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Subclinical infection

MedGen UID:
82906
•Concept ID:
C0275522
•
Disease or Syndrome
Synonyms: Asymptomatic Infection; Asymptomatic Infections; Inapparent Infection; Inapparent Infections; Infection, Asymptomatic; Infection, Inapparent; Infection, Subclinical; Subclinical Infection; Subclinical Infections
SNOMED CT: Subclinical infection (28456004)

Definition

Infection associated with no detectable symptoms but caused by microorganisms capable of producing easily recognizable diseases, such a poliomyelitis or mumps. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubclinical infection

Professional guidelines

PubMed

A guide to the management of hepatitis E infection during pregnancy.
Kar P, Sengupta A
Expert Rev Gastroenterol Hepatol 2019 Mar;13(3):205-211. Epub 2019 Jan 24 doi: 10.1080/17474124.2019.1568869. PMID: 30791760
Treatment of Chlamydial infections: 2014 update.
Kohlhoff SA, Hammerschlag MR
Expert Opin Pharmacother 2015 Feb;16(2):205-12. doi: 10.1517/14656566.2015.999041. PMID: 25579069
Treatment of chlamydial infections.
Hammerschlag MR, Kohlhoff SA
Expert Opin Pharmacother 2012 Mar;13(4):545-52. Epub 2012 Feb 9 doi: 10.1517/14656566.2012.658776. PMID: 22316336

Recent clinical studies

Etiology

Vaccines to prevent genital herpes.
Egan K, Hook LM, LaTourette P, Desmond A, Awasthi S, Friedman HM
Transl Res 2020 Jun;220:138-152. Epub 2020 Mar 16 doi: 10.1016/j.trsl.2020.03.004. PMID: 32272093Free PMC Article
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651
Dengue virus pathogenesis: an integrated view.
Martina BE, Koraka P, Osterhaus AD
Clin Microbiol Rev 2009 Oct;22(4):564-81. doi: 10.1128/CMR.00035-09. PMID: 19822889Free PMC Article
Anthrax in the Gambia: an epidemiological study.
Heyworth B, Ropp ME, Voos UG, Meinel HI, Darlow HM
Br Med J 1975 Oct 11;4(5988):79-82. doi: 10.1136/bmj.4.5988.79. PMID: 810213Free PMC Article

Diagnosis

Recent advances in the diagnosis of leptospirosis.
Verma V, Goyal M, Kala D, Gupta S, Kumar D, Kaushal A
Front Biosci (Landmark Ed) 2020 Mar 1;25(9):1655-1681. doi: 10.2741/4872. PMID: 32114449
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
Infectious and Sporadic Prion Diseases.
Knight R
Prog Mol Biol Transl Sci 2017;150:293-318. Epub 2017 Aug 14 doi: 10.1016/bs.pmbts.2017.06.010. PMID: 28838665
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651
Treatment of Chlamydial infections: 2014 update.
Kohlhoff SA, Hammerschlag MR
Expert Opin Pharmacother 2015 Feb;16(2):205-12. doi: 10.1517/14656566.2015.999041. PMID: 25579069

Therapy

Vaccines to prevent genital herpes.
Egan K, Hook LM, LaTourette P, Desmond A, Awasthi S, Friedman HM
Transl Res 2020 Jun;220:138-152. Epub 2020 Mar 16 doi: 10.1016/j.trsl.2020.03.004. PMID: 32272093Free PMC Article
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
A guide to the management of hepatitis E infection during pregnancy.
Kar P, Sengupta A
Expert Rev Gastroenterol Hepatol 2019 Mar;13(3):205-211. Epub 2019 Jan 24 doi: 10.1080/17474124.2019.1568869. PMID: 30791760
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651
Treatment of Chlamydial infections: 2014 update.
Kohlhoff SA, Hammerschlag MR
Expert Opin Pharmacother 2015 Feb;16(2):205-12. doi: 10.1517/14656566.2015.999041. PMID: 25579069

Prognosis

Vaccines to prevent genital herpes.
Egan K, Hook LM, LaTourette P, Desmond A, Awasthi S, Friedman HM
Transl Res 2020 Jun;220:138-152. Epub 2020 Mar 16 doi: 10.1016/j.trsl.2020.03.004. PMID: 32272093Free PMC Article
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651
Antibiotics for preterm rupture of membranes.
Kenyon S, Boulvain M, Neilson JP
Cochrane Database Syst Rev 2013 Dec 2;2013(12):CD001058. doi: 10.1002/14651858.CD001058.pub3. PMID: 24297389Free PMC Article
Silicone: a critical review.
Duffy DM
Adv Dermatol 1990;5:93-107; discussion 108-9. PMID: 2204381

Clinical prediction guides

Vaccines to prevent genital herpes.
Egan K, Hook LM, LaTourette P, Desmond A, Awasthi S, Friedman HM
Transl Res 2020 Jun;220:138-152. Epub 2020 Mar 16 doi: 10.1016/j.trsl.2020.03.004. PMID: 32272093Free PMC Article
Merkel cell polyomavirus and Langerhans cell neoplasm.
Murakami I, Wada N, Nakashima J, Iguchi M, Toi M, Hashida Y, Higuchi T, Daibata M, Matsushita M, Iwasaki T, Kuwamoto S, Horie Y, Nagata K, Hayashi K, Oka T, Yoshino T, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F
Cell Commun Signal 2018 Aug 22;16(1):49. doi: 10.1186/s12964-018-0261-y. PMID: 30134914Free PMC Article
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651
The immunopathogenesis of cryptococcal immune reconstitution inflammatory syndrome: understanding a conundrum.
Meya DB, Manabe YC, Boulware DR, Janoff EN
Curr Opin Infect Dis 2016 Feb;29(1):10-22. doi: 10.1097/QCO.0000000000000224. PMID: 26658650Free PMC Article
Silicone: a critical review.
Duffy DM
Adv Dermatol 1990;5:93-107; discussion 108-9. PMID: 2204381

Recent systematic reviews

Immunogenicity and seroefficacy of pneumococcal conjugate vaccines: a systematic review and network meta-analysis.
Feng S, McLellan J, Pidduck N, Roberts N, Higgins JP, Choi Y, Izu A, Jit M, Madhi SA, Mulholland K, Pollard AJ, Procter S, Temple B, Voysey M
Health Technol Assess 2024 Jul;28(34):1-109. doi: 10.3310/YWHA3079. PMID: 39046101Free PMC Article
Antibiotics for preterm rupture of membranes.
Kenyon S, Boulvain M, Neilson JP
Cochrane Database Syst Rev 2013 Dec 2;2013(12):CD001058. doi: 10.1002/14651858.CD001058.pub3. PMID: 24297389Free PMC Article
Antibiotics for preterm rupture of membranes.
Kenyon S, Boulvain M, Neilson JP
Cochrane Database Syst Rev 2010 Aug 4;(8):CD001058. doi: 10.1002/14651858.CD001058.pub2. PMID: 20687063
Antibiotics for preterm rupture of membranes.
Kenyon S, Boulvain M, Neilson J
Cochrane Database Syst Rev 2003;(2):CD001058. doi: 10.1002/14651858.CD001058. PMID: 12804398
Prophylactic antibiotics for inhibiting preterm labour with intact membranes.
King J, Flenady V
Cochrane Database Syst Rev 2002;(4):CD000246. doi: 10.1002/14651858.CD000246. PMID: 12519538

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