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Untreated Childhood Cerebral Astrocytoma

MedGen UID:
856830
•Concept ID:
C3897236
•
Neoplastic Process

Definition

A finding of cerebral astrocytoma in childhood that has not been treated. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUntreated Childhood Cerebral Astrocytoma

Professional guidelines

PubMed

Loco-regional treatment with temozolomide-loaded thermogels prevents glioblastoma recurrences in orthotopic human xenograft models.
Gherardini L, Vetri Buratti V, Maturi M, Inzalaco G, Locatelli E, Sambri L, Gargiulo S, Barone V, Bonente D, Bertelli E, Tortorella S, Franci L, Fioravanti A, Comes Franchini M, Chiariello M
Sci Rep 2023 Mar 21;13(1):4630. doi: 10.1038/s41598-023-31811-5. PMID: 36944737Free PMC Article
Pharmacotherapeutic Treatment of Glioblastoma: Where Are We to Date?
Gatto L, Di Nunno V, Franceschi E, Tosoni A, Bartolini S, Brandes AA
Drugs 2022 Apr;82(5):491-510. Epub 2022 Apr 9 doi: 10.1007/s40265-022-01702-6. PMID: 35397073
Tissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment.
Trautwein C, Zizmare L, Mäurer I, Bender B, Bayer B, Ernemann U, Tatagiba M, Grau SJ, Pichler BJ, Skardelly M, Tabatabai G
JCI Insight 2022 Feb 8;7(3) doi: 10.1172/jci.insight.153526. PMID: 34941573Free PMC Article

Recent clinical studies

Etiology

Cluster-based prognostication in glioblastoma: Unveiling heterogeneity based on diffusion and perfusion similarities.
Foltyn-Dumitru M, Kessler T, Sahm F, Wick W, Heiland S, Bendszus M, Vollmuth P, Schell M
Neuro Oncol 2024 Jun 3;26(6):1099-1108. doi: 10.1093/neuonc/noad259. PMID: 38153923Free PMC Article
Nitric oxide synthase inhibitors as potential therapeutic agents for gliomas: A systematic review.
Merenzon MA, Hincapie Arias E, Bhatia S, Shah AH, Higgins DMO, Villaverde M, Belgorosky D, Eijan AM
Nitric Oxide 2023 Sep 1;138-139:10-16. Epub 2023 Jun 4 doi: 10.1016/j.niox.2023.06.002. PMID: 37279819
Laser interstitial thermal therapy for newly diagnosed glioblastoma.
Muir M, Patel R, Traylor JI, de Almeida Bastos DC, Kamiya C, Li J, Rao G, Prabhu SS
Lasers Med Sci 2022 Apr;37(3):1811-1820. Epub 2021 Oct 23 doi: 10.1007/s10103-021-03435-6. PMID: 34687390
Recurrent venous thromboembolism in glioblastoma.
Edwin NC, Khoury MN, Sohal D, McCrae KR, Ahluwalia MS, Khorana AA
Thromb Res 2016 Jan;137:184-188. Epub 2015 Nov 22 doi: 10.1016/j.thromres.2015.11.027. PMID: 26657302
Bevacizumab in glioblastoma multiforme.
Specenier P
Expert Rev Anticancer Ther 2012 Jan;12(1):9-18. doi: 10.1586/era.11.179. PMID: 22149428

