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Abnormal sperm neck morphology

MedGen UID:
868307
•Concept ID:
C4022701
•
Finding
Synonym: Sperm neck anomaly
 
HPO: HP:0012866

Definition

A structural abnormality of the sperm neck. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal sperm neck morphology

Professional guidelines

PubMed

Sperm parameters in men with suspected infertility. Sperm characteristics, strict criteria sperm morphology analysis and hypoosmotic swelling test.
Andrade-Rocha FT
J Reprod Med 2001 Jun;46(6):577-82. PMID: 11441683
Quantitative ultramorphological analysis of human sperm: fifteen years of experience in the diagnosis and management of male factor infertility.
Bartoov B, Eltes F, Reichart M, Langzam J, Lederman H, Zabludovsky N
Arch Androl 1999 Jul-Aug;43(1):13-25. doi: 10.1080/014850199262698. PMID: 10445101
Quantitative ultramorphological (QUM) analysis of human sperm: diagnosis and management of male infertility.
Bartoov B, Eltes F, Reichart M, Langzam J, Lederman H, Zabludovsky N
Arch Androl 1999 May-Jun;42(3):161-77. doi: 10.1080/014850199262823. PMID: 10407647

Recent clinical studies

Etiology

Male reproductive function before and after the adjustment of the COVID-19 prevention policy: a multicenter study in China.
Li JZ, Wu H, Wang L, Wang YS, Kong F, Cao LQ, Liang M, Wang X, Yuan MZ
Asian J Androl 2024 May 1;26(3):308-314. Epub 2024 Apr 19 doi: 10.4103/aja202388. PMID: 38639721Free PMC Article
Lifestyle and semen quality: role of modifiable risk factors.
Jurewicz J, Radwan M, Sobala W, Ligocka D, Radwan P, Bochenek M, Hanke W
Syst Biol Reprod Med 2014 Feb;60(1):43-51. Epub 2013 Sep 30 doi: 10.3109/19396368.2013.840687. PMID: 24074254
Tales of the tail and sperm head aches: changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail.
Chemes HE, Alvarez Sedo C
Asian J Androl 2012 Jan;14(1):14-23. Epub 2011 Dec 26 doi: 10.1038/aja.2011.168. PMID: 22198630Free PMC Article
Isolated teratozoospermia: a cause of male sterility in the era of ICSI?
Francavilla S, Cordeschi G, Pelliccione F, Bocchio M, Francavilla F
Front Biosci 2007 Jan 1;12:69-88. doi: 10.2741/2049. PMID: 17127284
Sperm pathology: a step beyond descriptive morphology. Origin, characterization and fertility potential of abnormal sperm phenotypes in infertile men.
Chemes EH, Rawe YV
Hum Reprod Update 2003 Sep-Oct;9(5):405-28. doi: 10.1093/humupd/dmg034. PMID: 14640375

Diagnosis

Impact of semen oxidative stress on sperm quality: initial results from Vietnam.
Nguyen ND, Le MT, Dang HNT, Van Nguyen T, Nguyen QHV, Cao TN
J Int Med Res 2023 Aug;51(8):3000605231188655. doi: 10.1177/03000605231188655. PMID: 37572034Free PMC Article
Sperm morphology: assessment, pathophysiology, clinical relevance, and state of the art in 2017.
Gatimel N, Moreau J, Parinaud J, Léandri RD
Andrology 2017 Sep;5(5):845-862. Epub 2017 Jul 10 doi: 10.1111/andr.12389. PMID: 28692759
Lifestyle and semen quality: role of modifiable risk factors.
Jurewicz J, Radwan M, Sobala W, Ligocka D, Radwan P, Bochenek M, Hanke W
Syst Biol Reprod Med 2014 Feb;60(1):43-51. Epub 2013 Sep 30 doi: 10.3109/19396368.2013.840687. PMID: 24074254
Tales of the tail and sperm head aches: changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail.
Chemes HE, Alvarez Sedo C
Asian J Androl 2012 Jan;14(1):14-23. Epub 2011 Dec 26 doi: 10.1038/aja.2011.168. PMID: 22198630Free PMC Article
Quantitative ultramorphological (QUM) analysis of human sperm: diagnosis and management of male infertility.
Bartoov B, Eltes F, Reichart M, Langzam J, Lederman H, Zabludovsky N
Arch Androl 1999 May-Jun;42(3):161-77. doi: 10.1080/014850199262823. PMID: 10407647

