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Paranasal Sinus Polyp

MedGen UID:
75536
•Concept ID:
C0264231
•
Neoplastic Process
Synonyms: Accessory Sinus Polyp; Nasal sinus polyp; Polyp of accessory sinus; Polyp of Accessory Sinus; Polyp of nasal sinus; Polyp of Paranasal Sinus; Polyp of the Accessory Sinus; Polyp of the Paranasal Sinus
SNOMED CT: Nasal sinus polyp (32307003); Polyp of nasal sinus (32307003); Polyp of accessory sinus (32307003)

Definition

A polyp that arises from the paranasal sinus mucosa. Causes include allergic rhinitis, chronic sinusitis, and cystic fibrosis. It is characterized by the presence of edematous tissue infiltrated by inflammatory cells, including eosinophils. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParanasal Sinus Polyp

Professional guidelines

PubMed

Updated epithelial barrier dysfunction in chronic rhinosinusitis: Targeting pathophysiology and treatment response of tight junctions.
Huang ZQ, Liu J, Sun LY, Ong HH, Ye J, Xu Y, Wang DY
Allergy 2024 May;79(5):1146-1165. Epub 2024 Feb 19 doi: 10.1111/all.16064. PMID: 38372149
Current insight into treatment of chronic rhinosinusitis: Phenotypes, endotypes, and implications for targeted therapeutics.
Chapurin N, Wu J, Labby AB, Chandra RK, Chowdhury NI, Turner JH
J Allergy Clin Immunol 2022 Jul;150(1):22-32. Epub 2022 Apr 22 doi: 10.1016/j.jaci.2022.04.013. PMID: 35469844Free PMC Article
Clinical practice guideline (update): adult sinusitis.
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PMID: 25832968

Recent clinical studies

Etiology

Yardstick for the medical management of chronic rhinosinusitis.
Borish L, Baroody FM, Kim MS, Lieberman JA, Peters A, Stevens WW, Bernstein JA
Ann Allergy Asthma Immunol 2022 Feb;128(2):118-128. Epub 2021 Oct 20 doi: 10.1016/j.anai.2021.10.014. PMID: 34687874
Pediatric Versus Adult Chronic Rhinosinusitis.
Snidvongs K, Sangubol M, Poachanukoon O
Curr Allergy Asthma Rep 2020 Jun 6;20(8):29. doi: 10.1007/s11882-020-00924-6. PMID: 32506185
Nasal polyps and rhinosinusitis.
Kwah JH, Peters AT
Allergy Asthma Proc 2019 Nov 1;40(6):380-384. doi: 10.2500/aap.2019.40.4252. PMID: 31690375
Nasal Cavity and Paranasal Sinus Diseases Affecting Orbit.
Samil KS, Yasar C, Ercan A, Hanifi B, Hilal K
J Craniofac Surg 2015 Jun;26(4):e348-51. doi: 10.1097/SCS.0000000000001827. PMID: 26080260
Chapter 6: Nasal polyps.
Settipane RA, Peters AT, Chiu AG
Am J Rhinol Allergy 2013 May-Jun;27 Suppl 1:S20-5. doi: 10.2500/ajra.2013.27.3926. PMID: 23711034

Diagnosis

Chronic Rhinosinusitis.
Keating MK, Phillips JC, Phillips J
Am Fam Physician 2023 Oct;108(4):370-377. PMID: 37843944
Sphenochoanal polyps.
Bayazid L, Josephson GD
BMJ Case Rep 2023 May 2;16(5) doi: 10.1136/bcr-2022-251182. PMID: 37130643Free PMC Article
Pheno-Endotyping Antrochoanal Nasal Polyposis.
Garaycochea O, Van Strahlen CR, Alobid I, Mullol J
Curr Allergy Asthma Rep 2023 Mar;23(3):165-180. Epub 2023 Feb 11 doi: 10.1007/s11882-023-01066-1. PMID: 36773125
Chronic nasal dysfunction.
Jankowski R, Nguyen DT, Russel A, Toussaint B, Gallet P, Rumeau C
Eur Ann Otorhinolaryngol Head Neck Dis 2018 Feb;135(1):41-49. Epub 2017 Dec 14 doi: 10.1016/j.anorl.2017.11.006. PMID: 29249643
EDITORIAL.
Kennedy DW
Int Forum Allergy Rhinol 2016 Jun;6(6):555-6. doi: 10.1002/alr.21806. PMID: 27342395

Therapy

Chronic rhinosinusitis with nasal polyps (CRSwNP) treated with omalizumab, dupilumab, or mepolizumab: A systematic review of the current knowledge towards an attempt to compare agents' efficacy.
Papacharalampous GX, Constantinidis J, Fotiadis G, Zhang N, Bachert C, Katotomichelakis M
Int Forum Allergy Rhinol 2024 Jan;14(1):96-109. Epub 2023 Jul 18 doi: 10.1002/alr.23234. PMID: 37394893
Chronic Rhinosinusitis.
Keating MK, Phillips JC, Phillips J
Am Fam Physician 2023 Oct;108(4):370-377. PMID: 37843944
Sphenochoanal polyps.
Bayazid L, Josephson GD
BMJ Case Rep 2023 May 2;16(5) doi: 10.1136/bcr-2022-251182. PMID: 37130643Free PMC Article
Nasal polyps and rhinosinusitis.
Kwah JH, Peters AT
Allergy Asthma Proc 2019 Nov 1;40(6):380-384. doi: 10.2500/aap.2019.40.4252. PMID: 31690375
Clinical practice guideline (update): adult sinusitis.
Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, Brook I, Ashok Kumar K, Kramper M, Orlandi RR, Palmer JN, Patel ZM, Peters A, Walsh SA, Corrigan MD
Otolaryngol Head Neck Surg 2015 Apr;152(2 Suppl):S1-S39. doi: 10.1177/0194599815572097. PMID: 25832968

