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Dysthymic disorder

MedGen UID:
8517
•Concept ID:
C0013415
•
Mental or Behavioral Dysfunction
Synonyms: Disorder, Dysthymic; Dysthymia; Dysthymic Disorder; Dysthymic Disorders; Persistent Depressive Disorder, Dysthymia
SNOMED CT: Dysthymia (78667006)
 
Monarch Initiative: MONDO:0001442

Definition

Dysthymia is a chronic mood disorder characterized by persistent depressed mood present for at least two years, for most of the day and for more days than not. During the first two years of the disorder, there has never been a two week period during which the number and duration of symptoms were sufficient to meet the diagnostic requirements for a major depressive episode. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDysthymic disorder

Professional guidelines

PubMed

An update on the pharmacotherapeutic strategies for the treatment of dysthymic disorder: a systematic review.
Quagliato LA, Primavera D, Fornaro M, Preti A, Carta MG, Nardi AE
Expert Opin Pharmacother 2023 Sep-Dec;24(18):2035-2040. Epub 2024 Jan 5 doi: 10.1080/14656566.2023.2265809. PMID: 37787056
Antidepressants for the treatment of depression in people with cancer.
Vita G, Compri B, Matcham F, Barbui C, Ostuzzi G
Cochrane Database Syst Rev 2023 Mar 31;3(3):CD011006. doi: 10.1002/14651858.CD011006.pub4. PMID: 36999619Free PMC Article
Prevalence of depressive disorders and treatment in China: a cross-sectional epidemiological study.
Lu J, Xu X, Huang Y, Li T, Ma C, Xu G, Yin H, Xu X, Ma Y, Wang L, Huang Z, Yan Y, Wang B, Xiao S, Zhou L, Li L, Zhang Y, Chen H, Zhang T, Yan J, Ding H, Yu Y, Kou C, Shen Z, Jiang L, Wang Z, Sun X, Xu Y, He Y, Guo W, Jiang L, Li S, Pan W, Wu Y, Li G, Jia F, Shi J, Shen Z, Zhang N
Lancet Psychiatry 2021 Nov;8(11):981-990. Epub 2021 Sep 21 doi: 10.1016/S2215-0366(21)00251-0. PMID: 34559991

Recent clinical studies

Etiology

Current pharmacotherapeutic approaches for dysthymic disorder and persistent depressive disorder.
Carta MG, Paribello P, Nardi AE, Preti A
Expert Opin Pharmacother 2019 Oct;20(14):1743-1754. Epub 2019 Jul 10 doi: 10.1080/14656566.2019.1637419. PMID: 31290333
The re-labelling of dysthymic disorder to persistent depressive disorder in DSM-5: old wine in new bottles?
Rhebergen D, Graham R
Curr Opin Psychiatry 2014 Jan;27(1):27-31. doi: 10.1097/YCO.0000000000000022. PMID: 24270481
Dysthymia in a cross-cultural perspective.
Gureje O
Curr Opin Psychiatry 2011 Jan;24(1):67-71. doi: 10.1097/YCO.0b013e32834136a5. PMID: 21088583
Linking "big" personality traits to anxiety, depressive, and substance use disorders: a meta-analysis.
Kotov R, Gamez W, Schmidt F, Watson D
Psychol Bull 2010 Sep;136(5):768-821. doi: 10.1037/a0020327. PMID: 20804236
Depression and dysthymia.
Moore JD, Bona JR
Med Clin North Am 2001 May;85(3):631-44. doi: 10.1016/s0025-7125(05)70333-3. PMID: 11349477

Diagnosis

Review of dysthymia and persistent depressive disorder: history, correlates, and clinical implications.
Schramm E, Klein DN, Elsaesser M, Furukawa TA, Domschke K
Lancet Psychiatry 2020 Sep;7(9):801-812. doi: 10.1016/S2215-0366(20)30099-7. PMID: 32828168
Current pharmacotherapeutic approaches for dysthymic disorder and persistent depressive disorder.
Carta MG, Paribello P, Nardi AE, Preti A
Expert Opin Pharmacother 2019 Oct;20(14):1743-1754. Epub 2019 Jul 10 doi: 10.1080/14656566.2019.1637419. PMID: 31290333
Prevalence and correlates of DSM-5 major depressive and related disorders in the community.
Vandeleur CL, Fassassi S, Castelao E, Glaus J, Strippoli MF, Lasserre AM, Rudaz D, Gebreab S, Pistis G, Aubry JM, Angst J, Preisig M
Psychiatry Res 2017 Apr;250:50-58. Epub 2017 Jan 23 doi: 10.1016/j.psychres.2017.01.060. PMID: 28142066
Depression and dysthymia.
Moore JD, Bona JR
Med Clin North Am 2001 May;85(3):631-44. doi: 10.1016/s0025-7125(05)70333-3. PMID: 11349477
Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients.
Beck AT, Steer RA, Ball R, Ranieri W
J Pers Assess 1996 Dec;67(3):588-97. doi: 10.1207/s15327752jpa6703_13. PMID: 8991972

