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Sebaceous basal cell carcinoma

MedGen UID:
83180
•Concept ID:
C0334683
•
Neoplastic Process
Synonyms: Basal Cell Carcinoma with Sebaceous Differentiation; Basal cell carcinoma with sebaceous differentiation; Basal Cell Epithelioma with Sebaceous Differentiation; Basosebaceous Epithelioma; sebaceous basal cell carcinoma; Sebaceous Epithelioma; Skin Basal Cell Carcinoma with Sebaceous Differentiation; skin basosebaceous basal cell carcinoma
SNOMED CT: Basal cell carcinoma with sebaceous differentiation (400087001); Basal cell carcinoma with sebaceous differentiation (402533009)
 
Monarch Initiative: MONDO:0002942

Definition

A basal cell carcinoma of the skin that is characterized by sebaceous differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSebaceous basal cell carcinoma

Professional guidelines

PubMed

S2k guideline: Laser therapy of the skin.
Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675
Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
Eyelid and ocular surface carcinoma: diagnosis and management.
Yin VT, Merritt HA, Sniegowski M, Esmaeli B
Clin Dermatol 2015 Mar-Apr;33(2):159-69. doi: 10.1016/j.clindermatol.2014.10.008. PMID: 25704936

Recent clinical studies

Etiology

Genetics of adnexal tumors: An update.
Kervarrec T, Sohier P, Pissaloux D, de la Fouchardiere A, Cribier B, Battistella M, Macagno N
Ann Dermatol Venereol 2023 Sep;150(3):202-207. Epub 2023 Jun 1 doi: 10.1016/j.annder.2023.03.003. PMID: 37270318
Cutaneous sebaceous carcinoma.
Wu A, Rajak SN, Huilgol SC, James C, Selva D
Australas J Dermatol 2020 Aug;61(3):e283-e292. Epub 2020 Jan 19 doi: 10.1111/ajd.13234. PMID: 31956994
Pathology of eyelid tumors.
Pe'er J
Indian J Ophthalmol 2016 Mar;64(3):177-90. doi: 10.4103/0301-4738.181752. PMID: 27146927Free PMC Article
Basal cell carcinoma: pathophysiology.
Sehgal VN, Chatterjee K, Pandhi D, Khurana A
Skinmed 2014 May-Jun;12(3):176-81. PMID: 25134314
Nonmelanoma skin cancer.
Dubas LE, Ingraffea A
Facial Plast Surg Clin North Am 2013 Feb;21(1):43-53. doi: 10.1016/j.fsc.2012.10.003. PMID: 23369588

Diagnosis

Adnexal and Sebaceous Carcinomas.
Seger EW, Neill BC, Tolkachjov SN
Dermatol Clin 2023 Jan;41(1):117-132. Epub 2022 Oct 28 doi: 10.1016/j.det.2022.07.010. PMID: 36410972
Malignant lesions of the caruncle.
Gounder P, Selva D, Rajak SN
Eye (Lond) 2023 Apr;37(5):849-857. Epub 2022 Jun 21 doi: 10.1038/s41433-022-02124-0. PMID: 35729271Free PMC Article
Cutaneous sebaceous carcinoma.
Wu A, Rajak SN, Huilgol SC, James C, Selva D
Australas J Dermatol 2020 Aug;61(3):e283-e292. Epub 2020 Jan 19 doi: 10.1111/ajd.13234. PMID: 31956994
Histologic Mimics of Basal Cell Carcinoma.
Stanoszek LM, Wang GY, Harms PW
Arch Pathol Lab Med 2017 Nov;141(11):1490-1502. doi: 10.5858/arpa.2017-0222-RA. PMID: 29072946
Perioral dermatitis.
Lipozenčić J, Hadžavdić SL
Clin Dermatol 2014 Jan-Feb;32(1):125-30. doi: 10.1016/j.clindermatol.2013.05.034. PMID: 24314386

