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Abnormal hepatic iron concentration

MedGen UID:
868029
•Concept ID:
C4022420
•
Finding
Synonyms: Abnormal liver iron concentration; Abnormal liver iron level
 
HPO: HP:0040134

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal hepatic iron concentration

Professional guidelines

PubMed

Management of hemochromatosis. Hemochromatosis Management Working Group.
Barton JC, McDonnell SM, Adams PC, Brissot P, Powell LW, Edwards CQ, Cook JD, Kowdley KV
Ann Intern Med 1998 Dec 1;129(11):932-9. doi: 10.7326/0003-4819-129-11_part_2-199812011-00003. PMID: 9867745
Practice guideline development task force of the College of American Pathologists. Hereditary hemochromatosis.
Witte DL, Crosby WH, Edwards CQ, Fairbanks VF, Mitros FA
Clin Chim Acta 1996 Feb 28;245(2):139-200. doi: 10.1016/0009-8981(95)06212-2. PMID: 8867884
Influence of phlebotomy treatment on abnormal hypothalamic-pituitary function in genetic hemochromatosis.
Lufkin EG, Baldus WP, Bergstralh EJ, Kao PC
Mayo Clin Proc 1987 Jun;62(6):473-9. doi: 10.1016/s0025-6196(12)65472-x. PMID: 3106726

Recent clinical studies

Etiology

Prospective cardiac magnetic resonance imaging survey in myelodysplastic syndrome patients: insights from an Italian network.
Pepe A, Rizzo M, Galimberti S, Baratè C, Oliva EN, Arcioni F, Storti S, Renne S, Midiri M, Restaino G, Positano V, Mangione M, Meloni A
Ann Hematol 2021 May;100(5):1139-1147. Epub 2021 Mar 19 doi: 10.1007/s00277-021-04495-y. PMID: 33742225
Quantitative analysis of hepatic iron in patients suspected of coexisting iron overload and steatosis using multi-echo single-voxel magnetic resonance spectroscopy: Comparison with fat-saturated multi-echo gradient echo sequence.
Lin H, Fu C, Kannengiesser S, Cheng S, Shen J, Dong H, Yan F
J Magn Reson Imaging 2018 Jul;48(1):205-213. Epub 2018 Mar 7 doi: 10.1002/jmri.25967. PMID: 29513377
Overload hepatitides: quanti-qualitative analysis.
Martí-Bonmatí L, Alberich-Bayarri A, Sánchez-González J
Abdom Imaging 2012 Apr;37(2):180-7. doi: 10.1007/s00261-011-9762-5. PMID: 21643735
Management of hemochromatosis. Hemochromatosis Management Working Group.
Barton JC, McDonnell SM, Adams PC, Brissot P, Powell LW, Edwards CQ, Cook JD, Kowdley KV
Ann Intern Med 1998 Dec 1;129(11):932-9. doi: 10.7326/0003-4819-129-11_part_2-199812011-00003. PMID: 9867745
Practice guideline development task force of the College of American Pathologists. Hereditary hemochromatosis.
Witte DL, Crosby WH, Edwards CQ, Fairbanks VF, Mitros FA
Clin Chim Acta 1996 Feb 28;245(2):139-200. doi: 10.1016/0009-8981(95)06212-2. PMID: 8867884

Diagnosis

Prospective cardiac magnetic resonance imaging survey in myelodysplastic syndrome patients: insights from an Italian network.
Pepe A, Rizzo M, Galimberti S, Baratè C, Oliva EN, Arcioni F, Storti S, Renne S, Midiri M, Restaino G, Positano V, Mangione M, Meloni A
Ann Hematol 2021 May;100(5):1139-1147. Epub 2021 Mar 19 doi: 10.1007/s00277-021-04495-y. PMID: 33742225
Different forms of iron accumulation in the liver on MRI.
İdilman İS, Akata D, Özmen MN, Karçaaltıncaba M
Diagn Interv Radiol 2016 Jan-Feb;22(1):22-8. doi: 10.5152/dir.2015.15094. PMID: 26712679Free PMC Article
Overload hepatitides: quanti-qualitative analysis.
Martí-Bonmatí L, Alberich-Bayarri A, Sánchez-González J
Abdom Imaging 2012 Apr;37(2):180-7. doi: 10.1007/s00261-011-9762-5. PMID: 21643735
Management of hemochromatosis. Hemochromatosis Management Working Group.
Barton JC, McDonnell SM, Adams PC, Brissot P, Powell LW, Edwards CQ, Cook JD, Kowdley KV
Ann Intern Med 1998 Dec 1;129(11):932-9. doi: 10.7326/0003-4819-129-11_part_2-199812011-00003. PMID: 9867745
Practice guideline development task force of the College of American Pathologists. Hereditary hemochromatosis.
Witte DL, Crosby WH, Edwards CQ, Fairbanks VF, Mitros FA
Clin Chim Acta 1996 Feb 28;245(2):139-200. doi: 10.1016/0009-8981(95)06212-2. PMID: 8867884