Therapy

Antidepressants for the treatment of depression in people with cancer.
Vita G, Compri B, Matcham F, Barbui C, Ostuzzi G
Cochrane Database Syst Rev 2023 Mar 31;3(3):CD011006. doi: 10.1002/14651858.CD011006.pub4. PMID: 36999619Free PMC Article
Review of dysthymia and persistent depressive disorder: history, correlates, and clinical implications.
Schramm E, Klein DN, Elsaesser M, Furukawa TA, Domschke K
Lancet Psychiatry 2020 Sep;7(9):801-812. doi: 10.1016/S2215-0366(20)30099-7. PMID: 32828168
Current pharmacotherapeutic approaches for dysthymic disorder and persistent depressive disorder.
Carta MG, Paribello P, Nardi AE, Preti A
Expert Opin Pharmacother 2019 Oct;20(14):1743-1754. Epub 2019 Jul 10 doi: 10.1080/14656566.2019.1637419. PMID: 31290333
Prevalence and correlates of DSM-5 major depressive and related disorders in the community.
Vandeleur CL, Fassassi S, Castelao E, Glaus J, Strippoli MF, Lasserre AM, Rudaz D, Gebreab S, Pistis G, Aubry JM, Angst J, Preisig M
Psychiatry Res 2017 Apr;250:50-58. Epub 2017 Jan 23 doi: 10.1016/j.psychres.2017.01.060. PMID: 28142066
Dysthymic disorder in the elderly population.
Devanand DP
Int Psychogeriatr 2014 Jan;26(1):39-48. Epub 2013 Oct 23 doi: 10.1017/S104161021300166X. PMID: 24152873

Prognosis

Review of dysthymia and persistent depressive disorder: history, correlates, and clinical implications.
Schramm E, Klein DN, Elsaesser M, Furukawa TA, Domschke K
Lancet Psychiatry 2020 Sep;7(9):801-812. doi: 10.1016/S2215-0366(20)30099-7. PMID: 32828168
Prevalence and correlates of DSM-5 major depressive and related disorders in the community.
Vandeleur CL, Fassassi S, Castelao E, Glaus J, Strippoli MF, Lasserre AM, Rudaz D, Gebreab S, Pistis G, Aubry JM, Angst J, Preisig M
Psychiatry Res 2017 Apr;250:50-58. Epub 2017 Jan 23 doi: 10.1016/j.psychres.2017.01.060. PMID: 28142066
Long-term effects of child abuse and neglect on emotion processing in adulthood.
Young JC, Widom CS
Child Abuse Negl 2014 Aug;38(8):1369-81. Epub 2014 Apr 18 doi: 10.1016/j.chiabu.2014.03.008. PMID: 24747007Free PMC Article
The re-labelling of dysthymic disorder to persistent depressive disorder in DSM-5: old wine in new bottles?
Rhebergen D, Graham R
Curr Opin Psychiatry 2014 Jan;27(1):27-31. doi: 10.1097/YCO.0000000000000022. PMID: 24270481
Symptomatology in dysthymic and major depressive disorder.
Klein DN, Kocsis JH, McCullough JP, Holzer CE 3rd, Hirschfeld RM, Keller MB
Psychiatr Clin North Am 1996 Mar;19(1):41-53. doi: 10.1016/s0193-953x(05)70272-0. PMID: 8677219

Clinical prediction guides

Epidemiologic and genetic associations of female reproductive disorders with depression or dysthymia: a Mendelian randomization study.
Ling S, Dai Y, Weng R, Li Y, Wu W, Zhou Z, Zhong Z, Zheng Y
Sci Rep 2024 Mar 12;14(1):5984. doi: 10.1038/s41598-024-55993-8. PMID: 38472314Free PMC Article
A Two-Phase Pathogenetic Model of Depression after Stroke.
Werheid K
Gerontology 2015;62(1):33-9. Epub 2015 Jun 20 doi: 10.1159/000381876. PMID: 26113201
The re-labelling of dysthymic disorder to persistent depressive disorder in DSM-5: old wine in new bottles?
Rhebergen D, Graham R
Curr Opin Psychiatry 2014 Jan;27(1):27-31. doi: 10.1097/YCO.0000000000000022. PMID: 24270481
Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients.
Beck AT, Steer RA, Ball R, Ranieri W
J Pers Assess 1996 Dec;67(3):588-97. doi: 10.1207/s15327752jpa6703_13. PMID: 8991972
Chronic depression.
Scott J
Br J Psychiatry 1988 Sep;153:287-97. doi: 10.1192/bjp.153.3.287. PMID: 3074847

Recent systematic reviews

An update on the pharmacotherapeutic strategies for the treatment of dysthymic disorder: a systematic review.
Quagliato LA, Primavera D, Fornaro M, Preti A, Carta MG, Nardi AE
Expert Opin Pharmacother 2023 Sep-Dec;24(18):2035-2040. Epub 2024 Jan 5 doi: 10.1080/14656566.2023.2265809. PMID: 37787056
Antidepressants for the treatment of depression in people with cancer.
Vita G, Compri B, Matcham F, Barbui C, Ostuzzi G
Cochrane Database Syst Rev 2023 Mar 31;3(3):CD011006. doi: 10.1002/14651858.CD011006.pub4. PMID: 36999619Free PMC Article
The prevalence of depression in rheumatoid arthritis: a systematic review and meta-analysis.
Matcham F, Rayner L, Steer S, Hotopf M
Rheumatology (Oxford) 2013 Dec;52(12):2136-48. Epub 2013 Sep 3 doi: 10.1093/rheumatology/ket169. PMID: 24003249Free PMC Article
Acupuncture for depression.
Smith CA, Hay PP, Macpherson H
Cochrane Database Syst Rev 2010 Jan 20;(1):CD004046. doi: 10.1002/14651858.CD004046.pub3. PMID: 20091556
Acupuncture for depression.
Smith CA, Hay PP
Cochrane Database Syst Rev 2005 Apr 18;(2):CD004046. doi: 10.1002/14651858.CD004046.pub2. PMID: 15846693

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