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Essential tremor

MedGen UID:
78725
•Concept ID:
C0270736
•
Disease or Syndrome
Synonyms: Benign essential tremor syndrome; Presenile tremor syndrome
SNOMED CT: Essential tremor (609558009)
 
Related gene: DRD3
 
Monarch Initiative: MONDO:0003233
OMIM® Phenotypic series: PS190300
Orphanet: ORPHA862

Definition

A movement disorder characterized by involuntary and rhythmic shaking of parts of the body, most often the hands or arms, that can be triggered or worsened by physical or environmental stressors. Essential tremor may be progressive and can be inherited in an autosomal dominant manner. [from NCI]

Professional guidelines

PubMed

Diagnosis and Treatment of Essential Tremor.
Wagle Shukla A
Continuum (Minneap Minn) 2022 Oct 1;28(5):1333-1349. doi: 10.1212/CON.0000000000001181. PMID: 36222768
Essential tremor: diagnosis and management.
Shanker V
BMJ 2019 Aug 5;366:l4485. doi: 10.1136/bmj.l4485. PMID: 31383632
Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society.
Bhatia KP, Bain P, Bajaj N, Elble RJ, Hallett M, Louis ED, Raethjen J, Stamelou M, Testa CM, Deuschl G; Tremor Task Force of the International Parkinson and Movement Disorder Society
Mov Disord 2018 Jan;33(1):75-87. Epub 2017 Nov 30 doi: 10.1002/mds.27121. PMID: 29193359Free PMC Article

Recent clinical studies

Etiology

Essential tremor.
Louis ED
Handb Clin Neurol 2023;196:389-401. doi: 10.1016/B978-0-323-98817-9.00012-0. PMID: 37620080
Essential Tremor - Deep Brain Stimulation vs. Focused Ultrasound.
Ferreira Felloni Borges Y, Cheyuo C, Lozano AM, Fasano A
Expert Rev Neurother 2023 Jul-Dec;23(7):603-619. Epub 2023 Jun 8 doi: 10.1080/14737175.2023.2221789. PMID: 37288812
Magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results.
Cosgrove GR, Lipsman N, Lozano AM, Chang JW, Halpern C, Ghanouni P, Eisenberg H, Fishman P, Taira T, Schwartz ML, McDannold N, Hayes M, Ro S, Shah B, Gwinn R, Santini VE, Hynynen K, Elias WJ
J Neurosurg 2023 Apr 1;138(4):1028-1033. Epub 2022 Aug 5 doi: 10.3171/2022.6.JNS212483. PMID: 35932269Free PMC Article
Essential tremor.
Welton T, Cardoso F, Carr JA, Chan LL, Deuschl G, Jankovic J, Tan EK
Nat Rev Dis Primers 2021 Nov 11;7(1):83. doi: 10.1038/s41572-021-00314-w. PMID: 34764294
Clinical approach to tremor in children.
Torres-Russotto D
Parkinsonism Relat Disord 2019 Feb;59:111-116. Epub 2019 Mar 23 doi: 10.1016/j.parkreldis.2019.03.015. PMID: 30952437

Diagnosis

Essential tremor.
Louis ED
Handb Clin Neurol 2023;196:389-401. doi: 10.1016/B978-0-323-98817-9.00012-0. PMID: 37620080
Diagnosis and Treatment of Essential Tremor.
Wagle Shukla A
Continuum (Minneap Minn) 2022 Oct 1;28(5):1333-1349. doi: 10.1212/CON.0000000000001181. PMID: 36222768
Managing Essential Tremor.
Hopfner F, Deuschl G
Neurotherapeutics 2020 Oct;17(4):1603-1621. doi: 10.1007/s13311-020-00899-2. PMID: 32915385Free PMC Article
Essential tremor: diagnosis and management.
Shanker V
BMJ 2019 Aug 5;366:l4485. doi: 10.1136/bmj.l4485. PMID: 31383632
Clinical approach to tremor in children.
Torres-Russotto D
Parkinsonism Relat Disord 2019 Feb;59:111-116. Epub 2019 Mar 23 doi: 10.1016/j.parkreldis.2019.03.015. PMID: 30952437

Therapy

Medications used to treat tremors.
Frei K, Truong DD
J Neurol Sci 2022 Apr 15;435:120194. Epub 2022 Feb 19 doi: 10.1016/j.jns.2022.120194. PMID: 35279634
Managing Essential Tremor.
Hopfner F, Deuschl G
Neurotherapeutics 2020 Oct;17(4):1603-1621. doi: 10.1007/s13311-020-00899-2. PMID: 32915385Free PMC Article
Essential tremor: diagnosis and management.
Shanker V
BMJ 2019 Aug 5;366:l4485. doi: 10.1136/bmj.l4485. PMID: 31383632
Tremor.
Louis ED
Continuum (Minneap Minn) 2019 Aug;25(4):959-975. doi: 10.1212/CON.0000000000000748. PMID: 31356289
Essential Tremor.
Haubenberger D, Hallett M
N Engl J Med 2018 May 10;378(19):1802-1810. doi: 10.1056/NEJMcp1707928. PMID: 29742376

