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Rokitansky-Aschoff sinuses of the gallbladder

MedGen UID:
78636
•Concept ID:
C0267892
•
Disease or Syndrome
Synonyms: Intramural diverticulosis of the gallbladder; Rokitansky-Aschoff sinuses
SNOMED CT: Rokitansky-Aschoff sinuses (22149007); Aschoff-Rokitansky sinuses (22149007)
 
Monarch Initiative: MONDO:0043291

Definition

An abnormality characterized by macroscopic or microscopic outpouchings of gallbladder mucosa into the muscle of the gallbladder wall. It may be associated with cholecystitis or gallstones. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRokitansky-Aschoff sinuses of the gallbladder

Recent clinical studies

Etiology

Clinical strategies for differentiating IgG4-related cholecystitis from gallbladder carcinoma to avoid unnecessary surgical resection.
Zhang R, Lin HM, Cai ZX, Du SJ, Zeng H, Xu LB, Wang J, Liu C
Sci China Life Sci 2020 May;63(5):764-770. Epub 2019 Jul 17 doi: 10.1007/s11427-019-9539-6. PMID: 31321666
Adenomyomatosis Concomitant with Primary Gallbladder Carcinoma.
Morikawa T, Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Saisaka Y, Tokumaru T, Sui K, Iwata J, Matsumoto M, Morita S, Nishioka Y
Acta Med Okayama 2017 Apr;71(2):113-118. doi: 10.18926/AMO/54979. PMID: 28420892
Early gallbladder carcinoma has a favorable outcome but Rokitansky-Aschoff sinus involvement is an adverse prognostic factor.
Roa JC, Tapia O, Manterola C, Villaseca M, Guzman P, Araya JC, Bagci P, Saka B, Adsay V
Virchows Arch 2013 Nov;463(5):651-61. Epub 2013 Sep 11 doi: 10.1007/s00428-013-1478-1. PMID: 24022828
Rokitansky-Aschoff sinuses of the gallbladder are associated with black pigment gallstone formation: a scanning electron microscopy study.
Cariati A, Cetta F
Ultrastruct Pathol 2003 Jul-Aug;27(4):265-70. doi: 10.1080/01913120309913. PMID: 12907372

Diagnosis

Cyst of the gallbladder.
Yamazaki S, Takahashi Y, Seki H, Ochi Y, Horiuchi I, Kusama Y, Imai S, Kobayashi A
Surgery 2021 Aug;170(2):e5-e6. Epub 2021 Mar 4 doi: 10.1016/j.surg.2021.01.024. PMID: 34238431
Imaging-based algorithmic approach to gallbladder wall thickening.
Gupta P, Marodia Y, Bansal A, Kalra N, Kumar-M P, Sharma V, Dutta U, Sandhu MS
World J Gastroenterol 2020 Oct 28;26(40):6163-6181. doi: 10.3748/wjg.v26.i40.6163. PMID: 33177791Free PMC Article
Adenomyomatosis Concomitant with Primary Gallbladder Carcinoma.
Morikawa T, Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Saisaka Y, Tokumaru T, Sui K, Iwata J, Matsumoto M, Morita S, Nishioka Y
Acta Med Okayama 2017 Apr;71(2):113-118. doi: 10.18926/AMO/54979. PMID: 28420892
Diffuse Adenomyomatosis of the Gallbladder in a Child.
Eroğlu N, Erduran E, İmamoğlu M, Sağnak Z, Cansu A
J Pediatr Hematol Oncol 2016 Nov;38(8):e307-e309. doi: 10.1097/MPH.0000000000000640. PMID: 27403774
Rokitansky-Aschoff sinuses mimicking adenocarcinoma of the gallbladder: a study of 8 cases.
Dorantes-Heredia R, Chablé-Montero F, Henson DE, Albores-Saavedra J
Am J Surg Pathol 2013 Aug;37(8):1269-74. doi: 10.1097/PAS.0b013e318286bd39. PMID: 23715158

Prognosis

Imaging-based algorithmic approach to gallbladder wall thickening.
Gupta P, Marodia Y, Bansal A, Kalra N, Kumar-M P, Sharma V, Dutta U, Sandhu MS
World J Gastroenterol 2020 Oct 28;26(40):6163-6181. doi: 10.3748/wjg.v26.i40.6163. PMID: 33177791Free PMC Article
Clinical strategies for differentiating IgG4-related cholecystitis from gallbladder carcinoma to avoid unnecessary surgical resection.
Zhang R, Lin HM, Cai ZX, Du SJ, Zeng H, Xu LB, Wang J, Liu C
Sci China Life Sci 2020 May;63(5):764-770. Epub 2019 Jul 17 doi: 10.1007/s11427-019-9539-6. PMID: 31321666
Early gallbladder carcinoma has a favorable outcome but Rokitansky-Aschoff sinus involvement is an adverse prognostic factor.
Roa JC, Tapia O, Manterola C, Villaseca M, Guzman P, Araya JC, Bagci P, Saka B, Adsay V
Virchows Arch 2013 Nov;463(5):651-61. Epub 2013 Sep 11 doi: 10.1007/s00428-013-1478-1. PMID: 24022828
Rokitansky-Aschoff sinuses mimicking adenocarcinoma of the gallbladder: a study of 8 cases.
Dorantes-Heredia R, Chablé-Montero F, Henson DE, Albores-Saavedra J
Am J Surg Pathol 2013 Aug;37(8):1269-74. doi: 10.1097/PAS.0b013e318286bd39. PMID: 23715158

Clinical prediction guides

Imaging-based algorithmic approach to gallbladder wall thickening.
Gupta P, Marodia Y, Bansal A, Kalra N, Kumar-M P, Sharma V, Dutta U, Sandhu MS
World J Gastroenterol 2020 Oct 28;26(40):6163-6181. doi: 10.3748/wjg.v26.i40.6163. PMID: 33177791Free PMC Article
Rokitansky-Aschoff sinuses mimicking adenocarcinoma of the gallbladder: a study of 8 cases.
Dorantes-Heredia R, Chablé-Montero F, Henson DE, Albores-Saavedra J
Am J Surg Pathol 2013 Aug;37(8):1269-74. doi: 10.1097/PAS.0b013e318286bd39. PMID: 23715158

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