U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormality of endocrine pancreas physiology

MedGen UID:
868646
•Concept ID:
C4023047
•
Pathologic Function
HPO: HP:0012093

Definition

A function abnormality of the endocrine pancreas. [from HPO]

Professional guidelines

PubMed

Importance of multiple endocrine cell types in islet organoids for type 1 diabetes treatment.
Heaton ES, Jin S
Transl Res 2022 Dec;250:68-83. Epub 2022 Jun 28 doi: 10.1016/j.trsl.2022.06.014. PMID: 35772687
Clinical presentation, genotype-phenotype correlations, and outcome of pancreatic neuroendocrine tumors in Von Hippel-Lindau syndrome.
Penitenti F, Landoni L, Scardoni M, Piredda ML, Cingarlini S, Scarpa A, D'Onofrio M, Girelli D, Davi MV
Endocrine 2021 Oct;74(1):180-187. Epub 2021 May 25 doi: 10.1007/s12020-021-02752-8. PMID: 34036514Free PMC Article
Autoimmune Pancreatitis in Children: Characteristic Features, Diagnosis, and Management.
Scheers I, Palermo JJ, Freedman S, Wilschanski M, Shah U, Abu-El-Haija M, Barth B, Fishman DS, Gariepy C, Giefer MJ, Heyman MB, Himes RW, Husain SZ, Lin TK, Liu Q, Lowe M, Mascarenhas M, Morinville V, Ooi CY, Perito ER, Piccoli DA, Pohl JF, Schwarzenberg SJ, Troendle D, Werlin S, Zimmerman B, Uc A, Gonska T
Am J Gastroenterol 2017 Oct;112(10):1604-1611. Epub 2017 Apr 4 doi: 10.1038/ajg.2017.85. PMID: 28374818Free PMC Article

Recent clinical studies

Etiology

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus.
Xourafa G, Korbmacher M, Roden M
Nat Rev Endocrinol 2024 Jan;20(1):27-49. Epub 2023 Oct 16 doi: 10.1038/s41574-023-00898-1. PMID: 37845351
Chronic pancreatitis.
Kleeff J, Whitcomb DC, Shimosegawa T, Esposito I, Lerch MM, Gress T, Mayerle J, Drewes AM, Rebours V, Akisik F, Muñoz JED, Neoptolemos JP
Nat Rev Dis Primers 2017 Sep 7;3:17060. doi: 10.1038/nrdp.2017.60. PMID: 28880010
Type 2 diabetes mellitus.
DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, Hu FB, Kahn CR, Raz I, Shulman GI, Simonson DC, Testa MA, Weiss R
Nat Rev Dis Primers 2015 Jul 23;1:15019. doi: 10.1038/nrdp.2015.19. PMID: 27189025
Autoantibodies in type 1 diabetes.
Taplin CE, Barker JM
Autoimmunity 2008 Feb;41(1):11-8. doi: 10.1080/08916930701619169. PMID: 18176860
Mechanisms linking obesity to insulin resistance and type 2 diabetes.
Kahn SE, Hull RL, Utzschneider KM
Nature 2006 Dec 14;444(7121):840-6. doi: 10.1038/nature05482. PMID: 17167471

Diagnosis

Genetic hypercalcemia.
Cormier C
Joint Bone Spine 2019 Jul;86(4):459-466. Epub 2018 Oct 6 doi: 10.1016/j.jbspin.2018.10.001. PMID: 30300686
Chronic pancreatitis.
Kleeff J, Whitcomb DC, Shimosegawa T, Esposito I, Lerch MM, Gress T, Mayerle J, Drewes AM, Rebours V, Akisik F, Muñoz JED, Neoptolemos JP
Nat Rev Dis Primers 2017 Sep 7;3:17060. doi: 10.1038/nrdp.2017.60. PMID: 28880010
Chronic Pancreatitis.
Stram M, Liu S, Singhi AD
Surg Pathol Clin 2016 Dec;9(4):643-659. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.008. PMID: 27926364
Type 2 diabetes mellitus.
DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, Hu FB, Kahn CR, Raz I, Shulman GI, Simonson DC, Testa MA, Weiss R
Nat Rev Dis Primers 2015 Jul 23;1:15019. doi: 10.1038/nrdp.2015.19. PMID: 27189025
Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol.
Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R
Diabetologia 2011 Oct;54(10):2506-14. Epub 2011 Jun 9 doi: 10.1007/s00125-011-2204-7. PMID: 21656330Free PMC Article

