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Abnormal sperm tail morphology

MedGen UID:
868305
•Concept ID:
C4022699
•
Finding
Synonym: Sperm tail anomaly
 
HPO: HP:0012868

Definition

A structural abnormality of the sperm tail. [from HPO]

Conditions with this feature

Deafness-infertility syndrome
MedGen UID:
370197
•Concept ID:
C1970187
•
Disease or Syndrome
CATSPER-related male infertility results from abnormalities in sperm and can be either CATSPER-related nonsyndromic male infertility (NSMI) or the deafness-infertility syndrome (DIS) when associated with non-progressive prelingual sensorineural hearing loss. Males with NSMI have infertility while females have no symptoms. Males with DIS have both infertility and hearing loss, while females have only hearing loss. Routine semen analysis typically identifies abnormalities in sperm number, morphology, and motility. Otologic examination and audiologic assessment can identify hearing loss.
See: Condition Record
Deafness-infertility syndrome

Professional guidelines

PubMed

Evaluation of morphological criteria of sperm quality before in vitro fertilization and intracytoplasmic sperm injection.
Lasiene K, Gedrimas V, Vitkus A, Glinskyte S, Lasys V, Valanciute A, Sienkiewicz W
Pol J Vet Sci 2013;16(4):773-85. doi: 10.2478/pjvs-2013-0112. PMID: 24597318
Ciliary syndromes and treatment.
Klysik M
Pathol Res Pract 2008;204(2):77-88. doi: 10.1016/j.prp.2007.10.013. PMID: 18312782
Quantitative ultramorphological (QUM) analysis of human sperm: diagnosis and management of male infertility.
Bartoov B, Eltes F, Reichart M, Langzam J, Lederman H, Zabludovsky N
Arch Androl 1999 May-Jun;42(3):161-77. doi: 10.1080/014850199262823. PMID: 10407647

Recent clinical studies

Etiology

Age-Related Changes in Sperm Morphology and Analysis of Multiple Sperm Defects.
Kleshchev M, Osadchuk L, Osadchuk A
Front Biosci (Schol Ed) 2023 Sep 27;15(3):12. doi: 10.31083/j.fbs1503012. PMID: 37806952
Sperm abnormality and infertility in male mice treated with the recommended dose of dimethoate and its double.
Sasi SM, Alghoul NM, Awayn N, Elghoul A, Prastiya RA
Open Vet J 2023 Jul;13(7):873-878. Epub 2023 Jul 31 doi: 10.5455/OVJ.2023.v13.i7.9. PMID: 37614725Free PMC Article
Improvement of sperm morphology after surgical varicocele repair.
Morini D, Spaggiari G, Daolio J, Melli B, Nicoli A, De Feo G, Valli B, Viola D, Garganigo S, Magnani E, Pilia A, Polese A, Colla R, Simoni M, Aguzzoli L, Villani MT, Santi D
Andrology 2021 Jul;9(4):1176-1184. Epub 2021 May 6 doi: 10.1111/andr.13012. PMID: 33825345Free PMC Article
Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility.
Liu C, Tu C, Wang L, Wu H, Houston BJ, Mastrorosa FK, Zhang W, Shen Y, Wang J, Tian S, Meng L, Cong J, Yang S, Jiang Y, Tang S, Zeng Y, Lv M, Lin G, Li J, Saiyin H, He X, Jin L, Touré A, Ray PF, Veltman JA, Shi Q, O'Bryan MK, Cao Y, Tan YQ, Zhang F
Am J Hum Genet 2021 Feb 4;108(2):309-323. Epub 2021 Jan 19 doi: 10.1016/j.ajhg.2021.01.002. PMID: 33472045Free PMC Article
Teratozoospermia: spotlight on the main genetic actors in the human.
Coutton C, Escoffier J, Martinez G, Arnoult C, Ray PF
Hum Reprod Update 2015 Jul-Aug;21(4):455-85. Epub 2015 Apr 17 doi: 10.1093/humupd/dmv020. PMID: 25888788

