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Sudden Unexplained Infant Death

MedGen UID:
819039
•Concept ID:
C3814825
•
Disease or Syndrome

Definition

Unexpected death of an infant less than one year of age, whose cause of death is not immediately obvious prior to investigation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSudden Unexplained Infant Death

Professional guidelines

PubMed

Intervention during the Perinatal Period: Synthesis of the Clinical Practice Guidelines from the French National College of Midwives.
Barasinski C, Zaros C, Bercherie J, Bernard JY, Boisseau N, Camier A, Chanal C, Doray B, Dugravier R, Evrard A, Ficheux AS, Garlantézec R, Kadawathagedara M, Laurent-Vannier A, Lecorguillé M, Marie C, Molénat F, Pelé F, de Villepin BP, Rigourd V, Rousseau M, Storme L, Weiss S, Salinier C, Béranger R
J Midwifery Womens Health 2022 Nov;67 Suppl 1:S2-S16. doi: 10.1111/jmwh.13421. PMID: 36480672
Guidelines for postmortem protocol for ocular investigation of sudden unexplained infant death and suspected physical child abuse.
Gilliland MG, Levin AV, Enzenauer RW, Smith C, Parsons MA, Rorke-Adams LB, Lauridson JR, La Roche GR, Christmann LM, Mian M, Jentzen J, Simons KB, Morad Y, Alexander R, Jenny C, Wygnanski-Jaffe T
Am J Forensic Med Pathol 2007 Dec;28(4):323-9. doi: 10.1097/PAF.0b013e31815b4c00. PMID: 18043020
Child abuse, sudden infant death syndrome, and psychosocial development.
Botash AS, Fuller PG, Blatt SD, Cunningham A, Weinberger HL
Curr Opin Pediatr 1996 Apr;8(2):195-200. doi: 10.1097/00008480-199604000-00020. PMID: 8723817

Recent clinical studies

Etiology

Creating a Safe Sleep Environment for the Infant: What the Pediatric Nurse Needs to Know.
Newberry JA
J Pediatr Nurs 2019 Jan-Feb;44:119-122. Epub 2018 Dec 15 doi: 10.1016/j.pedn.2018.12.001. PMID: 30683277
Long QT syndrome and sudden unexpected infant death.
Van Niekerk C, Van Deventer BS, du Toit-Prinsloo L
J Clin Pathol 2017 Sep;70(9):808-813. Epub 2017 Jun 29 doi: 10.1136/jclinpath-2016-204199. PMID: 28663329
Vaccination and unexplained sudden death risk in Taiwanese infants.
Huang WT, Chen RT, Hsu YC, Glasser JW, Rhodes PH
Pharmacoepidemiol Drug Saf 2017 Jan;26(1):17-25. Epub 2016 Nov 28 doi: 10.1002/pds.4141. PMID: 27891698
Seasonal Timing of Infant Bronchiolitis, Apnea and Sudden Unexplained Infant Death.
Sloan CD, Gebretsadik T, Rosas-Salazar C, Wu P, Carroll KN, Mitchel E, Anderson LJ, Larkin EK, Hartert TV
PLoS One 2016;11(7):e0158521. Epub 2016 Jul 12 doi: 10.1371/journal.pone.0158521. PMID: 27404386Free PMC Article
Infant Co-Bedding: Practices and Teaching Strategies.
Cullen D, Vodde CR, Williams KJ, Stiffler D, Luna G
J Spec Pediatr Nurs 2016 Apr;21(2):54-63. Epub 2016 Apr 5 doi: 10.1111/jspn.12140. PMID: 27058962

Diagnosis

The added value of molecular-based diagnostics in the African forensic medical setting.
van Deventer BS, Makhoba MA, du Toit-Prinsloo L, van Niekerk C
Cardiovasc J Afr 2022 Sep-Oct;33(5):282-286. doi: 10.5830/CVJA-2022-050. PMID: 36326683Free PMC Article
Inconsistent classification of unexplained sudden deaths in infants and children hinders surveillance, prevention and research: recommendations from The 3rd International Congress on Sudden Infant and Child Death.
Goldstein RD, Blair PS, Sens MA, Shapiro-Mendoza CK, Krous HF, Rognum TO, Moon RY; 3rd International Congress on Sudden Infant and Child Death
Forensic Sci Med Pathol 2019 Dec;15(4):622-628. Epub 2019 Sep 9 doi: 10.1007/s12024-019-00156-9. PMID: 31502215Free PMC Article
Long QT syndrome and sudden unexpected infant death.
Van Niekerk C, Van Deventer BS, du Toit-Prinsloo L
J Clin Pathol 2017 Sep;70(9):808-813. Epub 2017 Jun 29 doi: 10.1136/jclinpath-2016-204199. PMID: 28663329
Improving sudden unexplained infant death investigation practices: an evaluation of the Centers for Disease Control and Prevention's SUID Investigation Training Academies.
Camperlengo L, Shapiro-Mendoza CK, Gibbs F
Am J Forensic Med Pathol 2014 Dec;35(4):278-82. doi: 10.1097/PAF.0000000000000123. PMID: 25330248
A functional approach to sudden unexplained infant deaths.
Corey TS, Hanzlick R, Howard J, Nelson C, Krous H; NAME Ad Hoc Committee on Sudden Unexplained Infant Death
Am J Forensic Med Pathol 2007 Sep;28(3):271-7. doi: 10.1097/01.paf.0000257385.25803.cf. PMID: 17721183

