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Abnormal CSF lactate concentration

MedGen UID:
868264
•Concept ID:
C4022656
•
Finding
Synonym: Abnormal CSF lactate level
 
HPO: HP:0030085

Definition

Abnormal concentration of lactate in the cerebrospinal fluid. [from HPO]

Professional guidelines

PubMed

Treatment of Kearns-Sayre syndrome with coenzyme Q10.
Ogasahara S, Nishikawa Y, Yorifuji S, Soga F, Nakamura Y, Takahashi M, Hashimoto S, Kono N, Tarui S
Neurology 1986 Jan;36(1):45-53. doi: 10.1212/wnl.36.1.45. PMID: 3941783

Recent clinical studies

Etiology

Cerebrospinal fluid findings in patients with hematologic neoplasms and meningeal infiltration.
Domingues RB, de Moura Leite FBV, Senne C
Acta Neurol Belg 2021 Dec;121(6):1543-1546. Epub 2020 Jun 10 doi: 10.1007/s13760-020-01397-0. PMID: 32519319
Cerebrospinal Fluid Glucose and Lactate Levels After Subarachnoid Hemorrhage: A Multicenter Retrospective Study.
Taccone FS, Badenes R, Arib S, Rubulotta F, Mirek S, Franchi F, Gordon S, Nadji A, Crippa IA, Stazi E, Bouhemad B, Lozano Roig A, Creteur J, Bilotta F
J Neurosurg Anesthesiol 2020 Apr;32(2):170-176. doi: 10.1097/ANA.0000000000000584. PMID: 31116707
Developmental outcomes and prevalence of SLC2A1 variants in young infants with hypoglycorrhachia.
Yu WH, Chen LW, Wang ST, Tu YF, Huang CC
Brain Dev 2019 Nov;41(10):854-861. Epub 2019 Jul 17 doi: 10.1016/j.braindev.2019.07.004. PMID: 31326153
Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma - method-comparison evaluations.
Almeida SM, Marquie-Beck J, Bhatt A, Letendre S, McCutchan A, Ellis R; HNRC Group
Arq Neuropsiquiatr 2014 Jul;72(7):500-5. doi: 10.1590/0004-282x20140076. PMID: 25054981Free PMC Article
Assessing cerebrospinal fluid abnormalities in neurosyphilis patients without human immunodeficiency virus infection.
Liu LL, Zhang HL, Huang SJ, Liu L, Tong ML, Lin LR, Chen YY, Xi Y, Guo XJ, Zhang YF
Int Immunopharmacol 2013 Dec;17(4):1120-4. doi: 10.1016/j.intimp.2013.10.008. PMID: 24459685

Diagnosis

Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma - method-comparison evaluations.
Almeida SM, Marquie-Beck J, Bhatt A, Letendre S, McCutchan A, Ellis R; HNRC Group
Arq Neuropsiquiatr 2014 Jul;72(7):500-5. doi: 10.1590/0004-282x20140076. PMID: 25054981Free PMC Article
Assessing cerebrospinal fluid abnormalities in neurosyphilis patients without human immunodeficiency virus infection.
Liu LL, Zhang HL, Huang SJ, Liu L, Tong ML, Lin LR, Chen YY, Xi Y, Guo XJ, Zhang YF
Int Immunopharmacol 2013 Dec;17(4):1120-4. doi: 10.1016/j.intimp.2013.10.008. PMID: 24459685
GLUT1 deficiency syndrome as a cause of encephalopathy that includes cognitive disability, treatment-resistant infantile epilepsy and a complex movement disorder.
Graham JM Jr
Eur J Med Genet 2012 May;55(5):332-4. Epub 2011 Dec 20 doi: 10.1016/j.ejmg.2011.11.009. PMID: 22212417Free PMC Article
1H magnetic resonance spectroscopy in human hydrocephalus.
Braun KP, Gooskens RH, Vandertop WP, Tulleken CA, van der Grond J
J Magn Reson Imaging 2003 Mar;17(3):291-9. doi: 10.1002/jmri.10270. PMID: 12594718
Cerebro-hepato-renal syndrome of Zellweger: clinical symptoms and relevant laboratory findings in 16 patients.
Govaerts L, Monnens L, Tegelaers W, Trijbels F, van Raay-Selten A
Eur J Pediatr 1982 Oct;139(2):125-8. doi: 10.1007/BF00441495. PMID: 7151832

