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Growth Failure of Unknown Etiology

MedGen UID:
858600
Concept ID:
C3899006
Finding

Definition

Subnormal linear growth rate in an infant, child or adolescent based on the normative values for the age and sex of the reference population; the cause of the growth failure is unknown. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrowth Failure of Unknown Etiology

Professional guidelines

PubMed

Freud LR, Galloway S, Crowley TB, Moldenhauer J, Swillen A, Breckpot J, Borrell A, Vora NL, Cuneo B, Hoffman H, Gilbert L, Nowakowska B, Geremek M, Kutkowska-Kaźmierczak A, Vermeesch JR, Devriendt K, Busa T, Sigaudy S, Vigneswaran T, Simpson JM, Dungan J, Gotteiner N, Gloning KP, Digilio MC, Unolt M, Putotto C, Marino B, Repetto G, Fadic M, Garcia-Minaur S, Achón Buil A, Thomas MA, Fruitman D, Beecroft T, Hui PW, Oskarsdottir S, Bradshaw R, Criebaum A, Norton ME, Lee T, Geiger M, Dunnington L, Isaac J, Wilkins-Haug L, Hunter L, Izzi C, Toscano M, Ghi T, McGlynn J, Romana Grati F, Emanuel BS, Gaiser K, Gaynor JW, Goldmuntz E, McGinn DE, Schindewolf E, Tran O, Zackai EH, Yan Q, Bassett AS, Wapner R, McDonald-McGinn DM
Am J Obstet Gynecol 2024 Mar;230(3):368.e1-368.e12. Epub 2023 Sep 16 doi: 10.1016/j.ajog.2023.09.005. PMID: 37717890
Mumtaz SM, Bhardwaj G, Goswami S, Tonk RK, Goyal RK, Abu-Izneid T, Pottoo FH
Curr Drug Targets 2021;22(4):429-442. doi: 10.2174/1389450121666200727115454. PMID: 32718288
Lee HW, Park JY, Ahn SH
Expert Rev Gastroenterol Hepatol 2016;10(2):177-86. Epub 2016 Jan 8 doi: 10.1586/17474124.2016.1125781. PMID: 26610256

Recent clinical studies

Etiology

Tan CY, Chan PS, Tan H, Tan SW, Lee CJM, Wang JW, Ye S, Werner H, Loh YJ, Lee YL, Ackers-Johnson M, Foo RSY, Jiang J
J Transl Med 2023 Oct 16;21(1):690. doi: 10.1186/s12967-023-04542-4. PMID: 37840136Free PMC Article
Elias G, Schonfeld M, Saleh S, Parrish M, Barmanova M, Weinman SA, Tikhanovich I
Hepatology 2023 Sep 1;78(3):803-819. Epub 2023 Mar 22 doi: 10.1097/HEP.0000000000000354. PMID: 36943063Free PMC Article
Luo Y, Jiang N, May HI, Luo X, Ferdous A, Schiattarella GG, Chen G, Li Q, Li C, Rothermel BA, Jiang D, Lavandero S, Gillette TG, Hill JA
Circulation 2021 Jul 6;144(1):34-51. Epub 2021 Apr 6 doi: 10.1161/CIRCULATIONAHA.120.052384. PMID: 33821668Free PMC Article
Gillison ML, Trotti AM, Harris J, Eisbruch A, Harari PM, Adelstein DJ, Jordan RCK, Zhao W, Sturgis EM, Burtness B, Ridge JA, Ringash J, Galvin J, Yao M, Koyfman SA, Blakaj DM, Razaq MA, Colevas AD, Beitler JJ, Jones CU, Dunlap NE, Seaward SA, Spencer S, Galloway TJ, Phan J, Dignam JJ, Le QT
Lancet 2019 Jan 5;393(10166):40-50. Epub 2018 Nov 15 doi: 10.1016/S0140-6736(18)32779-X. PMID: 30449625Free PMC Article
Martins P, Castela E
Orphanet J Rare Dis 2008 Oct 13;3:27. doi: 10.1186/1750-1172-3-27. PMID: 18851735Free PMC Article

Diagnosis

Rodón J, Damian S, Furqan M, García-Donas J, Imai H, Italiano A, Spanggaard I, Ueno M, Yokota T, Veronese ML, Oliveira N, Li X, Gilmartin A, Schaffer M, Goyal L
Nat Med 2024 Jun;30(6):1645-1654. Epub 2024 May 6 doi: 10.1038/s41591-024-02934-7. PMID: 38710951Free PMC Article
Zhang Y, Da Q, Cao S, Yan K, Shi Z, Miao Q, Li C, Hu L, Sun S, Wu W, Wu L, Chen F, Wang L, Gao Y, Huang Z, Shao Y, Chen H, Wei Y, Chen F, Han Y, Xie L, Ji Y
Circulation 2021 Aug 24;144(8):638-654. Epub 2021 Jun 8 doi: 10.1161/CIRCULATIONAHA.120.051094. PMID: 34098726
Nowak-Węgrzyn A, Katz Y, Mehr SS, Koletzko S
J Allergy Clin Immunol 2015 May;135(5):1114-24. doi: 10.1016/j.jaci.2015.03.025. PMID: 25956013
Martins P, Castela E
Orphanet J Rare Dis 2008 Oct 13;3:27. doi: 10.1186/1750-1172-3-27. PMID: 18851735Free PMC Article
Bataller R, Brenner DA
J Clin Invest 2005 Feb;115(2):209-18. doi: 10.1172/JCI24282. PMID: 15690074Free PMC Article

