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Thin toenail

MedGen UID:
767027
•Concept ID:
C3554113
•
Anatomical Abnormality; Finding
Synonym: Thin toenails
 
HPO: HP:0012746

Definition

Toenail that appears thin when viewed on end. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThin toenail

Conditions with this feature

Ectodermal dysplasia 6, hair/nail type
MedGen UID:
767025
•Concept ID:
C3554111
•
Disease or Syndrome
Some ectodermal dysplasias are here classified as congenital disorders characterized by abnormal development in 2 or more ectodermal structures (hair, nails, teeth, and sweat glands) without other systemic findings. Ectodermal dysplasia of the hair/nail type is a rare congenital condition characterized by hypotrichosis and nail dystrophy without nonectodermal or other ectodermal manifestations.
See: Condition Record
Ectodermal dysplasia 6, hair/nail type

Professional guidelines

PubMed

Fetal alcohol spectrum disorders - diagnostic difficulties in the neonatal period and new diagnostic approaches.
Jańczewska I, Wierzba J, Cichoń-Kotek M, Jańczewska A
Dev Period Med 2019;23(1):60-66. doi: 10.34763/devperiodmed.20192301.6066. PMID: 30954983Free PMC Article
Management of Plantar Keratodermas(Lessons from Pachyonychia Congenita).
Porter RM, Bravo AA, Smith FJD
J Am Podiatr Med Assoc 2017 Sep;107(5):428-435. doi: 10.7547/16-043. PMID: 29077501
Phenotype and genotype in 103 patients with tricho-rhino-phalangeal syndrome.
Maas SM, Shaw AC, Bikker H, Lüdecke HJ, van der Tuin K, Badura-Stronka M, Belligni E, Biamino E, Bonati MT, Carvalho DR, Cobben J, de Man SA, Den Hollander NS, Di Donato N, Garavelli L, Grønborg S, Herkert JC, Hoogeboom AJ, Jamsheer A, Latos-Bielenska A, Maat-Kievit A, Magnani C, Marcelis C, Mathijssen IB, Nielsen M, Otten E, Ousager LB, Pilch J, Plomp A, Poke G, Poluha A, Posmyk R, Rieubland C, Silengo M, Simon M, Steichen E, Stumpel C, Szakszon K, Polonkai E, van den Ende J, van der Steen A, van Essen T, van Haeringen A, van Hagen JM, Verheij JB, Mannens MM, Hennekam RC
Eur J Med Genet 2015 May;58(5):279-92. Epub 2015 Mar 16 doi: 10.1016/j.ejmg.2015.03.002. PMID: 25792522

Recent clinical studies

Etiology

Clinical and Molecular Genetic Analysis of Cases with Ectodermal Dysplasia.
Yapijakis C, Douka A, Gintoni I, Agiannitopoulos K, Vlachakis D, Chrousos GP
Adv Exp Med Biol 2023;1423:181-186. doi: 10.1007/978-3-031-31978-5_15. PMID: 37525042
Fosravuconazole to treat severe onychomycosis in the elderly.
Noguchi H, Matsumoto T, Kimura U, Hiruma M, Kano R, Kubo M, Fukushima S, Ihn H
J Dermatol 2021 Feb;48(2):228-231. Epub 2020 Oct 25 doi: 10.1111/1346-8138.15651. PMID: 33099769
Management of Plantar Keratodermas(Lessons from Pachyonychia Congenita).
Porter RM, Bravo AA, Smith FJD
J Am Podiatr Med Assoc 2017 Sep;107(5):428-435. doi: 10.7547/16-043. PMID: 29077501
Silicon: the health benefits of a metalloid.
Martin KR
Met Ions Life Sci 2013;13:451-73. doi: 10.1007/978-94-007-7500-8_14. PMID: 24470100
Internal fixation of nonunions.
Rodriguez-Merchan EC, Gomez-Castresana F
Clin Orthop Relat Res 2004 Feb;(419):13-20. doi: 10.1097/00003086-200402000-00004. PMID: 15021126

Diagnosis

Clinical and Molecular Genetic Analysis of Cases with Ectodermal Dysplasia.
Yapijakis C, Douka A, Gintoni I, Agiannitopoulos K, Vlachakis D, Chrousos GP
Adv Exp Med Biol 2023;1423:181-186. doi: 10.1007/978-3-031-31978-5_15. PMID: 37525042
Management of Plantar Keratodermas(Lessons from Pachyonychia Congenita).
Porter RM, Bravo AA, Smith FJD
J Am Podiatr Med Assoc 2017 Sep;107(5):428-435. doi: 10.7547/16-043. PMID: 29077501
Oculodentodigital dysplasia.
Doshi DC, Limdi PK, Parekh NV, Gohil NR
Indian J Ophthalmol 2016 Mar;64(3):227-30. doi: 10.4103/0301-4738.180191. PMID: 27146935Free PMC Article
Familial koilonychia.
Gao XH, Li X, Zhao Y, Wang Y, Chen HD
Int J Dermatol 2001 Apr;40(4):290-1. doi: 10.1046/j.1365-4362.2001.01212-5.x. PMID: 11454091
Olmsted syndrome.
Perry HO, Su WP
Semin Dermatol 1995 Jun;14(2):145-51. doi: 10.1016/s1085-5629(05)80011-2. PMID: 7640195