Therapy

The role of G-CSF neuroprotective effects in neonatal hypoxic-ischemic encephalopathy (HIE): current status.
Dumbuya JS, Chen L, Wu JY, Wang B
J Neuroinflammation 2021 Feb 21;18(1):55. doi: 10.1186/s12974-021-02084-4. PMID: 33612099Free PMC Article
Stress responsive neurohormones in depression and anxiety.
Ströhle A, Holsboer F
Pharmacopsychiatry 2003 Nov;36 Suppl 3:S207-14. doi: 10.1055/s-2003-45132. PMID: 14677081
Proton MR spectroscopy in a child with pyruvate dehydrogenase complex deficiency.
Rubio-Gozalbo ME, Heerschap A, Trijbels JM, De Meirleir L, Thijssen HO, Smeitink JA
Magn Reson Imaging 1999 Jul;17(6):939-44. doi: 10.1016/s0730-725x(99)00002-8. PMID: 10402601
Tardive dyskinesia and substrates of energy metabolism in CSF.
Goff DC, Tsai G, Beal MF, Coyle JT
Am J Psychiatry 1995 Dec;152(12):1730-6. doi: 10.1176/ajp.152.12.1730. PMID: 8526238
An unusual aminoacidopathy associated with mitochondrial encephalomyopathy.
Perry TL, Hansen S, Booth FA, Penn AM, Jones K, Dilling LA
J Inherit Metab Dis 1989;12(1):23-32. doi: 10.1007/BF01805527. PMID: 2501579

Prognosis

Cerebrospinal Fluid Glucose and Lactate Levels After Subarachnoid Hemorrhage: A Multicenter Retrospective Study.
Taccone FS, Badenes R, Arib S, Rubulotta F, Mirek S, Franchi F, Gordon S, Nadji A, Crippa IA, Stazi E, Bouhemad B, Lozano Roig A, Creteur J, Bilotta F
J Neurosurg Anesthesiol 2020 Apr;32(2):170-176. doi: 10.1097/ANA.0000000000000584. PMID: 31116707
Portable lactate analyzer for measuring lactate in cerebrospinal fluid (CSF) and plasma - method-comparison evaluations.
Almeida SM, Marquie-Beck J, Bhatt A, Letendre S, McCutchan A, Ellis R; HNRC Group
Arq Neuropsiquiatr 2014 Jul;72(7):500-5. doi: 10.1590/0004-282x20140076. PMID: 25054981Free PMC Article
Assessing cerebrospinal fluid abnormalities in neurosyphilis patients without human immunodeficiency virus infection.
Liu LL, Zhang HL, Huang SJ, Liu L, Tong ML, Lin LR, Chen YY, Xi Y, Guo XJ, Zhang YF
Int Immunopharmacol 2013 Dec;17(4):1120-4. doi: 10.1016/j.intimp.2013.10.008. PMID: 24459685
Mitochondrial diseases mimicking neurotransmitter defects.
Garcia-Cazorla A, Duarte S, Serrano M, Nascimento A, Ormazabal A, Carrilho I, Briones P, Montoya J, Garesse R, Sala-Castellvi P, Pineda M, Artuch R
Mitochondrion 2008 Jun;8(3):273-8. Epub 2008 May 21 doi: 10.1016/j.mito.2008.05.001. PMID: 18558519
Stress responsive neurohormones in depression and anxiety.
Ströhle A, Holsboer F
Pharmacopsychiatry 2003 Nov;36 Suppl 3:S207-14. doi: 10.1055/s-2003-45132. PMID: 14677081

Clinical prediction guides

Cerebrospinal Fluid Glucose and Lactate Levels After Subarachnoid Hemorrhage: A Multicenter Retrospective Study.
Taccone FS, Badenes R, Arib S, Rubulotta F, Mirek S, Franchi F, Gordon S, Nadji A, Crippa IA, Stazi E, Bouhemad B, Lozano Roig A, Creteur J, Bilotta F
J Neurosurg Anesthesiol 2020 Apr;32(2):170-176. doi: 10.1097/ANA.0000000000000584. PMID: 31116707
Developmental outcomes and prevalence of SLC2A1 variants in young infants with hypoglycorrhachia.
Yu WH, Chen LW, Wang ST, Tu YF, Huang CC
Brain Dev 2019 Nov;41(10):854-861. Epub 2019 Jul 17 doi: 10.1016/j.braindev.2019.07.004. PMID: 31326153
Stress responsive neurohormones in depression and anxiety.
Ströhle A, Holsboer F
Pharmacopsychiatry 2003 Nov;36 Suppl 3:S207-14. doi: 10.1055/s-2003-45132. PMID: 14677081
Proton MR spectroscopy in a child with pyruvate dehydrogenase complex deficiency.
Rubio-Gozalbo ME, Heerschap A, Trijbels JM, De Meirleir L, Thijssen HO, Smeitink JA
Magn Reson Imaging 1999 Jul;17(6):939-44. doi: 10.1016/s0730-725x(99)00002-8. PMID: 10402601
A near homoplasmic T8993G mtDNA mutation in a patient with atypic Leigh syndrome not present in the mother's tissues.
Degoul F, François D, Diry M, Ponsot G, Desguerre I, Héron B, Marsac C, Moutard ML
J Inherit Metab Dis 1997 Mar;20(1):49-53. doi: 10.1023/a:1005357506614. PMID: 9061567

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