Diagnosis

Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice.
Tan C, Meng L, Lv M, He X, Sha Y, Tang D, Tan Y, Hu T, He W, Tu C, Nie H, Zhang H, Du J, Lu G, Fan LQ, Cao Y, Lin G, Tan YQ
Am J Hum Genet 2022 Jan 6;109(1):157-171. Epub 2021 Dec 20 doi: 10.1016/j.ajhg.2021.11.022. PMID: 34932939Free PMC Article
The anatomy, movement, and functions of human sperm tail: an evolving mystery.
Kumar N, Singh AK
Biol Reprod 2021 Mar 11;104(3):508-520. doi: 10.1093/biolre/ioaa213. PMID: 33238303
Headless spermatozoa in infertile men.
Sha YW, Ding L, Wu JX, Lin SB, Wang X, Ji ZY, Li P
Andrologia 2017 Oct;49(8) Epub 2016 Oct 6 doi: 10.1111/and.12716. PMID: 27709648
Major regulatory mechanisms involved in sperm motility.
Pereira R, Sá R, Barros A, Sousa M
Asian J Androl 2017 Jan-Feb;19(1):5-14. doi: 10.4103/1008-682X.167716. PMID: 26680031Free PMC Article
Ciliary syndromes and treatment.
Klysik M
Pathol Res Pract 2008;204(2):77-88. doi: 10.1016/j.prp.2007.10.013. PMID: 18312782

Therapy

Age-Related Changes in Sperm Morphology and Analysis of Multiple Sperm Defects.
Kleshchev M, Osadchuk L, Osadchuk A
Front Biosci (Schol Ed) 2023 Sep 27;15(3):12. doi: 10.31083/j.fbs1503012. PMID: 37806952
Abnormal sperm morphology is associated with sensitization to inhaled allergens.
Adamczak R, Ukleja-Sokołowska N, Pasińska M, Zielińska J, Leśny M, Dubiel M
Int J Immunopathol Pharmacol 2022 Jan-Dec;36:20587384211066718. doi: 10.1177/20587384211066718. PMID: 34984934Free PMC Article
Major regulatory mechanisms involved in sperm motility.
Pereira R, Sá R, Barros A, Sousa M
Asian J Androl 2017 Jan-Feb;19(1):5-14. doi: 10.4103/1008-682X.167716. PMID: 26680031Free PMC Article
Another look at human sperm morphology.
Auger J, Jouannet P, Eustache F
Hum Reprod 2016 Jan;31(1):10-23. Epub 2015 Oct 14 doi: 10.1093/humrep/dev251. PMID: 26472152
Genetical and ultrastructural aspects of the immotile-cilia syndrome.
Afzelius BA
Am J Hum Genet 1981 Nov;33(6):852-64. PMID: 7034533Free PMC Article

Prognosis

Impact of semen oxidative stress on sperm quality: initial results from Vietnam.
Nguyen ND, Le MT, Dang HNT, Van Nguyen T, Nguyen QHV, Cao TN
J Int Med Res 2023 Aug;51(8):3000605231188655. doi: 10.1177/03000605231188655. PMID: 37572034Free PMC Article
Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice.
Tan C, Meng L, Lv M, He X, Sha Y, Tang D, Tan Y, Hu T, He W, Tu C, Nie H, Zhang H, Du J, Lu G, Fan LQ, Cao Y, Lin G, Tan YQ
Am J Hum Genet 2022 Jan 6;109(1):157-171. Epub 2021 Dec 20 doi: 10.1016/j.ajhg.2021.11.022. PMID: 34932939Free PMC Article
Improvement of sperm morphology after surgical varicocele repair.
Morini D, Spaggiari G, Daolio J, Melli B, Nicoli A, De Feo G, Valli B, Viola D, Garganigo S, Magnani E, Pilia A, Polese A, Colla R, Simoni M, Aguzzoli L, Villani MT, Santi D
Andrology 2021 Jul;9(4):1176-1184. Epub 2021 May 6 doi: 10.1111/andr.13012. PMID: 33825345Free PMC Article
Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility.
Liu C, Tu C, Wang L, Wu H, Houston BJ, Mastrorosa FK, Zhang W, Shen Y, Wang J, Tian S, Meng L, Cong J, Yang S, Jiang Y, Tang S, Zeng Y, Lv M, Lin G, Li J, Saiyin H, He X, Jin L, Touré A, Ray PF, Veltman JA, Shi Q, O'Bryan MK, Cao Y, Tan YQ, Zhang F
Am J Hum Genet 2021 Feb 4;108(2):309-323. Epub 2021 Jan 19 doi: 10.1016/j.ajhg.2021.01.002. PMID: 33472045Free PMC Article
Teratozoospermia: spotlight on the main genetic actors in the human.
Coutton C, Escoffier J, Martinez G, Arnoult C, Ray PF
Hum Reprod Update 2015 Jul-Aug;21(4):455-85. Epub 2015 Apr 17 doi: 10.1093/humupd/dmv020. PMID: 25888788

