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Skin Fibrohistiocytic Neoplasm

MedGen UID:
83400
•Concept ID:
C0346049
•
Neoplastic Process
Synonyms: Cutaneous Fibrohistiocytic Neoplasm; Fibrohistiocytic tumor; Fibrohistiocytic tumor of skin
SNOMED CT: Fibrohistiocytic tumor of skin (254749001); Fibrohistiocytic tumor (254749001)

Definition

A skin neoplasm composed of fibrohistiocytic cells, spindle fibrous cells, and histiocytes in a storiform pattern. [from NCI]

Professional guidelines

PubMed

Top 10 Differential Diagnoses for Desmoplastic Melanoma.
Fernandez-Flores A, Singh R, Cassarino DS
Head Neck Pathol 2023 Mar;17(1):143-153. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01536-y. PMID: 36928737Free PMC Article
Treatment Options for Multinucleate Cell Angiohistiocytoma: A Case Series and Review of the Literature.
Taibo A, Padin CP, Losada JDP, Fonseca E
J Cutan Med Surg 2023 May-Jun;27(3):219-225. Epub 2023 Mar 16 doi: 10.1177/12034754231163539. PMID: 36927096
Dermatofibrosarcoma protuberans in children: an update on the diagnosis and treatment.
Kornik RI, Muchard LK, Teng JM
Pediatr Dermatol 2012 Nov-Dec;29(6):707-13. Epub 2012 Jul 11 doi: 10.1111/j.1525-1470.2012.01767.x. PMID: 22780227

Recent clinical studies

Etiology

Cutaneous soft tissue tumors: how do we make sense of fibrous and "fibrohistiocytic" tumors with confusing names and similar appearances?
Hornick JL
Mod Pathol 2020 Jan;33(Suppl 1):56-65. Epub 2019 Oct 25 doi: 10.1038/s41379-019-0388-4. PMID: 31653978
Fibrohistiocytic Tumors.
Romano RC, Fritchie KJ
Clin Lab Med 2017 Sep;37(3):603-631. Epub 2017 Jun 15 doi: 10.1016/j.cll.2017.05.007. PMID: 28802503
Collapsing angiokeloidal dermatofibroma.
Schnebelen AM, Brown JA, Cheung WL, Hiatt KM, Smoller BR
Am J Dermatopathol 2012 Oct;34(7):e103-5. doi: 10.1097/DAD.0b013e31825625d5. PMID: 22576077
Cutaneous fibrohistiocytic tumours - an update.
Luzar B, Calonje E
Histopathology 2010 Jan;56(1):148-65. doi: 10.1111/j.1365-2559.2009.03447.x. PMID: 20055912
Malignant fibrous tumors.
Stadler FJ, Scott GA, Brown MD
Semin Cutan Med Surg 1998 Jun;17(2):141-52. doi: 10.1016/s1085-5629(98)80007-2. PMID: 9669607

Diagnosis

Cutaneous soft tissue tumors: how do we make sense of fibrous and "fibrohistiocytic" tumors with confusing names and similar appearances?
Hornick JL
Mod Pathol 2020 Jan;33(Suppl 1):56-65. Epub 2019 Oct 25 doi: 10.1038/s41379-019-0388-4. PMID: 31653978
Fibrohistiocytic Tumors.
Romano RC, Fritchie KJ
Clin Lab Med 2017 Sep;37(3):603-631. Epub 2017 Jun 15 doi: 10.1016/j.cll.2017.05.007. PMID: 28802503
Atrophic dermatofibroma.
Mota AN, Tortelly VD, Obadia DL, Silva RS
An Bras Dermatol 2013 Sep-Oct;88(5):793-5. doi: 10.1590/abd1806-4841.20132234. PMID: 24173186Free PMC Article
Fibrous and fibrohistiocytic neoplasms: an update.
Clarke LE
Dermatol Clin 2012 Oct;30(4):643-56, vi. Epub 2012 Aug 11 doi: 10.1016/j.det.2012.06.005. PMID: 23021051
Atrophic dermatofibroma.
Ohnishi T, Sasaki M, Nakai K, Watanabe S
J Eur Acad Dermatol Venereol 2004 Sep;18(5):580-3. doi: 10.1111/j.1468-3083.2004.00975.x. PMID: 15324399

Therapy

Successful treatment of metastatic fibrosarcomatous dermatofibrosarcoma protuberans with imatinib mesylate.
Kambayashi Y, Kasahara Y, Ohuchi K, Amagai R, Hashimoto A, Asano Y, Fujimura T
Dermatol Ther 2022 Oct;35(10):e15736. Epub 2022 Aug 8 doi: 10.1111/dth.15736. PMID: 35898161
SOX10 commonly stains scar in Mohs sections.
Donaldson MR, Weber LA
Dermatol Online J 2020 Jan 15;26(1) PMID: 32155034
Fibrous and fibrohistiocytic neoplasms: an update.
Clarke LE
Dermatol Clin 2012 Oct;30(4):643-56, vi. Epub 2012 Aug 11 doi: 10.1016/j.det.2012.06.005. PMID: 23021051
Multiple eruptive dermatofibromas and immunosuppression: report of two cases and review of the literature.
Zaccaria E, Rebora A, Rongioletti F
Int J Dermatol 2008 Jul;47(7):723-7. doi: 10.1111/j.1365-4632.2008.03575.x. PMID: 18613883
Chemosensitivity in pediatric dermatofibrosarcoma protuberans.
Ng A, Nishikawa H, Lander A, Grundy R
J Pediatr Hematol Oncol 2005 Feb;27(2):100-2. doi: 10.1097/01.mph.0000152861.05622.99. PMID: 15701986

