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Mixed cell type adenoma of parathyroid

MedGen UID:
83547
•Concept ID:
C0279701
•
Neoplastic Process
Synonyms: Mixed Cell Type Adenoma of Parathyroid; mixed cell type adenoma of parathyroid; Mixed Cell Type Adenoma of Parathyroid Gland; mixed cell type adenoma of parathyroid gland; Mixed Cell Type Adenoma of the Parathyroid; mixed cell type adenoma of the parathyroid; Mixed Cell Type Adenoma of the Parathyroid Gland; mixed cell type adenoma of the parathyroid gland; Parathyroid Gland Mixed Cell Type Adenoma; parathyroid gland mixed cell type adenoma; Parathyroid Mixed Cell Type Adenoma; parathyroid mixed cell type adenoma
 
Monarch Initiative: MONDO:0004304

Definition

A parathyroid gland adenoma that contains a mixture of neoplastic cells (chief cells, oncocytes, and clear cells). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMixed cell type adenoma of parathyroid

Recent clinical studies

Etiology

Are (99m)TC-Sestamibi Single Photon Emission Computed Tomography Scan Results Associated to the Parathyroid Cell Type in Primary Hyperparathyroidism?
Romero-Velez G, Noureldine SI, Rahman M, Bena JF, Burneikis T, Jin J
J Surg Res 2024 Jan;293:517-524. Epub 2023 Oct 11 doi: 10.1016/j.jss.2023.08.043. PMID: 37827030
Phenotypic Profiling and Molecular Mechanisms in Hyperparathyroidism-jaw Tumor Syndrome.
Tora R, Welch J, Sun J, Agarwal SK, Bell DA, Merino M, Weinstein LS, Simonds WF, Jha S
J Clin Endocrinol Metab 2023 Nov 17;108(12):3165-3177. doi: 10.1210/clinem/dgad368. PMID: 37339334Free PMC Article
Technetium Tc 99m sestamibi sensitivity in oxyphil cell-dominant parathyroid adenomas.
Bleier BS, LiVolsi VA, Chalian AA, Gimotty PA, Botbyl JD, Weber RS
Arch Otolaryngol Head Neck Surg 2006 Jul;132(7):779-82. doi: 10.1001/archotol.132.7.779. PMID: 16847189
Primary parathyroid tumors of the mediastinum: a clinicopathologic and immunohistochemical study of 17 cases.
Moran CA, Suster S
Am J Clin Pathol 2005 Nov;124(5):749-54. doi: 10.1309/WJEL-N05L-9A06-9DU0. PMID: 16203274
Ultrasound-guided fine-needle aspiration biopsy of the thyroid.
Tambouret R, Szyfelbein WM, Pitman MB
Cancer 1999 Oct 25;87(5):299-305. doi: 10.1002/(sici)1097-0142(19991025)87:5<299::aid-cncr10>3.0.co;2-m. PMID: 10536356

Diagnosis

Oncocytic Change in Thyroid Pathology.
Asa SL, Mete O
Front Endocrinol (Lausanne) 2021;12:678119. Epub 2021 May 3 doi: 10.3389/fendo.2021.678119. PMID: 34012422Free PMC Article
Technetium Tc 99m sestamibi sensitivity in oxyphil cell-dominant parathyroid adenomas.
Bleier BS, LiVolsi VA, Chalian AA, Gimotty PA, Botbyl JD, Weber RS
Arch Otolaryngol Head Neck Surg 2006 Jul;132(7):779-82. doi: 10.1001/archotol.132.7.779. PMID: 16847189
Primary parathyroid tumors of the mediastinum: a clinicopathologic and immunohistochemical study of 17 cases.
Moran CA, Suster S
Am J Clin Pathol 2005 Nov;124(5):749-54. doi: 10.1309/WJEL-N05L-9A06-9DU0. PMID: 16203274
Ultrasound-guided fine-needle aspiration biopsy of the thyroid.
Tambouret R, Szyfelbein WM, Pitman MB
Cancer 1999 Oct 25;87(5):299-305. doi: 10.1002/(sici)1097-0142(19991025)87:5<299::aid-cncr10>3.0.co;2-m. PMID: 10536356
Ultrastructure of human parathyroid cells in health and disease.
Cinti S, Sbarbati A
Microsc Res Tech 1995 Oct 1;32(2):164-79. doi: 10.1002/jemt.1070320210. PMID: 8580510

