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Cervical endometriosis

MedGen UID:
78705
•Concept ID:
C0269107
•
Disease or Syndrome
Synonyms: Cervical Endometriosis; cervical endometriosis; cervix endometriosis; endometriosis (disease) of uterine cervix; Endometriosis of cervix; endometriosis of cervix; uterine cervix endometriosis (disease)
SNOMED CT: Endometriosis of cervix (61640006)
 
HPO: HP:0012889
Monarch Initiative: MONDO:0002706

Definition

Abnormal growth of endometrial cells (which are normally limited to the uterus) within the cervix. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical endometriosis

Professional guidelines

PubMed

Cervical endometriosis: a diagnostic and management dilemma.
Phadnis SV, Doshi JS, Ogunnaike O, Coady A, Padwick M, Sanusi FA
Arch Gynecol Obstet 2005 Oct;272(4):289-93. Epub 2005 Oct 13 doi: 10.1007/s00404-005-0006-1. PMID: 16021490
Systematic review of the treatment of ovulatory infertility with clomiphene citrate and intrauterine insemination.
Costello MF
Aust N Z J Obstet Gynaecol 2004 Apr;44(2):93-102. doi: 10.1111/j.1479-828X.2004.00192.x. PMID: 15089830
The treatment of normospermic infertility by gamete intrafallopian transfer (GIFT).
Yovich JL, Matson PL, Blackledge DG, Turner SR, Richardson PA, Yovich JM, Edirisinghe WR
Br J Obstet Gynaecol 1988 Apr;95(4):361-6. doi: 10.1111/j.1471-0528.1988.tb06606.x. PMID: 3382609

Recent clinical studies

Etiology

Coexistence of cervical endometriosis with premalignant and malignant gynecological pathologies: report on a series of 27 cases.
Matalliotakis M, Matalliotaki C, Zervou MI, Krithinakis K, Kalogiannidis I, Goulielmos GN
Women Health 2021 Oct;61(9):896-901. Epub 2021 Oct 25 doi: 10.1080/03630242.2021.1991073. PMID: 34696701
Post-coital bleeding: a rare and unusual presentation of cervical endometriosis.
Selo-Ojeme D, Freeman-Wang T, Khan NH
Arch Gynecol Obstet 2006 Mar;273(6):370-3. Epub 2006 Jan 22 doi: 10.1007/s00404-005-0034-x. PMID: 16429321
Superficial endometriosis of the cervix: A source of abnormal glandular cells on cervicovaginal smears.
Szyfelbein WM, Baker PM, Bell DA
Diagn Cytopathol 2004 Feb;30(2):88-91. doi: 10.1002/dc.10418. PMID: 14755757
AGUS in cervical endometriosis.
Symonds DA, Reed TP, Didolkar SM, Graham RR
J Reprod Med 1997 Jan;42(1):39-43. PMID: 9018644
Cone biopsy causes cervical endometriosis and tubo-endometrioid metaplasia.
Ismail SM
Histopathology 1991 Feb;18(2):107-14. doi: 10.1111/j.1365-2559.1991.tb01452.x. PMID: 2010178

Diagnosis

A Rare Case of the Cervical Endometriosis and Overview of the Literature.
Atalay Mert S, Dilbaz B, Ercan EE, Sahin Duran F
Reprod Sci 2023 Sep;30(9):2882-2886. Epub 2023 Apr 20 doi: 10.1007/s43032-023-01238-4. PMID: 37079271
Diagnostic value of p16 and Ki-67 expression in cervical glandular intraepithelial disease: A review.
Pereira Pinto P, Zanine RM
Ann Diagn Pathol 2023 Feb;62:152054. Epub 2022 Oct 14 doi: 10.1016/j.anndiagpath.2022.152054. PMID: 36396551
Coexistence of cervical endometriosis with premalignant and malignant gynecological pathologies: report on a series of 27 cases.
Matalliotakis M, Matalliotaki C, Zervou MI, Krithinakis K, Kalogiannidis I, Goulielmos GN
Women Health 2021 Oct;61(9):896-901. Epub 2021 Oct 25 doi: 10.1080/03630242.2021.1991073. PMID: 34696701
Cervical endometriosis: case series and review of literature.
Wong FW, Lim CE, Karia S, Santos L
J Obstet Gynaecol Res 2010 Aug;36(4):916-9. doi: 10.1111/j.1447-0756.2010.01209.x. PMID: 20666970
The pathology of endometriosis: a survey of the many faces of a common disease emphasizing diagnostic pitfalls and unusual and newly appreciated aspects.
Clement PB
Adv Anat Pathol 2007 Jul;14(4):241-60. doi: 10.1097/PAP.0b013e3180ca7d7b. PMID: 17592255

