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Adenocarcinoma of Unknown Primary

MedGen UID:
83596
•Concept ID:
C0280096
•
Neoplastic Process

Definition

An adenocarcinoma which has metastasized from an unknown primary anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma of Unknown Primary

Professional guidelines

PubMed

Liver metastases from adenocarcinomas of unknown primary site: management and prognosis in 68 consecutive patients.
Algin E, Ozet A, Gumusay O, Yilmaz G, Buyukberber S, Coskun U, Baykara M, Cetin B, Yıldız R, Benekli M
Wien Klin Wochenschr 2016 Jan;128(1-2):42-7. Epub 2015 Sep 15 doi: 10.1007/s00508-015-0858-8. PMID: 26373751
Empirical chemotherapy for adenocarcinoma of unknown primary tumor site.
Sporn JR, Greenberg BR
Semin Oncol 1993 Jun;20(3):261-7. PMID: 7684858
The management of patients with adenocarcinoma and poorly differentiated carcinoma of unknown primary site.
Greco FA, Hainsworth JD
Semin Oncol 1989 Aug;16(4 Suppl 6):116-22. PMID: 2669133

Recent clinical studies

Etiology

Risk factors and predictors for tumor site origin in metastatic adenocarcinoma of unknown primary site.
Li X, Shao Y, Sheng L, Zhu J, Wang Z, Guo K, Sun L
Cancer Med 2021 Feb;10(3):974-988. Epub 2021 Jan 6 doi: 10.1002/cam4.3684. PMID: 33405390Free PMC Article
Mass-forming cholangiocarcinoma and adenocarcinoma of unknown primary: can they be distinguished on liver MRI?
Al Ansari N, Kim BS, Srirattanapong S, Semelka CT, Ramalho M, Altun E, Woosley JT, Calvo B, Semelka RC
Abdom Imaging 2014 Dec;39(6):1228-40. doi: 10.1007/s00261-014-0172-3. PMID: 24929668
Serum tumor markers.
Perkins GL, Slater ED, Sanders GK, Prichard JG
Am Fam Physician 2003 Sep 15;68(6):1075-82. PMID: 14524394
Adenocarcinoma of unknown primary site.
Song SY, Kim WS, Lee HR, Jung HS, Oh SY, Kim JH, Kim K, Nam EM, Oh YR, Jung CW, Yoon SS, Im YH, Lee HG, Kang WK, Park CH, Park K
Korean J Intern Med 2002 Dec;17(4):234-9. doi: 10.3904/kjim.2002.17.4.234. PMID: 12647637Free PMC Article
Poorly differentiated carcinoma and poorly differentiated adenocarcinoma of unknown primary tumor site.
Hainsworth JD, Greco FA
Semin Oncol 1993 Jun;20(3):279-86. PMID: 8503024

Diagnosis

Serum tumor markers.
Perkins GL, Slater ED, Sanders GK, Prichard JG
Am Fam Physician 2003 Sep 15;68(6):1075-82. PMID: 14524394
Adenocarcinoma of unknown primary site.
Song SY, Kim WS, Lee HR, Jung HS, Oh SY, Kim JH, Kim K, Nam EM, Oh YR, Jung CW, Yoon SS, Im YH, Lee HG, Kang WK, Park CH, Park K
Korean J Intern Med 2002 Dec;17(4):234-9. doi: 10.3904/kjim.2002.17.4.234. PMID: 12647637Free PMC Article
Metastatic adenocarcinoma of unknown primary origin.
Hammar SP
Hum Pathol 1998 Dec;29(12):1393-402. doi: 10.1016/s0046-8177(98)90007-7. PMID: 9865824
Poorly differentiated carcinoma or adenocarcinoma of unknown primary site: long-term results with cisplatin-based chemotherapy.
Greco FA, Hainsworth JD
Semin Oncol 1994 Oct;21(5 Suppl 12):77-82. PMID: 7992071
Poorly differentiated carcinoma and poorly differentiated adenocarcinoma of unknown primary tumor site.
Hainsworth JD, Greco FA
Semin Oncol 1993 Jun;20(3):279-86. PMID: 8503024