Therapy

INFLUENCE OF ADDING ZINC ARGINYLE-GLYCINATE TO IMPROVE EFFICACY OF BIOREGULATORY PEPTIDES OF THE PROSTATE GLAND IN TREATMENT OF PATIENTS WITH IMPAIRED SPERM PARAMETERS.
Rybalov M, Borovets S, Petlenko S, Krasnov A, Apryatina V
Georgian Med News 2022 Jul-Aug;(328-329):108-114. PMID: 36318852
Impaired semen quality, an increase of sperm morphological defects and DNA fragmentation associated with environmental pollution in urban population of young men from Western Siberia, Russia.
Kleshchev M, Osadchuk A, Osadchuk L
PLoS One 2021;16(10):e0258900. Epub 2021 Oct 22 doi: 10.1371/journal.pone.0258900. PMID: 34679097Free PMC Article
Homozygous pathogenic variants in ACTL9 cause fertilization failure and male infertility in humans and mice.
Dai J, Zhang T, Guo J, Zhou Q, Gu Y, Zhang J, Hu L, Zong Y, Song J, Zhang S, Dai C, Gong F, Lu G, Zheng W, Lin G
Am J Hum Genet 2021 Mar 4;108(3):469-481. Epub 2021 Feb 23 doi: 10.1016/j.ajhg.2021.02.004. PMID: 33626338Free PMC Article
Novel IFT140 variants cause spermatogenic dysfunction in humans.
Wang X, Sha YW, Wang WT, Cui YQ, Chen J, Yan W, Hou XT, Mei LB, Yu CC, Wang J
Mol Genet Genomic Med 2019 Sep;7(9):e920. Epub 2019 Aug 8 doi: 10.1002/mgg3.920. PMID: 31397098Free PMC Article
Evaluation of atorvastatin efficacy and toxicity on spermatozoa, accessory glands and gonadal hormones of healthy men: a pilot prospective clinical trial.
Pons-Rejraji H, Brugnon F, Sion B, Maqdasy S, Gouby G, Pereira B, Marceau G, Gremeau AS, Drevet J, Grizard G, Janny L, Tauveron I
Reprod Biol Endocrinol 2014 Jul 12;12:65. doi: 10.1186/1477-7827-12-65. PMID: 25016482Free PMC Article

Prognosis

Impact of semen oxidative stress on sperm quality: initial results from Vietnam.
Nguyen ND, Le MT, Dang HNT, Van Nguyen T, Nguyen QHV, Cao TN
J Int Med Res 2023 Aug;51(8):3000605231188655. doi: 10.1177/03000605231188655. PMID: 37572034Free PMC Article
A novel homozygous mutation in WDR19 induces disorganization of microtubules in sperm flagella and nonsyndromic asthenoteratospermia.
Ni X, Wang J, Lv M, Liu C, Zhong Y, Tian S, Wu H, Cheng H, Gao Y, Tan Q, Chen B, Li Q, Song B, Wei Z, Zhou P, He X, Zhang F, Cao Y
J Assist Reprod Genet 2020 Jun;37(6):1431-1439. Epub 2020 Apr 23 doi: 10.1007/s10815-020-01770-1. PMID: 32323121Free PMC Article
Novel IFT140 variants cause spermatogenic dysfunction in humans.
Wang X, Sha YW, Wang WT, Cui YQ, Chen J, Yan W, Hou XT, Mei LB, Yu CC, Wang J
Mol Genet Genomic Med 2019 Sep;7(9):e920. Epub 2019 Aug 8 doi: 10.1002/mgg3.920. PMID: 31397098Free PMC Article
Tales of the tail and sperm head aches: changing concepts on the prognostic significance of sperm pathologies affecting the head, neck and tail.
Chemes HE, Alvarez Sedo C
Asian J Androl 2012 Jan;14(1):14-23. Epub 2011 Dec 26 doi: 10.1038/aja.2011.168. PMID: 22198630Free PMC Article
Sperm pathology: a step beyond descriptive morphology. Origin, characterization and fertility potential of abnormal sperm phenotypes in infertile men.
Chemes EH, Rawe YV
Hum Reprod Update 2003 Sep-Oct;9(5):405-28. doi: 10.1093/humupd/dmg034. PMID: 14640375

Clinical prediction guides

Male reproductive function before and after the adjustment of the COVID-19 prevention policy: a multicenter study in China.
Li JZ, Wu H, Wang L, Wang YS, Kong F, Cao LQ, Liang M, Wang X, Yuan MZ
Asian J Androl 2024 May 1;26(3):308-314. Epub 2024 Apr 19 doi: 10.4103/aja202388. PMID: 38639721Free PMC Article
Impact of semen oxidative stress on sperm quality: initial results from Vietnam.
Nguyen ND, Le MT, Dang HNT, Van Nguyen T, Nguyen QHV, Cao TN
J Int Med Res 2023 Aug;51(8):3000605231188655. doi: 10.1177/03000605231188655. PMID: 37572034Free PMC Article
SEPT12-NDC1 Complexes Are Required for Mammalian Spermiogenesis.
Lai TH, Wu YY, Wang YY, Chen MF, Wang P, Chen TM, Wu YN, Chiang HS, Kuo PL, Lin YH
Int J Mol Sci 2016 Nov 16;17(11) doi: 10.3390/ijms17111911. PMID: 27854341Free PMC Article
Sperm head morphology is related to high deoxyribonucleic acid stainability assessed by sperm chromatin structure assay.
Zini A, Phillips S, Courchesne A, Boman JM, Baazeem A, Bissonnette F, Kadoch IJ, San Gabriel M
Fertil Steril 2009 Jun;91(6):2495-500. Epub 2008 Jun 13 doi: 10.1016/j.fertnstert.2008.03.032. PMID: 18555233
Functional competence of abnormal spermatozoa.
Sathananthan AH
Baillieres Clin Obstet Gynaecol 1994 Mar;8(1):141-56. doi: 10.1016/s0950-3552(05)80029-x. PMID: 8055671

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