Therapy

Polypoid endometriosis of the uterine cervix with Arias-Stella reaction in a patient taking phytoestrogens.
Félix A, Nogales FF, Arias-Stella J
Int J Gynecol Pathol 2010 Mar;29(2):185-8. doi: 10.1097/PGP.0b013e3181b7015e. PMID: 20173505
Systematic review of the treatment of ovulatory infertility with clomiphene citrate and intrauterine insemination.
Costello MF
Aust N Z J Obstet Gynaecol 2004 Apr;44(2):93-102. doi: 10.1111/j.1479-828X.2004.00192.x. PMID: 15089830
The use of carbon-dioxide laser surgery in the treatment of intraepithelial neoplasia of the uterine cervix.
Favalli G, Lomini M, Schreiber C, Ciravolo G, Junasevic J, Pecorelli S, Bianchi UA
Przegl Lek 1999;56(1):58-64. PMID: 10375929
AGUS in cervical endometriosis.
Symonds DA, Reed TP, Didolkar SM, Graham RR
J Reprod Med 1997 Jan;42(1):39-43. PMID: 9018644
Cone biopsy causes cervical endometriosis and tubo-endometrioid metaplasia.
Ismail SM
Histopathology 1991 Feb;18(2):107-14. doi: 10.1111/j.1365-2559.1991.tb01452.x. PMID: 2010178

Prognosis

Massive Hemorrhage Due to Cervical Endometriotic Cyst Rupture: Two Case Reports and a Literature Review.
Matoba Y, Tsuji K, Morisada T, Takahashi M, Kobayashi Y, Nakamura M, Banno K, Aoki D
Am J Case Rep 2021 Nov 24;22:e934120. doi: 10.12659/AJCR.934120. PMID: 34818313Free PMC Article
Fine needle aspiration cytology: a tool to diagnose cervical and vaginal endometriosis in low-income places.
Oliveira-Filho M, Rao VS, Eleutério J Jr, Medeiros FC
Acta Cytol 2013;57(2):203-6. Epub 2013 Feb 28 doi: 10.1159/000345898. PMID: 23406608
PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma.
Rabban JT, McAlhany S, Lerwill MF, Grenert JP, Zaloudek CJ
Am J Surg Pathol 2010 Feb;34(2):137-46. doi: 10.1097/PAS.0b013e3181c89c98. PMID: 20061933
The use of carbon-dioxide laser surgery in the treatment of intraepithelial neoplasia of the uterine cervix.
Favalli G, Lomini M, Schreiber C, Ciravolo G, Junasevic J, Pecorelli S, Bianchi UA
Przegl Lek 1999;56(1):58-64. PMID: 10375929
Clinical evaluation of follow-up methods and results of atypical glandular cells of undetermined significance (AGUS) detected on cervicovaginal Pap smears.
Kim TJ, Kim HS, Park CT, Park IS, Hong SR, Park JS, Shim JU
Gynecol Oncol 1999 May;73(2):292-8. doi: 10.1006/gyno.1999.5360. PMID: 10329049

Clinical prediction guides

A Rare Case of the Cervical Endometriosis and Overview of the Literature.
Atalay Mert S, Dilbaz B, Ercan EE, Sahin Duran F
Reprod Sci 2023 Sep;30(9):2882-2886. Epub 2023 Apr 20 doi: 10.1007/s43032-023-01238-4. PMID: 37079271
Massive Hemorrhage Due to Cervical Endometriotic Cyst Rupture: Two Case Reports and a Literature Review.
Matoba Y, Tsuji K, Morisada T, Takahashi M, Kobayashi Y, Nakamura M, Banno K, Aoki D
Am J Case Rep 2021 Nov 24;22:e934120. doi: 10.12659/AJCR.934120. PMID: 34818313Free PMC Article
Fine needle aspiration cytology: a tool to diagnose cervical and vaginal endometriosis in low-income places.
Oliveira-Filho M, Rao VS, Eleutério J Jr, Medeiros FC
Acta Cytol 2013;57(2):203-6. Epub 2013 Feb 28 doi: 10.1159/000345898. PMID: 23406608
Cervical endometriosis associated with malignant pleural mesothelioma mimicking cervical cancer--Occam's razor or the "third man".
Engel JB, Heuer S, Segerer S, Rauthe S, Dietl J, Hönig A
Fertil Steril 2011 Apr;95(5):1787.e5-7. Epub 2010 Dec 23 doi: 10.1016/j.fertnstert.2010.11.064. PMID: 21183177
CD10 and calretinin staining of endocervical glandular lesions, endocervical stroma and endometrioid adenocarcinomas of the uterine corpus: CD10 positivity is characteristic of, but not specific for, mesonephric lesions and is not specific for endometrial stroma.
McCluggage WG, Oliva E, Herrington CS, McBride H, Young RH
Histopathology 2003 Aug;43(2):144-50. doi: 10.1046/j.1365-2559.2003.01684.x. PMID: 12877729

Recent systematic reviews

Systematic review of the treatment of ovulatory infertility with clomiphene citrate and intrauterine insemination.
Costello MF
Aust N Z J Obstet Gynaecol 2004 Apr;44(2):93-102. doi: 10.1111/j.1479-828X.2004.00192.x. PMID: 15089830

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