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Adult Combined Hepatocellular Carcinoma and Cholangiocarcinoma

MedGen UID:
859699
•Concept ID:
C3900105
•
Neoplastic Process

Definition

A combined hepatocellular carcinoma and cholangiocarcinoma that occurs during adulthood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Combined Hepatocellular Carcinoma and Cholangiocarcinoma

Professional guidelines

PubMed

A new biomarker panel for differential diagnosis of cholangiocarcinoma: Results from an exploratory analysis.
Köhler B, Bes M, Chan HL, Esteban JI, Piratvisuth T, Sukeepaisarnjaroen W, Tanwandee T, Thongsawat S, Mang A, Morgenstern D, Swiatek-de Lange M, Dayyani F
Int J Biol Markers 2024 Jun;39(2):107-117. Epub 2024 Mar 28 doi: 10.1177/03936155241235185. PMID: 38549363
Intrahepatic cholangiocarcinoma and its differential diagnosis at MRI: how radiologist should assess MR features.
Granata V, Grassi R, Fusco R, Setola SV, Belli A, Ottaiano A, Nasti G, La Porta M, Danti G, Cappabianca S, Cutolo C, Petrillo A, Izzo F
Radiol Med 2021 Dec;126(12):1584-1600. Epub 2021 Nov 29 doi: 10.1007/s11547-021-01428-7. PMID: 34843029
Combined hepatocellular-cholangiocarcinoma: An update on epidemiology, classification, diagnosis and management.
Schizas D, Mastoraki A, Routsi E, Papapanou M, Tsapralis D, Vassiliu P, Toutouzas K, Felekouras E
Hepatobiliary Pancreat Dis Int 2020 Dec;19(6):515-523. Epub 2020 Jul 24 doi: 10.1016/j.hbpd.2020.07.004. PMID: 32753331

Recent clinical studies

Etiology

Tertiary lymphoid structures as a potential prognostic biomarker for combined hepatocellular-cholangiocarcinoma.
Gong W, Zhang S, Tian X, Chen W, He Y, Chen L, Ding T, Ren P, Shi L, Wu Q, Sun Y, Chen L, Guo H
Hepatol Int 2024 Aug;18(4):1310-1325. Epub 2024 May 20 doi: 10.1007/s12072-024-10694-2. PMID: 38767772Free PMC Article
Combined hepatocellular cholangiocarcinoma in hepatectomy specimens: A clinicopathologic analysis.
Patil N, Sahai P, Rastogi A, Sharma N, Shasthry SM, Mukund A, Laroia ST, Kumar G, Pamecha V, Sarin SK
Indian J Pathol Microbiol 2023 Oct-Dec;66(4):744-750. doi: 10.4103/ijpm.ijpm_357_22. PMID: 38084526
SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.
Shi L, Shen W, Davis MI, Kong K, Vu P, Saha SK, Adil R, Kreuzer J, Egan R, Lee TD, Greninger P, Shrimp JH, Zhao W, Wei TY, Zhou M, Eccleston J, Sussman J, Manocha U, Weerasekara V, Kondo H, Vijay V, Wu MJ, Kearney SE, Ho J, McClanaghan J, Murchie E, Crowther GS, Patnaik S, Boxer MB, Shen M, Ting DT, Kim WY, Stanger BZ, Deshpande V, Ferrone CR, Benes CH, Haas W, Hall MD, Bardeesy N
Nat Cancer 2023 Mar;4(3):365-381. Epub 2023 Mar 13 doi: 10.1038/s43018-023-00523-0. PMID: 36914816Free PMC Article
Combined hepatocellular-cholangiocarcinoma and its mimickers: Diagnostic pitfalls in surgical pathology.
Laohawetwanit T, Lerttanatum N, Wanpiyarat N, Manasilp N, Chaiparnich S
Ann Diagn Pathol 2021 Aug;53:151770. Epub 2021 Jun 16 doi: 10.1016/j.anndiagpath.2021.151770. PMID: 34147845
Yttrium-90 Radioembolization for Unresectable Combined Hepatocellular-Cholangiocarcinoma.
Chan LS, Sze DY, Poultsides GA, Louie JD, Abdelrazek Mohammed MA, Wang DS
Cardiovasc Intervent Radiol 2017 Sep;40(9):1383-1391. Epub 2017 Apr 21 doi: 10.1007/s00270-017-1648-7. PMID: 28432387