Therapy

Fosravuconazole to treat severe onychomycosis in the elderly.
Noguchi H, Matsumoto T, Kimura U, Hiruma M, Kano R, Kubo M, Fukushima S, Ihn H
J Dermatol 2021 Feb;48(2):228-231. Epub 2020 Oct 25 doi: 10.1111/1346-8138.15651. PMID: 33099769
Comparison of pigmentary side effects of taxanes and anthracyclines: an onychoscopic evaluation.
Yorulmaz A, Dogan M, Artuz F, Zengin N
Cutan Ocul Toxicol 2017 Jun;36(2):135-139. Epub 2016 May 10 doi: 10.3109/15569527.2016.1173698. PMID: 27086693
Urea: A Clinically Oriented Overview from Bench to Bedside.
Friedman AJ, von Grote EC, Meckfessel MH
J Drugs Dermatol 2016 May 1;15(5):633-9. PMID: 27168272
Internal fixation of nonunions.
Rodriguez-Merchan EC, Gomez-Castresana F
Clin Orthop Relat Res 2004 Feb;(419):13-20. doi: 10.1097/00003086-200402000-00004. PMID: 15021126
Slipped capital femoral epiphysis associated with radiation therapy.
Loder RT, Hensinger RN, Alburger PD, Aronsson DD, Beaty JH, Roy DR, Stanton RP, Turker R
J Pediatr Orthop 1998 Sep-Oct;18(5):630-6. doi: 10.1097/00004694-199809000-00015. PMID: 9746415

Prognosis

Management of Plantar Keratodermas(Lessons from Pachyonychia Congenita).
Porter RM, Bravo AA, Smith FJD
J Am Podiatr Med Assoc 2017 Sep;107(5):428-435. doi: 10.7547/16-043. PMID: 29077501
Dermatologic findings of focal dermal hypoplasia (Goltz syndrome).
Bree AF, Grange DK, Hicks MJ, Goltz RW
Am J Med Genet C Semin Med Genet 2016 Mar;172C(1):44-51. Epub 2016 Feb 9 doi: 10.1002/ajmg.c.31472. PMID: 26858134
Revision with plates of humeral nonunions secondary to failed intramedullary nailing.
Allende C, Paz A, Altube G, Boccolini H, Malvarez A, Allende B
Int Orthop 2014 Apr;38(4):899-903. Epub 2013 Nov 21 doi: 10.1007/s00264-013-2180-2. PMID: 24258153Free PMC Article
Laurin-Sandrow syndrome: review and redefinition.
Mariño-Enríquez A, Lapunzina P, Omeñaca F, Morales C, Rodríguez JI
Am J Med Genet A 2008 Oct 1;146A(19):2557-65. doi: 10.1002/ajmg.a.32393. PMID: 18792985
The treatment of fractures of the proximal humerus.
Lentz W, Meuser P
Arch Orthop Trauma Surg (1978) 1980;96(4):283-5. doi: 10.1007/BF00432866. PMID: 7396673

Clinical prediction guides

Management of Plantar Keratodermas(Lessons from Pachyonychia Congenita).
Porter RM, Bravo AA, Smith FJD
J Am Podiatr Med Assoc 2017 Sep;107(5):428-435. doi: 10.7547/16-043. PMID: 29077501
Revision with plates of humeral nonunions secondary to failed intramedullary nailing.
Allende C, Paz A, Altube G, Boccolini H, Malvarez A, Allende B
Int Orthop 2014 Apr;38(4):899-903. Epub 2013 Nov 21 doi: 10.1007/s00264-013-2180-2. PMID: 24258153Free PMC Article
Late-onset Rothmund-Thomson syndrome.
Kumar P, Sharma PK, Gautam RK, Jain RK, Kar HK
Int J Dermatol 2007 May;46(5):492-3. doi: 10.1111/j.1365-4632.2007.03248.x. PMID: 17472679
Use and abuse of flexible intramedullary nailing in children and adolescents.
Lascombes P, Haumont T, Journeau P
J Pediatr Orthop 2006 Nov-Dec;26(6):827-34. doi: 10.1097/01.bpo.0000235397.64783.d6. PMID: 17065959
Olmsted syndrome.
Perry HO, Su WP
Semin Dermatol 1995 Jun;14(2):145-51. doi: 10.1016/s1085-5629(05)80011-2. PMID: 7640195

Recent systematic reviews

Lateral femoral wall thickness in trochanteric hip fractures: a systematic review.
Selim A, Ponugoti N, Daoub A, Johnson-Lynn S, Rhee SJ
Hip Int 2024 Sep;34(5):668-676. Epub 2024 Aug 26 doi: 10.1177/11207000241267708. PMID: 39183629
Which fixation produces the best outcome for distal femoral fractures? Meta-analysis and systematic review of retrograde nailing versus distal femoral plating in 2432 patients and 33 studies.
Kim HS, Yoon YC, Lee SJ, Sim JA
Eur J Trauma Emerg Surg 2024 Jun;50(3):763-780. Epub 2023 Dec 7 doi: 10.1007/s00068-023-02393-8. PMID: 38057606

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