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Growth Failure of Unknown Etiology

MedGen UID:
858600
•Concept ID:
C3899006
•
Finding

Definition

Subnormal linear growth rate in an infant, child or adolescent based on the normative values for the age and sex of the reference population; the cause of the growth failure is unknown. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrowth Failure of Unknown Etiology

Professional guidelines

PubMed

Prenatal vs postnatal diagnosis of 22q11.2 deletion syndrome: cardiac and noncardiac outcomes through 1 year of age.
Freud LR, Galloway S, Crowley TB, Moldenhauer J, Swillen A, Breckpot J, Borrell A, Vora NL, Cuneo B, Hoffman H, Gilbert L, Nowakowska B, Geremek M, Kutkowska-Kaźmierczak A, Vermeesch JR, Devriendt K, Busa T, Sigaudy S, Vigneswaran T, Simpson JM, Dungan J, Gotteiner N, Gloning KP, Digilio MC, Unolt M, Putotto C, Marino B, Repetto G, Fadic M, Garcia-Minaur S, Achón Buil A, Thomas MA, Fruitman D, Beecroft T, Hui PW, Oskarsdottir S, Bradshaw R, Criebaum A, Norton ME, Lee T, Geiger M, Dunnington L, Isaac J, Wilkins-Haug L, Hunter L, Izzi C, Toscano M, Ghi T, McGlynn J, Romana Grati F, Emanuel BS, Gaiser K, Gaynor JW, Goldmuntz E, McGinn DE, Schindewolf E, Tran O, Zackai EH, Yan Q, Bassett AS, Wapner R, McDonald-McGinn DM
Am J Obstet Gynecol 2024 Mar;230(3):368.e1-368.e12. Epub 2023 Sep 16 doi: 10.1016/j.ajog.2023.09.005. PMID: 37717890
Management of Glioblastoma Multiforme by Phytochemicals: Applications of Nanoparticle-Based Targeted Drug Delivery System.
Mumtaz SM, Bhardwaj G, Goswami S, Tonk RK, Goyal RK, Abu-Izneid T, Pottoo FH
Curr Drug Targets 2021;22(4):429-442. doi: 10.2174/1389450121666200727115454. PMID: 32718288
An evaluation of entecavir for the treatment of chronic hepatitis B infection in adults.
Lee HW, Park JY, Ahn SH
Expert Rev Gastroenterol Hepatol 2016;10(2):177-86. Epub 2016 Jan 8 doi: 10.1586/17474124.2016.1125781. PMID: 26610256

Recent clinical studies

Etiology

Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity.
Tan CY, Chan PS, Tan H, Tan SW, Lee CJM, Wang JW, Ye S, Werner H, Loh YJ, Lee YL, Ackers-Johnson M, Foo RSY, Jiang J
J Transl Med 2023 Oct 16;21(1):690. doi: 10.1186/s12967-023-04542-4. PMID: 37840136Free PMC Article
Sepsis-induced endothelial dysfunction drives acute-on-chronic liver failure through Angiopoietin-2-HGF-C/EBPβ pathway.
Elias G, Schonfeld M, Saleh S, Parrish M, Barmanova M, Weinman SA, Tikhanovich I
Hepatology 2023 Sep 1;78(3):803-819. Epub 2023 Mar 22 doi: 10.1097/HEP.0000000000000354. PMID: 36943063Free PMC Article
Cooperative Binding of ETS2 and NFAT Links Erk1/2 and Calcineurin Signaling in the Pathogenesis of Cardiac Hypertrophy.
Luo Y, Jiang N, May HI, Luo X, Ferdous A, Schiattarella GG, Chen G, Li Q, Li C, Rothermel BA, Jiang D, Lavandero S, Gillette TG, Hill JA
Circulation 2021 Jul 6;144(1):34-51. Epub 2021 Apr 6 doi: 10.1161/CIRCULATIONAHA.120.052384. PMID: 33821668Free PMC Article
Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial.
Gillison ML, Trotti AM, Harris J, Eisbruch A, Harari PM, Adelstein DJ, Jordan RCK, Zhao W, Sturgis EM, Burtness B, Ridge JA, Ringash J, Galvin J, Yao M, Koyfman SA, Blakaj DM, Razaq MA, Colevas AD, Beitler JJ, Jones CU, Dunlap NE, Seaward SA, Spencer S, Galloway TJ, Phan J, Dignam JJ, Le QT
Lancet 2019 Jan 5;393(10166):40-50. Epub 2018 Nov 15 doi: 10.1016/S0140-6736(18)32779-X. PMID: 30449625Free PMC Article
Transposition of the great arteries.
Martins P, Castela E
Orphanet J Rare Dis 2008 Oct 13;3:27. doi: 10.1186/1750-1172-3-27. PMID: 18851735Free PMC Article

