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JAK2 NP_004963.1:p.G935R

MedGen UID:
822223
Concept ID:
C3829475
Cell or Molecular Dysfunction
Synonyms: JAK2 G935R; JAK2 Gly935Arg; JAK2 NP_004963.1:p.Gly935Arg; JAK2 p.G935R; JAK2 p.Gly935Arg; Janus Kinase 2 G935R; Janus Kinase 2 Gly935Arg; NP_004963.1:p.G935R; NP_004963.1:p.Gly935Arg; Tyrosine-Protein Kinase JAK2 G935R; Tyrosine-Protein Kinase JAK2 Gly935Arg

Definition

A change in the amino acid residue at position 935 in the tyrosine-protein kinase JAK2 protein where glycine has been replaced by arginine. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVJAK2 NP_004963.1:p.G935R

Professional guidelines

PubMed

Stonestrom AJ, Menghrajani KN, Devlin SM, Franch-Expósito S, Ptashkin RN, Patel SY, Spitzer B, Wu X, Jee J, Sánchez Vela P, Milbank JH, Shah RH, Mohanty AS, Brannon AR, Xiao W, Berger MF, Mantha S, Levine RL
Blood Adv 2024 Feb 27;8(4):846-856. doi: 10.1182/bloodadvances.2023011262. PMID: 38147626Free PMC Article

Recent clinical studies

Etiology

Ünlü İ, Tuncer MC, Özdemir İ
Acta Cir Bras 2024;39:e396624. Epub 2024 Sep 30 doi: 10.1590/acb396624. PMID: 39356934Free PMC Article
Saleem M, Aden LA, Mutchler AL, Basu C, Ertuglu LA, Sheng Q, Penner N, Hemnes AR, Park JH, Ishimwe JA, Laffer CL, Elijovich F, Wanjalla CN, de la Visitacion N, Kastner PD, Albritton CF, Ahmad T, Haynes AP, Yu J, Graber MK, Yasmin S, Wagner KU, Sayeski PP, Hatzopoulos AK, Gamazon ER, Bick AG, Kleyman TR, Kirabo A
Circ Res 2024 Oct 11;135(9):890-909. Epub 2024 Sep 12 doi: 10.1161/CIRCRESAHA.124.323595. PMID: 39263750Free PMC Article
Stonestrom AJ, Menghrajani KN, Devlin SM, Franch-Expósito S, Ptashkin RN, Patel SY, Spitzer B, Wu X, Jee J, Sánchez Vela P, Milbank JH, Shah RH, Mohanty AS, Brannon AR, Xiao W, Berger MF, Mantha S, Levine RL
Blood Adv 2024 Feb 27;8(4):846-856. doi: 10.1182/bloodadvances.2023011262. PMID: 38147626Free PMC Article
Lin YT, Chen WC, Tsai MH, Chen JY, Chien CY, Huang SC
Biomolecules 2021 Jul 20;11(7) doi: 10.3390/biom11071059. PMID: 34356683Free PMC Article
Zeiser R, Polverelli N, Ram R, Hashmi SK, Chakraverty R, Middeke JM, Musso M, Giebel S, Uzay A, Langmuir P, Hollaender N, Gowda M, Stefanelli T, Lee SJ, Teshima T, Locatelli F; REACH3 Investigators
N Engl J Med 2021 Jul 15;385(3):228-238. doi: 10.1056/NEJMoa2033122. PMID: 34260836

Diagnosis

Saleem M, Aden LA, Mutchler AL, Basu C, Ertuglu LA, Sheng Q, Penner N, Hemnes AR, Park JH, Ishimwe JA, Laffer CL, Elijovich F, Wanjalla CN, de la Visitacion N, Kastner PD, Albritton CF, Ahmad T, Haynes AP, Yu J, Graber MK, Yasmin S, Wagner KU, Sayeski PP, Hatzopoulos AK, Gamazon ER, Bick AG, Kleyman TR, Kirabo A
Circ Res 2024 Oct 11;135(9):890-909. Epub 2024 Sep 12 doi: 10.1161/CIRCRESAHA.124.323595. PMID: 39263750Free PMC Article
Xiang M, Lai Y, Shen J, Wei B, Liu H, Huang W
Comput Biol Chem 2024 Oct;112:108181. Epub 2024 Aug 23 doi: 10.1016/j.compbiolchem.2024.108181. PMID: 39182249
Zhou J, Zhou P, Zhang Y, Wang G, Fan Z
Dis Markers 2021;2021:9947047. Epub 2021 Aug 28 doi: 10.1155/2021/9947047. PMID: 34497676Free PMC Article

