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Tungiasis

MedGen UID:
78823
Concept ID:
C0277356
Disease or Syndrome
Synonyms: Chigger flea infection; S penetrans infection; Sarcopsylla penetrans infection; Tunga penetrans infectious disease
SNOMED CT: Tunga penetrans infestation (64612002); Tungiasis (64612002); Jigger disease (64612002); Chigoe disease (64612002); Infestation by sand flea (64612002); Sarcopsyllosis (64612002); Sand flea infestation (64612002); Tungiasis (sandflea) infestation (64612002); Jiggers infestation (64612002); Chigoe infestation (64612002); Niguiasis (64612002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0019498
Orphanet: ORPHA879

Definition

Tungiasis is a parasitic skin disease caused by the female sand flea <i>Tunga penetrans</i>. The disease is characterized by acute (multiple white, gray, or yellowish papular or nodular lesions with brown-black-colored opening at the center and peripheral erythema) and chronic inflammation in the feet with itchy/ painful lesions. Bacterial superinfection is common and result in debilitating clinical pathology (deep ulcers, gangrene, lymphangitis and septicemia), leading to impaired physical fitness and mobility. Tungiasis also involves hyperkeratosis, fissuration, nail hypertrophy, and loss of nails. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTungiasis

Professional guidelines

PubMed

Miller H, Trujillo-Trujillo J, Mutebi F, Feldmeier H
Braz J Infect Dis 2020 Mar-Apr;24(2):170-177. Epub 2020 Feb 24 doi: 10.1016/j.bjid.2020.01.004. PMID: 32105621Free PMC Article
Gibbs SS
Br J Dermatol 2008 Sep;159(4):981. doi: 10.1111/j.1365-2133.2008.08752.x. PMID: 18834485
Heukelbach J
Expert Rev Anti Infect Ther 2006 Feb;4(1):151-7. doi: 10.1586/14787210.4.1.151. PMID: 16441216

Recent clinical studies

Etiology

Abrha S, Heukelbach J, Peterson GM, Christenson JK, Carroll S, Kosari S, Bartholomeus A, Feldmeier H, Thomas J
Lancet Infect Dis 2021 Aug;21(8):e234-e245. Epub 2021 Jul 5 doi: 10.1016/S1473-3099(20)30853-7. PMID: 34237261
Coates SJ, Thomas C, Chosidow O, Engelman D, Chang AY
J Am Acad Dermatol 2020 Mar;82(3):551-569. Epub 2019 Jul 13 doi: 10.1016/j.jaad.2019.05.110. PMID: 31306729
Cunha PR, Flora TB, Kroumpouzos G
Dermatol Ther 2019 Jul;32(4):e12665. Epub 2018 Sep 14 doi: 10.1111/dth.12665. PMID: 30216601
Korzeniewski K, Juszczak D, Jerzemowski J
Int Marit Health 2015;66(3):173-80. doi: 10.5603/IMH.2015.0034. PMID: 26394319
Heukelbach J, Feldmeier H
Lancet 2004 Mar 13;363(9412):889-91. doi: 10.1016/S0140-6736(04)15738-3. PMID: 15032237

Diagnosis

Coates SJ, Thomas C, Chosidow O, Engelman D, Chang AY
J Am Acad Dermatol 2020 Mar;82(3):551-569. Epub 2019 Jul 13 doi: 10.1016/j.jaad.2019.05.110. PMID: 31306729
Krüger GM, Loro LS, Takita LC, Hans G Filho
An Bras Dermatol 2017 Sep-Oct;92(5):727-728. doi: 10.1590/abd1806-4841.20177239. PMID: 29166519Free PMC Article
Feldmeier H, Keysers A
Travel Med Infect Dis 2013 Nov-Dec;11(6):357-65. Epub 2013 Oct 18 doi: 10.1016/j.tmaid.2013.10.001. PMID: 24211240
Cestari TF, Pessato S, Ramos-e-Silva M
Clin Dermatol 2007 Mar-Apr;25(2):158-64. doi: 10.1016/j.clindermatol.2006.05.004. PMID: 17350494
Heukelbach J
Rev Inst Med Trop Sao Paulo 2005 Nov-Dec;47(6):307-13. doi: 10.1590/s0036-46652005000600001. PMID: 16553319