Therapy

Structure and function of the exocrine pancreas in patients with type 1 diabetes.
Alexandre-Heymann L, Mallone R, Boitard C, Scharfmann R, Larger E
Rev Endocr Metab Disord 2019 Jun;20(2):129-149. doi: 10.1007/s11154-019-09501-3. PMID: 31077020
Pathophysiology of the Effects of Alcohol Abuse on the Endocrine System.
Rachdaoui N, Sarkar DK
Alcohol Res 2017;38(2):255-276. PMID: 28988577Free PMC Article
Type 2 diabetes mellitus.
DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, Hu FB, Kahn CR, Raz I, Shulman GI, Simonson DC, Testa MA, Weiss R
Nat Rev Dis Primers 2015 Jul 23;1:15019. doi: 10.1038/nrdp.2015.19. PMID: 27189025
Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol.
Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R
Diabetologia 2011 Oct;54(10):2506-14. Epub 2011 Jun 9 doi: 10.1007/s00125-011-2204-7. PMID: 21656330Free PMC Article
Rosiglitazone.
Balfour JA, Plosker GL
Drugs 1999 Jun;57(6):921-30; discussion 931-2. doi: 10.2165/00003495-199957060-00007. PMID: 10400405

Prognosis

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus.
Xourafa G, Korbmacher M, Roden M
Nat Rev Endocrinol 2024 Jan;20(1):27-49. Epub 2023 Oct 16 doi: 10.1038/s41574-023-00898-1. PMID: 37845351
Genetic hypercalcemia.
Cormier C
Joint Bone Spine 2019 Jul;86(4):459-466. Epub 2018 Oct 6 doi: 10.1016/j.jbspin.2018.10.001. PMID: 30300686
Genetic Syndromes with Pancreatic Manifestations.
Pittman ME, Brosens LA, Wood LD
Surg Pathol Clin 2016 Dec;9(4):705-715. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.012. PMID: 27926368
Endocrine manifestations of von Hippel-Lindau disease.
Cassol C, Mete O
Arch Pathol Lab Med 2015 Feb;139(2):263-8. doi: 10.5858/arpa.2013-0520-RS. PMID: 25611110
Autoantibodies in type 1 diabetes.
Taplin CE, Barker JM
Autoimmunity 2008 Feb;41(1):11-8. doi: 10.1080/08916930701619169. PMID: 18176860

Clinical prediction guides

Inter-organ crosstalk during development and progression of type 2 diabetes mellitus.
Xourafa G, Korbmacher M, Roden M
Nat Rev Endocrinol 2024 Jan;20(1):27-49. Epub 2023 Oct 16 doi: 10.1038/s41574-023-00898-1. PMID: 37845351
SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells.
Iida H, Kono T, Lee CC, Krishnan P, Arvin MC, Weaver SA, Jarvela TS, Branco RCS, McLaughlin MR, Bone RN, Tong X, Arvan P, Lindberg I, Evans-Molina C
Diabetologia 2023 Nov;66(11):2042-2061. Epub 2023 Aug 4 doi: 10.1007/s00125-023-05979-4. PMID: 37537395Free PMC Article
Structure and function of the exocrine pancreas in patients with type 1 diabetes.
Alexandre-Heymann L, Mallone R, Boitard C, Scharfmann R, Larger E
Rev Endocr Metab Disord 2019 Jun;20(2):129-149. doi: 10.1007/s11154-019-09501-3. PMID: 31077020
Other organ involvement and clinical aspects of Wilson disease.
Dzieżyc K, Litwin T, Członkowska A
Handb Clin Neurol 2017;142:157-169. doi: 10.1016/B978-0-444-63625-6.00013-6. PMID: 28433099
Autoantibodies in type 1 diabetes.
Taplin CE, Barker JM
Autoimmunity 2008 Feb;41(1):11-8. doi: 10.1080/08916930701619169. PMID: 18176860

Recent systematic reviews

Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies.
Sanchez-Garrido MA, Tena-Sempere M
Mol Metab 2020 May;35:100937. Epub 2020 Feb 5 doi: 10.1016/j.molmet.2020.01.001. PMID: 32244180Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...