Therapy

Economic analysis of financial incentives for smoking cessation during pregnancy and postpartum.
Shepard DS, Slade EP, Nighbor TD, DeSarno MJ, Roemhildt ML, Williams RK, Higgins ST
Prev Med 2022 Dec;165(Pt B):107079. Epub 2022 May 6 doi: 10.1016/j.ypmed.2022.107079. PMID: 35533885Free PMC Article
Improving infant sleep safety via electronic health record communication: a randomized controlled trial.
Canty EA, Fogel BN, Batra EK, Schaefer EW, Beiler JS, Paul IM
BMC Pediatr 2020 Oct 8;20(1):468. doi: 10.1186/s12887-020-02369-2. PMID: 33032546Free PMC Article
Vaccination and unexplained sudden death risk in Taiwanese infants.
Huang WT, Chen RT, Hsu YC, Glasser JW, Rhodes PH
Pharmacoepidemiol Drug Saf 2017 Jan;26(1):17-25. Epub 2016 Nov 28 doi: 10.1002/pds.4141. PMID: 27891698
An Evidence-Based Infant Safe Sleep Program to Reduce Sudden Unexplained Infant Deaths.
Zachritz W, Fulmer M, Chaney N
Am J Nurs 2016 Nov;116(11):48-55. doi: 10.1097/01.NAJ.0000505590.78202.a2. PMID: 27787325
Seasonal Timing of Infant Bronchiolitis, Apnea and Sudden Unexplained Infant Death.
Sloan CD, Gebretsadik T, Rosas-Salazar C, Wu P, Carroll KN, Mitchel E, Anderson LJ, Larkin EK, Hartert TV
PLoS One 2016;11(7):e0158521. Epub 2016 Jul 12 doi: 10.1371/journal.pone.0158521. PMID: 27404386Free PMC Article

Prognosis

Long QT syndrome and sudden unexpected infant death.
Van Niekerk C, Van Deventer BS, du Toit-Prinsloo L
J Clin Pathol 2017 Sep;70(9):808-813. Epub 2017 Jun 29 doi: 10.1136/jclinpath-2016-204199. PMID: 28663329
Vaccination and unexplained sudden death risk in Taiwanese infants.
Huang WT, Chen RT, Hsu YC, Glasser JW, Rhodes PH
Pharmacoepidemiol Drug Saf 2017 Jan;26(1):17-25. Epub 2016 Nov 28 doi: 10.1002/pds.4141. PMID: 27891698
Investigating the Decline of Fetal and Infant Mortality Rates in Alaska During 2010 and 2011.
Prince CB, Young MB, Sappenfield W, Parrish JW
Matern Child Health J 2016 Apr;20(4):754-9. doi: 10.1007/s10995-015-1906-8. PMID: 26754348
When Baby Stops Breathing: Analysis of Mothers' Interviews.
Stiffler D, Cullen D, Stephenson E, Luna G, Hartman TD
Clin Nurs Res 2016 Jun;25(3):310-24. Epub 2015 Dec 9 doi: 10.1177/1054773815619580. PMID: 26655564
Sudden unexplained infant death in 20 regions in Europe: case control study.
Carpenter RG, Irgens LM, Blair PS, England PD, Fleming P, Huber J, Jorch G, Schreuder P
Lancet 2004 Jan 17;363(9404):185-91. doi: 10.1016/s0140-6736(03)15323-8. PMID: 14738790

Clinical prediction guides

Prominent Intrapulmonary Shunt Vessels and Altered Lung Development in Infants With Sudden Unexplained Infant Death.
Galambos C, Bush D, Abman SH, Caplan M
J Pediatr 2023 Apr;255:214-219.e1. Epub 2022 Nov 3 doi: 10.1016/j.jpeds.2022.10.026. PMID: 36336004
Take a deep breath and wake up: The protean role of serotonin preventing sudden death in infancy.
Cummings KJ, Leiter JC
Exp Neurol 2020 Apr;326:113165. Epub 2019 Dec 27 doi: 10.1016/j.expneurol.2019.113165. PMID: 31887304Free PMC Article
Long QT syndrome and sudden unexpected infant death.
Van Niekerk C, Van Deventer BS, du Toit-Prinsloo L
J Clin Pathol 2017 Sep;70(9):808-813. Epub 2017 Jun 29 doi: 10.1136/jclinpath-2016-204199. PMID: 28663329
Vaccination and unexplained sudden death risk in Taiwanese infants.
Huang WT, Chen RT, Hsu YC, Glasser JW, Rhodes PH
Pharmacoepidemiol Drug Saf 2017 Jan;26(1):17-25. Epub 2016 Nov 28 doi: 10.1002/pds.4141. PMID: 27891698
Investigating the Decline of Fetal and Infant Mortality Rates in Alaska During 2010 and 2011.
Prince CB, Young MB, Sappenfield W, Parrish JW
Matern Child Health J 2016 Apr;20(4):754-9. doi: 10.1007/s10995-015-1906-8. PMID: 26754348

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