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Abnormal epiphyseal ossification

MedGen UID:
866890
•Concept ID:
C4021246
•
Finding
Synonyms: Abnormal maturation of the end part of a bone; Abnormality of the mineralisation or ossification of the epiphyses
 
HPO: HP:0010656

Definition

An abnormality of the formation and mineralization of an epiphysis. [from HPO]

Professional guidelines

PubMed

Skeletal phenotype/genotype in progressive pseudorheumatoid chondrodysplasia.
Al Kaissi A, Kenis V, Jemaa LB, Sassi H, Shboul M, Grill F, Ganger R, Kircher SG
Clin Rheumatol 2020 Feb;39(2):553-560. Epub 2019 Oct 18 doi: 10.1007/s10067-019-04783-z. PMID: 31628567
Molecular prenatal diagnosis in 2 pregnancies at risk for spondyloepiphyseal dysplasia congenita.
Xia XY, Cui YX, Huang YF, Pan LJ, Feng Y, Yang B, Li XJ, Zhu PY, Shi YC, Liang Q
Clin Chim Acta 2008 Jan;387(1-2):153-7. Epub 2007 Sep 18 doi: 10.1016/j.cca.2007.09.006. PMID: 17920052
Proximal femoral focal deficiency: evaluation and management.
Bryant DD 3rd, Epps CH Jr
Orthopedics 1991 Jul;14(7):775-84. doi: 10.3928/0147-7447-19910701-08. PMID: 1871029

Recent clinical studies

Etiology

Skeletal phenotype/genotype in progressive pseudorheumatoid chondrodysplasia.
Al Kaissi A, Kenis V, Jemaa LB, Sassi H, Shboul M, Grill F, Ganger R, Kircher SG
Clin Rheumatol 2020 Feb;39(2):553-560. Epub 2019 Oct 18 doi: 10.1007/s10067-019-04783-z. PMID: 31628567
Apophysitis and Osteochondrosis: Common Causes of Pain in Growing Bones.
Achar S, Yamanaka J
Am Fam Physician 2019 May 15;99(10):610-618. PMID: 31083875
Growth impairment in mucopolysaccharidoses.
Melbouci M, Mason RW, Suzuki Y, Fukao T, Orii T, Tomatsu S
Mol Genet Metab 2018 May;124(1):1-10. Epub 2018 Mar 16 doi: 10.1016/j.ymgme.2018.03.004. PMID: 29627275Free PMC Article
Imaging of Pediatric Growth Plate Disturbances.
Nguyen JC, Markhardt BK, Merrow AC, Dwek JR
Radiographics 2017 Oct;37(6):1791-1812. doi: 10.1148/rg.2017170029. PMID: 29019753
Ulnar dysmelia.
Ogden JA, Watson HK, Bohne W
J Bone Joint Surg Am 1976 Jun;58(4):467-75. PMID: 818089

Diagnosis

Skeletal phenotype/genotype in progressive pseudorheumatoid chondrodysplasia.
Al Kaissi A, Kenis V, Jemaa LB, Sassi H, Shboul M, Grill F, Ganger R, Kircher SG
Clin Rheumatol 2020 Feb;39(2):553-560. Epub 2019 Oct 18 doi: 10.1007/s10067-019-04783-z. PMID: 31628567
Apophysitis and Osteochondrosis: Common Causes of Pain in Growing Bones.
Achar S, Yamanaka J
Am Fam Physician 2019 May 15;99(10):610-618. PMID: 31083875
Imaging of Pediatric Growth Plate Disturbances.
Nguyen JC, Markhardt BK, Merrow AC, Dwek JR
Radiographics 2017 Oct;37(6):1791-1812. doi: 10.1148/rg.2017170029. PMID: 29019753
Physeal bar equivalent.
Peterson HA, Shaughnessy WJ, Stans AA
J Pediatr Orthop B 2017 Nov;26(6):507-514. doi: 10.1097/BPB.0000000000000384. PMID: 27748675
Hypophosphatemic rickets due to perturbations in renal tubular function.
Penido MG, Alon US
Pediatr Nephrol 2014 Mar;29(3):361-73. Epub 2013 May 1 doi: 10.1007/s00467-013-2466-z. PMID: 23636577

