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Gastric dysplasia

MedGen UID:
78625
•Concept ID:
C0267111
•
Disease or Syndrome
Synonyms: Gastric Dysplasia; Gastric Glandular Intraepithelial Dysplasia; Gastric Glandular Intraepithelial Neoplasia; Gastric Intraepithelial Neoplasia; Gastric Intraepithelial Neoplasia (Dysplasia); Intraepithelial Neoplasia (Dysplasia) of Stomach; Intraepithelial Neoplasia (Dysplasia) of the Stomach; Stomach dysplasia; Stomach Intraepithelial Neoplasia (Dysplasia)
SNOMED CT: Stomach dysplasia (20915006); Gastric dysplasia (20915006)

Definition

A morphologic finding indicating the presence of dysplastic changes within the gastric mucosal epithelial cells. [from NCI]

Professional guidelines

PubMed

Helicobacter pylori Treatment and Gastric Cancer Risk After Endoscopic Resection of Dysplasia: A Nationwide Cohort Study.
Yoo HW, Hong SJ, Kim SH
Gastroenterology 2024 Feb;166(2):313-322.e3. Epub 2023 Oct 18 doi: 10.1053/j.gastro.2023.10.013. PMID: 37863270
Endoscopic diagnosis and treatment of gastric dysplasia and early cancer: Current evidence and what the future may hold.
Young E, Philpott H, Singh R
World J Gastroenterol 2021 Aug 21;27(31):5126-5151. doi: 10.3748/wjg.v27.i31.5126. PMID: 34497440Free PMC Article
British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma.
Banks M, Graham D, Jansen M, Gotoda T, Coda S, di Pietro M, Uedo N, Bhandari P, Pritchard DM, Kuipers EJ, Rodriguez-Justo M, Novelli MR, Ragunath K, Shepherd N, Dinis-Ribeiro M
Gut 2019 Sep;68(9):1545-1575. Epub 2019 Jul 5 doi: 10.1136/gutjnl-2018-318126. PMID: 31278206Free PMC Article

Recent clinical studies

Etiology

Helicobacter pylori Treatment and Gastric Cancer Risk After Endoscopic Resection of Dysplasia: A Nationwide Cohort Study.
Yoo HW, Hong SJ, Kim SH
Gastroenterology 2024 Feb;166(2):313-322.e3. Epub 2023 Oct 18 doi: 10.1053/j.gastro.2023.10.013. PMID: 37863270
Induction of Fibroblast Growth Factor Receptor 4 by Helicobacter pylori via Signal Transducer and Activator of Transcription 3 With a Feedforward Activation Loop Involving SRC Signaling in Gastric Cancer.
Zhang X, Soutto M, Chen Z, Bhat N, Zhu S, Eissmann MF, Ernst M, Lu H, Peng D, Xu Z, El-Rifai W
Gastroenterology 2022 Sep;163(3):620-636.e9. Epub 2022 May 17 doi: 10.1053/j.gastro.2022.05.016. PMID: 35588797Free PMC Article
British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma.
Banks M, Graham D, Jansen M, Gotoda T, Coda S, di Pietro M, Uedo N, Bhandari P, Pritchard DM, Kuipers EJ, Rodriguez-Justo M, Novelli MR, Ragunath K, Shepherd N, Dinis-Ribeiro M
Gut 2019 Sep;68(9):1545-1575. Epub 2019 Jul 5 doi: 10.1136/gutjnl-2018-318126. PMID: 31278206Free PMC Article
Diagnosis and management of gastric dysplasia.
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Gastric epithelial dysplasia.
Misdraji J, Lauwers GY
Semin Diagn Pathol 2002 Feb;19(1):20-30. PMID: 11936263

Diagnosis

Gastric Intestinal Metaplasia: Real Culprit or Innocent Bystander as a Precancerous Condition for Gastric Cancer?
Sugano K, Moss SF, Kuipers EJ
Gastroenterology 2023 Dec;165(6):1352-1366.e1. Epub 2023 Aug 29 doi: 10.1053/j.gastro.2023.08.028. PMID: 37652306
Endoscopic diagnosis and treatment of gastric dysplasia and early cancer: Current evidence and what the future may hold.
Young E, Philpott H, Singh R
World J Gastroenterol 2021 Aug 21;27(31):5126-5151. doi: 10.3748/wjg.v27.i31.5126. PMID: 34497440Free PMC Article
Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer.
Battista S, Ambrosio MR, Limarzi F, Gallo G, Saragoni L
Int J Mol Sci 2021 Jun 22;22(13) doi: 10.3390/ijms22136652. PMID: 34206291Free PMC Article
Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes.
Gullo I, Grillo F, Mastracci L, Vanoli A, Carneiro F, Saragoni L, Limarzi F, Ferro J, Parente P, Fassan M
Pathologica 2020 Sep;112(3):166-185. doi: 10.32074/1591-951X-166. PMID: 33179620Free PMC Article
British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma.
Banks M, Graham D, Jansen M, Gotoda T, Coda S, di Pietro M, Uedo N, Bhandari P, Pritchard DM, Kuipers EJ, Rodriguez-Justo M, Novelli MR, Ragunath K, Shepherd N, Dinis-Ribeiro M
Gut 2019 Sep;68(9):1545-1575. Epub 2019 Jul 5 doi: 10.1136/gutjnl-2018-318126. PMID: 31278206Free PMC Article