Therapy

Abrha S, Tesfaye W, Thomas J
Am J Trop Med Hyg 2021 Oct 26;105(5):1157-1162. doi: 10.4269/ajtmh.21-0427. PMID: 34731831Free PMC Article
Miller H, Trujillo-Trujillo J, Mutebi F, Feldmeier H
Braz J Infect Dis 2020 Mar-Apr;24(2):170-177. Epub 2020 Feb 24 doi: 10.1016/j.bjid.2020.01.004. PMID: 32105621Free PMC Article
Coates SJ, Thomas C, Chosidow O, Engelman D, Chang AY
J Am Acad Dermatol 2020 Mar;82(3):551-569. Epub 2019 Jul 13 doi: 10.1016/j.jaad.2019.05.110. PMID: 31306729
Nordlund JJ
Dermatol Ther 2009 Nov-Dec;22(6):503-17. doi: 10.1111/j.1529-8019.2009.01273.x. PMID: 19889135
Heukelbach J, Feldmeier H
Lancet 2004 Mar 13;363(9412):889-91. doi: 10.1016/S0140-6736(04)15738-3. PMID: 15032237

Prognosis

Miller H, Ocampo J, Ayala A, Trujillo J, Feldmeier H
PLoS Negl Trop Dis 2019 Feb;13(2):e0007068. Epub 2019 Feb 7 doi: 10.1371/journal.pntd.0007068. PMID: 30730885Free PMC Article
Lacarrubba F, Verzì AE, Dinotta F, Scavo S, Micali G
G Ital Dermatol Venereol 2015 Oct;150(5):521-31. PMID: 26333553
O'Brien BM
Travel Med Infect Dis 2009 May;7(3):125-46. Epub 2009 Apr 11 doi: 10.1016/j.tmaid.2009.03.003. PMID: 19411040
Heukelbach J, Gomide M, Araújo F Jr, Pinto NS, Santana RD, Brito JR, Feldmeier H
J Travel Med 2007 Nov-Dec;14(6):374-80. doi: 10.1111/j.1708-8305.2007.00156.x. PMID: 17995532
Romano C, Albanese G, Gianni C
Eur J Dermatol 2004 Jan-Feb;14(1):58-60. PMID: 14965799

Clinical prediction guides

Rasoamialy-Soa Razanakolona L, Raharisoa A, Soankasina AH, De La Croix Jaonasoa J, Nicolas P, Antilahy JA, Chebbah D, Akhoundi M, Izri A
Travel Med Infect Dis 2022 Nov-Dec;50:102449. Epub 2022 Sep 14 doi: 10.1016/j.tmaid.2022.102449. PMID: 36113754
Miller H, Trujillo-Trujillo J, Mutebi F, Feldmeier H
Braz J Infect Dis 2020 Mar-Apr;24(2):170-177. Epub 2020 Feb 24 doi: 10.1016/j.bjid.2020.01.004. PMID: 32105621Free PMC Article
Nazzaro G, Genovese G, Veraldi S
J Cutan Pathol 2019 Apr;46(4):251-255. Epub 2019 Feb 4 doi: 10.1111/cup.13410. PMID: 30632189
Lefebvre M, Capito C, Durant C, Hervier B, Grossi O
Med Mal Infect 2011 Sep;41(9):465-8. Epub 2011 Jun 23 doi: 10.1016/j.medmal.2011.05.007. PMID: 21703785
Veraldi S, Valsecchi M
Int J Dermatol 2007 Oct;46(10):1061-6. doi: 10.1111/j.1365-4632.2007.03280.x. PMID: 17910715

Recent systematic reviews

Tardin Martins AC, de Brito AR, Kurizky PS, Gonçalves RG, Santana YRT, de Carvalho FCA, Gomes CM
PLoS Negl Trop Dis 2021 Aug;15(8):e0009722. Epub 2021 Aug 20 doi: 10.1371/journal.pntd.0009722. PMID: 34415904Free PMC Article
Abrha S, Heukelbach J, Peterson GM, Christenson JK, Carroll S, Kosari S, Bartholomeus A, Feldmeier H, Thomas J
Lancet Infect Dis 2021 Aug;21(8):e234-e245. Epub 2021 Jul 5 doi: 10.1016/S1473-3099(20)30853-7. PMID: 34237261
Obebe OO, Aluko OO
Pathog Glob Health 2020 Oct;114(7):360-369. Epub 2020 Sep 10 doi: 10.1080/20477724.2020.1813489. PMID: 32909926Free PMC Article
Tomczyk S, Deribe K, Brooker SJ, Clark H, Rafique K, Knopp S, Utzinger J, Davey G
PLoS Negl Trop Dis 2014;8(11):e3285. Epub 2014 Nov 13 doi: 10.1371/journal.pntd.0003285. PMID: 25393620Free PMC Article
Zalaudek I, Giacomel J, Cabo H, Di Stefani A, Ferrara G, Hofmann-Wellenhof R, Malvehy J, Puig S, Stolz W, Argenziano G
Dermatology 2008;216(1):14-23. doi: 10.1159/000109353. PMID: 18032894

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