U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Acute Cellular Allograft Nephropathy

MedGen UID:
859709
•Concept ID:
C3900115
•
Disease or Syndrome

Definition

A sudden onset of T-cell mediated immune response occurring after transplantation, directed against donor kidney alloantigens. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Cellular Allograft Nephropathy

Professional guidelines

PubMed

The Second International Consensus Guidelines on the Management of BK Polyomavirus in Kidney Transplantation.
Kotton CN, Kamar N, Wojciechowski D, Eder M, Hopfer H, Randhawa P, Sester M, Comoli P, Tedesco Silva H, Knoll G, Brennan DC, Trofe-Clark J, Pape L, Axelrod D, Kiberd B, Wong G, Hirsch HH; Transplantation Society International BK Polyomavirus Consensus Group
Transplantation 2024 Sep 1;108(9):1834-1866. Epub 2024 Apr 12 doi: 10.1097/TP.0000000000004976. PMID: 38605438Free PMC Article
Diagnostic criteria of antibody-mediated rejection in kidney transplants.
Mosquera Reboredo JM, Vázquez Martul E
Nefrologia 2011;31(4):382-91. doi: 10.3265/Nefrologia.pre2011.Apr.10740. PMID: 21738242
Diagnosis and treatment of BK virus-associated transplant nephropathy.
Vats A, Randhawa PS, Shapiro R
Adv Exp Med Biol 2006;577:213-27. doi: 10.1007/0-387-32957-9_16. PMID: 16626039

Recent clinical studies

Etiology

The Second International Consensus Guidelines on the Management of BK Polyomavirus in Kidney Transplantation.
Kotton CN, Kamar N, Wojciechowski D, Eder M, Hopfer H, Randhawa P, Sester M, Comoli P, Tedesco Silva H, Knoll G, Brennan DC, Trofe-Clark J, Pape L, Axelrod D, Kiberd B, Wong G, Hirsch HH; Transplantation Society International BK Polyomavirus Consensus Group
Transplantation 2024 Sep 1;108(9):1834-1866. Epub 2024 Apr 12 doi: 10.1097/TP.0000000000004976. PMID: 38605438Free PMC Article
Emerging phenotypes in kidney transplant rejection.
Mengel M, Adam BA
Curr Opin Organ Transplant 2024 Apr 1;29(2):97-103. Epub 2023 Nov 30 doi: 10.1097/MOT.0000000000001130. PMID: 38032262
Decreased Renal Gluconeogenesis Is a Hallmark of Chronic Kidney Disease.
Verissimo T, Faivre A, Rinaldi A, Lindenmeyer M, Delitsikou V, Veyrat-Durebex C, Heckenmeyer C, Fernandez M, Berchtold L, Dalga D, Cohen C, Naesens M, Ricksten SE, Martin PY, Pugin J, Merlier F, Haupt K, Rutkowski JM, Moll S, Cippà PE, Legouis D, de Seigneux S
J Am Soc Nephrol 2022 Apr;33(4):810-827. Epub 2022 Mar 10 doi: 10.1681/ASN.2021050680. PMID: 35273087Free PMC Article
Biochemical Markers of Renal Function.
Krstic D, Tomic N, Radosavljevic B, Avramovic N, Dragutinovic V, Skodric SR, Colovic M
Curr Med Chem 2016;23(19):2018-40. doi: 10.2174/0929867323666160115130241. PMID: 26769095
Chronic allograft nephropathy.
Najafian B, Kasiske BL
Curr Opin Nephrol Hypertens 2008 Mar;17(2):149-55. doi: 10.1097/MNH.0b013e3282f4e514. PMID: 18277147

Diagnosis

The Second International Consensus Guidelines on the Management of BK Polyomavirus in Kidney Transplantation.
Kotton CN, Kamar N, Wojciechowski D, Eder M, Hopfer H, Randhawa P, Sester M, Comoli P, Tedesco Silva H, Knoll G, Brennan DC, Trofe-Clark J, Pape L, Axelrod D, Kiberd B, Wong G, Hirsch HH; Transplantation Society International BK Polyomavirus Consensus Group
Transplantation 2024 Sep 1;108(9):1834-1866. Epub 2024 Apr 12 doi: 10.1097/TP.0000000000004976. PMID: 38605438Free PMC Article
MicroRNAs in kidney injury and disease.
Mahtal N, Lenoir O, Tinel C, Anglicheau D, Tharaux PL
Nat Rev Nephrol 2022 Oct;18(10):643-662. Epub 2022 Aug 16 doi: 10.1038/s41581-022-00608-6. PMID: 35974169
New developments in transplant proteomics.
Ho J, Hirt-Minkowski P, Wilkins JA
Curr Opin Nephrol Hypertens 2017 May;26(3):229-234. doi: 10.1097/MNH.0000000000000319. PMID: 28221173
MicroRNAs in kidney transplantation.
Wilflingseder J, Reindl-Schwaighofer R, Sunzenauer J, Kainz A, Heinzel A, Mayer B, Oberbauer R
Nephrol Dial Transplant 2015 Jun;30(6):910-7. Epub 2014 Aug 28 doi: 10.1093/ndt/gfu280. PMID: 25170095Free PMC Article
Th1/Th2 cells.
Romagnani S
Inflamm Bowel Dis 1999 Nov;5(4):285-94. doi: 10.1097/00054725-199911000-00009. PMID: 10579123