Prognosis

Magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results.
Cosgrove GR, Lipsman N, Lozano AM, Chang JW, Halpern C, Ghanouni P, Eisenberg H, Fishman P, Taira T, Schwartz ML, McDannold N, Hayes M, Ro S, Shah B, Gwinn R, Santini VE, Hynynen K, Elias WJ
J Neurosurg 2023 Apr 1;138(4):1028-1033. Epub 2022 Aug 5 doi: 10.3171/2022.6.JNS212483. PMID: 35932269Free PMC Article
Technology of deep brain stimulation: current status and future directions.
Krauss JK, Lipsman N, Aziz T, Boutet A, Brown P, Chang JW, Davidson B, Grill WM, Hariz MI, Horn A, Schulder M, Mammis A, Tass PA, Volkmann J, Lozano AM
Nat Rev Neurol 2021 Feb;17(2):75-87. Epub 2020 Nov 26 doi: 10.1038/s41582-020-00426-z. PMID: 33244188Free PMC Article
Surgery for Dystonia and Tremor.
Crowell JL, Shah BB
Curr Neurol Neurosci Rep 2016 Mar;16(3):22. doi: 10.1007/s11910-016-0627-8. PMID: 26838349
Movement disorders in childhood.
Cardoso F
Parkinsonism Relat Disord 2014 Jan;20 Suppl 1:S13-6. doi: 10.1016/S1353-8020(13)70006-3. PMID: 24262164
Essential tremor.
Murray TJ
Can Med Assoc J 1981 Jun 15;124(12):1559-65, 1570. PMID: 7018658Free PMC Article

Clinical prediction guides

Severe and unclassifiable tremor.
Serrano-Dueñas M
Arq Neuropsiquiatr 2024 Oct;82(10):1-5. Epub 2024 Oct 13 doi: 10.1055/s-0044-1790196. PMID: 39396518
Magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor: 5-year follow-up results.
Cosgrove GR, Lipsman N, Lozano AM, Chang JW, Halpern C, Ghanouni P, Eisenberg H, Fishman P, Taira T, Schwartz ML, McDannold N, Hayes M, Ro S, Shah B, Gwinn R, Santini VE, Hynynen K, Elias WJ
J Neurosurg 2023 Apr 1;138(4):1028-1033. Epub 2022 Aug 5 doi: 10.3171/2022.6.JNS212483. PMID: 35932269Free PMC Article
Rationale and Evidence for Peripheral Nerve Stimulation for Treating Essential Tremor.
Wagle Shukla A
Tremor Other Hyperkinet Mov (N Y) 2022;12:20. Epub 2022 Jun 14 doi: 10.5334/tohm.685. PMID: 35949227Free PMC Article
Essential tremor.
Welton T, Cardoso F, Carr JA, Chan LL, Deuschl G, Jankovic J, Tan EK
Nat Rev Dis Primers 2021 Nov 11;7(1):83. doi: 10.1038/s41572-021-00314-w. PMID: 34764294
Diffusion along perivascular spaces reveals evidence supportive of glymphatic function impairment in Parkinson disease.
McKnight CD, Trujillo P, Lopez AM, Petersen K, Considine C, Lin YC, Yan Y, Kang H, Donahue MJ, Claassen DO
Parkinsonism Relat Disord 2021 Aug;89:98-104. Epub 2021 Jun 10 doi: 10.1016/j.parkreldis.2021.06.004. PMID: 34271425Free PMC Article

Recent systematic reviews

A Review of the Current Therapies, Challenges, and Future Directions of Transcranial Focused Ultrasound Technology: Advances in Diagnosis and Treatment.
Krishna V, Sammartino F, Rezai A
JAMA Neurol 2018 Feb 1;75(2):246-254. doi: 10.1001/jamaneurol.2017.3129. PMID: 29228074
Zonisamide for essential tremor.
Bruno E, Nicoletti A, Filippini G, Quattrocchi G, Colosimo C, Zappia M
Cochrane Database Syst Rev 2017 Aug 24;8(8):CD009684. doi: 10.1002/14651858.CD009684.pub2. PMID: 28836659Free PMC Article
Topiramate for essential tremor.
Bruno E, Nicoletti A, Quattrocchi G, Allegra R, Filippini G, Colosimo C, Zappia M
Cochrane Database Syst Rev 2017 Apr 14;4(4):CD009683. doi: 10.1002/14651858.CD009683.pub2. PMID: 28409827Free PMC Article
Pregabalin for essential tremor.
Bruno E, Nicoletti A, Quattrocchi G, Filippini G, Colosimo C, Zappia M
Cochrane Database Syst Rev 2016 Oct 20;10(10):CD009682. doi: 10.1002/14651858.CD009682.pub2. PMID: 27763691Free PMC Article
Essential tremor.
Ferreira JJ, Sampaio C
BMJ Clin Evid 2007 May 1;2007 PMID: 19454072Free PMC Article

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