Diagnosis

Pretreatment MR-based radiomics in patients with glioblastoma: A systematic review and meta-analysis of prognostic endpoints.
Choi Y, Jang J, Kim BS, Ahn KJ
Eur J Radiol 2023 Nov;168:111130. Epub 2023 Oct 5 doi: 10.1016/j.ejrad.2023.111130. PMID: 37827087
Novel murine glioblastoma models that reflect the immunotherapy resistance profile of a human disease.
Chen CH, Chin RL, Hartley GP, Lea ST, Engel BJ, Hsieh CE, Prasad R, Roszik J, Shingu T, Lizee GA, Heimberger AB, Millward SW, Hu J, Hong DS, Curran MA
Neuro Oncol 2023 Aug 3;25(8):1415-1427. doi: 10.1093/neuonc/noad025. PMID: 36705543Free PMC Article
Pharmacotherapeutic Treatment of Glioblastoma: Where Are We to Date?
Gatto L, Di Nunno V, Franceschi E, Tosoni A, Bartolini S, Brandes AA
Drugs 2022 Apr;82(5):491-510. Epub 2022 Apr 9 doi: 10.1007/s40265-022-01702-6. PMID: 35397073
Early Therapeutic Interventions for Newly Diagnosed Glioblastoma: Rationale and Review of the Literature.
Waqar M, Trifiletti DM, McBain C, O'Connor J, Coope DJ, Akkari L, Quinones-Hinojosa A, Borst GR
Curr Oncol Rep 2022 Mar;24(3):311-324. Epub 2022 Feb 4 doi: 10.1007/s11912-021-01157-0. PMID: 35119629Free PMC Article
Recurrent venous thromboembolism in glioblastoma.
Edwin NC, Khoury MN, Sohal D, McCrae KR, Ahluwalia MS, Khorana AA
Thromb Res 2016 Jan;137:184-188. Epub 2015 Nov 22 doi: 10.1016/j.thromres.2015.11.027. PMID: 26657302

Therapy

Immunotherapy drives mesenchymal tumor cell state shift and TME immune response in glioblastoma patients.
Hendriksen JD, Locallo A, Maarup S, Debnath O, Ishaque N, Hasselbach B, Skjøth-Rasmussen J, Yde CW, Poulsen HS, Lassen U, Weischenfeldt J
Neuro Oncol 2024 Aug 5;26(8):1453-1466. doi: 10.1093/neuonc/noae085. PMID: 38695342Free PMC Article
Pretreatment MR-based radiomics in patients with glioblastoma: A systematic review and meta-analysis of prognostic endpoints.
Choi Y, Jang J, Kim BS, Ahn KJ
Eur J Radiol 2023 Nov;168:111130. Epub 2023 Oct 5 doi: 10.1016/j.ejrad.2023.111130. PMID: 37827087
Pharmacotherapeutic Treatment of Glioblastoma: Where Are We to Date?
Gatto L, Di Nunno V, Franceschi E, Tosoni A, Bartolini S, Brandes AA
Drugs 2022 Apr;82(5):491-510. Epub 2022 Apr 9 doi: 10.1007/s40265-022-01702-6. PMID: 35397073
Recurrent venous thromboembolism in glioblastoma.
Edwin NC, Khoury MN, Sohal D, McCrae KR, Ahluwalia MS, Khorana AA
Thromb Res 2016 Jan;137:184-188. Epub 2015 Nov 22 doi: 10.1016/j.thromres.2015.11.027. PMID: 26657302
Bevacizumab in glioblastoma multiforme.
Specenier P
Expert Rev Anticancer Ther 2012 Jan;12(1):9-18. doi: 10.1586/era.11.179. PMID: 22149428

Prognosis

Immunotherapy drives mesenchymal tumor cell state shift and TME immune response in glioblastoma patients.
Hendriksen JD, Locallo A, Maarup S, Debnath O, Ishaque N, Hasselbach B, Skjøth-Rasmussen J, Yde CW, Poulsen HS, Lassen U, Weischenfeldt J
Neuro Oncol 2024 Aug 5;26(8):1453-1466. doi: 10.1093/neuonc/noae085. PMID: 38695342Free PMC Article
Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma.
Cheng YL, Banu MA, Zhao W, Rosenfeld SS, Canoll P, Sims PA
Cell Rep 2024 May 28;43(5):114139. Epub 2024 Apr 21 doi: 10.1016/j.celrep.2024.114139. PMID: 38652658Free PMC Article
Pretreatment MR-based radiomics in patients with glioblastoma: A systematic review and meta-analysis of prognostic endpoints.
Choi Y, Jang J, Kim BS, Ahn KJ
Eur J Radiol 2023 Nov;168:111130. Epub 2023 Oct 5 doi: 10.1016/j.ejrad.2023.111130. PMID: 37827087
Pharmacotherapeutic Treatment of Glioblastoma: Where Are We to Date?
Gatto L, Di Nunno V, Franceschi E, Tosoni A, Bartolini S, Brandes AA
Drugs 2022 Apr;82(5):491-510. Epub 2022 Apr 9 doi: 10.1007/s40265-022-01702-6. PMID: 35397073
Recurrent venous thromboembolism in glioblastoma.
Edwin NC, Khoury MN, Sohal D, McCrae KR, Ahluwalia MS, Khorana AA
Thromb Res 2016 Jan;137:184-188. Epub 2015 Nov 22 doi: 10.1016/j.thromres.2015.11.027. PMID: 26657302