Clinical prediction guides

Age-Related Changes in Sperm Morphology and Analysis of Multiple Sperm Defects.
Kleshchev M, Osadchuk L, Osadchuk A
Front Biosci (Schol Ed) 2023 Sep 27;15(3):12. doi: 10.31083/j.fbs1503012. PMID: 37806952
Prediction of Sperm Progression in Three Dimensions Using Rapid Optical Imaging and Dynamic Mechanical Modeling.
Nassir M, Levi M, Dardikman-Yoffe G, Mirsky SK, Shaked NT
Cells 2022 Apr 13;11(8) doi: 10.3390/cells11081319. PMID: 35455999Free PMC Article
Bi-allelic variants in DNHD1 cause flagellar axoneme defects and asthenoteratozoospermia in humans and mice.
Tan C, Meng L, Lv M, He X, Sha Y, Tang D, Tan Y, Hu T, He W, Tu C, Nie H, Zhang H, Du J, Lu G, Fan LQ, Cao Y, Lin G, Tan YQ
Am J Hum Genet 2022 Jan 6;109(1):157-171. Epub 2021 Dec 20 doi: 10.1016/j.ajhg.2021.11.022. PMID: 34932939Free PMC Article
Improvement of sperm morphology after surgical varicocele repair.
Morini D, Spaggiari G, Daolio J, Melli B, Nicoli A, De Feo G, Valli B, Viola D, Garganigo S, Magnani E, Pilia A, Polese A, Colla R, Simoni M, Aguzzoli L, Villani MT, Santi D
Andrology 2021 Jul;9(4):1176-1184. Epub 2021 May 6 doi: 10.1111/andr.13012. PMID: 33825345Free PMC Article
Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility.
Liu C, Tu C, Wang L, Wu H, Houston BJ, Mastrorosa FK, Zhang W, Shen Y, Wang J, Tian S, Meng L, Cong J, Yang S, Jiang Y, Tang S, Zeng Y, Lv M, Lin G, Li J, Saiyin H, He X, Jin L, Touré A, Ray PF, Veltman JA, Shi Q, O'Bryan MK, Cao Y, Tan YQ, Zhang F
Am J Hum Genet 2021 Feb 4;108(2):309-323. Epub 2021 Jan 19 doi: 10.1016/j.ajhg.2021.01.002. PMID: 33472045Free PMC Article

Recent systematic reviews

Genetic basis of acephalic spermatozoa syndrome, and intracytoplasmic sperm injection outcomes in infertile men: a systematic scoping review.
Mazaheri Moghaddam M, Mazaheri Moghaddam M, Hamzeiy H, Baghbanzadeh A, Pashazadeh F, Sakhinia E
J Assist Reprod Genet 2021 Mar;38(3):573-586. Epub 2021 Jan 15 doi: 10.1007/s10815-020-02008-w. PMID: 33452591Free PMC Article
Primary cilia: biosensors of the male reproductive tract.
Girardet L, Augière C, Asselin MP, Belleannée C
Andrology 2019 Sep;7(5):588-602. Epub 2019 May 26 doi: 10.1111/andr.12650. PMID: 31131532
Ultrasound of the male genital tract in relation to male reproductive health.
Lotti F, Maggi M
Hum Reprod Update 2015 Jan-Feb;21(1):56-83. Epub 2014 Jul 19 doi: 10.1093/humupd/dmu042. PMID: 25038770

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