U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Increased sialylation of N-linked protein glycosylation

MedGen UID:
868541
•Concept ID:
C4022940
•
Finding
HPO: HP:0012351

Definition

Increased addition of sialic acids to N-linked glycans. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased sialylation of N-linked protein glycosylation

Professional guidelines

PubMed

Glycosylation status of serum in inflammatory arthritis in response to anti-TNF treatment.
Collins ES, Galligan MC, Saldova R, Adamczyk B, Abrahams JL, Campbell MP, Ng CT, Veale DJ, Murphy TB, Rudd PM, Fitzgerald O
Rheumatology (Oxford) 2013 Sep;52(9):1572-82. Epub 2013 May 16 doi: 10.1093/rheumatology/ket189. PMID: 23681398

Recent clinical studies

Etiology

N-linked glycosylation of the M-protein variable region: glycoproteogenomics reveals a new layer of personalized complexity in multiple myeloma.
Langerhorst P, Baerenfaenger M, Kulkarni P, Nadal S, Wijnands C, Post MA, Noori S, vanDuijn MM, Joosten I, Dejoie T, van Gool AJ, Gloerich J, Lefeber DJ, Wessels HJCT, Jacobs JFM
Clin Chem Lab Med 2024 Jul 26;62(8):1626-1635. Epub 2024 Feb 9 doi: 10.1515/cclm-2023-1189. PMID: 38332688
High-Throughput and Site-Specific N-Glycosylation Analysis of Human Alpha-1-Acid Glycoprotein Offers a Great Potential for New Biomarker Discovery.
Keser T, Tijardović M, Gornik I, Lukić E, Lauc G, Gornik O, Novokmet M
Mol Cell Proteomics 2021;20:100044. Epub 2021 Jan 23 doi: 10.1074/mcp.RA120.002433. PMID: 33493676Free PMC Article
Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes.
Keser T, Gornik I, Vučković F, Selak N, Pavić T, Lukić E, Gudelj I, Gašparović H, Biočina B, Tilin T, Wennerström A, Männistö S, Salomaa V, Havulinna A, Wang W, Wilson JF, Chaturvedi N, Perola M, Campbell H, Lauc G, Gornik O
Diabetologia 2017 Dec;60(12):2352-2360. Epub 2017 Sep 13 doi: 10.1007/s00125-017-4426-9. PMID: 28905229
Glycosylation Analysis for Congenital Disorders of Glycosylation.
Li X, Raihan MA, Reynoso FJ, He M
Curr Protoc Hum Genet 2015 Jul 1;86:17.18.1-17.18.22. doi: 10.1002/0471142905.hg1718s86. PMID: 26132001
Glycosylation and liver cancer.
Mehta A, Herrera H, Block T
Adv Cancer Res 2015;126:257-79. Epub 2015 Feb 7 doi: 10.1016/bs.acr.2014.11.005. PMID: 25727150Free PMC Article

Diagnosis

N-linked glycosylation of the M-protein variable region: glycoproteogenomics reveals a new layer of personalized complexity in multiple myeloma.
Langerhorst P, Baerenfaenger M, Kulkarni P, Nadal S, Wijnands C, Post MA, Noori S, vanDuijn MM, Joosten I, Dejoie T, van Gool AJ, Gloerich J, Lefeber DJ, Wessels HJCT, Jacobs JFM
Clin Chem Lab Med 2024 Jul 26;62(8):1626-1635. Epub 2024 Feb 9 doi: 10.1515/cclm-2023-1189. PMID: 38332688
ST6GAL1 and α2-6 Sialylation Regulates IL-6 Expression and Secretion in Chronic Obstructive Pulmonary Disease.
Krick S, Helton ES, Easter M, Bollenbecker S, Denson R, Zaharias R, Cochran P, Vang S, Harris E, Wells JM, Barnes JW
Front Immunol 2021;12:693149. Epub 2021 Jul 5 doi: 10.3389/fimmu.2021.693149. PMID: 34290711Free PMC Article
Imaging Mass Spectrometry and Lectin Analysis of N-Linked Glycans in Carbohydrate Antigen-Defined Pancreatic Cancer Tissues.
McDowell CT, Klamer Z, Hall J, West CA, Wisniewski L, Powers TW, Angel PM, Mehta AS, Lewin DN, Haab BB, Drake RR
Mol Cell Proteomics 2021;20:100012. Epub 2020 Dec 8 doi: 10.1074/mcp.RA120.002256. PMID: 33581409Free PMC Article
Glycoqueuing: Isomer-Specific Quantification for Sialylation-Focused Glycomics.
Jin W, Wang C, Yang M, Wei M, Huang L, Wang Z
Anal Chem 2019 Aug 20;91(16):10492-10500. Epub 2019 Jul 31 doi: 10.1021/acs.analchem.9b01393. PMID: 31329418
Glycosylation Analysis for Congenital Disorders of Glycosylation.
Li X, Raihan MA, Reynoso FJ, He M
Curr Protoc Hum Genet 2015 Jul 1;86:17.18.1-17.18.22. doi: 10.1002/0471142905.hg1718s86. PMID: 26132001

