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Basal-like breast carcinoma

MedGen UID:
770987
•Concept ID:
C3642347
•
Neoplastic Process
Synonyms: Basal-Like Breast Cancer; basal-like breast cancer; Basal-Like Breast Carcinoma; basal-like breast carcinoma; Basal-Like Subtype of Breast Carcinoma; basal-like subtype of breast carcinoma
 
Monarch Initiative: MONDO:0004984

Definition

A biologic subset of breast carcinoma defined by high expression of genes characteristic of basal epithelial cells, including KRT5 and KRT17, annexin 8, CX3CL1, and TRIM29, and usually by lack of expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). It is the most common subtype of breast cancer associated with BRCA1 mutations, and is associated with a poor prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBasal-like breast carcinoma

Professional guidelines

PubMed

Albumin-bound paclitaxel (ABI-007; Abraxane) in the management of basal-like breast carcinoma.
Altundag K, Dede DS, Purnak T
J Clin Pathol 2007 Aug;60(8):958. doi: 10.1136/jcp.2006.042481. PMID: 17660346Free PMC Article

Recent clinical studies

Therapy

Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma.
Kumar AP, Loo SY, Shin SW, Tan TZ, Eng CB, Singh R, Putti TC, Ong CW, Salto-Tellez M, Goh BC, Park JI, Thiery JP, Pervaiz S, Clement MV
Antioxid Redox Signal 2014 May 20;20(15):2326-46. Epub 2013 Nov 14 doi: 10.1089/ars.2013.5295. PMID: 23964924Free PMC Article
Exploring novel targets of basal-like breast carcinoma by comparative gene profiling and mechanism analysis.
Wu YM, Hu W, Wang Y, Wang N, Gao L, Chen ZZ, Zheng WQ
Breast Cancer Res Treat 2013 Aug;141(1):23-32. Epub 2013 Aug 10 doi: 10.1007/s10549-013-2664-1. PMID: 23933801

Prognosis

Molecular Classification of Breast Cancer.
Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
Basal-like breast cancer: update on clinicopathologic, immunohistochemical, and molecular features.
Leidy J, Khan A, Kandil D
Arch Pathol Lab Med 2014 Jan;138(1):37-43. doi: 10.5858/arpa.2012-0439-RA. PMID: 24377810
Basal-like breast carcinoma: a phenotypically distinct entity.
Haupt B, Ro JY, Schwartz MR
Arch Pathol Lab Med 2010 Jan;134(1):130-3. doi: 10.5858/134.1.130. PMID: 20073617
Basal-like breast carcinoma: from expression profiling to routine practice.
Rakha E, Reis-Filho JS
Arch Pathol Lab Med 2009 Jun;133(6):860-8. doi: 10.5858/133.6.860. PMID: 19492878
Impact of basal-like breast carcinoma determination for a more specific therapy.
Rakha EA, Reis-Filho JS, Ellis IO
Pathobiology 2008;75(2):95-103. Epub 2008 Jun 10 doi: 10.1159/000123847. PMID: 18544964

Clinical prediction guides

Molecular Classification of Breast Cancer.
Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
A clinicopathological study of triple-negative breast carcinoma in a patient cohort from a tertiary care center in Sri Lanka.
Wijesinghe HD, Fernando J, Senarath U, Wijesinghe GK, S Lokuhetty MD
Indian J Pathol Microbiol 2020 Jul-Sep;63(3):388-396. doi: 10.4103/IJPM.IJPM_657_19. PMID: 32769327
MicroRNA-205 directly targets Krüppel-like factor 12 and is involved in invasion and apoptosis in basal-like breast carcinoma.
Guan B, Li Q, Shen L, Rao Q, Wang Y, Zhu Y, Zhou XJ, Li XH
Int J Oncol 2016 Aug;49(2):720-34. Epub 2016 Jun 8 doi: 10.3892/ijo.2016.3573. PMID: 27278159
Exploring novel targets of basal-like breast carcinoma by comparative gene profiling and mechanism analysis.
Wu YM, Hu W, Wang Y, Wang N, Gao L, Chen ZZ, Zheng WQ
Breast Cancer Res Treat 2013 Aug;141(1):23-32. Epub 2013 Aug 10 doi: 10.1007/s10549-013-2664-1. PMID: 23933801
A comprehensive morphological study for basal-like breast carcinomas with comparison to nonbasal-like carcinomas.
Cakir A, Gonul II, Uluoglu O
Diagn Pathol 2012 Oct 20;7:145. doi: 10.1186/1746-1596-7-145. PMID: 23082819Free PMC Article

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