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Carcinoid heart disease

MedGen UID:
762
Concept ID:
C0007093
Disease or Syndrome
Synonyms: Carcinoid Heart Disease; Carcinoid Heart Diseases; Heart Disease, Carcinoid; Heart Diseases, Carcinoid
SNOMED CT: Carcinoid heart disease (36222008)
 
Monarch Initiative: MONDO:0043529

Definition

Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarcinoid heart disease

Professional guidelines

PubMed

Hack M, Bhamidipati CM
Curr Probl Cancer 2024 Oct;52:101128. Epub 2024 Aug 21 doi: 10.1016/j.currproblcancer.2024.101128. PMID: 39173543
Jin C, Sharma AN, Thevakumar B, Majid M, Al Chalaby S, Takahashi N, Tanious A, Arockiam AD, Beri N, Amsterdam EA
Cardiology 2021;146(1):65-73. Epub 2020 Oct 16 doi: 10.1159/000507847. PMID: 33070143
Luis SA, Pellikka PA
Best Pract Res Clin Endocrinol Metab 2016 Jan;30(1):149-58. Epub 2015 Oct 9 doi: 10.1016/j.beem.2015.09.005. PMID: 26971851

Recent clinical studies

Etiology

Mattig I, Franke MR, Pschowski R, Brand A, Stangl K, Knebel F, Dreger H
Cardiovasc Ultrasound 2023 Sep 26;21(1):18. doi: 10.1186/s12947-023-00316-6. PMID: 37752548Free PMC Article
Das S, Stockton SS, Hassan SA
Oncologist 2023 Jul 5;28(7):575-583. doi: 10.1093/oncolo/oyad126. PMID: 37209415Free PMC Article
Delhomme C, Walter T, Arangalage D, Suc G, Hentic O, Cachier A, Alkhoder S, François L, Lombard-Bohas C, Iung B, Ruszniewski P, de Mestier L
J Neuroendocrinol 2023 Apr;35(4):e13262. Epub 2023 Apr 2 doi: 10.1111/jne.13262. PMID: 37005217
Bonou M, Kapelios CJ, Kaltsas G, Perreas K, Toutouzas K, Barbetseas J
Cardiology 2017;136(4):243-251. Epub 2016 Nov 11 doi: 10.1159/000450938. PMID: 27832643
Yuan SM
Braz J Cardiovasc Surg 2016 Sep-Oct;31(5):400-405. doi: 10.5935/1678-9741.20160079. PMID: 27982350Free PMC Article

Diagnosis

Grozinsky-Glasberg S, Davar J, Hofland J, Dobson R, Prasad V, Pascher A, Denecke T, Tesselaar MET, Panzuto F, Albåge A, Connolly HM, Obadia JF, Riechelmann R, Toumpanakis C
J Neuroendocrinol 2022 Jul;34(7):e13146. Epub 2022 May 25 doi: 10.1111/jne.13146. PMID: 35613326Free PMC Article
Dangol RK, Henricus MM
N Engl J Med 2022 May 26;386(21):e56. Epub 2022 May 21 doi: 10.1056/NEJMicm2118205. PMID: 35593702
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Hassan SA, Banchs J, Iliescu C, Dasari A, Lopez-Mattei J, Yusuf SW
Heart 2017 Oct;103(19):1488-1495. Epub 2017 Jun 8 doi: 10.1136/heartjnl-2017-311261. PMID: 28596302
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Therapy

Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Palaniswamy C, Frishman WH, Aronow WS
Cardiol Rev 2012 Jul-Aug;20(4):167-76. doi: 10.1097/CRD.0b013e31824c866e. PMID: 22314145
Gustafsson BI, Hauso O, Drozdov I, Kidd M, Modlin IM
Int J Cardiol 2008 Oct 13;129(3):318-24. Epub 2008 Jun 20 doi: 10.1016/j.ijcard.2008.02.019. PMID: 18571250
Bernheim AM, Connolly HM, Hobday TJ, Abel MD, Pellikka PA
Prog Cardiovasc Dis 2007 May-Jun;49(6):439-51. doi: 10.1016/j.pcad.2006.12.002. PMID: 17498524

