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PDGFRA Protein Variant

MedGen UID:
821374
Concept ID:
C3828626
Cell or Molecular Dysfunction
Synonyms: CD140a Antigen Protein Variant; PDGFR-Alpha Protein Variant; Platelet-Derived Growth Factor Receptor Alpha Protein Variant

Definition

A variation in the amino acid sequence for the platelet-derived growth factor receptor alpha protein. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Shomali W, Gotlib J
Am J Hematol 2019 Oct;94(10):1149-1167. doi: 10.1002/ajh.25617. PMID: 31423623
Helbig G
Expert Rev Clin Immunol 2018 Feb;14(2):163-170. Epub 2018 Jan 9 doi: 10.1080/1744666X.2018.1425142. PMID: 29303368
Roufosse F
Immunol Allergy Clin North Am 2015 Aug;35(3):561-75. doi: 10.1016/j.iac.2015.05.006. PMID: 26209900

Recent clinical studies

Etiology

Shomali W, Gotlib J
Am J Hematol 2019 Oct;94(10):1149-1167. doi: 10.1002/ajh.25617. PMID: 31423623
Helbig G
Expert Rev Clin Immunol 2018 Feb;14(2):163-170. Epub 2018 Jan 9 doi: 10.1080/1744666X.2018.1425142. PMID: 29303368
Tasian SK, Loh ML, Hunger SP
Blood 2017 Nov 9;130(19):2064-2072. Epub 2017 Oct 2 doi: 10.1182/blood-2017-06-743252. PMID: 28972016Free PMC Article
Reiter A, Gotlib J
Blood 2017 Feb 9;129(6):704-714. Epub 2016 Dec 27 doi: 10.1182/blood-2016-10-695973. PMID: 28028030
Doyle LA, Hornick JL
Histopathology 2014 Jan;64(1):53-67. Epub 2013 Nov 28 doi: 10.1111/his.12302. PMID: 24117705

Diagnosis

Serrano C, Bauer S, Gómez-Peregrina D, Kang YK, Jones RL, Rutkowski P, Mir O, Heinrich MC, Tap WD, Newberry K, Grassian A, Shi H, Bialick S, Schöffski P, Pantaleo MA, von Mehren M, Trent JC, George S
Ann Oncol 2023 Jul;34(7):615-625. Epub 2023 Apr 25 doi: 10.1016/j.annonc.2023.04.006. PMID: 37105265Free PMC Article
Tzankov A, Reichard KK, Hasserjian RP, Arber DA, Orazi A, Wang SA
Virchows Arch 2023 Jan;482(1):85-97. Epub 2022 Sep 7 doi: 10.1007/s00428-022-03402-8. PMID: 36068374
Jain S, Abraham A
Arch Pathol Lab Med 2020 Feb;144(2):150-155. Epub 2019 Oct 23 doi: 10.5858/arpa.2019-0194-RA. PMID: 31644323
Shomali W, Gotlib J
Am J Hematol 2019 Oct;94(10):1149-1167. doi: 10.1002/ajh.25617. PMID: 31423623
Flavahan WA, Drier Y, Liau BB, Gillespie SM, Venteicher AS, Stemmer-Rachamimov AO, Suvà ML, Bernstein BE
Nature 2016 Jan 7;529(7584):110-4. Epub 2015 Dec 23 doi: 10.1038/nature16490. PMID: 26700815Free PMC Article

Therapy

Serrano C, Bauer S, Gómez-Peregrina D, Kang YK, Jones RL, Rutkowski P, Mir O, Heinrich MC, Tap WD, Newberry K, Grassian A, Shi H, Bialick S, Schöffski P, Pantaleo MA, von Mehren M, Trent JC, George S
Ann Oncol 2023 Jul;34(7):615-625. Epub 2023 Apr 25 doi: 10.1016/j.annonc.2023.04.006. PMID: 37105265Free PMC Article
Kang YK, George S, Jones RL, Rutkowski P, Shen L, Mir O, Patel S, Zhou Y, von Mehren M, Hohenberger P, Villalobos V, Brahmi M, Tap WD, Trent J, Pantaleo MA, Schöffski P, He K, Hew P, Newberry K, Roche M, Heinrich MC, Bauer S
J Clin Oncol 2021 Oct 1;39(28):3128-3139. Epub 2021 Aug 3 doi: 10.1200/JCO.21.00217. PMID: 34343033Free PMC Article
Shomali W, Gotlib J
Am J Hematol 2019 Oct;94(10):1149-1167. doi: 10.1002/ajh.25617. PMID: 31423623
Heinrich MC, Maki RG, Corless CL, Antonescu CR, Harlow A, Griffith D, Town A, McKinley A, Ou WB, Fletcher JA, Fletcher CD, Huang X, Cohen DP, Baum CM, Demetri GD
J Clin Oncol 2008 Nov 20;26(33):5352-9. Epub 2008 Oct 27 doi: 10.1200/JCO.2007.15.7461. PMID: 18955458Free PMC Article
Pikman Y, Lee BH, Mercher T, McDowell E, Ebert BL, Gozo M, Cuker A, Wernig G, Moore S, Galinsky I, DeAngelo DJ, Clark JJ, Lee SJ, Golub TR, Wadleigh M, Gilliland DG, Levine RL
PLoS Med 2006 Jul;3(7):e270. doi: 10.1371/journal.pmed.0030270. PMID: 16834459Free PMC Article

