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Cutaneous lichen amyloidosis

MedGen UID:
812175
•Concept ID:
C3805845
•
Disease or Syndrome
HPO: HP:0032346

Definition

Lichen amyloidosis presents with multiple localized or rarely generalized, hyperpigmented grouped papules with a predilection for the shins, calves, ankles, and dorsa of the feet and thighs. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous lichen amyloidosis

Conditions with this feature

Multiple endocrine neoplasia type 2A
MedGen UID:
9958
•Concept ID:
C0025268
•
Neoplastic Process
Multiple endocrine neoplasia type 2 (MEN2) includes the following phenotypes: MEN2A, FMTC (familial medullary thyroid carcinoma, which may be a variant of MEN2A), and MEN2B. All three phenotypes involve high risk for development of medullary carcinoma of the thyroid (MTC); MEN2A and MEN2B involve an increased risk for pheochromocytoma; MEN2A involves an increased risk for parathyroid adenoma or hyperplasia. Additional features in MEN2B include mucosal neuromas of the lips and tongue, distinctive facies with enlarged lips, ganglioneuromatosis of the gastrointestinal tract, and a marfanoid habitus. MTC typically occurs in early childhood in MEN2B, early adulthood in MEN2A, and middle age in FMTC.
See: Condition Record
Multiple endocrine neoplasia type 2A

Professional guidelines

PubMed

Hereditary Medullary Thyroid Cancer Genotype-Phenotype Correlation.
Frank-Raue K, Raue F
Recent Results Cancer Res 2015;204:139-56. doi: 10.1007/978-3-319-22542-5_6. PMID: 26494387
Genetic testing for multiple endocrine neoplasia type 2.
Păun DL, Mohora M, Duţă C, Dumitrache C
Rom J Intern Med 2008;46(2):159-63. PMID: 19284088
RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors.
Kouvaraki MA, Shapiro SE, Perrier ND, Cote GJ, Gagel RF, Hoff AO, Sherman SI, Lee JE, Evans DB
Thyroid 2005 Jun;15(6):531-44. doi: 10.1089/thy.2005.15.531. PMID: 16029119

Recent clinical studies

Etiology

Multiple endocrine neoplasia type 2: A review.
Mathiesen JS, Effraimidis G, Rossing M, Rasmussen ÅK, Hoejberg L, Bastholt L, Godballe C, Oturai P, Feldt-Rasmussen U
Semin Cancer Biol 2022 Feb;79:163-179. Epub 2021 Apr 1 doi: 10.1016/j.semcancer.2021.03.035. PMID: 33812987
Elevated basal serum levels of calcitonin and simultaneous surgery of MEN2A-specific tumors.
Tang HX, Yang H, Li F, Cao ZL, Huang YT, Qi XP
Neoplasma 2021 Sep;68(5):1098-1106. Epub 2021 Jun 23 doi: 10.4149/neo_2021_210330N419. PMID: 34156257
Hereditary Medullary Thyroid Cancer Genotype-Phenotype Correlation.
Frank-Raue K, Raue F
Recent Results Cancer Res 2015;204:139-56. doi: 10.1007/978-3-319-22542-5_6. PMID: 26494387
RET mutation screening in familial cutaneous lichen amyloidosis and in skin amyloidosis associated with multiple endocrine neoplasia.
Hofstra RM, Sijmons RH, Stelwagen T, Stulp RP, Kousseff BG, Lips CJ, Steijlen PM, Van Voorst Vader PC, Buys CH
J Invest Dermatol 1996 Aug;107(2):215-8. doi: 10.1111/1523-1747.ep12329651. PMID: 8757765
Cutaneous lichen amyloidosis associated with multiple endocrine neoplasia type 2A.
Nunziata V, di Giovanni G, Lettera AM, D'Armiento M, Mancini M
Henry Ford Hosp Med J 1989;37(3-4):144-6. PMID: 2576949