Diagnosis

Combined hepatocellular cholangiocarcinoma in hepatectomy specimens: A clinicopathologic analysis.
Patil N, Sahai P, Rastogi A, Sharma N, Shasthry SM, Mukund A, Laroia ST, Kumar G, Pamecha V, Sarin SK
Indian J Pathol Microbiol 2023 Oct-Dec;66(4):744-750. doi: 10.4103/ijpm.ijpm_357_22. PMID: 38084526
Is nestin a diagnostic marker for combined hepatocellular-cholangiocarcinoma?
Sasaki M, Sato Y, Nakanuma Y
Histopathology 2022 Apr;80(5):859-868. Epub 2022 Mar 3 doi: 10.1111/his.14622. PMID: 35076959
Intrahepatic cholangiocarcinoma: Tumour heterogeneity and its clinical relevance.
Komuta M
Clin Mol Hepatol 2022 Jul;28(3):396-407. Epub 2022 Jan 14 doi: 10.3350/cmh.2021.0287. PMID: 35032970Free PMC Article
Update on the pathology of liver neoplasms.
Matsukuma KE, Yeh MM
Ann Diagn Pathol 2019 Feb;38:126-137. Epub 2018 Oct 12 doi: 10.1016/j.anndiagpath.2018.10.005. PMID: 30597357
Yttrium-90 Radioembolization for Unresectable Combined Hepatocellular-Cholangiocarcinoma.
Chan LS, Sze DY, Poultsides GA, Louie JD, Abdelrazek Mohammed MA, Wang DS
Cardiovasc Intervent Radiol 2017 Sep;40(9):1383-1391. Epub 2017 Apr 21 doi: 10.1007/s00270-017-1648-7. PMID: 28432387

Therapy

Unresectable Combined Hepatocellular-cholangiocarcinoma Treated with Combination Therapy Consisting of Durvalumab Plus Tremelimumab.
Unome S, Imai K, Miwa T, Hanai T, Suetsugu A, Takai K, Suzui N, Miyazaki T, Shimizu M
Intern Med 2024 Oct 1;63(19):2631-2636. Epub 2024 Mar 4 doi: 10.2169/internalmedicine.3071-23. PMID: 38432964Free PMC Article
Atezolizumab and bevacizumab for non-resectable or metastatic combined hepatocellular-cholangiocarcinoma: A multicentric retrospective study.
Gigante E, Bouattour M, Bedoya JU, Regnault H, Ziol M, Assenat E, Paradis V, Calderaro J, Ganne-Carrié N, Bouhier-Leporrier K, Amaddeo G, Nault JC
United European Gastroenterol J 2024 May;12(4):429-439. Epub 2023 Dec 7 doi: 10.1002/ueg2.12503. PMID: 38059651Free PMC Article
Systemic Therapy for Combined Hepatocellular-Cholangiocarcinoma: A Single-Institution Experience.
Trikalinos NA, Zhou A, Doyle MBM, Fowler KJ, Morton A, Vachharajani N, Amin M, Keller JW, Chapman WC, Brunt EM, Tan BR
J Natl Compr Canc Netw 2018 Oct;16(10):1193-1199. doi: 10.6004/jnccn.2018.7053. PMID: 30323089
Liver transplantation for intrahepatic cholangiocarcinoma.
Lee DD, Croome KP, Musto KR, Melendez J, Tranesh G, Nakhleh R, Taner CB, Nguyen JH, Patel T, Harnois DM
Liver Transpl 2018 May;24(5):634-644. doi: 10.1002/lt.25052. PMID: 29514406
Yttrium-90 Radioembolization for Unresectable Combined Hepatocellular-Cholangiocarcinoma.
Chan LS, Sze DY, Poultsides GA, Louie JD, Abdelrazek Mohammed MA, Wang DS
Cardiovasc Intervent Radiol 2017 Sep;40(9):1383-1391. Epub 2017 Apr 21 doi: 10.1007/s00270-017-1648-7. PMID: 28432387

