argatska A, Nonchev B
Folia Med (Plovdiv) 2021 Dec 31;63(6):834-838. doi: 10.3897/folmed.63.e59851. PMID: 35851240
Genazzani AD
Reprod Biomed Online 2016 Dec;33(6):770-780. Epub 2016 Sep 16 doi: 10.1016/j.rbmo.2016.08.024. PMID: 27717596

Recent clinical studies

Etiology

Yu ZW, Pu SD, Sun XT, Wang XC, Gao XY, Shan ZY
Clin Interv Aging 2023;18:1263-1274. Epub 2023 Aug 3 doi: 10.2147/CIA.S413584. PMID: 37554512Free PMC Article
Wu Z, Jiang Y, Li P, Wang Y, Zhang H, Li Z, Li X, Tao L, Gao B, Guo X
J Transl Med 2023 Jul 5;21(1):436. doi: 10.1186/s12967-023-04276-3. PMID: 37403157Free PMC Article
Liu C, Hua L, Liu K, Xin Z
J Endocrinol Invest 2023 Oct;46(10):2017-2029. Epub 2023 Feb 16 doi: 10.1007/s40618-023-02035-1. PMID: 36795243
Villanger GD, Ystrom E, Engel SM, Longnecker MP, Pettersen R, Rowe AD, Reichborn-Kjennerud T, Aase H
Paediatr Perinat Epidemiol 2020 Sep;34(5):590-596. Epub 2020 Feb 18 doi: 10.1111/ppe.12643. PMID: 32072662Free PMC Article
Genazzani AD
Reprod Biomed Online 2016 Dec;33(6):770-780. Epub 2016 Sep 16 doi: 10.1016/j.rbmo.2016.08.024. PMID: 27717596

Diagnosis

Li Y, Sun J, Jiao Y, Li N, Zhao W
J Clin Endocrinol Metab 2024 Feb 20;109(3):691-700. doi: 10.1210/clinem/dgad607. PMID: 37831130
Pappa T, Refetoff S
Front Endocrinol (Lausanne) 2021;12:656551. Epub 2021 Mar 31 doi: 10.3389/fendo.2021.656551. PMID: 33868182Free PMC Article
Laclaustra M, Moreno-Franco B, Lou-Bonafonte JM, Mateo-Gallego R, Casasnovas JA, Guallar-Castillon P, Cenarro A, Civeira F
Diabetes Care 2019 Feb;42(2):303-310. Epub 2018 Dec 14 doi: 10.2337/dc18-1410. PMID: 30552134
Grasberger H, Refetoff S
Best Pract Res Clin Endocrinol Metab 2017 Mar;31(2):183-194. Epub 2017 Mar 30 doi: 10.1016/j.beem.2017.03.004. PMID: 28648507Free PMC Article
Genazzani AD
Reprod Biomed Online 2016 Dec;33(6):770-780. Epub 2016 Sep 16 doi: 10.1016/j.rbmo.2016.08.024. PMID: 27717596

Therapy

Kjaergaard AD, Teumer A, Marouli E, Deloukas P, Kuś A, Sterenborg R, Åsvold BO, Medici M, Ellervik C
Hum Mol Genet 2022 Aug 17;31(15):2548-2559. doi: 10.1093/hmg/ddac052. PMID: 35225327
Argatska A, Nonchev B
Folia Med (Plovdiv) 2021 Dec 31;63(6):834-838. doi: 10.3897/folmed.63.e59851. PMID: 35851240
Lee KW, Shin Y, Lee S, Lee S
Front Endocrinol (Lausanne) 2021;12:803024. Epub 2022 Jan 18 doi: 10.3389/fendo.2021.803024. PMID: 35126314Free PMC Article
Genazzani AD
Reprod Biomed Online 2016 Dec;33(6):770-780. Epub 2016 Sep 16 doi: 10.1016/j.rbmo.2016.08.024. PMID: 27717596
Biondi B, Palmieri EA, Lombardi G, Fazio S
Thyroid 2002 Jun;12(6):505-10. doi: 10.1089/105072502760143890. PMID: 12165114

Prognosis

Cui C, Sui H, Wang Z, Zhang T, Zheng J, Yan H, Li Q, Mo Z, Liu L
Front Endocrinol (Lausanne) 2023;14:1267612. Epub 2023 Oct 16 doi: 10.3389/fendo.2023.1267612. PMID: 37908753Free PMC Article
Boltzmann M, Schmidt SB, Rollnik JD
Biomed Res Int 2022;2022:8447080. Epub 2022 Feb 10 doi: 10.1155/2022/8447080. PMID: 35187173Free PMC Article
Villanger GD, Ystrom E, Engel SM, Longnecker MP, Pettersen R, Rowe AD, Reichborn-Kjennerud T, Aase H
Paediatr Perinat Epidemiol 2020 Sep;34(5):590-596. Epub 2020 Feb 18 doi: 10.1111/ppe.12643. PMID: 32072662Free PMC Article
Laclaustra M, Moreno-Franco B, Lou-Bonafonte JM, Mateo-Gallego R, Casasnovas JA, Guallar-Castillon P, Cenarro A, Civeira F
Diabetes Care 2019 Feb;42(2):303-310. Epub 2018 Dec 14 doi: 10.2337/dc18-1410. PMID: 30552134
van Tienhoven-Wind LJ, Dullaart RP
Nutrients 2015 Feb 16;7(2):1352-77. doi: 10.3390/nu7021352. PMID: 25690422Free PMC Article

Clinical prediction guides

Cui C, Sui H, Wang Z, Zhang T, Zheng J, Yan H, Li Q, Mo Z, Liu L
Front Endocrinol (Lausanne) 2023;14:1267612. Epub 2023 Oct 16 doi: 10.3389/fendo.2023.1267612. PMID: 37908753Free PMC Article
Yu ZW, Pu SD, Sun XT, Wang XC, Gao XY, Shan ZY
Clin Interv Aging 2023;18:1263-1274. Epub 2023 Aug 3 doi: 10.2147/CIA.S413584. PMID: 37554512Free PMC Article
Miranda A, Sousa N
Brain Behav 2018 Feb;8(2):e00920. Epub 2018 Jan 24 doi: 10.1002/brb3.920. PMID: 29484271Free PMC Article
van Tienhoven-Wind LJ, Dullaart RP
Nutrients 2015 Feb 16;7(2):1352-77. doi: 10.3390/nu7021352. PMID: 25690422Free PMC Article
de Wardener HE
Physiol Rev 2001 Oct;81(4):1599-658. doi: 10.1152/physrev.2001.81.4.1599. PMID: 11581498

Recent systematic reviews

Santos JAR, Christoforou A, Trieu K, McKenzie BL, Downs S, Billot L, Webster J, Li M
Cochrane Database Syst Rev 2019 Feb 12;2(2):CD010734. doi: 10.1002/14651858.CD010734.pub2. PMID: 30746700Free PMC Article

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