U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Increased fucosylation of N-linked protein glycosylation

MedGen UID:
868538
•Concept ID:
C4022937
•
Finding
HPO: HP:0012354

Definition

Increased addition of fucose sugar units to N-linked glycans. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased fucosylation of N-linked protein glycosylation

Professional guidelines

PubMed

Glycosylation status of serum in inflammatory arthritis in response to anti-TNF treatment.
Collins ES, Galligan MC, Saldova R, Adamczyk B, Abrahams JL, Campbell MP, Ng CT, Veale DJ, Murphy TB, Rudd PM, Fitzgerald O
Rheumatology (Oxford) 2013 Sep;52(9):1572-82. Epub 2013 May 16 doi: 10.1093/rheumatology/ket189. PMID: 23681398

Recent clinical studies

Etiology

N-linked glycosylation of the M-protein variable region: glycoproteogenomics reveals a new layer of personalized complexity in multiple myeloma.
Langerhorst P, Baerenfaenger M, Kulkarni P, Nadal S, Wijnands C, Post MA, Noori S, vanDuijn MM, Joosten I, Dejoie T, van Gool AJ, Gloerich J, Lefeber DJ, Wessels HJCT, Jacobs JFM
Clin Chem Lab Med 2024 Jul 26;62(8):1626-1635. Epub 2024 Feb 9 doi: 10.1515/cclm-2023-1189. PMID: 38332688
Imaging Mass Spectrometry Reveals Alterations in N-Linked Glycosylation That Are Associated With Histopathological Changes in Nonalcoholic Steatohepatitis in Mouse and Human.
Ochoa-Rios S, O'Connor IP, Kent LN, Clouse JM, Hadjiyannis Y, Koivisto C, Pecot T, Angel PM, Drake RR, Leone G, Mehta AS, Rockey DC
Mol Cell Proteomics 2022 May;21(5):100225. Epub 2022 Mar 22 doi: 10.1016/j.mcpro.2022.100225. PMID: 35331917Free PMC Article
A pilot study of salivary N-glycome in HBV-induced chronic hepatitis, cirrhosis, and hepatocellular carcinoma.
Qin Y, Zhong Y, Ma T, Zhang J, Yang G, Guan F, Li Z, Li B
Glycoconj J 2017 Aug;34(4):523-535. Epub 2017 Apr 8 doi: 10.1007/s10719-017-9768-5. PMID: 28389847
Glycosylation and liver cancer.
Mehta A, Herrera H, Block T
Adv Cancer Res 2015;126:257-79. Epub 2015 Feb 7 doi: 10.1016/bs.acr.2014.11.005. PMID: 25727150Free PMC Article
Increased levels of tetra-antennary N-linked glycan but not core fucosylation are associated with hepatocellular carcinoma tissue.
Mehta A, Norton P, Liang H, Comunale MA, Wang M, Rodemich-Betesh L, Koszycki A, Noda K, Miyoshi E, Block T
Cancer Epidemiol Biomarkers Prev 2012 Jun;21(6):925-33. Epub 2012 Apr 6 doi: 10.1158/1055-9965.EPI-11-1183. PMID: 22490318Free PMC Article