Therapy

Epithelial cell states associated with kidney and allograft injury.
Hinze C, Lovric S, Halloran PF, Barasch J, Schmidt-Ott KM
Nat Rev Nephrol 2024 Jul;20(7):447-459. Epub 2024 Apr 17 doi: 10.1038/s41581-024-00834-0. PMID: 38632381
The Second International Consensus Guidelines on the Management of BK Polyomavirus in Kidney Transplantation.
Kotton CN, Kamar N, Wojciechowski D, Eder M, Hopfer H, Randhawa P, Sester M, Comoli P, Tedesco Silva H, Knoll G, Brennan DC, Trofe-Clark J, Pape L, Axelrod D, Kiberd B, Wong G, Hirsch HH; Transplantation Society International BK Polyomavirus Consensus Group
Transplantation 2024 Sep 1;108(9):1834-1866. Epub 2024 Apr 12 doi: 10.1097/TP.0000000000004976. PMID: 38605438Free PMC Article
Immune landscape of the kidney allograft in response to rejection.
Ahuja HK, Azim S, Maluf D, Mas VR
Clin Sci (Lond) 2023 Dec 22;137(24):1823-1838. doi: 10.1042/CS20230493. PMID: 38126208
Advances in the study of B cells in renal ischemia-reperfusion injury.
Fan H, Liu J, Sun J, Feng G, Li J
Front Immunol 2023;14:1216094. Epub 2023 Nov 1 doi: 10.3389/fimmu.2023.1216094. PMID: 38022595Free PMC Article
Mechanisms of action of mycophenolate mofetil.
Allison AC
Lupus 2005;14 Suppl 1:s2-8. doi: 10.1191/0961203305lu2109oa. PMID: 15803924

Prognosis

MicroRNAs in kidney injury and disease.
Mahtal N, Lenoir O, Tinel C, Anglicheau D, Tharaux PL
Nat Rev Nephrol 2022 Oct;18(10):643-662. Epub 2022 Aug 16 doi: 10.1038/s41581-022-00608-6. PMID: 35974169
Decreased Renal Gluconeogenesis Is a Hallmark of Chronic Kidney Disease.
Verissimo T, Faivre A, Rinaldi A, Lindenmeyer M, Delitsikou V, Veyrat-Durebex C, Heckenmeyer C, Fernandez M, Berchtold L, Dalga D, Cohen C, Naesens M, Ricksten SE, Martin PY, Pugin J, Merlier F, Haupt K, Rutkowski JM, Moll S, Cippà PE, Legouis D, de Seigneux S
J Am Soc Nephrol 2022 Apr;33(4):810-827. Epub 2022 Mar 10 doi: 10.1681/ASN.2021050680. PMID: 35273087Free PMC Article
The role of osteopontin in kidney diseases.
Kaleta B
Inflamm Res 2019 Feb;68(2):93-102. Epub 2018 Nov 19 doi: 10.1007/s00011-018-1200-5. PMID: 30456594
Biochemical Markers of Renal Function.
Krstic D, Tomic N, Radosavljevic B, Avramovic N, Dragutinovic V, Skodric SR, Colovic M
Curr Med Chem 2016;23(19):2018-40. doi: 10.2174/0929867323666160115130241. PMID: 26769095
MicroRNAs in kidney transplantation.
Wilflingseder J, Reindl-Schwaighofer R, Sunzenauer J, Kainz A, Heinzel A, Mayer B, Oberbauer R
Nephrol Dial Transplant 2015 Jun;30(6):910-7. Epub 2014 Aug 28 doi: 10.1093/ndt/gfu280. PMID: 25170095Free PMC Article

Clinical prediction guides

Epithelial cell states associated with kidney and allograft injury.
Hinze C, Lovric S, Halloran PF, Barasch J, Schmidt-Ott KM
Nat Rev Nephrol 2024 Jul;20(7):447-459. Epub 2024 Apr 17 doi: 10.1038/s41581-024-00834-0. PMID: 38632381
MicroRNAs in kidney injury and disease.
Mahtal N, Lenoir O, Tinel C, Anglicheau D, Tharaux PL
Nat Rev Nephrol 2022 Oct;18(10):643-662. Epub 2022 Aug 16 doi: 10.1038/s41581-022-00608-6. PMID: 35974169
Decreased Renal Gluconeogenesis Is a Hallmark of Chronic Kidney Disease.
Verissimo T, Faivre A, Rinaldi A, Lindenmeyer M, Delitsikou V, Veyrat-Durebex C, Heckenmeyer C, Fernandez M, Berchtold L, Dalga D, Cohen C, Naesens M, Ricksten SE, Martin PY, Pugin J, Merlier F, Haupt K, Rutkowski JM, Moll S, Cippà PE, Legouis D, de Seigneux S
J Am Soc Nephrol 2022 Apr;33(4):810-827. Epub 2022 Mar 10 doi: 10.1681/ASN.2021050680. PMID: 35273087Free PMC Article
Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression.
Brehm MA, Kenney LL, Wiles MV, Low BE, Tisch RM, Burzenski L, Mueller C, Greiner DL, Shultz LD
FASEB J 2019 Mar;33(3):3137-3151. Epub 2018 Nov 1 doi: 10.1096/fj.201800636R. PMID: 30383447Free PMC Article
Biochemical Markers of Renal Function.
Krstic D, Tomic N, Radosavljevic B, Avramovic N, Dragutinovic V, Skodric SR, Colovic M
Curr Med Chem 2016;23(19):2018-40. doi: 10.2174/0929867323666160115130241. PMID: 26769095

Recent systematic reviews

Hematopoietic cell-based and non-hematopoietic cell-based strategies for immune tolerance induction in living-donor renal transplantation: A systematic review.
Annamalai C, Kute V, Sheridan C, Halawa A
Transplant Rev (Orlando) 2023 Dec;37(4):100792. Epub 2023 Aug 19 doi: 10.1016/j.trre.2023.100792. PMID: 37709652

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...