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Increased urinary sulfate

MedGen UID:
868426
•Concept ID:
C4022820
•
Finding
Synonym: Increased urinary sulphate
 
HPO: HP:0012613

Definition

Elevated concentration of SO4(2-), i.e., sulfate, in the urine. [from HPO]

Conditions with this feature

Hypersulfaturia
MedGen UID:
1841147
•Concept ID:
C5830511
•
Disease or Syndrome
Hypersulfaturia (HYSULF) is an autosomal recessive condition characterized by increased urinary sulfate excretion due to defective renal sulfate reabsorption. The single reported patient with this condition presented with adult-onset perichondritis of the costovertebral joints (Pfau et al., 2023).
See: Condition Record
Hypersulfaturia

Professional guidelines

PubMed

Guidelines-similarities and dissimilarities: a systematic review of international clinical practice guidelines for pregnancy hypertension.
Scott G, Gillon TE, Pels A, von Dadelszen P, Magee LA
Am J Obstet Gynecol 2022 Feb;226(2S):S1222-S1236. Epub 2020 Aug 20 doi: 10.1016/j.ajog.2020.08.018. PMID: 32828743
Intravesical treatment for interstitial cystitis/painful bladder syndrome: a network meta-analysis.
Zhang W, Deng X, Liu C, Wang X
Int Urogynecol J 2017 Apr;28(4):515-525. Epub 2016 Sep 10 doi: 10.1007/s00192-016-3079-4. PMID: 27614759
Preeclampsia: pathophysiology, diagnosis, and management.
Lindheimer MD, Katz AI
Annu Rev Med 1989;40:233-50. doi: 10.1146/annurev.me.40.020189.001313. PMID: 2658750

Recent clinical studies

Etiology

Guidelines-similarities and dissimilarities: a systematic review of international clinical practice guidelines for pregnancy hypertension.
Scott G, Gillon TE, Pels A, von Dadelszen P, Magee LA
Am J Obstet Gynecol 2022 Feb;226(2S):S1222-S1236. Epub 2020 Aug 20 doi: 10.1016/j.ajog.2020.08.018. PMID: 32828743
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease.
Kikuchi K, Saigusa D, Kanemitsu Y, Matsumoto Y, Thanai P, Suzuki N, Mise K, Yamaguchi H, Nakamura T, Asaji K, Mukawa C, Tsukamoto H, Sato T, Oikawa Y, Iwasaki T, Oe Y, Tsukimi T, Fukuda NN, Ho HJ, Nanto-Hara F, Ogura J, Saito R, Nagao S, Ohsaki Y, Shimada S, Suzuki T, Toyohara T, Mishima E, Shima H, Akiyama Y, Akiyama Y, Ichijo M, Matsuhashi T, Matsuo A, Ogata Y, Yang CC, Suzuki C, Breeggemann MC, Heymann J, Shimizu M, Ogawa S, Takahashi N, Suzuki T, Owada Y, Kure S, Mano N, Soga T, Wada T, Kopp JB, Fukuda S, Hozawa A, Yamamoto M, Ito S, Wada J, Tomioka Y, Abe T
Nat Commun 2019 Apr 23;10(1):1835. doi: 10.1038/s41467-019-09735-4. PMID: 31015435Free PMC Article
Preventing urinary tract infections after menopause without antibiotics.
Caretto M, Giannini A, Russo E, Simoncini T
Maturitas 2017 May;99:43-46. Epub 2017 Feb 7 doi: 10.1016/j.maturitas.2017.02.004. PMID: 28364867
p-Cresyl Sulfate.
Gryp T, Vanholder R, Vaneechoutte M, Glorieux G
Toxins (Basel) 2017 Jan 29;9(2) doi: 10.3390/toxins9020052. PMID: 28146081Free PMC Article
Preeclampsia 2012.
Eiland E, Nzerue C, Faulkner M
J Pregnancy 2012;2012:586578. Epub 2012 Jul 11 doi: 10.1155/2012/586578. PMID: 22848831Free PMC Article

Diagnosis

Guidelines-similarities and dissimilarities: a systematic review of international clinical practice guidelines for pregnancy hypertension.
Scott G, Gillon TE, Pels A, von Dadelszen P, Magee LA
Am J Obstet Gynecol 2022 Feb;226(2S):S1222-S1236. Epub 2020 Aug 20 doi: 10.1016/j.ajog.2020.08.018. PMID: 32828743
Androgens in Cushing's Syndrome.
Arnaldi G, Martino M
Front Horm Res 2019;53:77-91. Epub 2019 Sep 9 doi: 10.1159/000494904. PMID: 31499501
Gitelman syndrome.
Cotovio P, Silva C, Oliveira N, Costa F
BMJ Case Rep 2013 Apr 11;2013 doi: 10.1136/bcr-2013-009095. PMID: 23585506Free PMC Article
Indinavir urolithiasis.
Wu DS, Stoller ML
Curr Opin Urol 2000 Nov;10(6):557-61. doi: 10.1097/00042307-200011000-00004. PMID: 11148725
Adrenal incidentaloma.
Arnaldi G, Masini AM, Giacchetti G, Taccaliti A, Faloia E, Mantero F
Braz J Med Biol Res 2000 Oct;33(10):1177-89. doi: 10.1590/s0100-879x2000001000007. PMID: 11004718

