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Diabetic Fetopathy

MedGen UID:: 810783
•Concept ID:: C1167662
•: Disease or Syndrome

Definition

A constellation of features seen in the hyperinsulinemic fetus of a diabetic mother that include macrosomia, postnatal hypoglycemia and polycythemia. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVDiabetic Fetopathy

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
- Fetal disorder
  - Diabetic Fetopathy

Professional guidelines

PubMed

Suboptimally Controlled Diabetes in Pregnancy: A Review to Guide Antepartum and Delivery Management.

Cate JJM, Bloom E, Chu A, Bauer ST, Kuller JA, Dotters-Katz SK
Obstet Gynecol Surv 2024 Jun;79(6):348-365. doi: 10.1097/OGX.0000000000001270. PMID: 38896431

Etiology, detection, and management of fetal macrosomia in pregnancies complicated by diabetes mellitus.

Sacks DA
Clin Obstet Gynecol 2007 Dec;50(4):980-9. doi: 10.1097/GRF.0b013e31815a6242. PMID: 17982341

Diagnosis and treatment of gestational diabetes according to amniotic fluid insulin levels.

Weiss PA, Hofmann HM, Winter RR, Lichtenegger W, Pürstner P, Haas J
Arch Gynecol 1986;239(2):81-91. doi: 10.1007/BF02133967. PMID: 3535694

See all (3)

Recent clinical studies

Etiology

Suboptimally Controlled Diabetes in Pregnancy: A Review to Guide Antepartum and Delivery Management.

Cate JJM, Bloom E, Chu A, Bauer ST, Kuller JA, Dotters-Katz SK
Obstet Gynecol Surv 2024 Jun;79(6):348-365. doi: 10.1097/OGX.0000000000001270. PMID: 38896431

Severe types of fetopathy are associated with changes in the serological proteome of diabetic mothers.

Kopylov AT, Papysheva O, Gribova I, Kaysheva AL, Kotaysch G, Kharitonova L, Mayatskaya T, Nurbekov MK, Schipkova E, Terekhina O, Morozov SG
Medicine (Baltimore) 2021 Nov 12;100(45):e27829. doi: 10.1097/MD.0000000000027829. PMID: 34766598 Free PMC Article

The use of pharmacotherapy in pregnancies with suspected diabetic fetopathy.

Sacks DA
J Matern Fetal Neonatal Med 2012 Jan;25(1):45-9. Epub 2011 Dec 7 doi: 10.3109/14767058.2012.626929. PMID: 22046973

Pancreatic disorders of pregnancy. Pregestational diabetes.

Healy K, Jovanovic-Peterson L, Peterson CM
Endocrinol Metab Clin North Am 1995 Mar;24(1):73-101. PMID: 7781628

Metabolic interactions of diabetes and pregnancy.

Buchanan TA, Kitzmiller JL
Annu Rev Med 1994;45:245-60. doi: 10.1146/annurev.med.45.1.245. PMID: 8198381

See all (17)

Diagnosis

Severe types of fetopathy are associated with changes in the serological proteome of diabetic mothers.

Newborns from women infected with COVID-19: somatic and metabolic status.

Borodina IA, Gil'miyarova FN, Gusyakova OA, Selezneva IA, Borisova OV, Potyakina EE, Kolot'eva NA, Kozlov AV, Gorbacheva IV, Kuznecova OY, Baldina OA, Vinogradova LN, Emel'yanova NG, Koroteeva YA
Klin Lab Diagn 2021 Aug 13;66(8):453-458. doi: 10.51620/0869-2084-2021-66-8-453-458. PMID: 34388314

Association of Proteins Modulating Immune Response and Insulin Clearance During Gestation with Antenatal Complications in Patients with Gestational or Type 2 Diabetes Mellitus.

Kopylov AT, Kaysheva AL, Papysheva O, Gribova I, Kotaysch G, Kharitonova L, Mayatskaya T, Krasheninnikova A, Morozov SG
Cells 2020 Apr 21;9(4) doi: 10.3390/cells9041032. PMID: 32326243 Free PMC Article

Garcia-Flores J, Cruceyra M, Cañamares M, Garicano A, Nieto O, Espada M, Lopez A, Tamarit I, Sainz De La Cuesta R
Gynecol Endocrinol 2016 Jul;32(7):548-52. Epub 2016 Feb 1 doi: 10.3109/09513590.2016.1138461. PMID: 26829514

Etiology, detection, and management of fetal macrosomia in pregnancies complicated by diabetes mellitus.

Sacks DA
Clin Obstet Gynecol 2007 Dec;50(4):980-9. doi: 10.1097/GRF.0b013e31815a6242. PMID: 17982341

See all (12)

Therapy

The use of pharmacotherapy in pregnancies with suspected diabetic fetopathy.

Sacks DA
J Matern Fetal Neonatal Med 2012 Jan;25(1):45-9. Epub 2011 Dec 7 doi: 10.3109/14767058.2012.626929. PMID: 22046973

Etiology, detection, and management of fetal macrosomia in pregnancies complicated by diabetes mellitus.

Sacks DA
Clin Obstet Gynecol 2007 Dec;50(4):980-9. doi: 10.1097/GRF.0b013e31815a6242. PMID: 17982341

Possible mechanisms of diabetic fetopathy.

Poletaev AB, Gnedenko BB, Makarova AA, Krasnopolsky VI, Budykina TS, Petrukhin VA, Morozov SG
Hum Antibodies 2000;9(4):189-97. PMID: 11341172

Indication and results of insulin therapy for gestational diabetes mellitus.

Hopp H, Vollert W, Ragosch V, Novak A, Weitzel HK, Glöckner E, Besch W
J Perinat Med 1996;24(5):521-30. doi: 10.1515/jpme.1996.24.5.521. PMID: 8950733

Diagnosis and treatment of gestational diabetes according to amniotic fluid insulin levels.

Weiss PA, Hofmann HM, Winter RR, Lichtenegger W, Pürstner P, Haas J
Arch Gynecol 1986;239(2):81-91. doi: 10.1007/BF02133967. PMID: 3535694

See all (8)

Prognosis

Gestational diabetes, obesity, and metabolic syndrome diagnosed during pregnancy.

Baliutavičienė D, Buinauskienė JB, Petrenko V, Danytė E, Žalinkevičius R
Metab Syndr Relat Disord 2012 Jun;10(3):214-7. Epub 2012 Feb 7 doi: 10.1089/met.2011.0067. PMID: 22313156

Relationship between sonographically estimated fetal subcutaneous adipose tissue measurements and neonatal skinfold measurements.

Buhling KJ, Doll I, Siebert G, Catalano PM
Ultrasound Obstet Gynecol 2012 May;39(5):558-62. doi: 10.1002/uog.10092. PMID: 21898636

Pregnancy in a woman suffering from type 1 diabetes associated with Addison's disease and Hashimoto's thyroiditis (fully developed Autoimmune Polyglandular Syndrome Type 2).

Stechova K, Bartaskova D, Mrstinova M, Cerny M, Snajderova M, Cinek O, Sumnik Z, Vavrinec J
Exp Clin Endocrinol Diabetes 2004 Jun;112(6):333-7. doi: 10.1055/s-2004-820912. PMID: 15216452

Amniotic fluid insulin levels identify the fetus at risk of neonatal hypoglycaemia.

Fraser RB, Bruce C
Diabet Med 1999 Jul;16(7):568-72. doi: 10.1046/j.1464-5491.1999.00104.x. PMID: 10445832

See all (5)