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Increased fucosylation of O-linked protein glycosylation

MedGen UID:: 868531
•Concept ID:: C4022930
•: Finding

HPO:	HP:0012361

Definition

Increased addition of fucose sugar units to O-linked glycans. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVIncreased fucosylation of O-linked protein glycosylation

Abnormality of metabolism/homeostasis
- Abnormal metabolism
  - Abnormal glycosylation
    - Abnormal protein glycosylation
      - Abnormal protein O-linked glycosylation
        Abnormal fucosylation of O-linked protein glycosylation
        Increased fucosylation of O-linked protein glycosylation

Recent clinical studies

Etiology

Alteration of the goat milk glycoproteins N/O-glycome at different lactation stages.

Lu Y, Li C, Liu J, Huang W, Yang Y, Jia Y, Liu T, Huang L, Wang Z
Food Chem 2021 Apr 16;342:128221. Epub 2020 Oct 12 doi: 10.1016/j.foodchem.2020.128221. PMID: 33092920

Changes in glycosylation of human bile-salt-stimulated lipase during lactation.

Landberg E, Huang Y, Strömqvist M, Mechref Y, Hansson L, Lundblad A, Novotny MV, Påhlsson P
Arch Biochem Biophys 2000 May 15;377(2):246-54. doi: 10.1006/abbi.2000.1778. PMID: 10845701

MUC1 glycoforms in breast cancer--cell line T47D as a model for carcinoma-associated alterations of 0-glycosylation.

Hanisch FG, Stadie TR, Deutzmann F, Peter-Katalinic J
Eur J Biochem 1996 Feb 15;236(1):318-27. doi: 10.1111/j.1432-1033.1996.00318.x. PMID: 8617281

See all (3)

Diagnosis

Identification of N- and O-linked glycans recognized by AAL in saliva of patients with atrophic gastritis and gastric cancer.

Shu J, Yu H, Du H, Zhang J, Zhang K, Li X, Xie H, Li Z
Cancer Biomark 2018;22(4):669-681. doi: 10.3233/CBM-171087. PMID: 29865036

Changes in the expression of N- and O-glycopeptides in patients with colorectal cancer and hepatocellular carcinoma quantified by full-MS scan FT-ICR and multiple reaction monitoring.

Darebna P, Novak P, Kucera R, Topolcan O, Sanda M, Goldman R, Pompach P
J Proteomics 2017 Feb 5;153:44-52. Epub 2016 Sep 16 doi: 10.1016/j.jprot.2016.09.004. PMID: 27646713 Free PMC Article

Carbohydrate and peptide structure of the alpha- and beta-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma.

Elliott MM, Kardana A, Lustbader JW, Cole LA
Endocrine 1997 Aug;7(1):15-32. doi: 10.1007/BF02778058. PMID: 9449027

Cancer-associated carbohydrates identified by monoclonal antibodies.

Sell S
Hum Pathol 1990 Oct;21(10):1003-19. doi: 10.1016/0046-8177(90)90250-9. PMID: 2210723

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Prognosis

Cancer-associated carbohydrates identified by monoclonal antibodies.

Sell S
Hum Pathol 1990 Oct;21(10):1003-19. doi: 10.1016/0046-8177(90)90250-9. PMID: 2210723

See all (1)

Clinical prediction guides

Changes in the expression of N- and O-glycopeptides in patients with colorectal cancer and hepatocellular carcinoma quantified by full-MS scan FT-ICR and multiple reaction monitoring.

Darebna P, Novak P, Kucera R, Topolcan O, Sanda M, Goldman R, Pompach P
J Proteomics 2017 Feb 5;153:44-52. Epub 2016 Sep 16 doi: 10.1016/j.jprot.2016.09.004. PMID: 27646713 Free PMC Article

See all (1)

MedGen

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Increased fucosylation of O-linked protein glycosylation

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Consumer resources

Reviews

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