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Acute Humoral Allograft Nephropathy

MedGen UID:
859708
•Concept ID:
C3900114
•
Disease or Syndrome

Definition

A sudden onset of B-cell mediated immune response occurring after transplantation, directed against donor kidney alloantigens. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Humoral Allograft Nephropathy

Professional guidelines

PubMed

Complement Components in the Diagnosis and Treatment after Kidney Transplantation-Is There a Missing Link?
Kielar M, Gala-Błądzińska A, Dumnicka P, Ceranowicz P, Kapusta M, Naumnik B, Kubiak G, Kuźniewski M, Kuśnierz-Cabala B
Biomolecules 2021 May 21;11(6) doi: 10.3390/biom11060773. PMID: 34064132Free PMC Article
Immunosuppressive treatment for kidney transplantation.
Zivčić-Ćosić S, Trobonjača Z, Rački S
Prilozi 2011;32(2):87-103. PMID: 22286615
Diagnostic criteria of antibody-mediated rejection in kidney transplants.
Mosquera Reboredo JM, Vázquez Martul E
Nefrologia 2011;31(4):382-91. doi: 10.3265/Nefrologia.pre2011.Apr.10740. PMID: 21738242

Recent clinical studies

Etiology

Complement Components in the Diagnosis and Treatment after Kidney Transplantation-Is There a Missing Link?
Kielar M, Gala-Błądzińska A, Dumnicka P, Ceranowicz P, Kapusta M, Naumnik B, Kubiak G, Kuźniewski M, Kuśnierz-Cabala B
Biomolecules 2021 May 21;11(6) doi: 10.3390/biom11060773. PMID: 34064132Free PMC Article
De Novo Thrombotic Microangiopathy in Renal Transplant Patients.
Özdemir BH, Ok Atılgan A, Yılmaz Akçay E, Özdemir G, Ayvazoğlu Soy E, Akdur A, Haberal M
Exp Clin Transplant 2018 Mar;16 Suppl 1(Suppl 1):131-135. doi: 10.6002/ect.TOND-TDTD2017.P27. PMID: 29528010
Renal allograft pathology in the sensitized patient.
Cornell LD
Curr Opin Organ Transplant 2013 Jun;18(3):327-36. doi: 10.1097/MOT.0b013e3283614c5a. PMID: 23619513
Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence.
Sellarés J, de Freitas DG, Mengel M, Reeve J, Einecke G, Sis B, Hidalgo LG, Famulski K, Matas A, Halloran PF
Am J Transplant 2012 Feb;12(2):388-99. Epub 2011 Nov 14 doi: 10.1111/j.1600-6143.2011.03840.x. PMID: 22081892
Diagnostic criteria of antibody-mediated rejection in kidney transplants.
Mosquera Reboredo JM, Vázquez Martul E
Nefrologia 2011;31(4):382-91. doi: 10.3265/Nefrologia.pre2011.Apr.10740. PMID: 21738242

Diagnosis

Complement Components in the Diagnosis and Treatment after Kidney Transplantation-Is There a Missing Link?
Kielar M, Gala-Błądzińska A, Dumnicka P, Ceranowicz P, Kapusta M, Naumnik B, Kubiak G, Kuźniewski M, Kuśnierz-Cabala B
Biomolecules 2021 May 21;11(6) doi: 10.3390/biom11060773. PMID: 34064132Free PMC Article
MicroRNAs in kidney transplantation.
Wilflingseder J, Reindl-Schwaighofer R, Sunzenauer J, Kainz A, Heinzel A, Mayer B, Oberbauer R
Nephrol Dial Transplant 2015 Jun;30(6):910-7. Epub 2014 Aug 28 doi: 10.1093/ndt/gfu280. PMID: 25170095Free PMC Article
Renal allograft pathology in the sensitized patient.
Cornell LD
Curr Opin Organ Transplant 2013 Jun;18(3):327-36. doi: 10.1097/MOT.0b013e3283614c5a. PMID: 23619513
Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence.
Sellarés J, de Freitas DG, Mengel M, Reeve J, Einecke G, Sis B, Hidalgo LG, Famulski K, Matas A, Halloran PF
Am J Transplant 2012 Feb;12(2):388-99. Epub 2011 Nov 14 doi: 10.1111/j.1600-6143.2011.03840.x. PMID: 22081892
Acute humoral renal allograft rejection.
Böhmig GA, Exner M, Watschinger B, Regele H
Curr Opin Urol 2002 Mar;12(2):95-9. doi: 10.1097/00042307-200203000-00003. PMID: 11859254