Diagnosis

N-linked glycosylation of the M-protein variable region: glycoproteogenomics reveals a new layer of personalized complexity in multiple myeloma.
Langerhorst P, Baerenfaenger M, Kulkarni P, Nadal S, Wijnands C, Post MA, Noori S, vanDuijn MM, Joosten I, Dejoie T, van Gool AJ, Gloerich J, Lefeber DJ, Wessels HJCT, Jacobs JFM
Clin Chem Lab Med 2024 Jul 26;62(8):1626-1635. Epub 2024 Feb 9 doi: 10.1515/cclm-2023-1189. PMID: 38332688
A highly specific antibody against the core fucose of the N-glycan in IgG identifies the pulmonary diseases and its regulation by CCL2.
Kanto N, Ohkawa Y, Kitano M, Maeda K, Shiida M, Ono T, Ota F, Kizuka Y, Kunimasa K, Nishino K, Mukai M, Seike M, Azuma A, Harada Y, Fukuda T, Gu J, Taniguchi N
J Biol Chem 2023 Dec;299(12):105365. Epub 2023 Oct 20 doi: 10.1016/j.jbc.2023.105365. PMID: 37865317Free PMC Article
Immunoassay for quantification of antigen-specific IgG fucosylation.
Šuštić T, Van Coillie J, Larsen MD, Derksen NIL, Szittner Z, Nouta J, Wang W, Damelang T, Rebergen I, Linty F, Visser R, Mok JY, Geerdes DM, van Esch WJE, de Taeye SW, van Gils MJ, van de Watering L, van der Schoot CE, Wuhrer M, Rispens T, Vidarsson G
EBioMedicine 2022 Jul;81:104109. Epub 2022 Jun 22 doi: 10.1016/j.ebiom.2022.104109. PMID: 35752106Free PMC Article
N-Glycosylation Patterns Correlate with Hepatocellular Carcinoma Genetic Subtypes.
DelaCourt A, Black A, Angel P, Drake R, Hoshida Y, Singal A, Lewin D, Taouli B, Lewis S, Schwarz M, Fiel MI, Mehta AS
Mol Cancer Res 2021 Nov;19(11):1868-1877. Epub 2021 Aug 11 doi: 10.1158/1541-7786.MCR-21-0348. PMID: 34380744Free PMC Article
Glycoqueuing: Isomer-Specific Quantification for Sialylation-Focused Glycomics.
Jin W, Wang C, Yang M, Wei M, Huang L, Wang Z
Anal Chem 2019 Aug 20;91(16):10492-10500. Epub 2019 Jul 31 doi: 10.1021/acs.analchem.9b01393. PMID: 31329418

Therapy

N-linked glycosylation of the M-protein variable region: glycoproteogenomics reveals a new layer of personalized complexity in multiple myeloma.
Langerhorst P, Baerenfaenger M, Kulkarni P, Nadal S, Wijnands C, Post MA, Noori S, vanDuijn MM, Joosten I, Dejoie T, van Gool AJ, Gloerich J, Lefeber DJ, Wessels HJCT, Jacobs JFM
Clin Chem Lab Med 2024 Jul 26;62(8):1626-1635. Epub 2024 Feb 9 doi: 10.1515/cclm-2023-1189. PMID: 38332688
ST6GAL1 and α2-6 Sialylation Regulates IL-6 Expression and Secretion in Chronic Obstructive Pulmonary Disease.
Krick S, Helton ES, Easter M, Bollenbecker S, Denson R, Zaharias R, Cochran P, Vang S, Harris E, Wells JM, Barnes JW
Front Immunol 2021;12:693149. Epub 2021 Jul 5 doi: 10.3389/fimmu.2021.693149. PMID: 34290711Free PMC Article
The "less-is-more" in therapeutic antibodies: Afucosylated anti-cancer antibodies with enhanced antibody-dependent cellular cytotoxicity.
Pereira NA, Chan KF, Lin PC, Song Z
MAbs 2018 Jul;10(5):693-711. doi: 10.1080/19420862.2018.1466767. PMID: 29733746Free PMC Article
Improved therapeutic efficacy of mammalian expressed-recombinant interferon gamma against ovarian cancer cells.
Razaghi A, Villacrés C, Jung V, Mashkour N, Butler M, Owens L, Heimann K
Exp Cell Res 2017 Oct 1;359(1):20-29. Epub 2017 Aug 10 doi: 10.1016/j.yexcr.2017.08.014. PMID: 28803068
N-linked glycan structures and their expressions change in the blood sera of ovarian cancer patients.
Alley WR Jr, Vasseur JA, Goetz JA, Svoboda M, Mann BF, Matei DE, Menning N, Hussein A, Mechref Y, Novotny MV
J Proteome Res 2012 Apr 6;11(4):2282-300. Epub 2012 Mar 7 doi: 10.1021/pr201070k. PMID: 22304416Free PMC Article