Therapy

Guidelines-similarities and dissimilarities: a systematic review of international clinical practice guidelines for pregnancy hypertension.
Scott G, Gillon TE, Pels A, von Dadelszen P, Magee LA
Am J Obstet Gynecol 2022 Feb;226(2S):S1222-S1236. Epub 2020 Aug 20 doi: 10.1016/j.ajog.2020.08.018. PMID: 32828743
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease.
Kikuchi K, Saigusa D, Kanemitsu Y, Matsumoto Y, Thanai P, Suzuki N, Mise K, Yamaguchi H, Nakamura T, Asaji K, Mukawa C, Tsukamoto H, Sato T, Oikawa Y, Iwasaki T, Oe Y, Tsukimi T, Fukuda NN, Ho HJ, Nanto-Hara F, Ogura J, Saito R, Nagao S, Ohsaki Y, Shimada S, Suzuki T, Toyohara T, Mishima E, Shima H, Akiyama Y, Akiyama Y, Ichijo M, Matsuhashi T, Matsuo A, Ogata Y, Yang CC, Suzuki C, Breeggemann MC, Heymann J, Shimizu M, Ogawa S, Takahashi N, Suzuki T, Owada Y, Kure S, Mano N, Soga T, Wada T, Kopp JB, Fukuda S, Hozawa A, Yamamoto M, Ito S, Wada J, Tomioka Y, Abe T
Nat Commun 2019 Apr 23;10(1):1835. doi: 10.1038/s41467-019-09735-4. PMID: 31015435Free PMC Article
Preventing urinary tract infections after menopause without antibiotics.
Caretto M, Giannini A, Russo E, Simoncini T
Maturitas 2017 May;99:43-46. Epub 2017 Feb 7 doi: 10.1016/j.maturitas.2017.02.004. PMID: 28364867
The gut-kidney axis.
Evenepoel P, Poesen R, Meijers B
Pediatr Nephrol 2017 Nov;32(11):2005-2014. Epub 2016 Nov 15 doi: 10.1007/s00467-016-3527-x. PMID: 27848096
Preeclampsia 2012.
Eiland E, Nzerue C, Faulkner M
J Pregnancy 2012;2012:586578. Epub 2012 Jul 11 doi: 10.1155/2012/586578. PMID: 22848831Free PMC Article

Prognosis

Fecal short chain fatty acids and urinary 3-indoxyl sulfate do not discriminate between patients with Crohn´s disease and ulcerative colitis and are not of diagnostic utility for predicting disease severity.
Tews HC, Elger T, Gunawan S, Fererberger T, Sommersberger S, Loibl J, Huss M, Liebisch G, Müller M, Kandulski A, Buechler C
Lipids Health Dis 2023 Oct 3;22(1):164. doi: 10.1186/s12944-023-01929-6. PMID: 37789460Free PMC Article
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease.
Kikuchi K, Saigusa D, Kanemitsu Y, Matsumoto Y, Thanai P, Suzuki N, Mise K, Yamaguchi H, Nakamura T, Asaji K, Mukawa C, Tsukamoto H, Sato T, Oikawa Y, Iwasaki T, Oe Y, Tsukimi T, Fukuda NN, Ho HJ, Nanto-Hara F, Ogura J, Saito R, Nagao S, Ohsaki Y, Shimada S, Suzuki T, Toyohara T, Mishima E, Shima H, Akiyama Y, Akiyama Y, Ichijo M, Matsuhashi T, Matsuo A, Ogata Y, Yang CC, Suzuki C, Breeggemann MC, Heymann J, Shimizu M, Ogawa S, Takahashi N, Suzuki T, Owada Y, Kure S, Mano N, Soga T, Wada T, Kopp JB, Fukuda S, Hozawa A, Yamamoto M, Ito S, Wada J, Tomioka Y, Abe T
Nat Commun 2019 Apr 23;10(1):1835. doi: 10.1038/s41467-019-09735-4. PMID: 31015435Free PMC Article
Preventing urinary tract infections after menopause without antibiotics.
Caretto M, Giannini A, Russo E, Simoncini T
Maturitas 2017 May;99:43-46. Epub 2017 Feb 7 doi: 10.1016/j.maturitas.2017.02.004. PMID: 28364867
p-Cresyl Sulfate.
Gryp T, Vanholder R, Vaneechoutte M, Glorieux G
Toxins (Basel) 2017 Jan 29;9(2) doi: 10.3390/toxins9020052. PMID: 28146081Free PMC Article
Adrenal incidentaloma.
Arnaldi G, Masini AM, Giacchetti G, Taccaliti A, Faloia E, Mantero F
Braz J Med Biol Res 2000 Oct;33(10):1177-89. doi: 10.1590/s0100-879x2000001000007. PMID: 11004718

