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Pediatric infratentorial ependymoma

MedGen UID:
82949
•Concept ID:
C0278599
•
Neoplastic Process
Synonyms: Childhood Infratentorial Ependymoma; childhood infratentorial ependymoma; infratentorial ependymoma; Pediatric Infratentorial Ependymoma; pediatric infratentorial ependymoma
 
Monarch Initiative: MONDO:0004248

Definition

An ependymoma that arises from the infratentorial region of the brain and occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPediatric infratentorial ependymoma

Professional guidelines

PubMed

Clinical Features, Treatment and Outcome of Childhood Glial Tumors.
Kara B, Ertan K, Karabagli P, Karabagli H, Yavas G, Caglayan AO, Koksal Y
Turk Neurosurg 2022;32(1):135-142. doi: 10.5137/1019-5149.JTN.34801-21.2. PMID: 34751424
Clinical profile, treatment and outcome of pediatric brain tumors in Serbia in a 10-year period: A national referral institution experience.
Stanić D, Grujičić D, Pekmezović T, Bokun J, Popović-Vuković M, Janić D, Paripović L, Ilić V, Pudrlja Slović M, Ilić R, Raičević S, Sarić M, Mišković I, Nidžović B, Nikitović M
PLoS One 2021;16(10):e0259095. Epub 2021 Oct 26 doi: 10.1371/journal.pone.0259095. PMID: 34699548Free PMC Article
Management of posterior fossa tumors and hydrocephalus in children: a review.
Lin CT, Riva-Cambrin JK
Childs Nerv Syst 2015 Oct;31(10):1781-9. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2781-8. PMID: 26351230

Recent clinical studies

Etiology

Mapping pediatric brain tumors to their origins in the developing cerebellum.
Okonechnikov K, Joshi P, Sepp M, Leiss K, Sarropoulos I, Murat F, Sill M, Beck P, Chan KC, Korshunov A, Sah F, Deng MY, Sturm D, DeSisto J, Donson AM, Foreman NK, Green AL, Robinson G, Orr BA, Gao Q, Darrow E, Hadley JL, Northcott PA, Gojo J, Kawauchi D, Hovestadt V, Filbin MG, von Deimling A, Zuckermann M, Pajtler KW, Kool M, Jones DTW, Jäger N, Kutscher LM, Kaessmann H, Pfister SM
Neuro Oncol 2023 Oct 3;25(10):1895-1909. doi: 10.1093/neuonc/noad124. PMID: 37534924Free PMC Article
Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Medulloblastoma: Clinical presentation.
Vinchon M, Leblond P
Neurochirurgie 2021 Feb;67(1):23-27. Epub 2019 Sep 5 doi: 10.1016/j.neuchi.2019.04.006. PMID: 31494131
Conformal Radiation Therapy for Pediatric Ependymoma, Chemotherapy for Incompletely Resected Ependymoma, and Observation for Completely Resected, Supratentorial Ependymoma.
Merchant TE, Bendel AE, Sabin ND, Burger PC, Shaw DW, Chang E, Wu S, Zhou T, Eisenstat DD, Foreman NK, Fuller CE, Anderson ET, Hukin J, Lau CC, Pollack IF, Laningham FH, Lustig RH, Armstrong FD, Handler MH, Williams-Hughes C, Kessel S, Kocak M, Ellison DW, Ramaswamy V
J Clin Oncol 2019 Apr 20;37(12):974-983. Epub 2019 Feb 27 doi: 10.1200/JCO.18.01765. PMID: 30811284Free PMC Article
Cerebellar mutism.
Tamburrini G, Frassanito P, Chieffo D, Massimi L, Caldarelli M, Di Rocco C
Childs Nerv Syst 2015 Oct;31(10):1841-51. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2803-6. PMID: 26351234

