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Duplication of phalanx of hand

MedGen UID:
866992
•Concept ID:
C4021349
•
Anatomical Abnormality
Synonym: Duplication of finger bones
 
HPO: HP:0009997

Definition

This term applies if one or more of the phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDuplication of phalanx of hand

Professional guidelines

PubMed

Opposable triphalangeal thumb: clinical features and results of treatment.
Ogino T, Ishii S, Kato H
J Hand Surg Am 1994 Jan;19(1):39-47. doi: 10.1016/0363-5023(94)90222-4. PMID: 8169367

Recent clinical studies

Etiology

Radiographic features and subtypes of congenital thumb duplication type C3 according to Wu et al. and their potential implications for surgical management: new classification and preliminary results.
Wu J, Hong K, Zhao H, Liao S, Chu J, Xu C, Zhu Y, Gong M, Zhao X, Zhu M, Li J, Li Y, Liu Y, Canavese F, Xu H
BMC Musculoskelet Disord 2024 Oct 11;25(1):802. doi: 10.1186/s12891-024-07916-x. PMID: 39394581Free PMC Article
Modified Wassel-Flatt Type III Radial Polydactyly: Subtypes and Their Outcomes.
Kim JK, Yoon JO, Shin YH, Lee SH
J Hand Surg Am 2024 Jan;49(1):60.e1-60.e8. Epub 2022 Jul 6 doi: 10.1016/j.jhsa.2022.04.024. PMID: 35803781
Reoperation after primary operation for pre-axial polydactyly of the hand: A 12-year experience at a single institute.
Shin YH, Yoon JO, Kim SS, Joo HS, Al-Dhafer BAA, Kim JK
J Plast Reconstr Aesthet Surg 2022 Aug;75(8):2658-2663. Epub 2022 Apr 22 doi: 10.1016/j.bjps.2022.04.015. PMID: 35570116
The anatomy of Wassel type IV-D thumb duplication.
He B, Liu G, Nan G
J Hand Surg Eur Vol 2017 Jun;42(5):516-522. Epub 2017 Feb 14 doi: 10.1177/1753193417691747. PMID: 28196434
Postoperative Growth in Radial Polydactyly: A Clinical Study.
Wang L, Tao X, Gao W, Ding J, Zhou Z, Feng X
J Hand Surg Am 2016 Sep;41(9):e273-8. Epub 2016 Jul 27 doi: 10.1016/j.jhsa.2016.06.012. PMID: 27475961

Diagnosis

Congenital Palmar Duplication of the Index Finger: Ventral Polydactyly With Ventral Dimelia.
Shintani K, Hidaka N, Sato M
J Hand Surg Am 2023 Mar;48(3):315.e1-315.e6. Epub 2022 Mar 12 doi: 10.1016/j.jhsa.2022.01.010. PMID: 35292177
Is an association of acro-osteolysis, bone fragility, and enchondromatosis a newfound disease caused by an amplification of PTHLH? A case report.
Echaubard S, Pebrel-Richard C, Chausset A, Kemeny JL, Merlin E, Laffargue F
Pediatr Rheumatol Online J 2022 Jul 30;20(1):58. doi: 10.1186/s12969-022-00720-8. PMID: 35908058Free PMC Article
The prenatal diagnosis and genetic counseling of chromosomal micro-duplication on 10q24.3 in a fetus: A case report and a brief review of the literature.
Lai S, Zhang X, Feng L, He M, Wang S
Medicine (Baltimore) 2020 Oct 16;99(42):e22533. doi: 10.1097/MD.0000000000022533. PMID: 33080687Free PMC Article
Robinow syndrome: a diagnosis at the fingertips.
Murali CN, Keena B, Zackai EH
Clin Dysmorphol 2018 Oct;27(4):135-137. doi: 10.1097/MCD.0000000000000230. PMID: 29864040Free PMC Article
The anatomy of Wassel type IV-D thumb duplication.
He B, Liu G, Nan G
J Hand Surg Eur Vol 2017 Jun;42(5):516-522. Epub 2017 Feb 14 doi: 10.1177/1753193417691747. PMID: 28196434