Prognosis

Clinicopathological characteristics and prognosis of combined hepatocellular cholangiocarcinoma.
Li Y, He D, Lu ZJ, Gu XF, Liu XY, Chen M, Tu YX, Zhou Y, Owen G, Zhang X, Jiang D
BMC Cancer 2024 Oct 7;24(1):1232. doi: 10.1186/s12885-024-12970-8. PMID: 39375615Free PMC Article
Tertiary lymphoid structures as a potential prognostic biomarker for combined hepatocellular-cholangiocarcinoma.
Gong W, Zhang S, Tian X, Chen W, He Y, Chen L, Ding T, Ren P, Shi L, Wu Q, Sun Y, Chen L, Guo H
Hepatol Int 2024 Aug;18(4):1310-1325. Epub 2024 May 20 doi: 10.1007/s12072-024-10694-2. PMID: 38767772Free PMC Article
Combined hepatocellular-cholangiocarcinoma and its mimickers: Diagnostic pitfalls in surgical pathology.
Laohawetwanit T, Lerttanatum N, Wanpiyarat N, Manasilp N, Chaiparnich S
Ann Diagn Pathol 2021 Aug;53:151770. Epub 2021 Jun 16 doi: 10.1016/j.anndiagpath.2021.151770. PMID: 34147845
Problematic lesions in cirrhotic liver mimicking hepatocellular carcinoma.
Kim MJ, Lee S, An C
Eur Radiol 2019 Sep;29(9):5101-5110. Epub 2019 Feb 20 doi: 10.1007/s00330-019-06030-0. PMID: 30788586
Yttrium-90 Radioembolization for Unresectable Combined Hepatocellular-Cholangiocarcinoma.
Chan LS, Sze DY, Poultsides GA, Louie JD, Abdelrazek Mohammed MA, Wang DS
Cardiovasc Intervent Radiol 2017 Sep;40(9):1383-1391. Epub 2017 Apr 21 doi: 10.1007/s00270-017-1648-7. PMID: 28432387

Clinical prediction guides

Tertiary lymphoid structures as a potential prognostic biomarker for combined hepatocellular-cholangiocarcinoma.
Gong W, Zhang S, Tian X, Chen W, He Y, Chen L, Ding T, Ren P, Shi L, Wu Q, Sun Y, Chen L, Guo H
Hepatol Int 2024 Aug;18(4):1310-1325. Epub 2024 May 20 doi: 10.1007/s12072-024-10694-2. PMID: 38767772Free PMC Article
Combined hepatocellular cholangiocarcinoma in hepatectomy specimens: A clinicopathologic analysis.
Patil N, Sahai P, Rastogi A, Sharma N, Shasthry SM, Mukund A, Laroia ST, Kumar G, Pamecha V, Sarin SK
Indian J Pathol Microbiol 2023 Oct-Dec;66(4):744-750. doi: 10.4103/ijpm.ijpm_357_22. PMID: 38084526
Computed Tomography Radiomics to Differentiate Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma.
Mahmoudi S, Bernatz S, Ackermann J, Koch V, Dos Santos DP, Grünewald LD, Yel I, Martin SS, Scholtz JE, Stehle A, Walter D, Zeuzem S, Wild PJ, Vogl TJ, Kinzler MN
Clin Oncol (R Coll Radiol) 2023 May;35(5):e312-e318. Epub 2023 Feb 1 doi: 10.1016/j.clon.2023.01.018. PMID: 36804153
Is nestin a diagnostic marker for combined hepatocellular-cholangiocarcinoma?
Sasaki M, Sato Y, Nakanuma Y
Histopathology 2022 Apr;80(5):859-868. Epub 2022 Mar 3 doi: 10.1111/his.14622. PMID: 35076959
Yttrium-90 Radioembolization for Unresectable Combined Hepatocellular-Cholangiocarcinoma.
Chan LS, Sze DY, Poultsides GA, Louie JD, Abdelrazek Mohammed MA, Wang DS
Cardiovasc Intervent Radiol 2017 Sep;40(9):1383-1391. Epub 2017 Apr 21 doi: 10.1007/s00270-017-1648-7. PMID: 28432387

Recent systematic reviews

Combined hepatocellular-cholangiocarcinoma: An update on epidemiology, classification, diagnosis and management.
Schizas D, Mastoraki A, Routsi E, Papapanou M, Tsapralis D, Vassiliu P, Toutouzas K, Felekouras E
Hepatobiliary Pancreat Dis Int 2020 Dec;19(6):515-523. Epub 2020 Jul 24 doi: 10.1016/j.hbpd.2020.07.004. PMID: 32753331
Pathological aspects of mucinous cholangiocarcinoma: A single-center experience and systematic review.
Laohawetwanit T, Klaikaew N
Pathol Int 2020 Sep;70(9):661-670. Epub 2020 Jul 7 doi: 10.1111/pin.12983. PMID: 32638458
Long-term outcomes of combined hepatocellular-cholangiocarcinoma after hepatectomy or liver transplantation: A systematic review and meta-analysis.
Li DB, Si XY, Wang SJ, Zhou YM
Hepatobiliary Pancreat Dis Int 2019 Feb;18(1):12-18. Epub 2018 Oct 25 doi: 10.1016/j.hbpd.2018.10.001. PMID: 30442549
A pooled analysis of combined liver and inferior vena cava resection for hepatic malignancy.
Zhou Y, Wu L, Xu D, Wan T, Si X
HPB (Oxford) 2017 Sep;19(9):768-774. Epub 2017 Jun 20 doi: 10.1016/j.hpb.2017.05.008. PMID: 28645571

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