Prognosis

Serrano C, Bauer S, Gómez-Peregrina D, Kang YK, Jones RL, Rutkowski P, Mir O, Heinrich MC, Tap WD, Newberry K, Grassian A, Shi H, Bialick S, Schöffski P, Pantaleo MA, von Mehren M, Trent JC, George S
Ann Oncol 2023 Jul;34(7):615-625. Epub 2023 Apr 25 doi: 10.1016/j.annonc.2023.04.006. PMID: 37105265Free PMC Article
Vaubel RA, Tian S, Remonde D, Schroeder MA, Mladek AC, Kitange GJ, Caron A, Kollmeyer TM, Grove R, Peng S, Carlson BL, Ma DJ, Sarkar G, Evers L, Decker PA, Yan H, Dhruv HD, Berens ME, Wang Q, Marin BM, Klee EW, Califano A, LaChance DH, Eckel-Passow JE, Verhaak RG, Sulman EP, Burns TC, Meyer FB, O'Neill BP, Tran NL, Giannini C, Jenkins RB, Parney IF, Sarkaria JN
Clin Cancer Res 2020 Mar 1;26(5):1094-1104. Epub 2019 Dec 18 doi: 10.1158/1078-0432.CCR-19-0909. PMID: 31852831Free PMC Article
Shomali W, Gotlib J
Am J Hematol 2019 Oct;94(10):1149-1167. doi: 10.1002/ajh.25617. PMID: 31423623
Reiter A, Gotlib J
Blood 2017 Feb 9;129(6):704-714. Epub 2016 Dec 27 doi: 10.1182/blood-2016-10-695973. PMID: 28028030
Flavahan WA, Drier Y, Liau BB, Gillespie SM, Venteicher AS, Stemmer-Rachamimov AO, Suvà ML, Bernstein BE
Nature 2016 Jan 7;529(7584):110-4. Epub 2015 Dec 23 doi: 10.1038/nature16490. PMID: 26700815Free PMC Article

Clinical prediction guides

Wallander K, Öfverholm I, Boye K, Tsagkozis P, Papakonstantinou A, Lin Y, Haglund de Flon F
J Intern Med 2023 Dec;294(6):690-707. Epub 2023 Sep 7 doi: 10.1111/joim.13717. PMID: 37643281
Reiter A, Gotlib J
Blood 2017 Feb 9;129(6):704-714. Epub 2016 Dec 27 doi: 10.1182/blood-2016-10-695973. PMID: 28028030
Appin CL, Brat DJ
Mol Aspects Med 2015 Nov;45:87-96. Epub 2015 May 21 doi: 10.1016/j.mam.2015.05.002. PMID: 26004297
Montgomery ND, Dunphy CH, Mooberry M, Laramore A, Foster MC, Park SI, Fedoriw YD
Arch Pathol Lab Med 2013 Feb;137(2):259-69. doi: 10.5858/arpa.2011-0597-RA. PMID: 23368869
Heinrich MC, Maki RG, Corless CL, Antonescu CR, Harlow A, Griffith D, Town A, McKinley A, Ou WB, Fletcher JA, Fletcher CD, Huang X, Cohen DP, Baum CM, Demetri GD
J Clin Oncol 2008 Nov 20;26(33):5352-9. Epub 2008 Oct 27 doi: 10.1200/JCO.2007.15.7461. PMID: 18955458Free PMC Article

Recent systematic reviews

Tesileanu CMS, Vallentgoed WR, French PJ, van den Bent MJ
Eur J Cancer 2022 Nov;175:214-223. Epub 2022 Sep 21 doi: 10.1016/j.ejca.2022.08.016. PMID: 36152406
Zhao Z, Zhang J, Zhang W, Tan S, Wei HT, You J, Guo S, Wang J, Chen P, Xu Y, Zong L
Curr Probl Cancer 2021 Jun;45(3):100705. Epub 2021 Jan 19 doi: 10.1016/j.currproblcancer.2020.100705. PMID: 33495025
Ding H, Yu X, Yu Y, Lao X, Hang C, Gao K, Jia Y, Yan Z
Oncol Rep 2020 Mar;43(3):751-764. Epub 2020 Jan 17 doi: 10.3892/or.2020.7470. PMID: 32020209

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