Therapy

Ünlü İ, Özdemir İ, Tuncer MC
Medicina (Kaunas) 2024 Oct 19;60(10) doi: 10.3390/medicina60101715. PMID: 39459502Free PMC Article
Saleem M, Aden LA, Mutchler AL, Basu C, Ertuglu LA, Sheng Q, Penner N, Hemnes AR, Park JH, Ishimwe JA, Laffer CL, Elijovich F, Wanjalla CN, de la Visitacion N, Kastner PD, Albritton CF, Ahmad T, Haynes AP, Yu J, Graber MK, Yasmin S, Wagner KU, Sayeski PP, Hatzopoulos AK, Gamazon ER, Bick AG, Kleyman TR, Kirabo A
Circ Res 2024 Oct 11;135(9):890-909. Epub 2024 Sep 12 doi: 10.1161/CIRCRESAHA.124.323595. PMID: 39263750Free PMC Article
Zhang S, Shen S, Ma P, Fan D
Int J Mol Sci 2022 Nov 11;23(22) doi: 10.3390/ijms232213921. PMID: 36430397Free PMC Article
Zeiser R, Polverelli N, Ram R, Hashmi SK, Chakraverty R, Middeke JM, Musso M, Giebel S, Uzay A, Langmuir P, Hollaender N, Gowda M, Stefanelli T, Lee SJ, Teshima T, Locatelli F; REACH3 Investigators
N Engl J Med 2021 Jul 15;385(3):228-238. doi: 10.1056/NEJMoa2033122. PMID: 34260836
Saenz DT, Fiskus W, Qian Y, Manshouri T, Rajapakshe K, Raina K, Coleman KG, Crew AP, Shen A, Mill CP, Sun B, Qiu P, Kadia TM, Pemmaraju N, DiNardo C, Kim MS, Nowak AJ, Coarfa C, Crews CM, Verstovsek S, Bhalla KN
Leukemia 2017 Sep;31(9):1951-1961. Epub 2017 Feb 2 doi: 10.1038/leu.2016.393. PMID: 28042144Free PMC Article

Prognosis

Stonestrom AJ, Menghrajani KN, Devlin SM, Franch-Expósito S, Ptashkin RN, Patel SY, Spitzer B, Wu X, Jee J, Sánchez Vela P, Milbank JH, Shah RH, Mohanty AS, Brannon AR, Xiao W, Berger MF, Mantha S, Levine RL
Blood Adv 2024 Feb 27;8(4):846-856. doi: 10.1182/bloodadvances.2023011262. PMID: 38147626Free PMC Article

Clinical prediction guides

Ünlü İ, Özdemir İ, Tuncer MC
Medicina (Kaunas) 2024 Oct 19;60(10) doi: 10.3390/medicina60101715. PMID: 39459502Free PMC Article
Pradhan R, Paul S, Acharya SS, Sinha S, Dash SR, Kundu CN
J Nutr Biochem 2024 Mar;125:109568. Epub 2024 Jan 6 doi: 10.1016/j.jnutbio.2024.109568. PMID: 38185347
Stonestrom AJ, Menghrajani KN, Devlin SM, Franch-Expósito S, Ptashkin RN, Patel SY, Spitzer B, Wu X, Jee J, Sánchez Vela P, Milbank JH, Shah RH, Mohanty AS, Brannon AR, Xiao W, Berger MF, Mantha S, Levine RL
Blood Adv 2024 Feb 27;8(4):846-856. doi: 10.1182/bloodadvances.2023011262. PMID: 38147626Free PMC Article
Lin YT, Chen WC, Tsai MH, Chen JY, Chien CY, Huang SC
Biomolecules 2021 Jul 20;11(7) doi: 10.3390/biom11071059. PMID: 34356683Free PMC Article
Zeiser R, Polverelli N, Ram R, Hashmi SK, Chakraverty R, Middeke JM, Musso M, Giebel S, Uzay A, Langmuir P, Hollaender N, Gowda M, Stefanelli T, Lee SJ, Teshima T, Locatelli F; REACH3 Investigators
N Engl J Med 2021 Jul 15;385(3):228-238. doi: 10.1056/NEJMoa2033122. PMID: 34260836

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