Diagnosis

Pemigatinib in previously treated solid tumors with activating FGFR1-FGFR3 alterations: phase 2 FIGHT-207 basket trial.
Rodón J, Damian S, Furqan M, García-Donas J, Imai H, Italiano A, Spanggaard I, Ueno M, Yokota T, Veronese ML, Oliveira N, Li X, Gilmartin A, Schaffer M, Goyal L
Nat Med 2024 Jun;30(6):1645-1654. Epub 2024 May 6 doi: 10.1038/s41591-024-02934-7. PMID: 38710951Free PMC Article
HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression.
Zhang Y, Da Q, Cao S, Yan K, Shi Z, Miao Q, Li C, Hu L, Sun S, Wu W, Wu L, Chen F, Wang L, Gao Y, Huang Z, Shao Y, Chen H, Wei Y, Chen F, Han Y, Xie L, Ji Y
Circulation 2021 Aug 24;144(8):638-654. Epub 2021 Jun 8 doi: 10.1161/CIRCULATIONAHA.120.051094. PMID: 34098726
Non-IgE-mediated gastrointestinal food allergy.
Nowak-Węgrzyn A, Katz Y, Mehr SS, Koletzko S
J Allergy Clin Immunol 2015 May;135(5):1114-24. doi: 10.1016/j.jaci.2015.03.025. PMID: 25956013
Transposition of the great arteries.
Martins P, Castela E
Orphanet J Rare Dis 2008 Oct 13;3:27. doi: 10.1186/1750-1172-3-27. PMID: 18851735Free PMC Article
Liver fibrosis.
Bataller R, Brenner DA
J Clin Invest 2005 Feb;115(2):209-18. doi: 10.1172/JCI24282. PMID: 15690074Free PMC Article

Therapy

Pemigatinib in previously treated solid tumors with activating FGFR1-FGFR3 alterations: phase 2 FIGHT-207 basket trial.
Rodón J, Damian S, Furqan M, García-Donas J, Imai H, Italiano A, Spanggaard I, Ueno M, Yokota T, Veronese ML, Oliveira N, Li X, Gilmartin A, Schaffer M, Goyal L
Nat Med 2024 Jun;30(6):1645-1654. Epub 2024 May 6 doi: 10.1038/s41591-024-02934-7. PMID: 38710951Free PMC Article
Idiopathic Pulmonary Fibrosis: Where do We Stand and How Far to Go?
Singh V, Ulasov I, Gupta S, Singh A, Roy VK, Kharwar RK
Discov Med 2024 Jan;36(180):22-47. doi: 10.24976/Discov.Med.202436180.3. PMID: 38273744
FGF2 Rescued Cisplatin-Injured Granulosa Cells through the NRF2-Autophagy Pathway.
Wang L, Cheng F, Pan R, Cui Z, She J, Zhang Y, Yang X
Int J Mol Sci 2023 Sep 18;24(18) doi: 10.3390/ijms241814215. PMID: 37762517Free PMC Article
Radiotherapy plus cetuximab or cisplatin in human papillomavirus-positive oropharyngeal cancer (NRG Oncology RTOG 1016): a randomised, multicentre, non-inferiority trial.
Gillison ML, Trotti AM, Harris J, Eisbruch A, Harari PM, Adelstein DJ, Jordan RCK, Zhao W, Sturgis EM, Burtness B, Ridge JA, Ringash J, Galvin J, Yao M, Koyfman SA, Blakaj DM, Razaq MA, Colevas AD, Beitler JJ, Jones CU, Dunlap NE, Seaward SA, Spencer S, Galloway TJ, Phan J, Dignam JJ, Le QT
Lancet 2019 Jan 5;393(10166):40-50. Epub 2018 Nov 15 doi: 10.1016/S0140-6736(18)32779-X. PMID: 30449625Free PMC Article
Non-IgE-mediated gastrointestinal food allergy.
Nowak-Węgrzyn A, Katz Y, Mehr SS, Koletzko S
J Allergy Clin Immunol 2015 May;135(5):1114-24. doi: 10.1016/j.jaci.2015.03.025. PMID: 25956013