Prognosis

Laskaratos FM, Davar J, Toumpanakis C
Curr Oncol Rep 2021 Mar 16;23(4):48. doi: 10.1007/s11912-021-01031-z. PMID: 33725214
Ito T, Lee L, Jensen RT
Curr Opin Endocrinol Diabetes Obes 2018 Feb;25(1):22-35. doi: 10.1097/MED.0000000000000376. PMID: 29120923Free PMC Article
Hassan SA, Banchs J, Iliescu C, Dasari A, Lopez-Mattei J, Yusuf SW
Heart 2017 Oct;103(19):1488-1495. Epub 2017 Jun 8 doi: 10.1136/heartjnl-2017-311261. PMID: 28596302
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Palaniswamy C, Frishman WH, Aronow WS
Cardiol Rev 2012 Jul-Aug;20(4):167-76. doi: 10.1097/CRD.0b013e31824c866e. PMID: 22314145

Clinical prediction guides

Mattig I, Franke MR, Pschowski R, Brand A, Stangl K, Knebel F, Dreger H
Cardiovasc Ultrasound 2023 Sep 26;21(1):18. doi: 10.1186/s12947-023-00316-6. PMID: 37752548Free PMC Article
Cope J, Maclean R, Hota S, Ramage JK, Mullholland N, Clement D, Brown S, Piper S, MaCarthy P, Wendler O, Srirajaskanthan R
Nucl Med Commun 2023 Nov 1;44(11):968-976. Epub 2023 Sep 4 doi: 10.1097/MNM.0000000000001749. PMID: 37661777
Hofland J, Lamarca A, Steeds R, Toumpanakis C, Srirajaskanthan R, Riechelmann R, Panzuto F, Frilling A, Denecke T, Christ E, Grozinsky-Glasberg S, Davar J; ENETS Carcinoid Heart Disease Task Force
J Neuroendocrinol 2022 Mar;34(3):e13060. Epub 2021 Nov 26 doi: 10.1111/jne.13060. PMID: 34825753Free PMC Article
Baron T, Bergsten J, Albåge A, Lundin L, Sörensen J, Öberg K, Flachskampf FA
JACC Cardiovasc Imaging 2021 Nov;14(11):2240-2253. Epub 2021 Apr 14 doi: 10.1016/j.jcmg.2020.12.030. PMID: 33865761
Bernheim AM, Connolly HM, Hobday TJ, Abel MD, Pellikka PA
Prog Cardiovasc Dis 2007 May-Jun;49(6):439-51. doi: 10.1016/j.pcad.2006.12.002. PMID: 17498524

Recent systematic reviews

O'Malley TJ, Jimenez DC, Saxena A, Weber MP, Samuels LE, Entwistle JW, Guy TS, Massey HT, Morris RJ, Tchantchaleishvili V
Surgery 2021 Aug;170(2):390-396. Epub 2021 Mar 31 doi: 10.1016/j.surg.2021.02.054. PMID: 33812754
Buchanan-Hughes A, Pashley A, Feuilly M, Marteau F, Pritchard DM, Singh S
Neuroendocrinology 2021;111(1-2):1-15. Epub 2020 Feb 25 doi: 10.1159/000506744. PMID: 32097914
Joish VN, Shah S, Tierce JC, Patel D, McKee C, Lapuerta P, Zacks J
Future Oncol 2019 Apr;15(12):1397-1406. Epub 2019 Feb 8 doi: 10.2217/fon-2018-0960. PMID: 30734573
Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366
Seymour N, Sawh SC
Can J Anaesth 2013 May;60(5):492-9. Epub 2013 Jan 18 doi: 10.1007/s12630-012-9879-1. PMID: 23328959

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