U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Glomerulomegaly

MedGen UID:
868212
Concept ID:
C4022604
Disease or Syndrome; Finding
Synonym: Glomeruli enlarged
 
HPO: HP:0030162

Definition

Abnormally large size of glomeruli. [from HPO]

Conditions with this feature

Glomerulopathy with fibronectin deposits 2
MedGen UID:
356149
Concept ID:
C1866075
Disease or Syndrome
Glomerulopathy with fibronectin deposits is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. Pathologic examination shows enlarged glomeruli with mesangial and subendothelial fibrillary deposits that show strong immunoreactivity to fibronectin (Castelletti et al., 2008). For a discussion of genetic heterogeneity of GFND, see 137950.

Professional guidelines

PubMed

Xu T, Sheng Z, Yao L
Front Med 2017 Sep;11(3):340-348. Epub 2017 Aug 8 doi: 10.1007/s11684-017-0570-3. PMID: 28791668
Ahmed MH
Expert Opin Emerg Drugs 2006 Nov;11(4):563-5. doi: 10.1517/14728214.11.4.563. PMID: 17064218

Recent clinical studies

Etiology

Hti Lar Seng NS, Lohana P, Chandra S, Jim B
Am J Med 2023 Oct;136(10):965-974. Epub 2023 Jul 13 doi: 10.1016/j.amjmed.2023.06.025. PMID: 37451390
Adeva-Andany MM, Funcasta-Calderón R, Fernández-Fernández C, Ameneiros-Rodríguez E, Vila-Altesor M, Castro-Quintela E
Pflugers Arch 2023 Aug;475(8):911-932. Epub 2023 Jun 1 doi: 10.1007/s00424-023-02821-z. PMID: 37261508Free PMC Article
Sandino J, Luzardo L, Morales E, Praga M
Nephron 2021;145(6):595-603. Epub 2021 Mar 5 doi: 10.1159/000513868. PMID: 33677441
Meyrier A
Nephron 2015;129(4):276-82. Epub 2015 Apr 2 doi: 10.1159/000381195. PMID: 25871843
Mathew AV, Okada S, Sharma K
Curr Diabetes Rev 2011 Jan;7(1):41-9. doi: 10.2174/157339911794273928. PMID: 21067508

Diagnosis

Ren YL, Li Y, Gao J, Zhou XJ, Yang L, Wang SX
BMC Nephrol 2023 Mar 15;24(1):54. doi: 10.1186/s12882-023-03096-3. PMID: 36922764Free PMC Article
Tsuboi N, Okabayashi Y
Semin Nephrol 2021 Jul;41(4):296-306. doi: 10.1016/j.semnephrol.2021.06.002. PMID: 34715960
Sandino J, Luzardo L, Morales E, Praga M
Nephron 2021;145(6):595-603. Epub 2021 Mar 5 doi: 10.1159/000513868. PMID: 33677441
Xu T, Sheng Z, Yao L
Front Med 2017 Sep;11(3):340-348. Epub 2017 Aug 8 doi: 10.1007/s11684-017-0570-3. PMID: 28791668
Adelman RD
Curr Opin Nephrol Hypertens 2002 May;11(3):331-5. doi: 10.1097/00041552-200205000-00010. PMID: 11981264

Therapy

Rodríguez-Rodríguez AE, Donate-Correa J, Luis-Lima S, Díaz-Martín L, Rodríguez-González C, Pérez-Pérez JA, Acosta-González NG, Fumero C, Navarro-Díaz M, López-Álvarez D, Villacampa-Jiménez J, Navarro-González JA, Ortiz A, Porrini E
Menopause 2021 Sep 27;28(11):1296-1306. doi: 10.1097/GME.0000000000001842. PMID: 34581293
Hanaoka H, Kuwana M, Takeuchi T
Int J Rheum Dis 2015 Sep;18(7):768-75. Epub 2015 Jul 14 doi: 10.1111/1756-185X.12682. PMID: 26179413
Sweiss N, Sharma K
Best Pract Res Clin Endocrinol Metab 2014 Jan;28(1):71-9. Epub 2013 Sep 5 doi: 10.1016/j.beem.2013.08.002. PMID: 24417947Free PMC Article
Ahmed MH
Expert Opin Emerg Drugs 2006 Nov;11(4):563-5. doi: 10.1517/14728214.11.4.563. PMID: 17064218
Prandota J
Drugs 1988 May;35(5):542-78. doi: 10.2165/00003495-198835050-00004. PMID: 3293970

Prognosis

Meyrier A
Nephrol Dial Transplant 2015 Nov;30(11):1833-41. Epub 2014 Dec 8 doi: 10.1093/ndt/gfu366. PMID: 25488894
Sweiss N, Sharma K
Best Pract Res Clin Endocrinol Metab 2014 Jan;28(1):71-9. Epub 2013 Sep 5 doi: 10.1016/j.beem.2013.08.002. PMID: 24417947Free PMC Article
Cleper R
Pediatr Endocrinol Rev 2012 Nov;10(1):152-63. PMID: 23469392
Hoy WE, Kincaid-Smith P, Hughson MD, Fogo AB, Sinniah R, Dowling J, Samuel T, Mott SA, Douglas-Denton RN, Bertram JF
Am J Kidney Dis 2010 Nov;56(5):983-93. Epub 2010 Aug 21 doi: 10.1053/j.ajkd.2010.05.010. PMID: 20728257
Adelman RD
Curr Opin Nephrol Hypertens 2002 May;11(3):331-5. doi: 10.1097/00041552-200205000-00010. PMID: 11981264

Clinical prediction guides

Ren YL, Li Y, Gao J, Zhou XJ, Yang L, Wang SX
BMC Nephrol 2023 Mar 15;24(1):54. doi: 10.1186/s12882-023-03096-3. PMID: 36922764Free PMC Article
Tsuboi N, Okabayashi Y
Semin Nephrol 2021 Jul;41(4):296-306. doi: 10.1016/j.semnephrol.2021.06.002. PMID: 34715960
Meyrier A
Nephrol Dial Transplant 2015 Nov;30(11):1833-41. Epub 2014 Dec 8 doi: 10.1093/ndt/gfu366. PMID: 25488894
Sweiss N, Sharma K
Best Pract Res Clin Endocrinol Metab 2014 Jan;28(1):71-9. Epub 2013 Sep 5 doi: 10.1016/j.beem.2013.08.002. PMID: 24417947Free PMC Article
Hoy WE, Kincaid-Smith P, Hughson MD, Fogo AB, Sinniah R, Dowling J, Samuel T, Mott SA, Douglas-Denton RN, Bertram JF
Am J Kidney Dis 2010 Nov;56(5):983-93. Epub 2010 Aug 21 doi: 10.1053/j.ajkd.2010.05.010. PMID: 20728257

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...