Therapy

Statistical Confirmation of a Method of US Determination of Bone Age.
Wan J, Zhao Y, Feng Q, Lv P, Hong K, Zhang C
Radiology 2021 Jul;300(1):176-183. Epub 2021 May 18 doi: 10.1148/radiol.2021204353. PMID: 34003051
Radiographic Characteristics of the Hand in Apert Syndrome.
Kracoff SL
J Hand Surg Asian Pac Vol 2020 Mar;25(1):82-86. doi: 10.1142/S2424835520500113. PMID: 32000596
Drug-induced Physeal Abnormalities in Preclinical Toxicity Studies.
Frazier KS
Toxicol Pathol 2017 Oct;45(7):869-875. Epub 2017 Jun 23 doi: 10.1177/0192623317713319. PMID: 28643552
Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation.
Chakkalakal SA, Uchibe K, Convente MR, Zhang D, Economides AN, Kaplan FS, Pacifici M, Iwamoto M, Shore EM
J Bone Miner Res 2016 Sep;31(9):1666-75. Epub 2016 Mar 12 doi: 10.1002/jbmr.2820. PMID: 26896819Free PMC Article
Percutaneous distraction lengthening in brachymetacarpia.
Volpi AD, Fragomen AT
Orthopedics 2011 Aug 8;34(8):e424-7. doi: 10.3928/01477447-20110627-29. PMID: 21815589

Prognosis

The Immature Pediatric Appendicular Skeleton.
Nguyen JC, Caine D
Semin Musculoskelet Radiol 2024 Aug;28(4):361-374. Epub 2024 Jul 29 doi: 10.1055/s-0044-1786151. PMID: 39074720
Imaging Review of Normal and Abnormal Skeletal Maturation.
Augusto ACL, Goes PCK, Flores DV, Costa MAF, Takahashi MS, Rodrigues ACO, Padula LC, Gasparetto TD, Nogueira-Barbosa MH, Aihara AY
Radiographics 2022 May-Jun;42(3):861-879. Epub 2022 Feb 25 doi: 10.1148/rg.210088. PMID: 35213260
Growth impairment in mucopolysaccharidoses.
Melbouci M, Mason RW, Suzuki Y, Fukao T, Orii T, Tomatsu S
Mol Genet Metab 2018 May;124(1):1-10. Epub 2018 Mar 16 doi: 10.1016/j.ymgme.2018.03.004. PMID: 29627275Free PMC Article
Hypophosphatemic rickets due to perturbations in renal tubular function.
Penido MG, Alon US
Pediatr Nephrol 2014 Mar;29(3):361-73. Epub 2013 May 1 doi: 10.1007/s00467-013-2466-z. PMID: 23636577
Ulnar dysmelia.
Ogden JA, Watson HK, Bohne W
J Bone Joint Surg Am 1976 Jun;58(4):467-75. PMID: 818089

Clinical prediction guides

The Immature Pediatric Appendicular Skeleton.
Nguyen JC, Caine D
Semin Musculoskelet Radiol 2024 Aug;28(4):361-374. Epub 2024 Jul 29 doi: 10.1055/s-0044-1786151. PMID: 39074720
Imaging Review of Normal and Abnormal Skeletal Maturation.
Augusto ACL, Goes PCK, Flores DV, Costa MAF, Takahashi MS, Rodrigues ACO, Padula LC, Gasparetto TD, Nogueira-Barbosa MH, Aihara AY
Radiographics 2022 May-Jun;42(3):861-879. Epub 2022 Feb 25 doi: 10.1148/rg.210088. PMID: 35213260
Physeal bar equivalent.
Peterson HA, Shaughnessy WJ, Stans AA
J Pediatr Orthop B 2017 Nov;26(6):507-514. doi: 10.1097/BPB.0000000000000384. PMID: 27748675
Epiphyseal clefts.
Harrison RB, Keats TE
Skeletal Radiol 1980 Feb;5(1):23-7. doi: 10.1007/BF00347094. PMID: 6767277
Ulnar dysmelia.
Ogden JA, Watson HK, Bohne W
J Bone Joint Surg Am 1976 Jun;58(4):467-75. PMID: 818089

Recent systematic reviews

Longitudinal Epiphyseal Bracket of the First Metatarsal Bone: Three Case Reports and a Review of the Literature.
Vlaić J, Bojić D, Rutz E, Antičević D
J Foot Ankle Surg 2018 Nov-Dec;57(6):1246-1252. Epub 2018 Aug 31 doi: 10.1053/j.jfas.2018.03.049. PMID: 30177452
The prevalence of Os acromiale: a systematic review and meta-analysis.
Yammine K
Clin Anat 2014 May;27(4):610-21. Epub 2013 Dec 2 doi: 10.1002/ca.22343. PMID: 24302513

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