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Untreated Childhood Diffuse Astrocytoma

MedGen UID:
856829
•Concept ID:
C3897235
•
Neoplastic Process

Definition

A finding of diffuse astrocytoma in childhood that has not been treated. [from NCI]

Recent clinical studies

Etiology

Preradiation high-dose intravenous methotrexate with leucovorin rescue for untreated primary childhood brain tumors.
Allen JC, Walker R, Rosen G
J Clin Oncol 1988 Apr;6(4):649-53. doi: 10.1200/JCO.1988.6.4.649. PMID: 3258630
Long-term follow-up of patients with optic glioma.
Kanamori M, Shibuya M, Yoshida J, Takayasu M, Kageyama N
Childs Nerv Syst 1985;1(5):272-8. doi: 10.1007/BF00272025. PMID: 4084911

Diagnosis

Characteristics of children ≤36 months of age with DIPG: A report from the international DIPG registry.
Bartlett AL, Lane A, Chaney B, Escorza NY, Black K, Cochrane A, Minturn J, Bartels U, Warren K, Hansford J, Ziegler D, Diez B, Goldman S, Packer R, Kieran M, DeWire-Schottmiller M, Erker C, Monje-Deisseroth M, Wagner L, Koschmann C, Dorris K, Shih CS, Hassall T, Samson Y, Fisher P, Wang SS, Tsui K, Sevlever G, Zhu X, Dexheimer P, Asher A, Fuller C, Drissi R, Jones B, Leach J, Fouladi M
Neuro Oncol 2022 Dec 1;24(12):2190-2199. doi: 10.1093/neuonc/noac123. PMID: 35552452Free PMC Article
A large de novo 9p21.3 deletion in a girl affected by astrocytoma and multiple melanoma.
Frigerio S, Disciglio V, Manoukian S, Peissel B, Della Torre G, Maurichi A, Collini P, Pasini B, Gotti G, Ferrari A, Rivoltini L, Massimino M, Rodolfo M
BMC Med Genet 2014 May 17;15:59. doi: 10.1186/1471-2350-15-59. PMID: 24884915Free PMC Article
Development, characterization, and reversal of acquired resistance to the MEK1 inhibitor selumetinib (AZD6244) in an in vivo model of childhood astrocytoma.
Bid HK, Kibler A, Phelps DA, Manap S, Xiao L, Lin J, Capper D, Oswald D, Geier B, DeWire M, Smith PD, Kurmasheva RT, Mo X, Fernandez S, Houghton PJ
Clin Cancer Res 2013 Dec 15;19(24):6716-29. Epub 2013 Oct 16 doi: 10.1158/1078-0432.CCR-13-0842. PMID: 24132923Free PMC Article
Identification and characterisation of childhood cerebellar tumours by in vivo proton MRS.
Davies NP, Wilson M, Harris LM, Natarajan K, Lateef S, Macpherson L, Sgouros S, Grundy RG, Arvanitis TN, Peet AC
NMR Biomed 2008 Oct;21(8):908-18. doi: 10.1002/nbm.1283. PMID: 18613254
Preradiation high-dose intravenous methotrexate with leucovorin rescue for untreated primary childhood brain tumors.
Allen JC, Walker R, Rosen G
J Clin Oncol 1988 Apr;6(4):649-53. doi: 10.1200/JCO.1988.6.4.649. PMID: 3258630