Therapy

Phenotypic Profiling and Molecular Mechanisms in Hyperparathyroidism-jaw Tumor Syndrome.
Tora R, Welch J, Sun J, Agarwal SK, Bell DA, Merino M, Weinstein LS, Simonds WF, Jha S
J Clin Endocrinol Metab 2023 Nov 17;108(12):3165-3177. doi: 10.1210/clinem/dgad368. PMID: 37339334Free PMC Article
Ultrasound-guided fine-needle aspiration biopsy of the thyroid.
Tambouret R, Szyfelbein WM, Pitman MB
Cancer 1999 Oct 25;87(5):299-305. doi: 10.1002/(sici)1097-0142(19991025)87:5<299::aid-cncr10>3.0.co;2-m. PMID: 10536356

Prognosis

Oncocytic Change in Thyroid Pathology.
Asa SL, Mete O
Front Endocrinol (Lausanne) 2021;12:678119. Epub 2021 May 3 doi: 10.3389/fendo.2021.678119. PMID: 34012422Free PMC Article
Technetium Tc 99m sestamibi sensitivity in oxyphil cell-dominant parathyroid adenomas.
Bleier BS, LiVolsi VA, Chalian AA, Gimotty PA, Botbyl JD, Weber RS
Arch Otolaryngol Head Neck Surg 2006 Jul;132(7):779-82. doi: 10.1001/archotol.132.7.779. PMID: 16847189
Primary parathyroid tumors of the mediastinum: a clinicopathologic and immunohistochemical study of 17 cases.
Moran CA, Suster S
Am J Clin Pathol 2005 Nov;124(5):749-54. doi: 10.1309/WJEL-N05L-9A06-9DU0. PMID: 16203274

Clinical prediction guides

Are (99m)TC-Sestamibi Single Photon Emission Computed Tomography Scan Results Associated to the Parathyroid Cell Type in Primary Hyperparathyroidism?
Romero-Velez G, Noureldine SI, Rahman M, Bena JF, Burneikis T, Jin J
J Surg Res 2024 Jan;293:517-524. Epub 2023 Oct 11 doi: 10.1016/j.jss.2023.08.043. PMID: 37827030
Oncocytic Change in Thyroid Pathology.
Asa SL, Mete O
Front Endocrinol (Lausanne) 2021;12:678119. Epub 2021 May 3 doi: 10.3389/fendo.2021.678119. PMID: 34012422Free PMC Article
Technetium Tc 99m sestamibi sensitivity in oxyphil cell-dominant parathyroid adenomas.
Bleier BS, LiVolsi VA, Chalian AA, Gimotty PA, Botbyl JD, Weber RS
Arch Otolaryngol Head Neck Surg 2006 Jul;132(7):779-82. doi: 10.1001/archotol.132.7.779. PMID: 16847189
A genotypic and histopathological study of a large Dutch kindred with hyperparathyroidism-jaw tumor syndrome.
Haven CJ, Wong FK, van Dam EW, van der Juijt R, van Asperen C, Jansen J, Rosenberg C, de Wit M, Roijers J, Hoppener J, Lips CJ, Larsson C, Teh BT, Morreau H
J Clin Endocrinol Metab 2000 Apr;85(4):1449-54. doi: 10.1210/jcem.85.4.6518. PMID: 10770180
Multiple endocrine adenomatosis of mixed type.
Hansen OP, Hansen M, Hansen HH, Rose B
Acta Med Scand 1976;200(4):327-31. doi: 10.1111/j.0954-6820.1976.tb08240.x. PMID: 10717

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