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Decreased mitochondrial number

MedGen UID:
868102
•Concept ID:
C4022493
•
Finding
HPO: HP:0040013

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased mitochondrial number

Professional guidelines

PubMed

Astrocyte-to-neuron reprogramming and crosstalk in the treatment of Parkinson's disease.
Wang Y, Xia Y, Kou L, Yin S, Chi X, Li J, Sun Y, Wu J, Zhou Q, Zou W, Jin Z, Huang J, Xiong N, Wang T
Neurobiol Dis 2023 Aug;184:106224. Epub 2023 Jul 9 doi: 10.1016/j.nbd.2023.106224. PMID: 37433411
Pathophysiology and mechanisms of primary sarcopenia (Review).
Nishikawa H, Fukunishi S, Asai A, Yokohama K, Nishiguchi S, Higuchi K
Int J Mol Med 2021 Aug;48(2) Epub 2021 Jun 29 doi: 10.3892/ijmm.2021.4989. PMID: 34184088
Delayed treatment with an autophagy inhibitor 3-MA alleviates the progression of hyperuricemic nephropathy.
Shi Y, Tao M, Ma X, Hu Y, Huang G, Qiu A, Zhuang S, Liu N
Cell Death Dis 2020 Jun 17;11(6):467. doi: 10.1038/s41419-020-2673-z. PMID: 32555189Free PMC Article

Recent clinical studies

Etiology

The nuclear receptor RORα protects against angiotensin II-induced cardiac hypertrophy and heart failure.
Beak JY, Kang HS, Huang W, Myers PH, Bowles DE, Jetten AM, Jensen BC
Am J Physiol Heart Circ Physiol 2019 Jan 1;316(1):H186-H200. Epub 2018 Nov 2 doi: 10.1152/ajpheart.00531.2018. PMID: 30387679Free PMC Article

Therapy

MITA modulated autophagy flux promotes cell death in breast cancer cells.
Bhatelia K, Singh K, Prajapati P, Sripada L, Roy M, Singh R
Cell Signal 2017 Jul;35:73-83. Epub 2017 Mar 31 doi: 10.1016/j.cellsig.2017.03.024. PMID: 28366813

Clinical prediction guides

TIGAR regulates mitochondrial functions through SIRT1-PGC1α pathway and translocation of TIGAR into mitochondria in skeletal muscle.
Geng J, Wei M, Yuan X, Liu Z, Wang X, Zhang D, Luo L, Wu J, Guo W, Qin ZH
FASEB J 2019 May;33(5):6082-6098. Epub 2019 Feb 6 doi: 10.1096/fj.201802209R. PMID: 30726106
MITA modulated autophagy flux promotes cell death in breast cancer cells.
Bhatelia K, Singh K, Prajapati P, Sripada L, Roy M, Singh R
Cell Signal 2017 Jul;35:73-83. Epub 2017 Mar 31 doi: 10.1016/j.cellsig.2017.03.024. PMID: 28366813
Emerging roles of hypoxia-inducible factors and reactive oxygen species in cancer and pluripotent stem cells.
Saito S, Lin YC, Tsai MH, Lin CS, Murayama Y, Sato R, Yokoyama KK
Kaohsiung J Med Sci 2015 Jun;31(6):279-86. Epub 2015 Apr 25 doi: 10.1016/j.kjms.2015.03.002. PMID: 26043406

Supplemental Content

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