Prognosis

Increases in Tumor N-Glycan Polylactosamines Associated with Advanced HER2-Positive and Triple-Negative Breast Cancer Tissues.
Scott DA, Casadonte R, Cardinali B, Spruill L, Mehta AS, Carli F, Simone N, Kriegsmann M, Del Mastro L, Kriegsmann J, Drake RR
Proteomics Clin Appl 2019 Jan;13(1):e1800014. doi: 10.1002/prca.201800014. PMID: 30592377Free PMC Article
Release of urinary extracellular vesicles in prostate cancer is associated with altered urinary N-glycosylation profile.
Vermassen T, D'Herde K, Jacobus D, Van Praet C, Poelaert F, Lumen N, Callewaert N, Decaestecker K, Villeirs G, Hoebeke P, Van Belle S, Rottey S, Delanghe J
J Clin Pathol 2017 Oct;70(10):838-846. Epub 2017 Mar 30 doi: 10.1136/jclinpath-2016-204312. PMID: 28360190
Glycosylation pattern of anti-platelet IgG is stable during pregnancy and predicts clinical outcome in alloimmune thrombocytopenia.
Sonneveld ME, Natunen S, Sainio S, Koeleman CA, Holst S, Dekkers G, Koelewijn J, Partanen J, van der Schoot CE, Wuhrer M, Vidarsson G
Br J Haematol 2016 Jul;174(2):310-20. Epub 2016 Mar 28 doi: 10.1111/bjh.14053. PMID: 27017954
Classical galactosaemia: novel insights in IgG N-glycosylation and N-glycan biosynthesis.
Maratha A, Stockmann H, Coss KP, Estela Rubio-Gozalbo M, Knerr I, Fitzgibbon M, McVeigh TP, Foley P, Moss C, Colhoun HO, van Erven B, Stephens K, Doran P, Rudd P, Treacy E
Eur J Hum Genet 2016 Jul;24(7):976-84. Epub 2016 Jan 6 doi: 10.1038/ejhg.2015.254. PMID: 26733289Free PMC Article
Novel glycan biomarkers for the detection of lung cancer.
Arnold JN, Saldova R, Galligan MC, Murphy TB, Mimura-Kimura Y, Telford JE, Godwin AK, Rudd PM
J Proteome Res 2011 Apr 1;10(4):1755-64. Epub 2011 Mar 16 doi: 10.1021/pr101034t. PMID: 21214223

Clinical prediction guides

A highly specific antibody against the core fucose of the N-glycan in IgG identifies the pulmonary diseases and its regulation by CCL2.
Kanto N, Ohkawa Y, Kitano M, Maeda K, Shiida M, Ono T, Ota F, Kizuka Y, Kunimasa K, Nishino K, Mukai M, Seike M, Azuma A, Harada Y, Fukuda T, Gu J, Taniguchi N
J Biol Chem 2023 Dec;299(12):105365. Epub 2023 Oct 20 doi: 10.1016/j.jbc.2023.105365. PMID: 37865317Free PMC Article
Glycomic Profiling Highlights Increased Fucosylation in Pseudomyxoma Peritonei.
Saarinen L, Nummela P, Leinonen H, Heiskanen A, Thiel A, Haglund C, Lepistö A, Satomaa T, Hautaniemi S, Ristimäki A
Mol Cell Proteomics 2018 Nov;17(11):2107-2118. Epub 2018 Aug 2 doi: 10.1074/mcp.RA118.000615. PMID: 30072579Free PMC Article
Classical galactosaemia: novel insights in IgG N-glycosylation and N-glycan biosynthesis.
Maratha A, Stockmann H, Coss KP, Estela Rubio-Gozalbo M, Knerr I, Fitzgibbon M, McVeigh TP, Foley P, Moss C, Colhoun HO, van Erven B, Stephens K, Doran P, Rudd P, Treacy E
Eur J Hum Genet 2016 Jul;24(7):976-84. Epub 2016 Jan 6 doi: 10.1038/ejhg.2015.254. PMID: 26733289Free PMC Article
Glycosylation and liver cancer.
Mehta A, Herrera H, Block T
Adv Cancer Res 2015;126:257-79. Epub 2015 Feb 7 doi: 10.1016/bs.acr.2014.11.005. PMID: 25727150Free PMC Article
Changes in plasma and IgG N-glycome during childhood and adolescence.
Pucic M, Muzinic A, Novokmet M, Skledar M, Pivac N, Lauc G, Gornik O
Glycobiology 2012 Jul;22(7):975-82. Epub 2012 Mar 16 doi: 10.1093/glycob/cws062. PMID: 22426998

Recent systematic reviews

Expression of genes that control core fucosylation in hepatocellular carcinoma: Systematic review.
Norton PA, Mehta AS
World J Gastroenterol 2019 Jun 21;25(23):2947-2960. doi: 10.3748/wjg.v25.i23.2947. PMID: 31249452Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...