Diagnosis

Posterior fossa tumors in children: current insights.
Formentin C, Joaquim AF, Ghizoni E
Eur J Pediatr 2023 Nov;182(11):4833-4850. Epub 2023 Sep 8 doi: 10.1007/s00431-023-05189-5. PMID: 37679511
Medulloblastoma: Clinical presentation.
Vinchon M, Leblond P
Neurochirurgie 2021 Feb;67(1):23-27. Epub 2019 Sep 5 doi: 10.1016/j.neuchi.2019.04.006. PMID: 31494131
Conformal Radiation Therapy for Pediatric Ependymoma, Chemotherapy for Incompletely Resected Ependymoma, and Observation for Completely Resected, Supratentorial Ependymoma.
Merchant TE, Bendel AE, Sabin ND, Burger PC, Shaw DW, Chang E, Wu S, Zhou T, Eisenstat DD, Foreman NK, Fuller CE, Anderson ET, Hukin J, Lau CC, Pollack IF, Laningham FH, Lustig RH, Armstrong FD, Handler MH, Williams-Hughes C, Kessel S, Kocak M, Ellison DW, Ramaswamy V
J Clin Oncol 2019 Apr 20;37(12):974-983. Epub 2019 Feb 27 doi: 10.1200/JCO.18.01765. PMID: 30811284Free PMC Article
Posterior Fossa Tumors.
Brandão LA, Young Poussaint T
Neuroimaging Clin N Am 2017 Feb;27(1):1-37. doi: 10.1016/j.nic.2016.08.001. PMID: 27889018
Cerebellar mutism.
Tamburrini G, Frassanito P, Chieffo D, Massimi L, Caldarelli M, Di Rocco C
Childs Nerv Syst 2015 Oct;31(10):1841-51. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2803-6. PMID: 26351234

Therapy

Meta-Analysis of Apparent Diffusion Coefficient in Pediatric Medulloblastoma, Ependymoma, and Pilocytic Astrocytoma.
Dury RJ, Lourdusamy A, Macarthur DC, Peet AC, Auer DP, Grundy RG, Dineen RA
J Magn Reson Imaging 2022 Jul;56(1):147-157. Epub 2021 Nov 29 doi: 10.1002/jmri.28007. PMID: 34842328
Conformal Radiation Therapy for Pediatric Ependymoma, Chemotherapy for Incompletely Resected Ependymoma, and Observation for Completely Resected, Supratentorial Ependymoma.
Merchant TE, Bendel AE, Sabin ND, Burger PC, Shaw DW, Chang E, Wu S, Zhou T, Eisenstat DD, Foreman NK, Fuller CE, Anderson ET, Hukin J, Lau CC, Pollack IF, Laningham FH, Lustig RH, Armstrong FD, Handler MH, Williams-Hughes C, Kessel S, Kocak M, Ellison DW, Ramaswamy V
J Clin Oncol 2019 Apr 20;37(12):974-983. Epub 2019 Feb 27 doi: 10.1200/JCO.18.01765. PMID: 30811284Free PMC Article
Cerebellar mutism.
Tamburrini G, Frassanito P, Chieffo D, Massimi L, Caldarelli M, Di Rocco C
Childs Nerv Syst 2015 Oct;31(10):1841-51. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2803-6. PMID: 26351234
Treatment of posterior fossa tumors in children.
Muzumdar D, Ventureyra EC
Expert Rev Neurother 2010 Apr;10(4):525-46. doi: 10.1586/ern.10.28. PMID: 20367206
Pediatric glial tumors.
Cohen KJ, Broniscer A, Glod J
Curr Treat Options Oncol 2001 Dec;2(6):529-36. doi: 10.1007/s11864-001-0074-9. PMID: 12057098

Prognosis

Posterior fossa tumors in children: current insights.
Formentin C, Joaquim AF, Ghizoni E
Eur J Pediatr 2023 Nov;182(11):4833-4850. Epub 2023 Sep 8 doi: 10.1007/s00431-023-05189-5. PMID: 37679511
Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Medulloblastoma: Clinical presentation.
Vinchon M, Leblond P
Neurochirurgie 2021 Feb;67(1):23-27. Epub 2019 Sep 5 doi: 10.1016/j.neuchi.2019.04.006. PMID: 31494131
Pediatric ependymoma: GNAO1, ASAH1, IMMT and IPO7 protein expression and 5-year prognosis correlation.
Pérez-Ramírez M, García-Méndez A, Siordia-Reyes AG, Chavarría A, Gómez C, García-Hernández N
Clin Neurol Neurosurg 2019 Nov;186:105488. Epub 2019 Aug 12 doi: 10.1016/j.clineuro.2019.105488. PMID: 31505435
Cerebellar mutism.
Tamburrini G, Frassanito P, Chieffo D, Massimi L, Caldarelli M, Di Rocco C
Childs Nerv Syst 2015 Oct;31(10):1841-51. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2803-6. PMID: 26351234