Clinical prediction guides

Effects of forest environment (Shinrin-yoku/Forest bathing) on health promotion and disease prevention -the Establishment of "Forest Medicine".
Li Q
Environ Health Prev Med 2022;27:43. doi: 10.1265/ehpm.22-00160. PMID: 36328581Free PMC Article
The Evolving View of Uremic Toxicity.
Meijers B, Lowenstein J
Toxins (Basel) 2022 Apr 12;14(4) doi: 10.3390/toxins14040274. PMID: 35448883Free PMC Article
Guidelines-similarities and dissimilarities: a systematic review of international clinical practice guidelines for pregnancy hypertension.
Scott G, Gillon TE, Pels A, von Dadelszen P, Magee LA
Am J Obstet Gynecol 2022 Feb;226(2S):S1222-S1236. Epub 2020 Aug 20 doi: 10.1016/j.ajog.2020.08.018. PMID: 32828743
Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease.
Kikuchi K, Saigusa D, Kanemitsu Y, Matsumoto Y, Thanai P, Suzuki N, Mise K, Yamaguchi H, Nakamura T, Asaji K, Mukawa C, Tsukamoto H, Sato T, Oikawa Y, Iwasaki T, Oe Y, Tsukimi T, Fukuda NN, Ho HJ, Nanto-Hara F, Ogura J, Saito R, Nagao S, Ohsaki Y, Shimada S, Suzuki T, Toyohara T, Mishima E, Shima H, Akiyama Y, Akiyama Y, Ichijo M, Matsuhashi T, Matsuo A, Ogata Y, Yang CC, Suzuki C, Breeggemann MC, Heymann J, Shimizu M, Ogawa S, Takahashi N, Suzuki T, Owada Y, Kure S, Mano N, Soga T, Wada T, Kopp JB, Fukuda S, Hozawa A, Yamamoto M, Ito S, Wada J, Tomioka Y, Abe T
Nat Commun 2019 Apr 23;10(1):1835. doi: 10.1038/s41467-019-09735-4. PMID: 31015435Free PMC Article
Urinary sulfated glycosaminoglycan insufficiency and chondroitin sulfate supplement in urolithiasis.
Dissayabutra T, Kalpongnukul N, Chindaphan K, Srisa-Art M, Ungjaroenwathana W, Kaewwongse M, Iampenkhae K, Tosukhowong P
PLoS One 2019;14(3):e0213180. Epub 2019 Mar 7 doi: 10.1371/journal.pone.0213180. PMID: 30845174Free PMC Article

Recent systematic reviews

Guidelines-similarities and dissimilarities: a systematic review of international clinical practice guidelines for pregnancy hypertension.
Scott G, Gillon TE, Pels A, von Dadelszen P, Magee LA
Am J Obstet Gynecol 2022 Feb;226(2S):S1222-S1236. Epub 2020 Aug 20 doi: 10.1016/j.ajog.2020.08.018. PMID: 32828743
Safety of Symptomatic Slow-Acting Drugs for Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis.
Honvo G, Reginster JY, Rabenda V, Geerinck A, Mkinsi O, Charles A, Rizzoli R, Cooper C, Avouac B, Bruyère O
Drugs Aging 2019 Apr;36(Suppl 1):65-99. doi: 10.1007/s40266-019-00662-z. PMID: 31073924Free PMC Article
Prebiotic, Probiotic, and Synbiotic Supplementation in Chronic Kidney Disease: A Systematic Review and Meta-analysis.
McFarlane C, Ramos CI, Johnson DW, Campbell KL
J Ren Nutr 2019 May;29(3):209-220. Epub 2018 Oct 23 doi: 10.1053/j.jrn.2018.08.008. PMID: 30366767
Intravesical hyaluronic acid and chondroitin sulfate for recurrent urinary tract infections: systematic review and meta-analysis.
Goddard JC, Janssen DAW
Int Urogynecol J 2018 Jul;29(7):933-942. Epub 2017 Nov 27 doi: 10.1007/s00192-017-3508-z. PMID: 29181550Free PMC Article
A systematic review and meta-analysis on the use of phosphodiesterase 5 inhibitors alone or in combination with α-blockers for lower urinary tract symptoms due to benign prostatic hyperplasia.
Gacci M, Corona G, Salvi M, Vignozzi L, McVary KT, Kaplan SA, Roehrborn CG, Serni S, Mirone V, Carini M, Maggi M
Eur Urol 2012 May;61(5):994-1003. Epub 2012 Feb 25 doi: 10.1016/j.eururo.2012.02.033. PMID: 22405510

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