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Upper eyelid retraction

MedGen UID:
810983
•Concept ID:
C2187340
•
Finding
Synonym: Abnormal retraction of upper eyelid
SNOMED CT: Abnormal retraction of upper eyelid (700344004)
 
HPO: HP:0500044

Definition

An elevation of the eyelid above the normal level in the primary position. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUpper eyelid retraction

Professional guidelines

PubMed

Change in upper eyelid position after teprotumumab treatment for thyroid eye disease.
Rosenblatt TR, Chiou CA, Yoon MK, Lee NG, Wolkow N, Freitag SK
Orbit 2024 Jun;43(3):337-343. Epub 2024 Mar 11 doi: 10.1080/01676830.2024.2323543. PMID: 38466206
Triamcinolone acetonide injection in the treatment of upper eyelid retraction in Graves' ophthalmopathy evaluated by 3.0 Tesla magnetic resonance imaging.
Duan M, Xu DD, Zhou HL, Fang HY, Meng W, Wang YN, Jin ZY, Chen Y, Zhang ZH
Indian J Ophthalmol 2022 May;70(5):1736-1741. doi: 10.4103/ijo.IJO_2228_21. PMID: 35502063Free PMC Article
Nonsurgical management of upper eyelid margin asymmetry using hyaluronic acid gel filler.
Mancini R, Khadavi NM, Goldberg RA
Ophthalmic Plast Reconstr Surg 2011 Jan-Feb;27(1):1-3. doi: 10.1097/IOP.0b013e3181c2a16d. PMID: 20551854

Recent clinical studies

Etiology

The Art of Upper Eyelid Retraction Repair.
Alsulaiman N, AlTayash SF, Alkadi DY, Alsuhaibani AH
Int Ophthalmol Clin 2023 Jul 1;63(3):59-73. Epub 2023 Jun 22 doi: 10.1097/IIO.0000000000000460. PMID: 37439610
Nonsurgical treatment for upper eyelid retraction in patients with inactive Graves' orbitopathy.
Vokurka Topljak S, Galiot Delić M, Mandić K, Perić S, Baretić M, Juri Mandić J
Int Ophthalmol 2023 Jul;43(7):2291-2299. Epub 2023 Jan 1 doi: 10.1007/s10792-022-02625-7. PMID: 36587368Free PMC Article
Contralateral eyelid elevation following unilateral upper eyelid retraction repair.
Wong MB, Maamari RN, Couch SM
Orbit 2022 Aug;41(4):452-456. Epub 2021 May 25 doi: 10.1080/01676830.2021.1931352. PMID: 34030599
Results of surgical correction of upper eyelid retraction in Graves' Orbitopathy.
Pinas D, O B De Keizer R, Wubbels RJ, van den Bosch WA, Paridaens D
Acta Ophthalmol 2021 Jun;99(4):e608-e613. Epub 2020 Sep 15 doi: 10.1111/aos.14622. PMID: 32930505
Incidence and clinical characteristics of pediatric eyelid retraction.
Olayanju JA, Griepentrog GJ, Mohney BG
J AAPOS 2019 Aug;23(4):213.e1-213.e4. Epub 2019 Jun 20 doi: 10.1016/j.jaapos.2019.03.004. PMID: 31229605Free PMC Article

Diagnosis

Nonsurgical treatment for upper eyelid retraction in patients with inactive Graves' orbitopathy.
Vokurka Topljak S, Galiot Delić M, Mandić K, Perić S, Baretić M, Juri Mandić J
Int Ophthalmol 2023 Jul;43(7):2291-2299. Epub 2023 Jan 1 doi: 10.1007/s10792-022-02625-7. PMID: 36587368Free PMC Article
Middle-aged Woman With Atypical Upper Eyelid Retraction.
Homer NA, Darrow M
JAMA Ophthalmol 2022 Sep 1;140(9):902-903. doi: 10.1001/jamaophthalmol.2022.1532. PMID: 35708672
Incidence and clinical characteristics of pediatric eyelid retraction.
Olayanju JA, Griepentrog GJ, Mohney BG
J AAPOS 2019 Aug;23(4):213.e1-213.e4. Epub 2019 Jun 20 doi: 10.1016/j.jaapos.2019.03.004. PMID: 31229605Free PMC Article
Anatomic Considerations in Thyroid Eye Disease.
Dutton JJ
Ophthalmic Plast Reconstr Surg 2018 Jul/Aug;34(4S Suppl 1):S7-S12. doi: 10.1097/IOP.0000000000001122. PMID: 29870437
Graves upper eyelid retraction.
Cruz AA, Ribeiro SF, Garcia DM, Akaishi PM, Pinto CT
Surv Ophthalmol 2013 Jan-Feb;58(1):63-76. doi: 10.1016/j.survophthal.2012.02.007. PMID: 23217588