Therapy

Rodón J, Damian S, Furqan M, García-Donas J, Imai H, Italiano A, Spanggaard I, Ueno M, Yokota T, Veronese ML, Oliveira N, Li X, Gilmartin A, Schaffer M, Goyal L
Nat Med 2024 Jun;30(6):1645-1654. Epub 2024 May 6 doi: 10.1038/s41591-024-02934-7. PMID: 38710951Free PMC Article
Singh V, Ulasov I, Gupta S, Singh A, Roy VK, Kharwar RK
Discov Med 2024 Jan;36(180):22-47. doi: 10.24976/Discov.Med.202436180.3. PMID: 38273744
Wang L, Cheng F, Pan R, Cui Z, She J, Zhang Y, Yang X
Int J Mol Sci 2023 Sep 18;24(18) doi: 10.3390/ijms241814215. PMID: 37762517Free PMC Article
Gillison ML, Trotti AM, Harris J, Eisbruch A, Harari PM, Adelstein DJ, Jordan RCK, Zhao W, Sturgis EM, Burtness B, Ridge JA, Ringash J, Galvin J, Yao M, Koyfman SA, Blakaj DM, Razaq MA, Colevas AD, Beitler JJ, Jones CU, Dunlap NE, Seaward SA, Spencer S, Galloway TJ, Phan J, Dignam JJ, Le QT
Lancet 2019 Jan 5;393(10166):40-50. Epub 2018 Nov 15 doi: 10.1016/S0140-6736(18)32779-X. PMID: 30449625Free PMC Article
Nowak-Węgrzyn A, Katz Y, Mehr SS, Koletzko S
J Allergy Clin Immunol 2015 May;135(5):1114-24. doi: 10.1016/j.jaci.2015.03.025. PMID: 25956013

Prognosis

Ogawa T, Shichino S, Ueha S, Matsushima K
Int Immunol 2021 Nov 25;33(12):665-671. doi: 10.1093/intimm/dxab040. PMID: 34270737Free PMC Article
Rupérez C, Ferrer-Curriu G, Cervera-Barea A, Florit L, Guitart-Mampel M, Garrabou G, Zamora M, Crispi F, Fernandez-Solà J, Lupón J, Bayes-Genis A, Villarroya F, Planavila A
J Exp Med 2021 May 3;218(5) doi: 10.1084/jem.20201206. PMID: 33635944Free PMC Article
Jarrett H, Barnett C
Curr Opin HIV AIDS 2017 Nov;12(6):566-571. doi: 10.1097/COH.0000000000000418. PMID: 28902721
Nowak-Węgrzyn A, Katz Y, Mehr SS, Koletzko S
J Allergy Clin Immunol 2015 May;135(5):1114-24. doi: 10.1016/j.jaci.2015.03.025. PMID: 25956013
Mieli-Vergani G, Vergani D
Semin Immunopathol 2009 Sep;31(3):371-81. Epub 2009 Jun 17 doi: 10.1007/s00281-009-0171-6. PMID: 19533128

Clinical prediction guides

Zhao T, Sun Z, Lai X, Lu H, Liu L, Li S, Yuan JH, Guo Z
J Transl Med 2023 Sep 11;21(1):614. doi: 10.1186/s12967-023-04470-3. PMID: 37697303Free PMC Article
Zhang Y, Da Q, Cao S, Yan K, Shi Z, Miao Q, Li C, Hu L, Sun S, Wu W, Wu L, Chen F, Wang L, Gao Y, Huang Z, Shao Y, Chen H, Wei Y, Chen F, Han Y, Xie L, Ji Y
Circulation 2021 Aug 24;144(8):638-654. Epub 2021 Jun 8 doi: 10.1161/CIRCULATIONAHA.120.051094. PMID: 34098726
Chowdhury F, Wang L, Al-Raqad M, Amor DJ, Baxová A, Bendová Š, Biamino E, Brusco A, Caluseriu O, Cox NJ, Froukh T, Gunay-Aygun M, Hančárová M, Haynes D, Heide S, Hoganson G, Kaname T, Keren B, Kosaki K, Kubota K, Lemons JM, Magriña MA, Mark PR, McDonald MT, Montgomery S, Morley GM, Ohnishi H, Okamoto N, Rodriguez-Buritica D, Rump P, Sedláček Z, Schatz K, Streff H, Uehara T, Walia JS, Wheeler PG, Wiesener A, Zweier C, Kawakami K, Wentzensen IM, Lalani SR, Siu VM, Bi W, Balci TB
Genet Med 2021 Jul;23(7):1234-1245. Epub 2021 Apr 6 doi: 10.1038/s41436-021-01129-6. PMID: 33824499
Baujat G, Le Merrer M
Orphanet J Rare Dis 2007 Jun 4;2:27. doi: 10.1186/1750-1172-2-27. PMID: 17547743Free PMC Article
Schonfeld G
Annu Rev Nutr 1995;15:23-34. doi: 10.1146/annurev.nu.15.070195.000323. PMID: 8527219

Recent systematic reviews

Tan S, Sivakumar S, Segelov E, Nicholls SJ, Nelson AJ
Cancer Epidemiol 2023 Apr;83:102334. Epub 2023 Jan 18 doi: 10.1016/j.canep.2023.102334. PMID: 36669376
Negri E, Coletta R, Morabito A
J Pediatr Surg 2020 Sep;55(9):1809-1814. Epub 2020 Mar 23 doi: 10.1016/j.jpedsurg.2020.03.009. PMID: 32278545

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