Prognosis

Macrophages in lung fibrosis.
Ogawa T, Shichino S, Ueha S, Matsushima K
Int Immunol 2021 Nov 25;33(12):665-671. doi: 10.1093/intimm/dxab040. PMID: 34270737Free PMC Article
Meteorin-like/Meteorin-β protects heart against cardiac dysfunction.
Rupérez C, Ferrer-Curriu G, Cervera-Barea A, Florit L, Guitart-Mampel M, Garrabou G, Zamora M, Crispi F, Fernandez-Solà J, Lupón J, Bayes-Genis A, Villarroya F, Planavila A
J Exp Med 2021 May 3;218(5) doi: 10.1084/jem.20201206. PMID: 33635944Free PMC Article
HIV-associated pulmonary hypertension.
Jarrett H, Barnett C
Curr Opin HIV AIDS 2017 Nov;12(6):566-571. doi: 10.1097/COH.0000000000000418. PMID: 28902721
Non-IgE-mediated gastrointestinal food allergy.
Nowak-Węgrzyn A, Katz Y, Mehr SS, Koletzko S
J Allergy Clin Immunol 2015 May;135(5):1114-24. doi: 10.1016/j.jaci.2015.03.025. PMID: 25956013
Biliary atresia.
Mieli-Vergani G, Vergani D
Semin Immunopathol 2009 Sep;31(3):371-81. Epub 2009 Jun 17 doi: 10.1007/s00281-009-0171-6. PMID: 19533128

Clinical prediction guides

Tamoxifen exerts anti-peritoneal fibrosis effects by inhibiting H19-activated VEGFA transcription.
Zhao T, Sun Z, Lai X, Lu H, Liu L, Li S, Yuan JH, Guo Z
J Transl Med 2023 Sep 11;21(1):614. doi: 10.1186/s12967-023-04470-3. PMID: 37697303Free PMC Article
HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression.
Zhang Y, Da Q, Cao S, Yan K, Shi Z, Miao Q, Li C, Hu L, Sun S, Wu W, Wu L, Chen F, Wang L, Gao Y, Huang Z, Shao Y, Chen H, Wei Y, Chen F, Han Y, Xie L, Ji Y
Circulation 2021 Aug 24;144(8):638-654. Epub 2021 Jun 8 doi: 10.1161/CIRCULATIONAHA.120.051094. PMID: 34098726
Haploinsufficiency of PRR12 causes a spectrum of neurodevelopmental, eye, and multisystem abnormalities.
Chowdhury F, Wang L, Al-Raqad M, Amor DJ, Baxová A, Bendová Š, Biamino E, Brusco A, Caluseriu O, Cox NJ, Froukh T, Gunay-Aygun M, Hančárová M, Haynes D, Heide S, Hoganson G, Kaname T, Keren B, Kosaki K, Kubota K, Lemons JM, Magriña MA, Mark PR, McDonald MT, Montgomery S, Morley GM, Ohnishi H, Okamoto N, Rodriguez-Buritica D, Rump P, Sedláček Z, Schatz K, Streff H, Uehara T, Walia JS, Wheeler PG, Wiesener A, Zweier C, Kawakami K, Wentzensen IM, Lalani SR, Siu VM, Bi W, Balci TB
Genet Med 2021 Jul;23(7):1234-1245. Epub 2021 Apr 6 doi: 10.1038/s41436-021-01129-6. PMID: 33824499
Ellis-van Creveld syndrome.
Baujat G, Le Merrer M
Orphanet J Rare Dis 2007 Jun 4;2:27. doi: 10.1186/1750-1172-2-27. PMID: 17547743Free PMC Article
The hypobetalipoproteinemias.
Schonfeld G
Annu Rev Nutr 1995;15:23-34. doi: 10.1146/annurev.nu.15.070195.000323. PMID: 8527219

Recent systematic reviews

Cardiovascular risk factor reporting in immune checkpoint inhibitor trials: A systematic review.
Tan S, Sivakumar S, Segelov E, Nicholls SJ, Nelson AJ
Cancer Epidemiol 2023 Apr;83:102334. Epub 2023 Jan 18 doi: 10.1016/j.canep.2023.102334. PMID: 36669376
Congenital short bowel syndrome: systematic review of a rare condition.
Negri E, Coletta R, Morabito A
J Pediatr Surg 2020 Sep;55(9):1809-1814. Epub 2020 Mar 23 doi: 10.1016/j.jpedsurg.2020.03.009. PMID: 32278545

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