Clinical prediction guides

Cluster-based prognostication in glioblastoma: Unveiling heterogeneity based on diffusion and perfusion similarities.
Foltyn-Dumitru M, Kessler T, Sahm F, Wick W, Heiland S, Bendszus M, Vollmuth P, Schell M
Neuro Oncol 2024 Jun 3;26(6):1099-1108. doi: 10.1093/neuonc/noad259. PMID: 38153923Free PMC Article
Pretreatment MR-based radiomics in patients with glioblastoma: A systematic review and meta-analysis of prognostic endpoints.
Choi Y, Jang J, Kim BS, Ahn KJ
Eur J Radiol 2023 Nov;168:111130. Epub 2023 Oct 5 doi: 10.1016/j.ejrad.2023.111130. PMID: 37827087
The effect of temozolomide on apoptosis-related gene expression changes in glioblastoma cells.
Vidomanova E, Majercikova Z, Dibdiakova K, Pilchova I, Racay P, Hatok J
Bratisl Lek Listy 2022;123(4):236-243. doi: 10.4149/BLL_2022_038. PMID: 35294208
Laser interstitial thermal therapy for newly diagnosed glioblastoma.
Muir M, Patel R, Traylor JI, de Almeida Bastos DC, Kamiya C, Li J, Rao G, Prabhu SS
Lasers Med Sci 2022 Apr;37(3):1811-1820. Epub 2021 Oct 23 doi: 10.1007/s10103-021-03435-6. PMID: 34687390
Diencephalic syndrome revisited.
Burr IM, Slonim AE, Danish RK, Gadoth N, Butler IJ
J Pediatr 1976 Mar;88(3):439-44. doi: 10.1016/s0022-3476(76)80260-0. PMID: 1245953

Recent systematic reviews

Pretreatment MR-based radiomics in patients with glioblastoma: A systematic review and meta-analysis of prognostic endpoints.
Choi Y, Jang J, Kim BS, Ahn KJ
Eur J Radiol 2023 Nov;168:111130. Epub 2023 Oct 5 doi: 10.1016/j.ejrad.2023.111130. PMID: 37827087
Nitric oxide synthase inhibitors as potential therapeutic agents for gliomas: A systematic review.
Merenzon MA, Hincapie Arias E, Bhatia S, Shah AH, Higgins DMO, Villaverde M, Belgorosky D, Eijan AM
Nitric Oxide 2023 Sep 1;138-139:10-16. Epub 2023 Jun 4 doi: 10.1016/j.niox.2023.06.002. PMID: 37279819
The effects of cannabinoids on glioblastoma growth: A systematic review with meta-analysis of animal model studies.
Luís Â, Marcelino H, Rosa C, Domingues F, Pereira L, Cascalheira JF
Eur J Pharmacol 2020 Jun 5;876:173055. Epub 2020 Mar 4 doi: 10.1016/j.ejphar.2020.173055. PMID: 32145324
Magnetic resonance perfusion for differentiating low-grade from high-grade gliomas at first presentation.
Abrigo JM, Fountain DM, Provenzale JM, Law EK, Kwong JS, Hart MG, Tam WWS
Cochrane Database Syst Rev 2018 Jan 22;1(1):CD011551. doi: 10.1002/14651858.CD011551.pub2. PMID: 29357120Free PMC Article

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