Diagnosis

Thyroid Malignancy and Cutaneous Lichen Amyloidosis: Key Points Amid RET Pathogenic Variants in Medullary Thyroid Cancer/Multiple Endocrine Neoplasia Type 2 (MEN2).
Stanescu LS, Ghemigian A, Ciobica ML, Nistor C, Ciuche A, Radu AM, Sandru F, Carsote M
Int J Mol Sci 2024 Sep 10;25(18) doi: 10.3390/ijms25189765. PMID: 39337252Free PMC Article
A unique case of concurrent cutaneous lichen amyloidosis and myxedema.
Gaghan L, Paci K, Foulke G, Googe PB, Lugo-Somolinos A
Dermatol Online J 2022 Jun 15;28(3) doi: 10.5070/D328357783. PMID: 36259802
MEN 2A-related cutaneous lichen amyloidosis: report of three kindred and systematic literature review of clinical, biochemical and molecular characteristics.
Scapineli JO, Ceolin L, Puñales MK, Dora JM, Maia AL
Fam Cancer 2016 Oct;15(4):625-33. doi: 10.1007/s10689-016-9892-6. PMID: 26920351
Hereditary Medullary Thyroid Cancer Genotype-Phenotype Correlation.
Frank-Raue K, Raue F
Recent Results Cancer Res 2015;204:139-56. doi: 10.1007/978-3-319-22542-5_6. PMID: 26494387
Rare syndromes.
Jabbour SA, Davidovici BB, Wolf R
Clin Dermatol 2006 Jul-Aug;24(4):299-316. doi: 10.1016/j.clindermatol.2006.04.005. PMID: 16828412

Therapy

Clinical resolution of generalized lichen amyloidosis with dupilumab: a new alternative therapy.
Humeda Y, Beasley J, Calder K
Dermatol Online J 2020 Dec 15;26(12) PMID: 33423428
Comparative study of phototherapy (UVB) vs. photochemotherapy (PUVA) vs. topical steroids in the treatment of primary cutaneous lichen amyloidosis.
Jin AG, Por A, Wee LK, Kai CK, Leok GC
Photodermatol Photoimmunol Photomed 2001 Feb;17(1):42-3. doi: 10.1034/j.1600-0781.2001.017001042.x. PMID: 11169176

Prognosis

Multiple endocrine neoplasia type 2: A review.
Mathiesen JS, Effraimidis G, Rossing M, Rasmussen ÅK, Hoejberg L, Bastholt L, Godballe C, Oturai P, Feldt-Rasmussen U
Semin Cancer Biol 2022 Feb;79:163-179. Epub 2021 Apr 1 doi: 10.1016/j.semcancer.2021.03.035. PMID: 33812987
Long-term follow-up of RET Y791F carriers in Denmark 1994-2017: A National Cohort Study.
Høxbroe Michaelsen S, Ornstrup MJ, Poulsen MM, Bennedbaek FN, Gaustadnes M, Rossing M, Darling P, Vestergaard P, Mathiesen JS
J Surg Oncol 2019 May;119(6):687-693. Epub 2019 Jan 15 doi: 10.1002/jso.25371. PMID: 30644554
Genotype-Phenotype Correlation in Indian Patients with MEN2-Associated Pheochromocytoma and Comparison of Clinico-Pathological Attributes with Apparently Sporadic Adrenal Pheochromocytoma.
Rajan S, Zaidi G, Agarwal G, Mishra A, Agarwal A, Mishra SK, Bhatia E
World J Surg 2016 Mar;40(3):690-6. doi: 10.1007/s00268-015-3255-6. PMID: 26438242
Hereditary Medullary Thyroid Cancer Genotype-Phenotype Correlation.
Frank-Raue K, Raue F
Recent Results Cancer Res 2015;204:139-56. doi: 10.1007/978-3-319-22542-5_6. PMID: 26494387

Clinical prediction guides

Hereditary Medullary Thyroid Cancer Genotype-Phenotype Correlation.
Frank-Raue K, Raue F
Recent Results Cancer Res 2015;204:139-56. doi: 10.1007/978-3-319-22542-5_6. PMID: 26494387
Identification of the Cys634-->Tyr mutation of the RET proto-oncogene in a pedigree with multiple endocrine neoplasia type 2A and localized cutaneous lichen amyloidosis.
Ceccherini I, Romei C, Barone V, Pacini F, Martino E, Loviselli A, Pinchera A, Romeo G
J Endocrinol Invest 1994 Mar;17(3):201-4. doi: 10.1007/BF03347719. PMID: 7914213
Multiple endocrine neoplasia type 2a associated with cutaneous lichen amyloidosis.
Gagel RF, Levy ML, Donovan DT, Alford BR, Wheeler T, Tschen JA
Ann Intern Med 1989 Nov 15;111(10):802-6. doi: 10.7326/0003-4819-111-10-802. PMID: 2573304

Recent systematic reviews

MEN 2A-related cutaneous lichen amyloidosis: report of three kindred and systematic literature review of clinical, biochemical and molecular characteristics.
Scapineli JO, Ceolin L, Puñales MK, Dora JM, Maia AL
Fam Cancer 2016 Oct;15(4):625-33. doi: 10.1007/s10689-016-9892-6. PMID: 26920351

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