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Toenail onycholysis

MedGen UID:
868085
•Concept ID:
C4022476
•
Disease or Syndrome; Finding
Synonyms: Detachment of toenails; Onycholysis of toenails
 
HPO: HP:0040040

Definition

Painless and spontaneous separation of a toenail from the nail bed. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVToenail onycholysis

Professional guidelines

PubMed

Green nail: Etiology and treatment of chloronychia.
Baran R, Richert B
Hand Surg Rehabil 2024 Apr;43S:101653. doi: 10.1016/j.hansur.2024.101653. PMID: 38879229
Optimal diagnosis and management of common nail disorders.
Lee DK, Lipner SR
Ann Med 2022 Dec;54(1):694-712. doi: 10.1080/07853890.2022.2044511. PMID: 35238267Free PMC Article
Treatment options--development of consensus guidelines.
Lecha M, Effendy I, Feuilhade de Chauvin M, Di Chiacchio N, Baran R; Taskforce on Onychomycosis Education
J Eur Acad Dermatol Venereol 2005 Sep;19 Suppl 1:25-33. doi: 10.1111/j.1468-3083.2005.01284.x. PMID: 16120203

Recent clinical studies

Etiology

Modeling Occupational Fingernail Onycholysis Disorders in the Population of US Astronauts Who Have Engaged in Extravehicular Activity.
Reid CR, Charvat JM, Mcfarland SM, Norcross JR, Benson E, England S, Rajulu S
Hum Factors 2023 Sep;65(6):988-1000. Epub 2021 Dec 27 doi: 10.1177/00187208211062299. PMID: 34961336
Nail Psoriasis.
Canal-García E, Bosch-Amate X, Belinchón I, Puig L
Actas Dermosifiliogr 2022 May;113(5):481-490. Epub 2022 Feb 2 doi: 10.1016/j.ad.2022.01.006. PMID: 35697407
Nail cosmetics: a dermatological perspective.
Dinani N, George S
Clin Exp Dermatol 2019 Aug;44(6):599-605. Epub 2019 Feb 21 doi: 10.1111/ced.13929. PMID: 30793352
Drug-related nail disease.
Piraccini BM, Alessandrini A
Clin Dermatol 2013 Sep-Oct;31(5):618-26. doi: 10.1016/j.clindermatol.2013.06.013. PMID: 24079591
Common nail disorders.
Shemer A, Daniel CR 3rd
Clin Dermatol 2013 Sep-Oct;31(5):578-86. doi: 10.1016/j.clindermatol.2013.06.015. PMID: 24079587

Diagnosis

Nail Psoriasis.
Canal-García E, Bosch-Amate X, Belinchón I, Puig L
Actas Dermosifiliogr 2022 May;113(5):481-490. Epub 2022 Feb 2 doi: 10.1016/j.ad.2022.01.006. PMID: 35697407
Optimal diagnosis and management of common nail disorders.
Lee DK, Lipner SR
Ann Med 2022 Dec;54(1):694-712. doi: 10.1080/07853890.2022.2044511. PMID: 35238267Free PMC Article
Onychomycosis: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL, Barankin B, Leung AAM, Wong AHC
Recent Pat Inflamm Allergy Drug Discov 2020;14(1):32-45. doi: 10.2174/1872213X13666191026090713. PMID: 31738146Free PMC Article
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails.
Lacouture M, Sibaud V
Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39. doi: 10.1007/s40257-018-0384-3. PMID: 30374901Free PMC Article
Finger and toenail onycholysis.
Zaias N, Escovar SX, Zaiac MN
J Eur Acad Dermatol Venereol 2015 May;29(5):848-53. Epub 2014 Dec 16 doi: 10.1111/jdv.12862. PMID: 25512134