Therapy

Botulinum toxin type A in the treatment of focal hand dystonia after surgical treatment for thumb duplication.
Santamato A, Panza F, Solfrizzi V, Frisardi V, Moretti B, Notarnicola A, Neve A, Ranieri M, Fiore P
Orthopedics 2009 Jul;32(7):529. doi: 10.3928/01477447-20090527-07. PMID: 19634837

Prognosis

Modified Wassel-Flatt Type III Radial Polydactyly: Subtypes and Their Outcomes.
Kim JK, Yoon JO, Shin YH, Lee SH
J Hand Surg Am 2024 Jan;49(1):60.e1-60.e8. Epub 2022 Jul 6 doi: 10.1016/j.jhsa.2022.04.024. PMID: 35803781
Use of the duplication range concept for understanding morphology and predicting prognosis in thumb polydactyly.
Saito S, Makino A, Yamanaka H, Tsuge I, Morimoto N
J Hand Surg Eur Vol 2023 Jan;48(1):10-19. Epub 2022 Oct 6 doi: 10.1177/17531934221126864. PMID: 36204982
An intragenic duplication of TRPS1 leading to abnormal transcripts and causing trichorhinophalangeal syndrome type I.
Zepeda-Mendoza CJ, Cousin MA, Basu S, Jenkinson G, Oliver G, Pittock ST, Baughn LB, Klee EW, Babovic-Vuksanovic D
Cold Spring Harb Mol Case Stud 2019 Dec;5(6) Epub 2019 Dec 13 doi: 10.1101/mcs.a004655. PMID: 31662300Free PMC Article
Robinow syndrome: a diagnosis at the fingertips.
Murali CN, Keena B, Zackai EH
Clin Dysmorphol 2018 Oct;27(4):135-137. doi: 10.1097/MCD.0000000000000230. PMID: 29864040Free PMC Article
The anatomy of Wassel type IV-D thumb duplication.
He B, Liu G, Nan G
J Hand Surg Eur Vol 2017 Jun;42(5):516-522. Epub 2017 Feb 14 doi: 10.1177/1753193417691747. PMID: 28196434

Clinical prediction guides

Use of the duplication range concept for understanding morphology and predicting prognosis in thumb polydactyly.
Saito S, Makino A, Yamanaka H, Tsuge I, Morimoto N
J Hand Surg Eur Vol 2023 Jan;48(1):10-19. Epub 2022 Oct 6 doi: 10.1177/17531934221126864. PMID: 36204982
Is an association of acro-osteolysis, bone fragility, and enchondromatosis a newfound disease caused by an amplification of PTHLH? A case report.
Echaubard S, Pebrel-Richard C, Chausset A, Kemeny JL, Merlin E, Laffargue F
Pediatr Rheumatol Online J 2022 Jul 30;20(1):58. doi: 10.1186/s12969-022-00720-8. PMID: 35908058Free PMC Article
Reoperation after primary operation for pre-axial polydactyly of the hand: A 12-year experience at a single institute.
Shin YH, Yoon JO, Kim SS, Joo HS, Al-Dhafer BAA, Kim JK
J Plast Reconstr Aesthet Surg 2022 Aug;75(8):2658-2663. Epub 2022 Apr 22 doi: 10.1016/j.bjps.2022.04.015. PMID: 35570116
Opening wedge phalangeal osteotomy for correction of Wassel type IV-D thumb duplication.
Wang K, Ai F, Zhou P, Liu Z, Chen Z, Chen J
Handchir Mikrochir Plast Chir 2020 Apr;52(2):147-150. Epub 2019 Oct 9 doi: 10.1055/a-0893-6659. PMID: 31597168
Opposable triphalangeal thumb: clinical features and results of treatment.
Ogino T, Ishii S, Kato H
J Hand Surg Am 1994 Jan;19(1):39-47. doi: 10.1016/0363-5023(94)90222-4. PMID: 8169367

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