Increased mannosylation of N-linked protein glycosylation

MedGen UID:: 868535
•Concept ID:: C4022934
•: Finding

HPO:	HP:0012357

Definition

Increased addition of mannose to N-linked glycans. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVIncreased mannosylation of N-linked protein glycosylation

Abnormality of metabolism/homeostasis
- Abnormal metabolism
  - Abnormal glycosylation
    - Abnormal protein glycosylation
      - Abnormal protein N-linked glycosylation
        Abnormal mannosylation of N-linked protein glycosylation
        Increased mannosylation of N-linked protein glycosylation

Recent clinical studies

Etiology

Abnormal N-linked glycosylation of cortical AMPA receptor subunits in schizophrenia.

Tucholski J, Simmons MS, Pinner AL, Haroutunian V, McCullumsmith RE, Meador-Woodruff JH
Schizophr Res 2013 May;146(1-3):177-83. Epub 2013 Feb 23 doi: 10.1016/j.schres.2013.01.031. PMID: 23462048 Free PMC Article

Characterization of spontaneously generated prion-like conformers in cultured cells.

Zou RS, Fujioka H, Guo JP, Xiao X, Shimoji M, Kong C, Chen C, Tasnadi M, Voma C, Yuan J, Moudjou M, Laude H, Petersen RB, Zou WQ
Aging (Albany NY) 2011 Oct;3(10):968-84. doi: 10.18632/aging.100370. PMID: 21990137 Free PMC Article

Improved effector functions of a therapeutic monoclonal Lewis Y-specific antibody by glycoform engineering.

Schuster M, Umana P, Ferrara C, Brünker P, Gerdes C, Waxenecker G, Wiederkum S, Schwager C, Loibner H, Himmler G, Mudde GC
Cancer Res 2005 Sep 1;65(17):7934-41. doi: 10.1158/0008-5472.CAN-04-4212. PMID: 16140965

Biosynthesis and intracellular transport of the receptor for platelet-derived growth factor.

Claesson-Welsh L, Rönnstrand L, Heldin CH
Proc Natl Acad Sci U S A 1987 Dec;84(24):8796-800. doi: 10.1073/pnas.84.24.8796. PMID: 2827155 Free PMC Article

See all (4)

Diagnosis

Abnormal N-linked glycosylation of cortical AMPA receptor subunits in schizophrenia.

Increased levels and defective glycosylation of MRPs in ovarian carcinoma cells resistant to oxaliplatin.

Beretta GL, Benedetti V, Cossa G, Assaraf YG, Bram E, Gatti L, Corna E, Carenini N, Colangelo D, Howell SB, Zunino F, Perego P
Biochem Pharmacol 2010 Apr 15;79(8):1108-17. Epub 2009 Dec 31 doi: 10.1016/j.bcp.2009.12.002. PMID: 20005867

Expression of rat beta(1,4)-N-acetylglucosaminyltransferase III in Nicotiana tabacum remodels the plant-specific N-glycosylation.

Frey AD, Karg SR, Kallio PT
Plant Biotechnol J 2009 Jan;7(1):33-48. Epub 2008 Sep 3 doi: 10.1111/j.1467-7652.2008.00370.x. PMID: 18778316

Methods in enzymology: O-glycosylation of proteins.

Peter-Katalinić J
Methods Enzymol 2005;405:139-71. doi: 10.1016/S0076-6879(05)05007-X. PMID: 16413314

The E3-20.5K membrane protein of subgroup B human adenoviruses contains O-linked and complex N-linked oligosaccharides.

Hawkins LK, Wold WS
Virology 1995 Jul 10;210(2):335-44. doi: 10.1006/viro.1995.1350. PMID: 7618271

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Prognosis

The E3-20.5K membrane protein of subgroup B human adenoviruses contains O-linked and complex N-linked oligosaccharides.

Hawkins LK, Wold WS
Virology 1995 Jul 10;210(2):335-44. doi: 10.1006/viro.1995.1350. PMID: 7618271

See all (1)

Clinical prediction guides

N-Glycosylation of Asparagine 130 in the Extracellular Domain of the Human Calcitonin Receptor Significantly Increases Peptide Hormone Affinity.

Lee SM, Booe JM, Gingell JJ, Sjoelund V, Hay DL, Pioszak AA
Biochemistry 2017 Jul 5;56(26):3380-3393. Epub 2017 Jun 26 doi: 10.1021/acs.biochem.7b00256. PMID: 28614667 Free PMC Article

Expression of N-Acetylglucosaminyltransferase III Suppresses α2,3-Sialylation, and Its Distinctive Functions in Cell Migration Are Attributed to α2,6-Sialylation Levels.

Lu J, Isaji T, Im S, Fukuda T, Kameyama A, Gu J
J Biol Chem 2016 Mar 11;291(11):5708-5720. Epub 2016 Jan 22 doi: 10.1074/jbc.M115.712836. PMID: 26801611 Free PMC Article

Characterization of spontaneously generated prion-like conformers in cultured cells.

Increased levels and defective glycosylation of MRPs in ovarian carcinoma cells resistant to oxaliplatin.

Effect of differential N-linked and O-linked mannosylation on recognition of fungal antigens by dendritic cells.

Lam JS, Huang H, Levitz SM
PLoS One 2007 Oct 10;2(10):e1009. doi: 10.1371/journal.pone.0001009. PMID: 17925857 Free PMC Article

See all (11)