Clinical prediction guides

Posterior fossa tumors in children: current insights.
Formentin C, Joaquim AF, Ghizoni E
Eur J Pediatr 2023 Nov;182(11):4833-4850. Epub 2023 Sep 8 doi: 10.1007/s00431-023-05189-5. PMID: 37679511
Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Medulloblastoma: Clinical presentation.
Vinchon M, Leblond P
Neurochirurgie 2021 Feb;67(1):23-27. Epub 2019 Sep 5 doi: 10.1016/j.neuchi.2019.04.006. PMID: 31494131
Pediatric ependymoma: GNAO1, ASAH1, IMMT and IPO7 protein expression and 5-year prognosis correlation.
Pérez-Ramírez M, García-Méndez A, Siordia-Reyes AG, Chavarría A, Gómez C, García-Hernández N
Clin Neurol Neurosurg 2019 Nov;186:105488. Epub 2019 Aug 12 doi: 10.1016/j.clineuro.2019.105488. PMID: 31505435
Conformal Radiation Therapy for Pediatric Ependymoma, Chemotherapy for Incompletely Resected Ependymoma, and Observation for Completely Resected, Supratentorial Ependymoma.
Merchant TE, Bendel AE, Sabin ND, Burger PC, Shaw DW, Chang E, Wu S, Zhou T, Eisenstat DD, Foreman NK, Fuller CE, Anderson ET, Hukin J, Lau CC, Pollack IF, Laningham FH, Lustig RH, Armstrong FD, Handler MH, Williams-Hughes C, Kessel S, Kocak M, Ellison DW, Ramaswamy V
J Clin Oncol 2019 Apr 20;37(12):974-983. Epub 2019 Feb 27 doi: 10.1200/JCO.18.01765. PMID: 30811284Free PMC Article

Recent systematic reviews

Recurrent pediatric infratentorial ependymomas: a systematic review and meta-analysis on outcomes and molecular classification.
Montgomery EY, Thirunavu V, Pagadala M, Shlobin NA, Plant-Fox AS, Lam S, DeCuypere M
J Neurosurg Pediatr 2023 Feb 1;31(2):132-142. Epub 2022 Nov 25 doi: 10.3171/2022.10.PEDS22154. PMID: 36433871
Meta-Analysis of Apparent Diffusion Coefficient in Pediatric Medulloblastoma, Ependymoma, and Pilocytic Astrocytoma.
Dury RJ, Lourdusamy A, Macarthur DC, Peet AC, Auer DP, Grundy RG, Dineen RA
J Magn Reson Imaging 2022 Jul;56(1):147-157. Epub 2021 Nov 29 doi: 10.1002/jmri.28007. PMID: 34842328
A systematic review and meta-analysis of outcomes in pediatric, recurrent ependymoma.
Byer L, Kline CN, Coleman C, Allen IE, Whitaker E, Mueller S
J Neurooncol 2019 Sep;144(3):445-452. Epub 2019 Sep 9 doi: 10.1007/s11060-019-03255-3. PMID: 31502040
A systematic review of neuropsychological outcomes following posterior fossa tumor surgery in children.
Hanzlik E, Woodrome SE, Abdel-Baki M, Geller TJ, Elbabaa SK
Childs Nerv Syst 2015 Oct;31(10):1869-75. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2867-3. PMID: 26351236
A systematic review of treatment outcomes in pediatric patients with intracranial ependymomas.
Cage TA, Clark AJ, Aranda D, Gupta N, Sun PP, Parsa AT, Auguste KI
J Neurosurg Pediatr 2013 Jun;11(6):673-81. Epub 2013 Mar 29 doi: 10.3171/2013.2.PEDS12345. PMID: 23540528

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