Prognosis

Top 10 Differential Diagnoses for Desmoplastic Melanoma.
Fernandez-Flores A, Singh R, Cassarino DS
Head Neck Pathol 2023 Mar;17(1):143-153. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01536-y. PMID: 36928737Free PMC Article
Cutaneous soft tissue tumors: how do we make sense of fibrous and "fibrohistiocytic" tumors with confusing names and similar appearances?
Hornick JL
Mod Pathol 2020 Jan;33(Suppl 1):56-65. Epub 2019 Oct 25 doi: 10.1038/s41379-019-0388-4. PMID: 31653978
Fibrous and fibrohistiocytic neoplasms: an update.
Clarke LE
Dermatol Clin 2012 Oct;30(4):643-56, vi. Epub 2012 Aug 11 doi: 10.1016/j.det.2012.06.005. PMID: 23021051
Plexiform fibrohistiocytic tumor.
Thirumala S, Rhyne CD, Bodhireddy S
Indian J Pathol Microbiol 2008 Apr-Jun;51(2):245-6. doi: 10.4103/0377-4929.41670. PMID: 18603695
Malignant fibrous tumors.
Stadler FJ, Scott GA, Brown MD
Semin Cutan Med Surg 1998 Jun;17(2):141-52. doi: 10.1016/s1085-5629(98)80007-2. PMID: 9669607

Clinical prediction guides

Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review.
Seifi G, Kalantari Y, Etesami I
J Dtsch Dermatol Ges 2022 Dec;20(12):1569-1579. Epub 2022 Dec 4 doi: 10.1111/ddg.14888. PMID: 36464809
Surgical excision margins for fibrohistiocytic tumors, including atypical fibroxanthoma and undifferentiated pleomorphic sarcoma: A probability model based on a systematic review.
Jibbe A, Worley B, Miller CH, Alam M
J Am Acad Dermatol 2022 Oct;87(4):833-840. Epub 2021 Sep 26 doi: 10.1016/j.jaad.2021.09.036. PMID: 34587553
Cutaneous soft tissue tumors: how do we make sense of fibrous and "fibrohistiocytic" tumors with confusing names and similar appearances?
Hornick JL
Mod Pathol 2020 Jan;33(Suppl 1):56-65. Epub 2019 Oct 25 doi: 10.1038/s41379-019-0388-4. PMID: 31653978
The Role of CD34 and D2-40 in the Differentiation of Dermatofibroma and Dermatofibrosarcoma Protuberans.
Sadullahoğlu C, Dere Y, Atasever TR, Öztop MT, Karaaslan Ö
Turk Patoloji Derg 2017;1(1):223-227. doi: 10.5146/tjpath.2017.01402. PMID: 28832078
Atrophic dermatofibroma.
Ohnishi T, Sasaki M, Nakai K, Watanabe S
J Eur Acad Dermatol Venereol 2004 Sep;18(5):580-3. doi: 10.1111/j.1468-3083.2004.00975.x. PMID: 15324399

Recent systematic reviews

Multiple dermatofibromas, associated clinical and histological characteristics: A systematic review.
Seifi G, Kalantari Y, Etesami I
J Dtsch Dermatol Ges 2022 Dec;20(12):1569-1579. Epub 2022 Dec 4 doi: 10.1111/ddg.14888. PMID: 36464809
Surgical excision margins for fibrohistiocytic tumors, including atypical fibroxanthoma and undifferentiated pleomorphic sarcoma: A probability model based on a systematic review.
Jibbe A, Worley B, Miller CH, Alam M
J Am Acad Dermatol 2022 Oct;87(4):833-840. Epub 2021 Sep 26 doi: 10.1016/j.jaad.2021.09.036. PMID: 34587553
Time to recurrence after surgical excision of atypical fibroxanthoma-updated systematic review and meta-analysis.
Phan K, Onggo J
Australas J Dermatol 2019 Aug;60(3):e220-e222. Epub 2019 Feb 21 doi: 10.1111/ajd.13010. PMID: 30793288
Atypical fibroxanthoma: Systematic review and meta-analysis of treatment with Mohs micrographic surgery or excision.
Tolkachjov SN, Kelley BF, Alahdab F, Erwin PJ, Brewer JD
J Am Acad Dermatol 2018 Nov;79(5):929-934.e6. Epub 2018 Jul 5 doi: 10.1016/j.jaad.2018.06.048. PMID: 29981390
Generalized multinucleate cell angiohistiocytoma: case report and literature review.
Wang M, Abdul-Fattah B, Wang C, Zhao Y, Qu X, Al-Muriesh M, Wang X, Zhu L, Qian Y, Huang C, Chen S
J Cutan Pathol 2017 Feb;44(2):125-134. Epub 2016 Nov 28 doi: 10.1111/cup.12853. PMID: 27813137

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