Therapy

Iron overload in congenital haemolytic anaemias: role of hepcidin and cytokines and predictive value of ferritin and transferrin saturation.
Barcellini W, Zaninoni A, Gregorini AI, Soverini G, Duca L, Fattizzo B, Giannotta JA, Pedrotti P, Vercellati C, Marcello AP, Fermo E, Bianchi P, Cappellini MD
Br J Haematol 2019 May;185(3):523-531. Epub 2019 Mar 3 doi: 10.1111/bjh.15811. PMID: 30828802
Organ iron accumulation in chronically transfused children with sickle cell anaemia: baseline results from the TWiTCH trial.
Wood JC, Cohen AR, Pressel SL, Aygun B, Imran H, Luchtman-Jones L, Thompson AA, Fuh B, Schultz WH, Davis BR, Ware RE; TWiTCH Investigators
Br J Haematol 2016 Jan;172(1):122-30. Epub 2015 Nov 2 doi: 10.1111/bjh.13791. PMID: 26523836Free PMC Article
Transfusion iron overload in adults with acute leukemia: manifestations and therapy.
Barton JC, Bertoli LF
Am J Med Sci 2000 Feb;319(2):73-8. doi: 10.1097/00000441-200002000-00001. PMID: 10698089
Non-transferrin-bound iron and hepatic dysfunction in African dietary iron overload.
McNamara L, MacPhail AP, Mandishona E, Bloom P, Paterson AC, Rouault TA, Gordeuk VR
J Gastroenterol Hepatol 1999 Feb;14(2):126-32. doi: 10.1046/j.1440-1746.1999.01830.x. PMID: 10029292
Hereditary hemochromatosis. Diagnosis in siblings and children.
Edwards CQ, Carroll M, Bray P, Cartwright GE
N Engl J Med 1977 Jul 7;297(1):7-13. doi: 10.1056/NEJM197707072970102. PMID: 865566

Prognosis

Iron overload in congenital haemolytic anaemias: role of hepcidin and cytokines and predictive value of ferritin and transferrin saturation.
Barcellini W, Zaninoni A, Gregorini AI, Soverini G, Duca L, Fattizzo B, Giannotta JA, Pedrotti P, Vercellati C, Marcello AP, Fermo E, Bianchi P, Cappellini MD
Br J Haematol 2019 May;185(3):523-531. Epub 2019 Mar 3 doi: 10.1111/bjh.15811. PMID: 30828802
Right and left ventricular function and myocardial scarring in adult patients with sickle cell disease: a comprehensive magnetic resonance assessment of hepatic and myocardial iron overload.
Junqueira FP, Fernandes JL, Cunha GM, T A Kubo T, M A O Lima C, B P Lima D, Uellendhal M, Sales SR, A S Cunha C, L R de Pessoa V, L C Lobo C, Marchiori E
J Cardiovasc Magn Reson 2013 Sep 19;15(1):83. doi: 10.1186/1532-429X-15-83. PMID: 24050721Free PMC Article
Predicting iron overload in hyperferritinemia.
Olynyk JK, Gan E, Tan T
Clin Gastroenterol Hepatol 2009 Mar;7(3):359-62. Epub 2008 Nov 21 doi: 10.1016/j.cgh.2008.11.010. PMID: 19095082
Clinical significance of hepatic iron deposition and serum iron values in patients with chronic hepatitis C infection.
Metwally MA, Zein CO, Zein NN
Am J Gastroenterol 2004 Feb;99(2):286-91. doi: 10.1111/j.1572-0241.2004.04049.x. PMID: 15046219
Current concepts in rational therapy for haemochromatosis.
Crawford DH, Halliday JW
Drugs 1991 Jun;41(6):875-82. doi: 10.2165/00003495-199141060-00005. PMID: 1715264

Clinical prediction guides

Clinical and biochemical understanding of Zinc interaction during liver diseases: A paradigm shift.
Lubna S, Ahmad R
J Trace Elem Med Biol 2023 May;77:127130. Epub 2023 Jan 5 doi: 10.1016/j.jtemb.2023.127130. PMID: 36641955
Prevalence of HFE-related haemochromatosis and secondary causes of hyperferritinaemia and their association with iron overload in 1059 French patients treated by venesection.
Le Gac G, Scotet V, Gourlaouen I, L'Hostis C, Merour MC, Karim Z, Deugnier Y, Bardou-Jacquet E, Lefebvre T, Assari S, Ferec C
Aliment Pharmacol Ther 2022 Apr;55(8):1016-1027. Epub 2022 Feb 4 doi: 10.1111/apt.16775. PMID: 35122291
Different forms of iron accumulation in the liver on MRI.
İdilman İS, Akata D, Özmen MN, Karçaaltıncaba M
Diagn Interv Radiol 2016 Jan-Feb;22(1):22-8. doi: 10.5152/dir.2015.15094. PMID: 26712679Free PMC Article
Predicting iron overload in hyperferritinemia.
Olynyk JK, Gan E, Tan T
Clin Gastroenterol Hepatol 2009 Mar;7(3):359-62. Epub 2008 Nov 21 doi: 10.1016/j.cgh.2008.11.010. PMID: 19095082
Interrelationships between circulating gastrin and iron status in mice and humans.
Kovac S, Smith K, Anderson GJ, Burgess JR, Shulkes A, Baldwin GS
Am J Physiol Gastrointest Liver Physiol 2008 Oct;295(4):G855-61. Epub 2008 Aug 28 doi: 10.1152/ajpgi.90359.2008. PMID: 18755804Free PMC Article

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