Therapy

Complement Components in the Diagnosis and Treatment after Kidney Transplantation-Is There a Missing Link?
Kielar M, Gala-Błądzińska A, Dumnicka P, Ceranowicz P, Kapusta M, Naumnik B, Kubiak G, Kuźniewski M, Kuśnierz-Cabala B
Biomolecules 2021 May 21;11(6) doi: 10.3390/biom11060773. PMID: 34064132Free PMC Article
De Novo Thrombotic Microangiopathy in Renal Transplant Patients.
Özdemir BH, Ok Atılgan A, Yılmaz Akçay E, Özdemir G, Ayvazoğlu Soy E, Akdur A, Haberal M
Exp Clin Transplant 2018 Mar;16 Suppl 1(Suppl 1):131-135. doi: 10.6002/ect.TOND-TDTD2017.P27. PMID: 29528010
Immunosuppressive treatment for kidney transplantation.
Zivčić-Ćosić S, Trobonjača Z, Rački S
Prilozi 2011;32(2):87-103. PMID: 22286615
Diagnostic criteria of antibody-mediated rejection in kidney transplants.
Mosquera Reboredo JM, Vázquez Martul E
Nefrologia 2011;31(4):382-91. doi: 10.3265/Nefrologia.pre2011.Apr.10740. PMID: 21738242
Acute humoral renal allograft rejection.
Böhmig GA, Exner M, Watschinger B, Regele H
Curr Opin Urol 2002 Mar;12(2):95-9. doi: 10.1097/00042307-200203000-00003. PMID: 11859254

Prognosis

De Novo Thrombotic Microangiopathy in Renal Transplant Patients.
Özdemir BH, Ok Atılgan A, Yılmaz Akçay E, Özdemir G, Ayvazoğlu Soy E, Akdur A, Haberal M
Exp Clin Transplant 2018 Mar;16 Suppl 1(Suppl 1):131-135. doi: 10.6002/ect.TOND-TDTD2017.P27. PMID: 29528010
MicroRNAs in kidney transplantation.
Wilflingseder J, Reindl-Schwaighofer R, Sunzenauer J, Kainz A, Heinzel A, Mayer B, Oberbauer R
Nephrol Dial Transplant 2015 Jun;30(6):910-7. Epub 2014 Aug 28 doi: 10.1093/ndt/gfu280. PMID: 25170095Free PMC Article
Clinical role of the renal transplant biopsy.
Williams WW, Taheri D, Tolkoff-Rubin N, Colvin RB
Nat Rev Nephrol 2012 Jan 10;8(2):110-21. doi: 10.1038/nrneph.2011.213. PMID: 22231130Free PMC Article
Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence.
Sellarés J, de Freitas DG, Mengel M, Reeve J, Einecke G, Sis B, Hidalgo LG, Famulski K, Matas A, Halloran PF
Am J Transplant 2012 Feb;12(2):388-99. Epub 2011 Nov 14 doi: 10.1111/j.1600-6143.2011.03840.x. PMID: 22081892
Diagnostic criteria of antibody-mediated rejection in kidney transplants.
Mosquera Reboredo JM, Vázquez Martul E
Nefrologia 2011;31(4):382-91. doi: 10.3265/Nefrologia.pre2011.Apr.10740. PMID: 21738242

Clinical prediction guides

Antibody-Mediated Acute Vascular Rejection of Kidney Allografts: Fifteen-Year Follow-up.
Rodríguez Cubillo B, Pérez Flores I, Calvo N, Pascual A, Cortés JA, Moreno MA, Blanco J, Sánchez Fructuoso A
Transplant Proc 2016 Nov;48(9):2917-2919. doi: 10.1016/j.transproceed.2016.09.015. PMID: 27932107
Cell-mediated and humoral acute vascular rejection and graft loss: A registry study.
Teo RZ, Wong G, Russ GR, Lim WH
Nephrology (Carlton) 2016 Feb;21(2):147-55. doi: 10.1111/nep.12577. PMID: 26243593
Clinical and pathological analyses of chronic vascular rejection after kidney transplantation.
Shimizu T, Toma H, Shibahara R, Tsunoyama K, Izuka J, Nozaki T, Ishida H, Tanabe K, Honda K, Koike J
Nephrology (Carlton) 2015 Jul;20 Suppl 2:20-5. doi: 10.1111/nep.12464. PMID: 26031581
Beyond C4d: the ultrastructural appearances of endothelium in ABO-incompatible renal allografts.
Bröcker V, Pfaffenbach A, Habicht A, Chatzikyrkou C, Kreipe HH, Haller H, Scheffner I, Gwinner W, Zilian E, Immenschuh S, Schwarz A, Horn PA, Heinemann FM, Becker JU
Nephrol Dial Transplant 2013 Dec;28(12):3101-9. Epub 2013 Sep 29 doi: 10.1093/ndt/gft373. PMID: 24081856
Hepatitis C, acute humoral rejection, and renal allograft survival.
Forman JP, Tolkoff-Rubin N, Pascual M, Lin J
J Am Soc Nephrol 2004 Dec;15(12):3249-55. doi: 10.1097/01.ASN.0000145896.16153.43. PMID: 15579529

Recent systematic reviews

Current indication of plasma exchanges in nephrology: a systematic review.
Seck SM, Bertrand D, Boucar D
Saudi J Kidney Dis Transpl 2011 Mar;22(2):219-24. PMID: 21422617

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