Prognosis

Updated epithelial barrier dysfunction in chronic rhinosinusitis: Targeting pathophysiology and treatment response of tight junctions.
Huang ZQ, Liu J, Sun LY, Ong HH, Ye J, Xu Y, Wang DY
Allergy 2024 May;79(5):1146-1165. Epub 2024 Feb 19 doi: 10.1111/all.16064. PMID: 38372149
Update on allergic fungal rhinosinusitis.
Chua AJ, Jafar A, Luong AU
Ann Allergy Asthma Immunol 2023 Sep;131(3):300-306. Epub 2023 Feb 26 doi: 10.1016/j.anai.2023.02.018. PMID: 36854353
Nasal polyps and rhinosinusitis.
Kwah JH, Peters AT
Allergy Asthma Proc 2019 Nov 1;40(6):380-384. doi: 10.2500/aap.2019.40.4252. PMID: 31690375
Chapter 7: Nasal polyps.
Georgy MS, Peters AT
Allergy Asthma Proc 2012 May-Jun;33 Suppl 1:22-23. doi: 10.2500/aap.2012.33.3537. PMID: 22794680
Mycotic sinusitis.
Eloy P, Bertrand B, Rombeaux P, Delos M, Trigaux JP
Acta Otorhinolaryngol Belg 1997;51(4):339-52. PMID: 9444380

Clinical prediction guides

The current findings in eosinophilic chronic rhinosinusitis.
Tsuda T, Suzuki M, Kato Y, Kidoguchi M, Kumai T, Fujieda S, Sakashita M
Auris Nasus Larynx 2024 Feb;51(1):51-60. Epub 2023 Aug 11 doi: 10.1016/j.anl.2023.08.002. PMID: 37574421
Isolated Sphenoid Sinus Disease in Children.
Kotowski M, Szydlowski J
Int J Environ Res Public Health 2023 Jan 2;20(1) doi: 10.3390/ijerph20010847. PMID: 36613169Free PMC Article
Exhalation Delivery Systems for Application of Intranasal Corticosteroids.
Kovacs AJ, Adappa ND, Kuan EC
Ear Nose Throat J 2021 Jun;100(5):309-313. Epub 2020 Dec 11 doi: 10.1177/0145561320980194. PMID: 33305974
Precision Medicine in Chronic Rhinosinusitis with Nasal Polyps.
Avdeeva K, Fokkens W
Curr Allergy Asthma Rep 2018 Mar 24;18(4):25. doi: 10.1007/s11882-018-0776-8. PMID: 29574586Free PMC Article
Chapter 7: Nasal polyps.
Georgy MS, Peters AT
Allergy Asthma Proc 2012 May-Jun;33 Suppl 1:22-23. doi: 10.2500/aap.2012.33.3537. PMID: 22794680

Recent systematic reviews

Chronic rhinosinusitis with nasal polyps (CRSwNP) treated with omalizumab, dupilumab, or mepolizumab: A systematic review of the current knowledge towards an attempt to compare agents' efficacy.
Papacharalampous GX, Constantinidis J, Fotiadis G, Zhang N, Bachert C, Katotomichelakis M
Int Forum Allergy Rhinol 2024 Jan;14(1):96-109. Epub 2023 Jul 18 doi: 10.1002/alr.23234. PMID: 37394893
Surgery for nasal polyposis in cystic fibrosis.
Almeida PRL, Person OC, Puga ME, Atallah ÁN, Trevisani VF
Cochrane Database Syst Rev 2023 Dec 8;12(12):CD014084. doi: 10.1002/14651858.CD014084.pub2. PMID: 38063253Free PMC Article
Sphenochoanal polyps in children - a systematic review (1995‒2021).
Tywoniuk K, Haber K, Mierzwiński J
Braz J Otorhinolaryngol 2022 Nov-Dec;88 Suppl 5(Suppl 5):S179-S187. Epub 2022 Mar 21 doi: 10.1016/j.bjorl.2022.02.006. PMID: 36127268Free PMC Article
Isolated sphenoid sinus opacifications: a systematic review and meta-analysis.
Moss WJ, Finegersh A, Jafari A, Panuganti B, Coffey CS, DeConde A, Husseman J
Int Forum Allergy Rhinol 2017 Dec;7(12):1201-1206. Epub 2017 Oct 12 doi: 10.1002/alr.22023. PMID: 29024448
Systematic review and meta-analysis of total intravenous anesthesia and endoscopic sinus surgery.
DeConde AS, Thompson CF, Wu EC, Suh JD
Int Forum Allergy Rhinol 2013 Oct;3(10):848-54. Epub 2013 Jul 10 doi: 10.1002/alr.21196. PMID: 23843351

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