Therapy

Efinaconazole in Onychomycosis.
Gupta AK, Talukder M
Am J Clin Dermatol 2022 Mar;23(2):207-218. Epub 2021 Dec 13 doi: 10.1007/s40257-021-00660-1. PMID: 34902110
Onychomycosis: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL, Barankin B, Leung AAM, Wong AHC
Recent Pat Inflamm Allergy Drug Discov 2020;14(1):32-45. doi: 10.2174/1872213X13666191026090713. PMID: 31738146Free PMC Article
Nail cosmetics: a dermatological perspective.
Dinani N, George S
Clin Exp Dermatol 2019 Aug;44(6):599-605. Epub 2019 Feb 21 doi: 10.1111/ced.13929. PMID: 30793352
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails.
Lacouture M, Sibaud V
Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39. doi: 10.1007/s40257-018-0384-3. PMID: 30374901Free PMC Article
Photoonycholysis.
Baran R, Juhlin L
Photodermatol Photoimmunol Photomed 2002 Aug;18(4):202-7. doi: 10.1034/j.1600-0781.2002.00760.x. PMID: 12390677

Prognosis

Clinical and onychoscopic characteristics of subungual glomus tumor: a cross-sectional study.
Grover C, Jayasree P, Kaliyadan F
Int J Dermatol 2021 Jun;60(6):693-702. Epub 2020 Dec 17 doi: 10.1111/ijd.15358. PMID: 33332614
Nail changes in alopecia areata: an update and review.
Chelidze K, Lipner SR
Int J Dermatol 2018 Jul;57(7):776-783. Epub 2018 Jan 10 doi: 10.1111/ijd.13866. PMID: 29318582
Point-of-Care Diagnosis of Onychomycosis by Dermoscopy.
Bodman MA
J Am Podiatr Med Assoc 2017 Sep;107(5):413-418. doi: 10.7547/16-183. PMID: 29077504
The burden of nail psoriasis: an introduction.
Baran R
Dermatology 2010;221 Suppl 1:1-5. Epub 2010 Aug 9 doi: 10.1159/000316169. PMID: 20733309
Onychomycosis: diagnosis and definition of cure.
Scher RK, Tavakkol A, Sigurgeirsson B, Hay RJ, Joseph WS, Tosti A, Fleckman P, Ghannoum M, Armstrong DG, Markinson BC, Elewski BE
J Am Acad Dermatol 2007 Jun;56(6):939-44. Epub 2007 Feb 16 doi: 10.1016/j.jaad.2006.12.019. PMID: 17307276

Clinical prediction guides

Onychomycosis: An Updated Review.
Leung AKC, Lam JM, Leong KF, Hon KL, Barankin B, Leung AAM, Wong AHC
Recent Pat Inflamm Allergy Drug Discov 2020;14(1):32-45. doi: 10.2174/1872213X13666191026090713. PMID: 31738146Free PMC Article
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails.
Lacouture M, Sibaud V
Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39. doi: 10.1007/s40257-018-0384-3. PMID: 30374901Free PMC Article
Drug-related nail disease.
Piraccini BM, Alessandrini A
Clin Dermatol 2013 Sep-Oct;31(5):618-26. doi: 10.1016/j.clindermatol.2013.06.013. PMID: 24079591
Drug-induced nail abnormalities.
Piraccini BM, Iorizzo M, Tosti A
Am J Clin Dermatol 2003;4(1):31-7. doi: 10.2165/00128071-200304010-00004. PMID: 12477371
Photoonycholysis.
Baran R, Juhlin L
Photodermatol Photoimmunol Photomed 2002 Aug;18(4):202-7. doi: 10.1034/j.1600-0781.2002.00760.x. PMID: 12390677

Recent systematic reviews

Dermoscopic features of nail psoriasis: a systematic review.
Rachadi H, Chiheb S
Int J Dermatol 2024 Aug;63(8):1013-1019. Epub 2024 Mar 22 doi: 10.1111/ijd.17138. PMID: 38520074
Dermoscopic features of psoriasis of the skin, scalp and nails - a systematic review.
Golińska J, Sar-Pomian M, Rudnicka L
J Eur Acad Dermatol Venereol 2019 Apr;33(4):648-660. doi: 10.1111/jdv.15344. PMID: 30422349
Is there a psoriasis skin phenotype associated with psoriatic arthritis? Systematic literature review.
Rouzaud M, Sevrain M, Villani AP, Barnetche T, Paul C, Richard MA, Jullien D, Misery L, Le Maître M, Aractingi S, Aubin F, Joly P, Cantagrel A, Ortonne JP, Beylot-Barry M
J Eur Acad Dermatol Venereol 2014 Aug;28 Suppl 5:17-26. doi: 10.1111/jdv.12562. PMID: 24985559

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