Therapy

Nonsurgical treatment for upper eyelid retraction in patients with inactive Graves' orbitopathy.
Vokurka Topljak S, Galiot Delić M, Mandić K, Perić S, Baretić M, Juri Mandić J
Int Ophthalmol 2023 Jul;43(7):2291-2299. Epub 2023 Jan 1 doi: 10.1007/s10792-022-02625-7. PMID: 36587368Free PMC Article
Changes in eyelid position after glaucoma filtering surgery.
Salvá-Palomeque T, Muñoz-Ramón P, Rebolleda G, Aguado-Casanova V, Ye-Zhu C, Muñoz-Negrete FJ
Eur J Ophthalmol 2022 Sep;32(5):2886-2892. Epub 2021 Nov 23 doi: 10.1177/11206721211063723. PMID: 34812089
Contralateral eyelid elevation following unilateral upper eyelid retraction repair.
Wong MB, Maamari RN, Couch SM
Orbit 2022 Aug;41(4):452-456. Epub 2021 May 25 doi: 10.1080/01676830.2021.1931352. PMID: 34030599
Bovine Acellular Dermal Matrix for Levator Lengthening in Thyroid-Related Upper-Eyelid Retraction.
Sun J, Liu X, Zhang Y, Huang Y, Zhong S, Fang S, Zhuang A, Li Y, Zhou H, Fan X
Med Sci Monit 2018 May 2;24:2728-2734. doi: 10.12659/MSM.909306. PMID: 29718902Free PMC Article
Aesthetic considerations in upper eyelid retraction surgery.
Papageorgiou KI, Ang M, Chang SH, Kohn J, Martinez S, Goldberg RA
Ophthalmic Plast Reconstr Surg 2012 Nov-Dec;28(6):419-23. doi: 10.1097/IOP.0b013e318263c56e. PMID: 23138201

Prognosis

Results of surgical correction of upper eyelid retraction in Graves' Orbitopathy.
Pinas D, O B De Keizer R, Wubbels RJ, van den Bosch WA, Paridaens D
Acta Ophthalmol 2021 Jun;99(4):e608-e613. Epub 2020 Sep 15 doi: 10.1111/aos.14622. PMID: 32930505
Course of upper eyelid retraction in thyroid eye disease.
Lee DC, Young SM, Kim YD, Woo KI
Br J Ophthalmol 2020 Feb;104(2):254-259. Epub 2019 May 11 doi: 10.1136/bjophthalmol-2018-313578. PMID: 31079052
Incidence and clinical characteristics of pediatric eyelid retraction.
Olayanju JA, Griepentrog GJ, Mohney BG
J AAPOS 2019 Aug;23(4):213.e1-213.e4. Epub 2019 Jun 20 doi: 10.1016/j.jaapos.2019.03.004. PMID: 31229605Free PMC Article
The success rate of TED upper eyelid retraction reoperations.
Golan S, Rootman DB, Goldberg RA
Orbit 2016 Dec;35(6):335-338. Epub 2016 Aug 25 doi: 10.1080/01676830.2016.1193546. PMID: 27560939
The ocular surface in thyroid diseases.
Versura P, Campos EC
Curr Opin Allergy Clin Immunol 2010 Oct;10(5):486-92. doi: 10.1097/ACI.0b013e32833e1749. PMID: 20724921

Clinical prediction guides

Hyaluronic acid gel injection for dysthyroid upper eyelid retraction in Asian patients.
Young SM, Kim JH, Kim YD, Karnsiritanont V, Lang SS, Woo KI
Orbit 2023 Aug;42(4):389-396. Epub 2022 Sep 9 doi: 10.1080/01676830.2022.2117385. PMID: 36082627
Results of surgical correction of upper eyelid retraction in Graves' Orbitopathy.
Pinas D, O B De Keizer R, Wubbels RJ, van den Bosch WA, Paridaens D
Acta Ophthalmol 2021 Jun;99(4):e608-e613. Epub 2020 Sep 15 doi: 10.1111/aos.14622. PMID: 32930505
Course of upper eyelid retraction in thyroid eye disease.
Lee DC, Young SM, Kim YD, Woo KI
Br J Ophthalmol 2020 Feb;104(2):254-259. Epub 2019 May 11 doi: 10.1136/bjophthalmol-2018-313578. PMID: 31079052
The success rate of TED upper eyelid retraction reoperations.
Golan S, Rootman DB, Goldberg RA
Orbit 2016 Dec;35(6):335-338. Epub 2016 Aug 25 doi: 10.1080/01676830.2016.1193546. PMID: 27560939
The ocular surface in thyroid diseases.
Versura P, Campos EC
Curr Opin Allergy Clin Immunol 2010 Oct;10(5):486-92. doi: 10.1097/ACI.0b013e32833e1749. PMID: 20724921

Recent systematic reviews

Influence of orbital decompression on upper eyelid retraction in Graves' orbitopathy: a systematic review and meta-analysis.
Al-Qadi M, Hussain A
Orbit 2024 Aug;43(4):549-554. Epub 2023 Aug 23 doi: 10.1080/01676830.2023.2248621. PMID: 37611061

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