Therapy

Development, characterization, and reversal of acquired resistance to the MEK1 inhibitor selumetinib (AZD6244) in an in vivo model of childhood astrocytoma.
Bid HK, Kibler A, Phelps DA, Manap S, Xiao L, Lin J, Capper D, Oswald D, Geier B, DeWire M, Smith PD, Kurmasheva RT, Mo X, Fernandez S, Houghton PJ
Clin Cancer Res 2013 Dec 15;19(24):6716-29. Epub 2013 Oct 16 doi: 10.1158/1078-0432.CCR-13-0842. PMID: 24132923Free PMC Article
Post-laminectomy rotokyphoscoliosis causing paraplegia in long term: case report.
Duman I, Guzelkucuk U, Yilmaz B, Tan AK
J Spinal Cord Med 2012 May;35(3):175-7. doi: 10.1179/2045772311Y.0000000052. PMID: 22507027Free PMC Article
Phase II evaluation of topotecan for pediatric central nervous system tumors.
Blaney SM, Phillips PC, Packer RJ, Heideman RL, Berg SL, Adamson PC, Allen JC, Sallan SE, Jakacki RI, Lange BJ, Reaman GH, Horowitz ME, Poplack DG, Balis FM
Cancer 1996 Aug 1;78(3):527-31. doi: 10.1002/(SICI)1097-0142(19960801)78:3<527::AID-CNCR21>3.0.CO;2-#. PMID: 8697400
Preradiation high-dose intravenous methotrexate with leucovorin rescue for untreated primary childhood brain tumors.
Allen JC, Walker R, Rosen G
J Clin Oncol 1988 Apr;6(4):649-53. doi: 10.1200/JCO.1988.6.4.649. PMID: 3258630

Prognosis

Characteristics of children ≤36 months of age with DIPG: A report from the international DIPG registry.
Bartlett AL, Lane A, Chaney B, Escorza NY, Black K, Cochrane A, Minturn J, Bartels U, Warren K, Hansford J, Ziegler D, Diez B, Goldman S, Packer R, Kieran M, DeWire-Schottmiller M, Erker C, Monje-Deisseroth M, Wagner L, Koschmann C, Dorris K, Shih CS, Hassall T, Samson Y, Fisher P, Wang SS, Tsui K, Sevlever G, Zhu X, Dexheimer P, Asher A, Fuller C, Drissi R, Jones B, Leach J, Fouladi M
Neuro Oncol 2022 Dec 1;24(12):2190-2199. doi: 10.1093/neuonc/noac123. PMID: 35552452Free PMC Article
Preradiation high-dose intravenous methotrexate with leucovorin rescue for untreated primary childhood brain tumors.
Allen JC, Walker R, Rosen G
J Clin Oncol 1988 Apr;6(4):649-53. doi: 10.1200/JCO.1988.6.4.649. PMID: 3258630
Long-term follow-up of patients with optic glioma.
Kanamori M, Shibuya M, Yoshida J, Takayasu M, Kageyama N
Childs Nerv Syst 1985;1(5):272-8. doi: 10.1007/BF00272025. PMID: 4084911

Clinical prediction guides

Characteristics of children ≤36 months of age with DIPG: A report from the international DIPG registry.
Bartlett AL, Lane A, Chaney B, Escorza NY, Black K, Cochrane A, Minturn J, Bartels U, Warren K, Hansford J, Ziegler D, Diez B, Goldman S, Packer R, Kieran M, DeWire-Schottmiller M, Erker C, Monje-Deisseroth M, Wagner L, Koschmann C, Dorris K, Shih CS, Hassall T, Samson Y, Fisher P, Wang SS, Tsui K, Sevlever G, Zhu X, Dexheimer P, Asher A, Fuller C, Drissi R, Jones B, Leach J, Fouladi M
Neuro Oncol 2022 Dec 1;24(12):2190-2199. doi: 10.1093/neuonc/noac123. PMID: 35552452Free PMC Article
Development, characterization, and reversal of acquired resistance to the MEK1 inhibitor selumetinib (AZD6244) in an in vivo model of childhood astrocytoma.
Bid HK, Kibler A, Phelps DA, Manap S, Xiao L, Lin J, Capper D, Oswald D, Geier B, DeWire M, Smith PD, Kurmasheva RT, Mo X, Fernandez S, Houghton PJ
Clin Cancer Res 2013 Dec 15;19(24):6716-29. Epub 2013 Oct 16 doi: 10.1158/1078-0432.CCR-13-0842. PMID: 24132923Free PMC Article

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