Therapy

Immunochemotherapy achieved a complete response for metastatic adenocarcinoma of unknown primary based on gene expression profiling: a case report and review of the literature.
Sheng J, Pan H, Han W
Front Immunol 2023;14:1181444. Epub 2023 Apr 19 doi: 10.3389/fimmu.2023.1181444. PMID: 37153561Free PMC Article
Liver metastases from adenocarcinomas of unknown primary site: management and prognosis in 68 consecutive patients.
Algin E, Ozet A, Gumusay O, Yilmaz G, Buyukberber S, Coskun U, Baykara M, Cetin B, Yıldız R, Benekli M
Wien Klin Wochenschr 2016 Jan;128(1-2):42-7. Epub 2015 Sep 15 doi: 10.1007/s00508-015-0858-8. PMID: 26373751
Therapy of adenocarcinoma of unknown primary: are we making progress?
Greco FA
J Natl Compr Canc Netw 2008 Nov;6(10):1061-7. doi: 10.6004/jnccn.2008.0079. PMID: 19176201
Adenocarcinoma of unknown primary site.
Song SY, Kim WS, Lee HR, Jung HS, Oh SY, Kim JH, Kim K, Nam EM, Oh YR, Jung CW, Yoon SS, Im YH, Lee HG, Kang WK, Park CH, Park K
Korean J Intern Med 2002 Dec;17(4):234-9. doi: 10.3904/kjim.2002.17.4.234. PMID: 12647637Free PMC Article
Poorly differentiated carcinoma or adenocarcinoma of unknown primary site: long-term results with cisplatin-based chemotherapy.
Greco FA, Hainsworth JD
Semin Oncol 1994 Oct;21(5 Suppl 12):77-82. PMID: 7992071

Prognosis

Immunochemotherapy achieved a complete response for metastatic adenocarcinoma of unknown primary based on gene expression profiling: a case report and review of the literature.
Sheng J, Pan H, Han W
Front Immunol 2023;14:1181444. Epub 2023 Apr 19 doi: 10.3389/fimmu.2023.1181444. PMID: 37153561Free PMC Article
Risk factors and predictors for tumor site origin in metastatic adenocarcinoma of unknown primary site.
Li X, Shao Y, Sheng L, Zhu J, Wang Z, Guo K, Sun L
Cancer Med 2021 Feb;10(3):974-988. Epub 2021 Jan 6 doi: 10.1002/cam4.3684. PMID: 33405390Free PMC Article
Therapy of adenocarcinoma of unknown primary: are we making progress?
Greco FA
J Natl Compr Canc Netw 2008 Nov;6(10):1061-7. doi: 10.6004/jnccn.2008.0079. PMID: 19176201
Adenocarcinoma of unknown primary site.
Song SY, Kim WS, Lee HR, Jung HS, Oh SY, Kim JH, Kim K, Nam EM, Oh YR, Jung CW, Yoon SS, Im YH, Lee HG, Kang WK, Park CH, Park K
Korean J Intern Med 2002 Dec;17(4):234-9. doi: 10.3904/kjim.2002.17.4.234. PMID: 12647637Free PMC Article
Poorly differentiated carcinoma and poorly differentiated adenocarcinoma of unknown primary tumor site.
Hainsworth JD, Greco FA
Semin Oncol 1993 Jun;20(3):279-86. PMID: 8503024

Clinical prediction guides

Immunochemotherapy achieved a complete response for metastatic adenocarcinoma of unknown primary based on gene expression profiling: a case report and review of the literature.
Sheng J, Pan H, Han W
Front Immunol 2023;14:1181444. Epub 2023 Apr 19 doi: 10.3389/fimmu.2023.1181444. PMID: 37153561Free PMC Article
Risk factors and predictors for tumor site origin in metastatic adenocarcinoma of unknown primary site.
Li X, Shao Y, Sheng L, Zhu J, Wang Z, Guo K, Sun L
Cancer Med 2021 Feb;10(3):974-988. Epub 2021 Jan 6 doi: 10.1002/cam4.3684. PMID: 33405390Free PMC Article
Mass-forming cholangiocarcinoma and adenocarcinoma of unknown primary: can they be distinguished on liver MRI?
Al Ansari N, Kim BS, Srirattanapong S, Semelka CT, Ramalho M, Altun E, Woosley JT, Calvo B, Semelka RC
Abdom Imaging 2014 Dec;39(6):1228-40. doi: 10.1007/s00261-014-0172-3. PMID: 24929668
Adenocarcinoma of unknown primary site.
Song SY, Kim WS, Lee HR, Jung HS, Oh SY, Kim JH, Kim K, Nam EM, Oh YR, Jung CW, Yoon SS, Im YH, Lee HG, Kang WK, Park CH, Park K
Korean J Intern Med 2002 Dec;17(4):234-9. doi: 10.3904/kjim.2002.17.4.234. PMID: 12647637Free PMC Article
Poorly differentiated carcinoma and poorly differentiated adenocarcinoma of unknown primary tumor site.
Hainsworth JD, Greco FA
Semin Oncol 1993 Jun;20(3):279-86. PMID: 8503024

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