Therapy

Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
Advances in Immunotherapy and Periocular Malignancy.
Habib LA, Wolkow N, Freitag SK, Yoon MK
Semin Ophthalmol 2019;34(4):327-333. Epub 2019 Jun 9 doi: 10.1080/08820538.2019.1620813. PMID: 31177931
Sebaceous Carcinoma: A Review of the Scientific Literature.
Knackstedt T, Samie FH
Curr Treat Options Oncol 2017 Aug;18(8):47. doi: 10.1007/s11864-017-0490-0. PMID: 28681210
Perioral dermatitis.
Lipozenčić J, Hadžavdić SL
Clin Dermatol 2014 Jan-Feb;32(1):125-30. doi: 10.1016/j.clindermatol.2013.05.034. PMID: 24314386
Perioral dermatitis.
Lipozencic J, Ljubojevic S
Clin Dermatol 2011 Mar-Apr;29(2):157-61. doi: 10.1016/j.clindermatol.2010.09.007. PMID: 21396555

Prognosis

Adnexal and Sebaceous Carcinomas.
Seger EW, Neill BC, Tolkachjov SN
Dermatol Clin 2023 Jan;41(1):117-132. Epub 2022 Oct 28 doi: 10.1016/j.det.2022.07.010. PMID: 36410972
The Role of Podoplanin in Skin Diseases.
Asai J
Int J Mol Sci 2022 Jan 24;23(3) doi: 10.3390/ijms23031310. PMID: 35163233Free PMC Article
Periocular skin cancer: Diagnosis and management.
Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650
What's New in Eyelid Tumors.
Silverman N, Shinder R
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):143-152. doi: 10.22608/APO.201701. PMID: 28399340
Eyelid and ocular surface carcinoma: diagnosis and management.
Yin VT, Merritt HA, Sniegowski M, Esmaeli B
Clin Dermatol 2015 Mar-Apr;33(2):159-69. doi: 10.1016/j.clindermatol.2014.10.008. PMID: 25704936

Clinical prediction guides

Carcinoid-Like Cell Arrangements in Basal Cell Carcinoma: A Study of 11 Cases.
Goto K, Oishi T, Yoshikawa S
Int J Surg Pathol 2023 Dec;31(8):1466-1472. Epub 2023 Feb 27 doi: 10.1177/10668969231157781. PMID: 36843540
The Role of Podoplanin in Skin Diseases.
Asai J
Int J Mol Sci 2022 Jan 24;23(3) doi: 10.3390/ijms23031310. PMID: 35163233Free PMC Article
Molecular pathology of skin adnexal tumours.
Plotzke JM, Adams DJ, Harms PW
Histopathology 2022 Jan;80(1):166-183. doi: 10.1111/his.14441. PMID: 34197659
Human Papillomavirus Related Neoplasia of the Ocular Adnexa.
Ramberg I, Heegaard S
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081522. PMID: 34452388Free PMC Article
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149

Recent systematic reviews

Rate of Benign and Malignant Secondary Tumors Associated With Nevus Sebaceous: A Systematic Review and Meta-Analysis.
Pang S, Cevik J, Sreedharan S, Wilks DJ
Ann Plast Surg 2024 Jun 1;92(6):711-719. Epub 2024 May 9 doi: 10.1097/SAP.0000000000003879. PMID: 38725109
Characterization of sebaceous and non-sebaceous cutaneous manifestations in patients with lynch syndrome: a systematic review.
Aziz S, O'Sullivan H, Heelan K, Alam A, McVeigh TP
Fam Cancer 2023 Apr;22(2):167-175. Epub 2022 Nov 23 doi: 10.1007/s10689-022-00319-8. PMID: 36418753Free PMC Article
Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article
Programmed cell death 1 protein and programmed death-ligand 1 inhibitors in the treatment of nonmelanoma skin cancer: A systematic review.
Choi FD, Kraus CN, Elsensohn AN, Carley SK, Lehmer LM, Nguyen RT, Linden KG, Shiu J
J Am Acad Dermatol 2020 Feb;82(2):440-459. Epub 2019 Jun 1 doi: 10.1016/j.jaad.2019.05.077. PMID: 31163235
Application of intense pulsed light in the treatment of dermatologic disease: a systematic review.
Wat H, Wu DC, Rao J, Goldman MP
Dermatol Surg 2014 Apr;40(4):359-77. Epub 2014 Feb 4 doi: 10.1111/dsu.12424. PMID: 24495252

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