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Basal-like breast carcinoma

MedGen UID:
770987
•Concept ID:
C3642347
•
Neoplastic Process
Synonyms: Basal-Like Breast Cancer; basal-like breast cancer; Basal-Like Breast Carcinoma; basal-like breast carcinoma; Basal-Like Subtype of Breast Carcinoma; basal-like subtype of breast carcinoma
 
Monarch Initiative: MONDO:0004984

Definition

A biologic subset of breast carcinoma defined by high expression of genes characteristic of basal epithelial cells, including KRT5 and KRT17, annexin 8, CX3CL1, and TRIM29, and usually by lack of expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). It is the most common subtype of breast cancer associated with BRCA1 mutations, and is associated with a poor prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBasal-like breast carcinoma

Professional guidelines

PubMed

Albumin-bound paclitaxel (ABI-007; Abraxane) in the management of basal-like breast carcinoma.
Altundag K, Dede DS, Purnak T
J Clin Pathol 2007 Aug;60(8):958. doi: 10.1136/jcp.2006.042481. PMID: 17660346Free PMC Article

Recent clinical studies

Etiology

Nuclear CSPP1 expression defined subtypes of basal-like breast cancer.
Sternemalm J, Russnes HG, Zhao X, Risberg B, Nord S, Caldas C, Børresen-Dale AL, Stokke T, Patzke S
Br J Cancer 2014 Jul 15;111(2):326-38. Epub 2014 Jun 5 doi: 10.1038/bjc.2014.297. PMID: 24901235Free PMC Article
Basal-like breast cancer: update on clinicopathologic, immunohistochemical, and molecular features.
Leidy J, Khan A, Kandil D
Arch Pathol Lab Med 2014 Jan;138(1):37-43. doi: 10.5858/arpa.2012-0439-RA. PMID: 24377810
Exploring novel targets of basal-like breast carcinoma by comparative gene profiling and mechanism analysis.
Wu YM, Hu W, Wang Y, Wang N, Gao L, Chen ZZ, Zheng WQ
Breast Cancer Res Treat 2013 Aug;141(1):23-32. Epub 2013 Aug 10 doi: 10.1007/s10549-013-2664-1. PMID: 23933801
p16INK4a expression in basal-like breast carcinoma.
Bohn OL, Fuertes-Camilo M, Navarro L, Saldivar J, Sanchez-Sosa S
Int J Clin Exp Pathol 2010 Jun 30;3(6):600-7. PMID: 20661408Free PMC Article
CD109 expression in basal-like breast carcinoma.
Hasegawa M, Moritani S, Murakumo Y, Sato T, Hagiwara S, Suzuki C, Mii S, Jijiwa M, Enomoto A, Asai N, Ichihara S, Takahashi M
Pathol Int 2008 May;58(5):288-94. doi: 10.1111/j.1440-1827.2008.02225.x. PMID: 18429827

Diagnosis

Basal-like breast cancer: update on clinicopathologic, immunohistochemical, and molecular features.
Leidy J, Khan A, Kandil D
Arch Pathol Lab Med 2014 Jan;138(1):37-43. doi: 10.5858/arpa.2012-0439-RA. PMID: 24377810
Exploring novel targets of basal-like breast carcinoma by comparative gene profiling and mechanism analysis.
Wu YM, Hu W, Wang Y, Wang N, Gao L, Chen ZZ, Zheng WQ
Breast Cancer Res Treat 2013 Aug;141(1):23-32. Epub 2013 Aug 10 doi: 10.1007/s10549-013-2664-1. PMID: 23933801
Basal-like breast carcinoma: a phenotypically distinct entity.
Haupt B, Ro JY, Schwartz MR
Arch Pathol Lab Med 2010 Jan;134(1):130-3. doi: 10.5858/134.1.130. PMID: 20073617
Impact of basal-like breast carcinoma determination for a more specific therapy.
Rakha EA, Reis-Filho JS, Ellis IO
Pathobiology 2008;75(2):95-103. Epub 2008 Jun 10 doi: 10.1159/000123847. PMID: 18544964
CD109 expression in basal-like breast carcinoma.
Hasegawa M, Moritani S, Murakumo Y, Sato T, Hagiwara S, Suzuki C, Mii S, Jijiwa M, Enomoto A, Asai N, Ichihara S, Takahashi M
Pathol Int 2008 May;58(5):288-94. doi: 10.1111/j.1440-1827.2008.02225.x. PMID: 18429827