Therapy

Colorectal dysplasia in chronic inflammatory bowel disease: a contemporary consensus classification and interobserver study.
Harpaz N, Goldblum JR, Shepherd NA, Riddell RH, Rubio CA, Vieth M, Wang HH, Odze RD
Hum Pathol 2023 Aug;138:49-61. Epub 2023 May 27 doi: 10.1016/j.humpath.2023.05.008. PMID: 37247824
Helicobacter Pylori: a comprehensive review for primary care providers.
Nelson A, Bi Y, Harris D
Rom J Intern Med 2021 Jun 1;59(2):112-118. Epub 2021 May 8 doi: 10.2478/rjim-2020-0043. PMID: 33565305
Diagnosis and management of gastric dysplasia.
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Safety of proton pump inhibitors and risk of gastric cancers: review of literature and pathophysiological mechanisms.
Ko Y, Tang J, Sanagapalli S, Kim BS, Leong RW
Expert Opin Drug Saf 2016 Jan;15(1):53-63. Epub 2015 Dec 14 doi: 10.1517/14740338.2016.1118050. PMID: 26560097
Review article: Antioxidant micronutrients and gastric cancer.
Correa P, Malcom G, Schmidt B, Fontham E, Ruiz B, Bravo JC, Bravo LE, Zarama G, Realpe JL
Aliment Pharmacol Ther 1998 Feb;12 Suppl 1:73-82. doi: 10.1111/j.1365-2036.1998.00006.x. PMID: 9701005

Prognosis

Helicobacter pylori Treatment and Gastric Cancer Risk After Endoscopic Resection of Dysplasia: A Nationwide Cohort Study.
Yoo HW, Hong SJ, Kim SH
Gastroenterology 2024 Feb;166(2):313-322.e3. Epub 2023 Oct 18 doi: 10.1053/j.gastro.2023.10.013. PMID: 37863270
Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer.
Battista S, Ambrosio MR, Limarzi F, Gallo G, Saragoni L
Int J Mol Sci 2021 Jun 22;22(13) doi: 10.3390/ijms22136652. PMID: 34206291Free PMC Article
Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes.
Gullo I, Grillo F, Mastracci L, Vanoli A, Carneiro F, Saragoni L, Limarzi F, Ferro J, Parente P, Fassan M
Pathologica 2020 Sep;112(3):166-185. doi: 10.32074/1591-951X-166. PMID: 33179620Free PMC Article
British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma.
Banks M, Graham D, Jansen M, Gotoda T, Coda S, di Pietro M, Uedo N, Bhandari P, Pritchard DM, Kuipers EJ, Rodriguez-Justo M, Novelli MR, Ragunath K, Shepherd N, Dinis-Ribeiro M
Gut 2019 Sep;68(9):1545-1575. Epub 2019 Jul 5 doi: 10.1136/gutjnl-2018-318126. PMID: 31278206Free PMC Article
Gastric dysplasia.
Sipponen P
Curr Top Pathol 1990;81:61-76. doi: 10.1007/978-3-642-74662-8_3. PMID: 2407446

Clinical prediction guides

Pathology and Clinical Relevance of Gastric Epithelial Dysplasia.
Ushiku T, Lauwers GY
Gastroenterol Clin North Am 2024 Mar;53(1):39-55. doi: 10.1016/j.gtc.2023.11.003. PMID: 38280750
Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes.
Gullo I, Grillo F, Mastracci L, Vanoli A, Carneiro F, Saragoni L, Limarzi F, Ferro J, Parente P, Fassan M
Pathologica 2020 Sep;112(3):166-185. doi: 10.32074/1591-951X-166. PMID: 33179620Free PMC Article
Diagnosis and management of gastric dysplasia.
Sung JK
Korean J Intern Med 2016 Mar;31(2):201-9. Epub 2016 Feb 26 doi: 10.3904/kjim.2016.021. PMID: 26932397Free PMC Article
Screening for and surveillance of gastric cancer.
Compare D, Rocco A, Nardone G
World J Gastroenterol 2014 Oct 14;20(38):13681-91. doi: 10.3748/wjg.v20.i38.13681. PMID: 25320506Free PMC Article
Gastric dysplasia.
Sipponen P
Curr Top Pathol 1990;81:61-76. doi: 10.1007/978-3-642-74662-8_3. PMID: 2407446

Recent systematic reviews

Incidence Rate of Gastric Cancer Adenocarcinoma in Patients With Gastric Dysplasia: A Systematic Review and Meta-Analysis.
Akbari M, Kardeh B, Tabrizi R, Ahmadizar F, Lankarani KB
J Clin Gastroenterol 2019 Nov/Dec;53(10):703-710. doi: 10.1097/MCG.0000000000001257. PMID: 31415022
Gastric cancer in patients with gastric atrophy and intestinal metaplasia: A systematic review and meta-analysis.
Akbari M, Tabrizi R, Kardeh S, Lankarani KB
PLoS One 2019;14(7):e0219865. Epub 2019 Jul 26 doi: 10.1371/journal.pone.0219865. PMID: 31348819Free PMC Article

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