Therapy

N-linked glycosylation of the M-protein variable region: glycoproteogenomics reveals a new layer of personalized complexity in multiple myeloma.
Langerhorst P, Baerenfaenger M, Kulkarni P, Nadal S, Wijnands C, Post MA, Noori S, vanDuijn MM, Joosten I, Dejoie T, van Gool AJ, Gloerich J, Lefeber DJ, Wessels HJCT, Jacobs JFM
Clin Chem Lab Med 2024 Jul 26;62(8):1626-1635. Epub 2024 Feb 9 doi: 10.1515/cclm-2023-1189. PMID: 38332688
ST6GAL1 and α2-6 Sialylation Regulates IL-6 Expression and Secretion in Chronic Obstructive Pulmonary Disease.
Krick S, Helton ES, Easter M, Bollenbecker S, Denson R, Zaharias R, Cochran P, Vang S, Harris E, Wells JM, Barnes JW
Front Immunol 2021;12:693149. Epub 2021 Jul 5 doi: 10.3389/fimmu.2021.693149. PMID: 34290711Free PMC Article
Increased branching and sialylation of N-linked glycans correlate with an improved pharmacokinetic profile for BAY 81-8973 compared with other full-length rFVIII products.
Teare JM, Kates DS, Shah A, Garger S
Drug Des Devel Ther 2019;13:941-948. Epub 2019 Mar 22 doi: 10.2147/DDDT.S188171. PMID: 30962676Free PMC Article
N-linked glycan structures and their expressions change in the blood sera of ovarian cancer patients.
Alley WR Jr, Vasseur JA, Goetz JA, Svoboda M, Mann BF, Matei DE, Menning N, Hussein A, Mechref Y, Novotny MV
J Proteome Res 2012 Apr 6;11(4):2282-300. Epub 2012 Mar 7 doi: 10.1021/pr201070k. PMID: 22304416Free PMC Article
Increasing the sialylation of therapeutic glycoproteins: the potential of the sialic acid biosynthetic pathway.
Bork K, Horstkorte R, Weidemann W
J Pharm Sci 2009 Oct;98(10):3499-508. doi: 10.1002/jps.21684. PMID: 19199295

Prognosis

High-Throughput and Site-Specific N-Glycosylation Analysis of Human Alpha-1-Acid Glycoprotein Offers a Great Potential for New Biomarker Discovery.
Keser T, Tijardović M, Gornik I, Lukić E, Lauc G, Gornik O, Novokmet M
Mol Cell Proteomics 2021;20:100044. Epub 2021 Jan 23 doi: 10.1074/mcp.RA120.002433. PMID: 33493676Free PMC Article
Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes.
Keser T, Gornik I, Vučković F, Selak N, Pavić T, Lukić E, Gudelj I, Gašparović H, Biočina B, Tilin T, Wennerström A, Männistö S, Salomaa V, Havulinna A, Wang W, Wilson JF, Chaturvedi N, Perola M, Campbell H, Lauc G, Gornik O
Diabetologia 2017 Dec;60(12):2352-2360. Epub 2017 Sep 13 doi: 10.1007/s00125-017-4426-9. PMID: 28905229
Antigen specificity determines anti-red blood cell IgG-Fc alloantibody glycosylation and thereby severity of haemolytic disease of the fetus and newborn.
Sonneveld ME, Koelewijn J, de Haas M, Admiraal J, Plomp R, Koeleman CA, Hipgrave Ederveen AL, Ligthart P, Wuhrer M, van der Schoot CE, Vidarsson G
Br J Haematol 2017 Feb;176(4):651-660. Epub 2016 Nov 28 doi: 10.1111/bjh.14438. PMID: 27891581
Glycosylation pattern of anti-platelet IgG is stable during pregnancy and predicts clinical outcome in alloimmune thrombocytopenia.
Sonneveld ME, Natunen S, Sainio S, Koeleman CA, Holst S, Dekkers G, Koelewijn J, Partanen J, van der Schoot CE, Wuhrer M, Vidarsson G
Br J Haematol 2016 Jul;174(2):310-20. Epub 2016 Mar 28 doi: 10.1111/bjh.14053. PMID: 27017954
Novel glycan biomarkers for the detection of lung cancer.
Arnold JN, Saldova R, Galligan MC, Murphy TB, Mimura-Kimura Y, Telford JE, Godwin AK, Rudd PM
J Proteome Res 2011 Apr 1;10(4):1755-64. Epub 2011 Mar 16 doi: 10.1021/pr101034t. PMID: 21214223

Clinical prediction guides

Distinct patterns of plaque and microglia glycosylation in Alzheimer's disease.
Fastenau C, Bunce M, Keating M, Wickline J, Hopp SC, Bieniek KF
Brain Pathol 2024 Jul;34(4):e13267. Epub 2024 May 9 doi: 10.1111/bpa.13267. PMID: 38724175Free PMC Article
A functional spleen contributes to afucosylated IgG in humans.
Wojcik I, Schmidt DE, de Neef LA, Rab MAE, Meek B, de Weerdt O, Wuhrer M, van der Schoot CE, Zwaginga JJ, de Haas M, Falck D, Vidarsson G
Sci Rep 2021 Dec 15;11(1):24045. doi: 10.1038/s41598-021-03196-w. PMID: 34911982Free PMC Article
N-linked glycosylation modulates the immunogenicity of recombinant human factor VIII in hemophilia A mice.
Lai JD, Swystun LL, Cartier D, Nesbitt K, Zhang C, Hough C, Dennis JW, Lillicrap D
Haematologica 2018 Nov;103(11):1925-1936. Epub 2018 Jul 12 doi: 10.3324/haematol.2018.188219. PMID: 30002126Free PMC Article
N-linked glycan truncation causes enhanced clearance of plasma-derived von Willebrand factor.
O'Sullivan JM, Aguila S, McRae E, Ward SE, Rawley O, Fallon PG, Brophy TM, Preston RJ, Brady L, Sheils O, Chion A, O'Donnell JS
J Thromb Haemost 2016 Dec;14(12):2446-2457. Epub 2016 Dec 9 doi: 10.1111/jth.13537. PMID: 27732771
Glycosylation and liver cancer.
Mehta A, Herrera H, Block T
Adv Cancer Res 2015;126:257-79. Epub 2015 Feb 7 doi: 10.1016/bs.acr.2014.11.005. PMID: 25727150Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...