Therapy

Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma.
Kumar AP, Loo SY, Shin SW, Tan TZ, Eng CB, Singh R, Putti TC, Ong CW, Salto-Tellez M, Goh BC, Park JI, Thiery JP, Pervaiz S, Clement MV
Antioxid Redox Signal 2014 May 20;20(15):2326-46. Epub 2013 Nov 14 doi: 10.1089/ars.2013.5295. PMID: 23964924Free PMC Article
Exploring novel targets of basal-like breast carcinoma by comparative gene profiling and mechanism analysis.
Wu YM, Hu W, Wang Y, Wang N, Gao L, Chen ZZ, Zheng WQ
Breast Cancer Res Treat 2013 Aug;141(1):23-32. Epub 2013 Aug 10 doi: 10.1007/s10549-013-2664-1. PMID: 23933801

Prognosis

Molecular Classification of Breast Cancer.
Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
The Clinicopathological Significance of Basal Markers in Early-Stage Invasive Carcinoma of No Special Type of the Breast.
Dirilenoglu F, Etit DA, Taskaynatan H, Elmali F
Turk Patoloji Derg 2020;36(3):195-204. doi: 10.5146/tjpath.2020.01487. PMID: 32364614Free PMC Article
Basal-like breast cancer: update on clinicopathologic, immunohistochemical, and molecular features.
Leidy J, Khan A, Kandil D
Arch Pathol Lab Med 2014 Jan;138(1):37-43. doi: 10.5858/arpa.2012-0439-RA. PMID: 24377810
High expression of indoleamine 2,3-dioxygenase in the tumour is associated with medullary features and favourable outcome in basal-like breast carcinoma.
Jacquemier J, Bertucci F, Finetti P, Esterni B, Charafe-Jauffret E, Thibult ML, Houvenaeghel G, Van den Eynde B, Birnbaum D, Olive D, Xerri L
Int J Cancer 2012 Jan 1;130(1):96-104. doi: 10.1002/ijc.25979. PMID: 21328335
Impact of basal-like breast carcinoma determination for a more specific therapy.
Rakha EA, Reis-Filho JS, Ellis IO
Pathobiology 2008;75(2):95-103. Epub 2008 Jun 10 doi: 10.1159/000123847. PMID: 18544964

Clinical prediction guides

Molecular Classification of Breast Cancer.
Roy M, Fowler AM, Ulaner GA, Mahajan A
PET Clin 2023 Oct;18(4):441-458. Epub 2023 May 31 doi: 10.1016/j.cpet.2023.04.002. PMID: 37268505
MicroRNA-205 directly targets Krüppel-like factor 12 and is involved in invasion and apoptosis in basal-like breast carcinoma.
Guan B, Li Q, Shen L, Rao Q, Wang Y, Zhu Y, Zhou XJ, Li XH
Int J Oncol 2016 Aug;49(2):720-34. Epub 2016 Jun 8 doi: 10.3892/ijo.2016.3573. PMID: 27278159
Exploring novel targets of basal-like breast carcinoma by comparative gene profiling and mechanism analysis.
Wu YM, Hu W, Wang Y, Wang N, Gao L, Chen ZZ, Zheng WQ
Breast Cancer Res Treat 2013 Aug;141(1):23-32. Epub 2013 Aug 10 doi: 10.1007/s10549-013-2664-1. PMID: 23933801
Keratin 17 expression correlates with tumor progression and poor prognosis in gastric adenocarcinoma.
Ide M, Kato T, Ogata K, Mochiki E, Kuwano H, Oyama T
Ann Surg Oncol 2012 Oct;19(11):3506-14. Epub 2012 Jun 14 doi: 10.1245/s10434-012-2437-9. PMID: 22695933
High expression of indoleamine 2,3-dioxygenase in the tumour is associated with medullary features and favourable outcome in basal-like breast carcinoma.
Jacquemier J, Bertucci F, Finetti P, Esterni B, Charafe-Jauffret E, Thibult ML, Houvenaeghel G, Van den Eynde B, Birnbaum D, Olive D, Xerri L
Int J Cancer 2012 Jan 1;130(1):96-104. doi: 10.1002/ijc.25979. PMID: 21328335

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